Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms19124106
Keywords
spaceflight; microgravity; gene expression; liver; kidney; gene array; gene expression; transcriptome; apoptosis; Cdkn1a; CYP4A1
Funding
- NASA [NNX13AN32G, NNX12AM93G, NNX10AP01G]
- Durham Veterans Affairs Medical Center
- Veterans Health Administration Office of Research and Development in the Department of Veterans Affairs
- NASA [467478, NNX13AN32G, 125021, NNX10AP01G] Funding Source: Federal RePORTER
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Understanding genome wide, tissue-specific, and spaceflight-induced changes in gene expression is critical to develop effective countermeasures. Transcriptome analysis has been performed on diverse tissues harvested from animals flown in space, but not the kidney. We determined the genome wide gene expression using a gene array analysis of kidney and liver tissue from mice flown in space for 12 days versus ground based control animals. By comparing the transcriptome of liver and kidney from animals flown in space versus ground control animals, we tested a unique hypothesis: Are there common gene expression pathways activated in multiple tissue types in response to spaceflight stimuli? Although there were tissue-specific changes, both liver and kidney overexpressed genes in the same four areas: (a) cellular responses to peptides, hormones, and nitrogen/organonitrogen compounds; (b) apoptosis and cell death; (c) fat cell differentiation and (d) negative regulation of protein kinase.
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