The Controversial Role of TGF-β in Neovascular Age-Related Macular Degeneration Pathogenesis

TGF-β concentrations and activity are down-regulated in the aqueous humor of patients with neovascular age-related macular degeneration

(2018) Gian Marco Tosi et al.   Scientific Reports

Aqueous Humor Levels of Vasoactive Molecules Correlate with Vitreous Levels and Macular Edema in Central Retinal Vein Occlusion

(2018) Hidetaka Noma et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Topical Ocular Delivery of TGF-β1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases

(2017) Chiara Platania et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MIR-27a regulates the TGF-β signaling pathway by targeting SMAD2 and SMAD4 in lung cancer

(2017) Dong-Kyu Chae et al.   MOLECULAR CARCINOGENESIS

Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility

(2017) Erine H. Budi et al.   TRENDS IN CELL BIOLOGY

TGF-β participates choroid neovascularization through Smad2/3-VEGF/TNF-α signaling in mice with Laser-induced wet age-related macular degeneration

(2017) Xiaolei Wang et al.   Scientific Reports

Retinal and Circulating miRNAs in Age-Related Macular Degeneration: An In vivo Animal and Human Study

(2017) Giovanni L. Romano et al.   Frontiers in Pharmacology

Aqueous humour concentrations of TGF-β, PLGF and FGF-1 and total retinal blood flow in patients with early non-proliferative diabetic retinopathy

(2016) Lee-Anne Khuu et al.   ACTA OPHTHALMOLOGICA

Retinal Angiogenesis Effects of TGF-β1 and Paracrine Factors Secreted from Human Placental Stem Cells in Response to a Pathological Environment

(2016) Kyung-Sul Kim et al.   CELL TRANSPLANTATION

TGF-β1 prevents rat retinal insult induced by amyloid-β (1–42) oligomers

(2016) Vincenzo Fisichella et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular mechanisms of subretinal fibrosis in age-related macular degeneration

(2016) Keijiro Ishikawa et al.   EXPERIMENTAL EYE RESEARCH

Epithelial–mesenchymal transition of the retinal pigment epithelium causes choriocapillaris atrophy

(2016) Andreas Ohlmann et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Inhibition of development of laser-induced choroidal neovascularization with suppression of infiltration of macrophages in Smad3-null mice

(2016) Hiroki Iwanishi et al.   LABORATORY INVESTIGATION

The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis

(2016) Ruoshuang Zhang et al.   PLoS One

Transcriptional Control by the SMADs

(2016) Caroline S. Hill   Cold Spring Harbor Perspectives in Biology

Structural Biology and Evolution of the TGF-β Family

(2016) Andrew P. Hinck et al.   Cold Spring Harbor Perspectives in Biology

Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review

(2016) Xiaodong Sun et al.   Drug Design Development and Therapy

BMP9/ALK1 inhibits neovascularization in mouse models of age-related macular degeneration

(2016) Kalonji Ntumba et al.   Oncotarget

Targeting the cAMP and Transforming Growth Factor-β Pathway Increases Proliferation to Promote Re-Epithelialization of Human Stem Cell-Derived Retinal Pigment Epithelium

(2016) Parul Choudhary et al.   Stem Cells Translational Medicine

Two Bioactive Molecular Weight Fractions of a Conditioned Medium Enhance RPE Cell Survival on Age-Related Macular Degeneration and Aged Bruch's Membrane

(2016) Ilene K. Sugino et al.   Translational Vision Science & Technology

Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor β signalling and angiogenesis

(2015) Khader Awwad et al.   CARDIOVASCULAR RESEARCH

TGF-β2 secretion from RPE decreases with polarization and becomes apically oriented

(2015) Louis Hirsch et al.   CYTOKINE

Transforming Growth Factor Beta Family: Insight into the Role of Growth Factors in Regulation of Fracture Healing Biology and Potential Clinical Applications

(2015) Łukasz A. Poniatowski et al.   MEDIATORS OF INFLAMMATION

TGF-β1 Induced Transdifferentiation of RPE Cells is Mediated by TAK1

(2015) Zeev Dvashi et al.   PLoS One

Biological Activity Differences between TGF-β1 and TGF-β3 Correlate with Differences in the Rigidity and Arrangement of Their Component Monomers

(2014) Tao Huang et al.   BIOCHEMISTRY

Müller glial cells inhibit proliferation of retinal endothelial cells via TGF-β2 and Smad signaling

(2014) Yousef Yafai et al.   GLIA

The role of BMPs in endothelial cell function and dysfunction

(2014) Laura A. Dyer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Identification of Chemokines and Growth Factors in Proliferative Diabetic Retinopathy Vitreous

(2014) Ying Dai et al.   Biomed Research International

TGF-β2 promotes RPE cell invasion into a collagen gel by mediating urokinase-type plasminogen activator (uPA) expression

(2013) Koji Sugioka et al.   EXPERIMENTAL EYE RESEARCH

TGF-  Signaling Protects Retinal Neurons from Programmed Cell Death during the Development of the Mammalian Eye

(2013) B. M. Braunger et al.   JOURNAL OF NEUROSCIENCE

LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling

(2013) Xiaomeng Wang et al.   NATURE

Seven new loci associated with age-related macular degeneration

(2013) Lars G Fritsche et al.   NATURE GENETICS

Laser-induced choroidal neovascularization model to study age-related macular degeneration in mice

(2013) Vincent Lambert et al.   Nature Protocols

Risk of Scar in the Comparison of Age-related Macular Degeneration Treatments Trials

(2013) Ebenezer Daniel et al.   OPHTHALMOLOGY

Transforming Growth Factor-Beta Inhibition Reduces Progression of Early Choroidal Neovascularization Lesions in Rats: P17 and P144 Peptides

(2013) Javier Zarranz-Ventura et al.   PLoS One

Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9

(2012) Jing Xu et al.   ANGIOGENESIS

Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions

(2012) F. Itoh et al.   BLOOD

Vascular Injury Triggers Krüppel-Like Factor 6 Mobilization and Cooperation With Specificity Protein 1 to Promote Endothelial Activation Through Upregulation of the Activin Receptor-Like Kinase 1 Gene

(2012) Eva M. Garrido-Martín et al.   CIRCULATION RESEARCH

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

Animal models of age related macular degeneration

(2012) Mark E. Pennesi et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of VEGF expression in human retinal cells by cytokines: Implications for the role of inflammation in age-related macular degeneration

(2011) Chandrasekharam N. Nagineni et al.   JOURNAL OF CELLULAR PHYSIOLOGY

TGF-β signaling is required for maintenance of retinal ganglion cell differentiation and survival

(2011) T.E. Walshe et al.   NEUROSCIENCE

Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis

(2011) Quan-Ming Zou   ONCOLOGY REPORTS

Snail Involves in the Transforming Growth Factor β1-Mediated Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells

(2011) Hui Li et al.   PLoS One

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis

(2010) Sara I. Cunha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β and microvessel homeostasis

(2010) Tony E. Walshe   MICROVASCULAR RESEARCH

ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration

(2009) Bridgette N. Ray et al.   CARCINOGENESIS

TGF-β Is Required for Vascular Barrier Function, Endothelial Survival and Homeostasis of the Adult Microvasculature

(2009) Tony E. Walshe et al.   PLoS One

L- and S-endoglin differentially modulate TGF 1 signaling mediated by ALK1 and ALK5 in L6E9 myoblasts

(2008) S. Velasco et al.   JOURNAL OF CELL SCIENCE

Role of TGF-  in proliferative vitreoretinal diseases and ROCK as a therapeutic target

(2008) T. Kita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA