Case report: relevance of metabolite identification to detect new synthetic opioid intoxications illustrated by U-47700

In vitro Characterization of NPS Metabolites Produced by Human Liver Microsomes and the HepaRG Cell Line Using Liquid Chromatographyhigh Resolution Mass Spectrometry (LC-HRMS) Analysis: Application to Furanyl Fentanyl

(2018) Camille Richeval et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Different in vitro and in vivo tools for elucidating the human metabolism of alpha-cathinone-derived drugs of abuse

(2018) Sascha K. Manier et al.   Drug Testing and Analysis

Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

(2018) Michael H. Baumann et al.   NEUROPHARMACOLOGY

Postmortem concentration distribution in fatal cases involving the synthetic opioid U-47700

(2017) Marek Dziadosz et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Misuse of Novel Synthetic Opioids

(2017) Matthew P. Prekupec et al.   Journal of Addiction Medicine

U-47700: A Not So New Opioid

(2017) Timothy P Rohrig et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Toxicokinetics of the Synthetic Cathinone α-Pyrrolidinohexanophenone

(2017) Yuji Fujita et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Confirmation of Carfentanil, U-47700 and Other Synthetic Opioids in a Human Performance Case by LC–MS-MS

(2017) Joshua Seither et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

U-47700: A Clinical Review of the Literature

(2017) Kerry Anne Rambaran et al.   JOURNAL OF EMERGENCY MEDICINE

Opioid analgesics-related pharmacokinetic drug interactions: from the perspectives of evidence based on randomized controlled trials and clinical risk management

(2017) Xiu-qin Feng et al.   Journal of Pain Research

Updating the list of known opioids through identification and characterization of the new opioid derivative 3,4-dichloro-N-(2-(diethylamino)cyclohexyl)-N-methylbenzamide (U-49900)

(2017) D. Fabregat-Safont et al.   Scientific Reports

Metabolism of Carfentanil, an Ultra-Potent Opioid, in Human Liver Microsomes and Human Hepatocytes by High-Resolution Mass Spectrometry

(2016) Michael G. Feasel et al.   AAPS Journal

A case of U-47700 overdose with laboratory confirmation and metabolite identification

(2016) Matthew J. Jones et al.   CLINICAL TOXICOLOGY

Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS)

(2016) Andrea E. Steuer et al.   Drug Testing and Analysis

The first reported fatality associated with the synthetic opioid 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700) and implications for forensic analysis

(2016) Simon P. Elliott et al.   Drug Testing and Analysis

A case of acute intoxication due to combined use of fentanyl and 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide (U-47700)

(2016) Vera Coopman et al.   FORENSIC SCIENCE INTERNATIONAL

Comparing fatal cases involving U-47700

(2016) Xiulu Ruan et al.   Forensic Science Medicine and Pathology

U-47700. An old opioid becomes a recent danger

(2016) Panagiota Nikolaou et al.   Forensic Toxicology

Analysis of U-47700, a Novel Synthetic Opioid, in Human Urine by LC–MS–MS and LC–QToF

(2016) Steven W. Fleming et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Analysis of Novel Synthetic Opioids U-47700, U-50488 and Furanyl Fentanyl by LC–MS/MS in Postmortem Casework

(2016) Amanda L. A. Mohr et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Effects of Paroxetine, a CYP2D6 Inhibitor, on the Pharmacokinetic Properties of Hydrocodone After Coadministration With a Single-entity, Once-daily, Extended-release Hydrocodone Tablet

(2015) Ram P. Kapil et al.   CLINICAL THERAPEUTICS

Screening approach by ultra-high performance liquid chromatography–tandem mass spectrometry for the blood quantification of thirty-four toxic principles of plant origin. Application to forensic toxicology

(2015) Jérémy Carlier et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Identification of phase I and II metabolites of the new designer drugα-pyrrolidinohexiophenone (α-PHP) in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)

(2015) Michael Paul et al.   JOURNAL OF MASS SPECTROMETRY

LC-QTOF-MS as a superior strategy to immunoassay for the comprehensive analysis of synthetic cannabinoids in urine

(2014) Robert Kronstrand et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products

(2014) Nahoko Uchiyama et al.   Forensic Toxicology

Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)

(2014) Julie A. Marusich et al.   NEUROPHARMACOLOGY

Drug concentrations in post-mortem femoral blood compared with therapeutic concentrations in plasma

(2013) Terhi Launiainen et al.   Drug Testing and Analysis

Fatal Case of a 27-Year-Old Male After Taking Iboga in Withdrawal Treatment: GC-MS/MS Determination of Ibogaine and Ibogamine in Iboga Roots and Postmortem Biological Material

(2013) Cédric Mazoyer et al.   JOURNAL OF FORENSIC SCIENCES

A Fatality Following Ingestion of the Designer Drug Meta-Chlorophenylpiperazine (mCPP) in an Asthmatic-HPLC-MS/MS Detection in Biofluids and Hair

(2012) Yvan P. Gaillard et al.   JOURNAL OF FORENSIC SCIENCES

Practical aspects concerning validation and quality control for forensic and clinical bioanalytical quantitative methods

(2011) Sarah M. R. Wille et al.   ACCREDITATION AND QUALITY ASSURANCE

Qualitative studies on the metabolism and the toxicological detection of the fentanyl-derived designer drugs 3-methylfentanyl and isofentanyl in rats using liquid chromatography–linear ion trap–mass spectrometry (LC-MSn)

(2011) Markus R. Meyer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY