Article
Obstetrics & Gynecology
Serhat Toprak, Eda Adeviye Sahin, Hanifi Sahin, Yusuf Aytac Tohma, Ercan Yilmaz, Mehmet Mutlu Meydanli
Summary: Lymphovascular space invasion, primary tumor diameter of at least 3 cm, and at least 50% deep myometrial invasion are independent predictors of cervical stromal involvement in patients with endometrioid-type endometrial cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Oncology
Weitao Zhuang, Hansheng Wu, Rixin Chen, Xiaosong Ben, Shujie Huang, Zihao Zhou, Junhan Wu, Yong Tang, Guibin Qiao
Summary: This study analyzed the staging value of lymphovascular invasion (LVI) in esophageal squamous cell carcinoma (ESCC). The results showed that LVI is an independent prognostic factor for clinical-pathological relevance and prognosis in ESCC patients, and can further improve the predictive accuracy of staging models.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Eric M. Anderson, Michael Luu, Mitchell Kamrava
Summary: The presence of lymph node involvement in endometrial cancer patients guides treatment decisions. This study used a database of patients diagnosed between 2004 and 2016 to identify predictors of lymph node involvement. In addition to tumor characteristics, patient age and race were found to be associated with a higher risk of lymph node involvement.
Article
Oncology
Eric M. Anderson, Michael Luu, Diana J. Lu, Eric M. Chung, Mitchell Kamrava
Summary: This study aimed to investigate the risk factors for lymph node involvement in patients with less common histologies of endometrial cancer. The study found that predictors of lymph node positivity in non-endometrioid endometrial cancer patients are similar to endometrial adenocarcinoma, which could be helpful in making adjuvant treatment decisions for these less common histologies.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Sang Il Kim, Joo Hee Yoon, Sung Jong Lee, Min Jong Song, Jin Hwi Kim, Hae Nam Lee, Gyul Jung, Ji Geun Yoo
Summary: The study identified tumor size, depth of myometrial invasion, and presence of cervical stromal invasion as risk factors for lymphovascular space invasion (LVSI) in patients with endometrioid endometrial cancer. A simplified LVSI prediction model was developed and shown to have good predictive value for clinical use.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Duygu Koc Keles, Sehnaz Evrimler, Neslihan Merd, Evrim Erdemoglu
Summary: This study investigated the role of MRI quantitative assessment in staging and risk stratification of endometrial cancer. The findings suggest that parameters such as tumor area ratio, tumor volume ratio, and apparent diffusion coefficient can improve the accuracy of preoperative staging and help in identifying high-risk groups based on stage, grade, and invasion status.
Article
Oncology
Damiano Arciuolo, Antonio Travaglino, Angela Santoro, Giulia Scaglione, Nicoletta D'Alessandris, Michele Valente, Frediano Inzani, Rossella Accarino, Alessia Piermattei, Roberta Benvenuto, Antonio Raffone, Camilla Nero, Silvia Pelligra, Francesco Fanfani, Massimo Mascolo, Gian Franco Zannoni
Summary: The expression of L1CAM in MELF glands is associated with lymph node involvement in low-grade endometrioid carcinomas. This study suggests that L1CAM may play a role in the development of the MELF pattern and could be used as a predictor for lymph node spread in endometrial carcinoma patients.
Article
Oncology
Jingya Chen, Xiaorong Wang, Haoyi Lv, Wei zhang, Ying Tian, Lina Song, Zhongqiu Wang
Summary: A radiomics model based on MRI scans and clinical characteristics was developed to predict lymphovascular invasion in endometrial cancer patients. The model performed well in training, internal validation, and external validation cohorts. This noninvasive tool could be useful for predicting LVSI in EC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Hongxiang Yang, Aijing Li, Aili Li, Fei Zhao, Tongyan Zhang
Summary: KRT15 is abnormally increased in endometrial cancer (EC) tissue and is associated with lymphovascular invasion, stromal cervical invasion, and poor prognosis in EC patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thierry L. Lefebvre, Yoshiko Ueno, Anthony Dohan, Avishek Chatterjee, Martin Vallieres, Eric Winter-Reinhold, Sameh Saif, Ives R. Levesque, Xing Ziggy Zeng, Reza Forghani, Jan Seuntjens, Philippe Soyer, Peter Savadjiev, Caroline Reinhold
Summary: This study evaluated the performance of multiparametric MRI three-dimensional radiomics-based machine learning models in endometrial carcinoma. The results showed that radiomics had better performance than radiologists in identifying high-risk histopathologic markers and advanced-stage endometrial carcinoma.
Article
Medicine, General & Internal
Tong Chen, Mingchuan Wang, Xianbin Cheng, Yizhuo Wang, Yang Jiang, Xuedong Fang, Huijie Xiao
Summary: Lymphovascular invasion (LVI) and/or perineural invasion (PNI) can serve as high-risk factors for prognosis of rectal cancer, predicting survival and guiding adjuvant therapy. Differentiation grade and staging are closely related to LVI or PNI. Simultaneous occurrence of LVI and PNI is an independent prognostic factor.
Review
Medicine, General & Internal
Svetlana Mateva, Margarita Nikolova, Angel Yordanov
Summary: Endometrioid endometrial adenocarcinoma is the most common malignancy of the female genital tract, and the assessment of myometrial invasion depth is crucial for accurate staging. The various patterns of invasion can result in difficulties and controversies in precise assessment of invasion depth.
Article
Oncology
Franziska Siegenthaler, Elisabeth Epstein, Carol A. Buchi, Andrea Gmur, Flurina A. C. M. Saner, Tilman T. Rau, Joseph W. Carlson, Michael D. Mueller, Sara Imboden
Summary: The aim of this study was to determine the prognostic dependence of LVSI from the molecular signature. The presence of LVSI was associated with recurrence in each subgroup of patients with MMRd, p53abn, and NSMP endometrial cancer, and LVSI remained an independent predictor of recurrence in NSMP endometrial cancer patients.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
M. Reyes Oliver-Perez, Pablo Padilla-Iserte, Octavio Arencibia-Sanchez, Cristina Martin-Arriscado, Juan Carlos Muruzabal, Berta Diaz-Feijoo, Silvia Cabrera, Pluvio Coronado, M. Belen Martin-Salamanca, Manuel Pantoja-Garrido, Josefa Marcos-Sanmartin, Elena Cabezas-Lopez, Cristina Lorenzo, Duska Beric, Jose Ramon Rodriguez-Hernandez, Fernando Roldan-Rivas, Juan Gilabert-Estelles, Lourdes Sanchez, Maria Laseca-Modrego, Carmen Tauste-Rubio, Blanca Gil-Ibanez, Alvaro Tejerizo-Garcia
Summary: In patients with early-stage endometrioid endometrial cancer, the presence of lymph vascular space involvement (LVSI) is associated with nodal metastases, shorter disease-free survival and overall survival. However, the impact of LVSI on recurrence patterns and optimal adjuvant treatment is unclear. Our study aims to analyze oncological outcomes and recurrence patterns based on LVSI status in these patients, and determine preoperative predictors of positive LVSI.
Article
Oncology
Alicia Leon-Castillo, Nanda Horeweg, Elke E. M. Peters, Tessa Rutten, Natalja ter Haar, Vincent T. H. B. M. Smit, Cor D. Kroon, Marie Boennelycke, Estrid Hogdall, Claus Hogdall, Remi R. A. Nout, Carien L. Creutzberg, Gitte Ortoft, Tjalling Bosse
Summary: The study evaluates the clinical outcome of molecular subgroups in high-grade endometrial cancer (EC) patients staged with lymphadenectomy and those without adjuvant treatment. The molecular classification has strong prognostic value, independent of clinicopathological factors. The unfavorable prognosis of early-stage p53abn EC is not due to undetected lymph node metastasis, and the indolent behavior of POLEmut EC is independent of adjuvant treatment.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alba Mota, Sara S. Oltra, Pier Selenica, Cristian P. Moiola, Carlos Casas-Arozamena, Carlos Lopez-Gil, Eva Diaz, Sonia Gatius, Maria Ruiz-Miro, Ana Calvo, Alejandro Rojo-Sebastian, Pablo Hurtado, Roberto Pineiro, Eva Colas, Antonio Gil-Moreno, Jorge S. Reis-Filho, Laura Muinelo-Romay, Miguel Abal, Xavier Matias-Guiu, Britta Weigelt, Gema Moreno-Bueno
Summary: Analyzing intratumor genetic heterogeneity (ITGH) in endometrial carcinoma (EC) using sequencing technologies can help understand tumor evolution, prognosis, and guide personalized therapy. This study characterized the spatial and temporal heterogeneity of nine ECs and identified somatic mutations through whole-exome sequencing. The phylogenetic tree analysis revealed the correlation between tumor progression, prognosis, and recurrent disease, and also guided the selection of personalized therapy for a patient with ambiguous EC.
Article
Pathology
Sonia Gatius, Ana Velasco, Mar Varela, Miriam Cuatrecasas, Pedro Jares, Lisa Setaffy, Benjamin Bonhomme, Almudena Santon, Kristina Lindemann, Sabrina Croce, Ben Davidson, Sigurd Lax, Jose Palacios, Xavier Matias-Guiu
Summary: The determination of microsatellite instability (MSI) and mismatch repair deficiency (MMRD) is crucial for the diagnosis and prognosis of endometrial carcinomas (ECs), identification of Lynch syndrome carriers, and selection of patients for immunotherapy. The Idylla(TM) MSI assay is a rapid and highly concordant test for MSI in EC. It does not require non-tumoral tissue and can be performed in about 150 min.
Article
Environmental Sciences
Paula Peremiquel-Trillas, Jon Frias-Gomez, Laia Alemany, Alberto Ameijide, Mireia Vilardell, Rafael Marcos-Gragera, Sonia Paytubi, Jordi Ponce, Jose Manuel Martinez, Marta Pineda, Joan Brunet, Xavier Matias-Guiu, Maria Carulla, Jaume Galceran, Angel Izquierdo, Josep M. Borras, Laura Costas, Ramon Cleries
Summary: This study predicts a decline in ovarian cancer incidence and mortality rates in Catalonia by 2030, particularly among women aged 45 years and above. The risk of developing ovarian cancer decreases with later birth year, though there is a rebound among women born in the 1980s. Decreased mortality rates were observed during the period of diagnosis and death, but older women still have higher ovarian cancer mortality compared to other age groups.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Computer Science, Artificial Intelligence
Daniel Jimenez-Sanchez, Mikel Ariz, Hang Chang, Xavier Matias-Guiu, Carlos E. de Andrea, Carlos Ortiz-de-Solorzano
Summary: NaroNet is a deep learning framework that models the multi-scale tumor microenvironment from multiplex-stained cancer tissue images and provides patient-level interpretable predictions. The model learns the influence of cell phenotypes, cell neighborhoods, and neighborhood interactions on predicting the correct label through unsupervised learning.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Public, Environmental & Occupational Health
Laura Costas, Jon Frias-Gomez, Yolanda Benavente Moreno, Paula Peremiquel-Trillas, Alvaro Carmona, Javier de Francisco, Victor Cano, Sonia Paytubi, Beatriz Pelegrina, Jose Manuel Martinez, Marta Pineda, Joan Brunet, August Vidal, Xavier Matias-Guiu, Xavier Bosch, Jordi Ponce, Manolis Kogevinas, Silvia De Sanjose, Laia Alemany
Summary: After adjusting for potential confounders, an inverse but not statistically significant association was found between night shift work and endometrial cancer (OR=0.64; 95% CI=0.35 to 1.16). The associations were independent of shift type (permanent or rotating nights) or duration of night work. No statistically significant association was observed between endometrial cancer and sleep duration, while inconsistent patterns were seen for chronotype and endometrial cancer risk.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Anna Ruiz-Mitjana, Raul Navaridas, Maria Vidal-Sabanes, Aida Perramon-Gueell, Andree Yeramian, Isidre Felip, Nuria Eritja, Joaquim Egea, Mario Encinas, Xavier Matias-Guiu, Xavier Dolcet
Summary: The extracellular matrix and cell polarity are crucial for maintaining cellular homeostasis and preventing carcinogenesis. This study investigates the role of extracellular matrix in the cellular response to TGF-beta. It shows that the absence of extracellular matrix inhibits apoptosis and promotes epithelial-to-mesenchymal transition in response to TGF-beta. The molecular mechanisms underlying these cellular responses involve AKT, ERK, and SMAD pathways.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Maria-Eulalia Fernandez-Montoli, Fatima Heydari, Fabrizia Lavecchia, Miquel-Angel Pavon, Esther Guerra, Xavier Matias-Guiu, Maria-Dolores Marti, Sara Tous
Summary: This retrospective study aimed to assess the long-term response to imiquimod in patients with vulvar HSIL and to analyze the role of HPV in the persistence or recurrence of vulvar HSIL after imiquimod treatment. The results showed that imiquimod effectively treated vulvar HSIL, with a higher number of complete and partial responses. Patients who had a partial or no response to imiquimod had a higher risk of recurrence, especially in immunosuppressed patients. The study also found that patients who tested positive for HPV after imiquimod treatment were more likely to experience recurrence.
Article
Oncology
James E. Barrett, Allison Jones, Iona Evans, Chiara Herzog, Daniel Reisel, Adeola Olaitan, Tim Mould, Nicola MacDonald, Konstantinos Doufekas, Claire Newton, Emma J. Crosbie, Line Bjorge, Nicoletta Colombo, Lukas Dostalek, Laura Costas, Paula Peremiquel-Trillas, Jordi Ponce, Xavier Matias-Guiu, Michal Zikan, David Cibula, Jiangrong Wang, Karin Sundstroem, Joakim Dillner, Martin Widschwendter
Summary: To reduce the morbidity caused by aggressive treatment for advanced endometrial cancer, it is necessary to identify women at risk and detect the cancer earlier. A new test called WID-EC based on DNA methylation was developed and validated in different sets of samples, showing promising results in identifying women with or at risk of endometrial cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cell Biology
Yaiza Jung-Garcia, Oscar Maiques, Joanne Monger, Irene Rodriguez-Hernandez, Bruce Fanshawe, Marie-Charlotte Domart, Matthew J. Renshaw, Rosa M. Marti, Xavier Matias-Guiu, Lucy M. Collinson, Victoria Sanz-Moreno, Jeremy G. Carlton
Summary: Metastasis involves cancer cells spreading from the primary tumor to other sites. Researchers discovered increased expression of the protein LAP1 in metastatic melanoma cells, primary melanoma tumors, and metastases. They found that a shorter isoform of LAP1, LAP1C, supports constrained cell migration and invasion by allowing a weaker coupling between the nuclear envelope and the nuclear lamina. This suggests that LAP1 contributes to melanoma aggressiveness.
NATURE CELL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Laura Devis-Jauregui, August Vidal, Laura Plata-Pena, Maria Santacana, Sandra Garcia-Mulero, Nuria Bonifaci, Eulalia Noguera-Delgado, Nuria Ruiz, Marta Gil, Eduard Dorca, Francisco J. Llobet, Laura Coll-Iglesias, Katja Gassner, Maria Martinez-Iniesta, Ruth Rodriguez-Barrueco, Marc Barahona, Lola Marti, Francesc Vinals, Jordi Ponce, Rebeca Sanz-Pamplona, Josep M. Piulats, Ana Vivancos, Xavier Matias-Guiu, Alberto Villanueva, David Llobet-Navas
Summary: To address the clinical management challenges in endometrial cancer (EC), researchers have generated a collection of patient-derived orthoxenograft (PDOX) mouse models, which provide a valuable tool for studying and developing precision medicine in EC.
Article
Oncology
Jara Palomero, Carla Panisello, Maria Lozano-Rabella, Ricky Tirtakasuma, Judit Diaz-Gomez, Daniela Grases, Helena Pasamar, Laura Arregui, Eduard Dorca Duch, Esther Guerra Fernandez, Ana Vivancos, Carlos E. de Andrea, Ignacio Melero, Jordi Ponce, August Vidal, Josep Maria Piulats, Xavier Matias-Guiu, Alena Gros
Summary: Our study investigates the prevalence, phenotype, specificity and prognostic value of tumor infiltrating lymphocytes (TILs) in endometrial cancer (EC). We found that CD8(+)TILs expressing high levels of PD-1 and CD39 were associated with tumor reactivity and improved patient survival. The co-expression of inhibitory and activation markers on PD-1(hi) CD4(+) T cells was also observed, which accumulated antitumor T cells and correlated with prolonged survival in EC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cell Biology
Giorgia Sonzini, Sofia Granados-Aparici, Sabina Sanegre, Angel Diaz-Lagares, Juan Diaz-Martin, Carlos de Andrea, Nuria Eritja, Aida Bao-Caamano, Nicolas Costa-Fraga, David Garcia-Ros, Carmen Salguero-Aranda, Ben Davidson, Rafael Lopez-Lopez, Ignacio Melero, Samuel Navarro, Santiago Ramon y Cajal, Enrique de Alava, Xavier Matias-Guiu, Rosa Noguera
Summary: In this study, digital pathology and omics analyses were used to investigate the tumor microenvironment and molecular features of uterine adenocarcinoma, uterine leiomyosarcoma, and their lung metastases. The results showed differences in the reticulin fiber scaffolding and immune cell infiltration between the invasive tumor front and metastatic tumors, which could potentially improve metastatic prediction and identify therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Marike S. Lombaers, Karlijn M. C. Cornel, Nicole C. M. Visser, Johan Bulten, Heidi V. N. Kuesters-Vandevelde, Frederic Amant, Dorry Boll, Peter Bronsert, Eva Colas, Peggy M. A. J. Geomini, Antonio Gil-Moreno, Dennis van Hamont, Jutta Huvila, Camilla A. Krakstad, Arjan A. Kraayenbrink, Martin Koskas, Gemma Mancebo, Xavier Matias-Guiu, Huy M. Ngo, Brenda M. Pijlman, Maria Caroline Vos, Vit Weinberger, Marc P. L. M. W. Snijders, Sebastiaan W. S. van Koeverden, Ingfrid S. Haldorsen, Casper Reijnen, Johanna M. A. Pijnenborg
Summary: Patients with high-grade uterine cancer have a higher risk of cancer spreading to the lymph nodes compared to patients with low-grade uterine cancer. CA125, a marker detectable in blood, is associated with increased tumor spread. This study aimed to assess the predictive value of CA125 for uterine cancer spread and survival and the additional value of CT scan in high-grade uterine cancer. The findings showed that elevated CA125 was associated with advanced stage, lymph node metastasis, and a worse prognosis in high-grade uterine cancer.
Article
Chemistry, Multidisciplinary
Raul Navaridas, Maria Vidal-Sabanes, Anna Ruiz-Mitjana, Gisela Altes, Aida Perramon-Guell, Andree Yeramian, Joaquim Egea, Mario Encinas, Sonia Gatius, Xavier Matias-Guiu, Xavier Dolcet
Summary: Simultaneous deletion of Pten and p53 in endometrial epithelial cells is sufficient to trigger epithelial-to-mesenchymal transition, leading to the development of metastatic uterine carcinosarcomas.
Article
Oncology
Jonathan S. Berek, Xavier Matias-Guiu, Carien Creutzberg, Christina Fotopoulou, David Gaffney, Sean Kehoe, Kristina Lindemann, David Mutch, Endometrial Canc Staging Subcomm, FIGO Womens Canc Comm
Summary: Since the 2009 update of the FIGO staging system, there have been significant advances in understanding the pathologic and molecular features of endometrial cancer. The new staging system aims to better define prognostic groups and create substages to guide more appropriate treatment.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)