Article
Social Sciences, Mathematical Methods
Joseph N. Luchman
Summary: This article introduces the method of dominance analysis and two commands, domin and domme, in Stata that can be used for this purpose. It provides steps for calculating dominance statistics, examples of data analysis, and interpretation of results. The article also touches on computational considerations for users applying larger models.
Article
Social Sciences, Mathematical Methods
Ben Jann
Summary: This article discusses the method of relative distribution analysis and introduces Stata software that implements various elements of the methodology. The software, reldist, can estimate relative cumulative distribution, density, polarization, divergence, and other summary measures of relative ranks. It also provides functionalities such as location and shape decompositions and covariate balancing, with statistical inference implemented using influence functions and support for estimation on complex samples.
Article
Environmental Sciences
Wenjing Wu, Zhicheng Du, Ying Wang, Yuqin Zhang, Shirui Chen, Xu Ju, Gonghua Wu, Zhiqaing Li, Jie Sun, Jie Jiang, Weihua Hu, Ziqiang Lin, Yanji Qu, Jianpeng Xiao, Wangjian Zhang, Yuantao Hao
Summary: This study examined the protective association between greenness and respiratory mortality in China. It also investigated the potential roles of air pollution (PM2.5, PM10, or NO2) in the causal pathway between greenness and respiratory mortality.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Public, Environmental & Occupational Health
An-Shun Tai, Le-Hsuan Liao, Sheng-Hsuan Lin
Summary: Path-specific effects play a critical role in evaluating mediation with multiple mediators. The conventional definition has caused controversy and misinterpretation of the results. This study proposes strategies to decompose fully mediated interaction and shows the importance of reclassifying the interaction for accurate interpretation of mediation analysis results.
Article
Marine & Freshwater Biology
Myung Gil Park, Ahsong Kim, Boo Seong Jeon, Miran Kim
Summary: This study investigated the role of parasite mediation in planktonic protists predator-prey interactions, showing how parasites can influence predator's utilization of prey that it would not otherwise consume, and the importance of parasite infection cycle in this process. The presence of parasitoid seemed to promote co-occurrence of three protists in either inedible prey- or predator-dominated environments.
Article
Public, Environmental & Occupational Health
Alfredo Morabia
Summary: In 1931, Edgar Sydenstricker challenged the common belief that the 1918 influenza outbreak affected the rich and poor alike, instead finding that both morbidity and mortality from the flu had been higher among the poor. Using data from a 1918 US national survey, economic status and household crowding were identified as factors contributing to the poor's higher influenza burden. This study helped build the evidence base linking poverty to ill health.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Psychology, Clinical
Yi Li, Kazuki Yoshida, Jay S. Kaufman, Maya B. Mathur
Summary: This article provides an overview of regression-based causal mediation analysis in the field of traumatic stress and offers guidance on conducting mediation analysis using the R package regmedint. The authors discuss the causal interpretations of the estimated quantities in causal mediation analysis, including total, direct, and indirect effects, especially when there is an interaction between exposure and mediator. They also discuss the necessary assumptions and suitable study designs for valid estimation of these causal quantities, as well as the differences between causal mediation analysis and traditional methods of mediation. By using data from a published longitudinal study, the authors illustrate how to conduct and interpret mediation analysis using regmedint and compare the results to those obtained using traditional methods, highlighting the importance of accounting for exposure-mediator interaction.
PSYCHOLOGICAL TRAUMA-THEORY RESEARCH PRACTICE AND POLICY
(2023)
Article
Neurosciences
Cesar Higgins Tejera, Erin B. Ware, Lindsay C. Kobayashi, Mingzhou Fu, Margaret Hicken, Matthew Zawistowski, Bhramar Mukherjee, Kelly M. Bakulski
Summary: In a nationally representative sample in the United States, elevated cystatin C was found to be associated with dementia prevalence. The study also suggested that the effect of cystatin C on racial disparities in dementia may be moderated by race/ethnicity. These findings provide evidence of the importance of cystatin C in brain health and its potential role in racial disparities in dementia.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Social Sciences, Mathematical Methods
Roger B. Newson, Milena Falcaro
Summary: Logistic and probit models are popular regression models for binary outcomes, but the robit model provides a robust alternative by replacing the normal distribution with a Student's t distribution, resulting in less influence of outliers. Robit regression models are particularly suitable for estimating inverse-probability weights and propensity scoring.
Article
Social Sciences, Mathematical Methods
Juan D. Diaz, Ivan Gutierrez, Jorge Rivera
Summary: The blopmatching estimator is a nonparametric matching estimator proposed for average treatment effects in observational studies, utilizing solutions of linear programming problems to build weighting schemes for imputing missing potential outcomes. This article introduces blopmatch, a new command implementing these estimators.
Article
Multidisciplinary Sciences
Roheena Zafar, Inayat Ur Rehman, Yasar Shah, Long Chiau Ming, Hui Poh Goh, Khang Wen Goh
Summary: Patients with chronic kidney disease (CKD) in Pakistan, especially those in private hospitals, face a higher risk of potential drug-drug interactions (pDDIs). Older age and a higher number of prescribed drugs are independent risk factors for pDDIs.
Article
Public, Environmental & Occupational Health
Ningning Zhang, Ge Liang, Mengying Liu, Guowei Zheng, Hailan Yu, Yage Shi, Yihe Zhang, Hao Wang, Yapeng Li, Yuming Xu, Jie Lu
Summary: The study found that individuals with metabolically healthy obesity (MHO), metabolically unhealthy non-obesity (MUNO), or metabolically unhealthy obesity (MUO) had an increased risk of stroke compared to the metabolically healthy non-obesity (MHNO) group. Obesity and metabolic abnormalities had an additive interaction for stroke risk, with females showing a 14.0% attributable proportion.
PREVENTIVE MEDICINE
(2021)
Article
Computer Science, Information Systems
Kai Jia, Xiao Yu, Chen Zhang, Wenhua Hu, Dongdong Zhao, Jianwen Xiang
Summary: This article proposes a novel hybrid aging prediction framework called DGRU, which effectively predicts the medium and long-term variations of aging indicators and performs well in formulating the rejuvenation schedule. The framework utilizes the STL method for preprocessing and the GRU neural network for modeling the time-series relationship between the data. Experimental results demonstrate that DGRU outperforms other models and is a promising solution for high-precision software aging prediction.
IEEE TRANSACTIONS ON EMERGING TOPICS IN COMPUTING
(2023)
Article
Psychology, Mathematical
Cooper B. Hodges, Bryant M. Stone, Paula K. Johnson, James H. Carter, Chelsea K. Sawyers, Patricia R. Roby, Hannah M. Lindsey
Summary: Researcher degrees of freedom can affect hypothesis test results, and inconsistencies between statistical software packages can lead to different conclusions. A research investigation compared results obtained from various statistical tests conducted on different software packages. Inconsistencies were found, particularly in the computation of Pearson's chi-square test on 2 x 2 tables, where p-values reported by different software packages varied greatly due to sample size differences.
BEHAVIOR RESEARCH METHODS
(2023)
Article
Communication
R. Lance Holbert, Hyunjin Song, Morgan E. Ellithorpe, Heather L. Lamarre, Elizabeth S. Baik, Colleen M. Tolan
Summary: Recent analytical work emphasizes the need to assess mediated interactions in mediation models and provides a theory-driven decision tree. In addition, the Monte Carlo simulations and data analysis reveal the relative upsides and minimal risk of assessing mediated interactions, as well as the downsides of not exploring these relationships.
HUMAN COMMUNICATION RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas M. Maddox, Yang Song, Joseph Allen, Paul S. Chan, Adeela Khan, Jane J. Lee, Joshua Mitchell, William J. Oetgen, Angelo Ponirakis, Claire Segawa, John A. Spertus, Fran Thorpe, Salim S. Virani, Frederick A. Masoudi
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Christopher T. Sciria, Thomas M. Maddox, Lucas Marzec, Benjamin Rodwin, Salim S. Virani, Amarnath Annapureddy, James Freeman, Ali O'Hare, Yuyin Liu, Yang Song, Gheorghe Doros, Yue Zheng, Jane J. Lee, Ramesh Daggubati, Lina Vadlamani, Christopher Cannon, Nihar R. Desai
CLINICAL CARDIOLOGY
(2020)
Review
Medicine, General & Internal
Gerald Chi, Jane J. Lee, Adeel Jamil, Vamsikrishna Gunnam, Homa Najafi, Sahar Memar Montazerin, Fahimehalsadat Shojaei, Jolanta Marszalek
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Virology
Jane J. Lee, Sahar M. Montazerin, Adeel Jamil, Umer Jamil, Jolanta Marszalek, Michael L. Chuang, Gerald Chi
Summary: The study suggests that elevated RDW levels are associated with adverse outcomes in COVID-19 patients, particularly in those who died or developed more severe symptoms. Further research is needed to explore the potential of RDW as a biomarker for predicting disease severity and its mechanistic link with COVID-19 pathophysiology.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Medicine, Research & Experimental
Fahimehalsadat Shojaei, Zahra Habibi, Sogand Goudarzi, Fatemeh Dehghani Firouzabadi, Sahar Memar Montazerin, Homa Najafi, Farima Kahe, Kaveh Momenzadeh, Mahshid Mir, Faris Khan, Umer Jamil, Adeel Jamil, Jane J. Lee, Gerald Chi
Summary: COVID-19 is associated with various cardiovascular disorders, including TTC and SCAD, with a potential reciprocal causation. The hypothesis provides a theoretical basis for evaluating cardiovascular manifestations in COVID-19 patients.
MEDICAL HYPOTHESES
(2021)
Article
Cardiac & Cardiovascular Systems
Lawrence A. Leiter, Deepak L. Bhatt, Darren K. McGuire, Hwee Teoh, Kim Fox, Tabassome Simon, Shamir R. Mehta, Eli I. Lev, Robert G. Kiss, Anthony J. Dalby, Hector Bueno, Wilhelm Ridderstrale, Anders Himmelmann, Jayne Prats, Yuyin Liu, Jane J. Lee, John Amerena, Mikhail N. Kosiborod, Philippe Gabriel Steg
Summary: The THEMIS study and its subanalysis THEMIS-PCI showed that ticagrelor plus aspirin had a favorable net clinical benefit in individuals with type 2 diabetes and stable coronary artery disease, particularly among those who had previous percutaneous coronary intervention. The efficacy of ticagrelor plus aspirin on reducing major adverse cardiovascular events was generally consistent across subgroups, while the major bleeding event rate was increased by ticagrelor across all subgroups. Additionally, in THEMIS-PCI but not in the overall THEMIS population, ticagrelor generally produced a favorable net clinical benefit across different diabetes-related factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Editorial Material
Virology
Gerald Chi, Sahar Memar Montazerin, Jane J. Lee
Article
Statistics & Probability
Jeremiah Zhe Liu, Wenying Deng, Jane Lee, Pi-I Debby Lin, Linda Valeri, David C. Christiani, David C. Bellinger, Robert O. Wright, Maitreyi M. Mazumdar, Brent A. Coull
Summary: Gene-environment and nutrition-environment studies often involve testing high-dimensional interactions between variables with complex nonlinear effects. The proposed CVEK method learns appropriate functions for main effects and guards against over-fitting, suggesting potential for nutritional interventions to mitigate adverse impacts of in utero metal exposures on children's neurodevelopment.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Gerald Chi, Jane J. Lee, Syed H. A. Kazmi, Clara Fitzgerald, Sahar Memar Montazerin, Arzu Kalayci, Serge Korjian, Mark Heise, Lawrence Deckelbaum, Peter Libby, Deepak L. Bhatt, C. Michael Gibson
Summary: This study analyzed seven phase III interventional trials involving 82,727 recent ACS patients, finding pooled rates of recurrent major adverse cardiovascular events at 4.1% and 8.3% at 90 and 360 days. Approximately 49% of events occurred within the first 90 days. The results suggest that a lower magnitude of relative risk reduction (RRR) is required for late MACE to achieve 90% statistical power, while a lower magnitude of absolute risk reduction (ARR) is needed for early MACE.
CLINICAL CARDIOLOGY
(2022)
Review
Medicine, Research & Experimental
Gerald Chi, Jane J. Lee, Sahar M. Montazerin, Jolanta Marszalek
Summary: Low hemoglobin-to-red cell distribution width ratio is associated with disease progression, relapse, and higher mortality risk in cancer patients.
BIOMARKERS IN MEDICINE
(2022)
Review
Peripheral Vascular Disease
Arzu Kalayci, C. Michael Gibson, Paul M. Ridker, Samuel D. Wright, Bronwyn A. Kingwell, Serge Korjian, Gerald Chi, Jane J. Lee, Pierluigi Tricoci, S. Hassan Kazmi, Clara Fitzgerald, Alka Shaunik, Gail Berman, Danielle Duffy, Peter Libby
Summary: Elevating HDL-C levels may not necessarily improve cardiovascular outcomes, as the focus has shifted towards enhancing the anti-atherosclerotic functions of HDL particles. Among ApoA-I therapies, CSL112 appears promising in overcoming current challenges.
CURRENT ATHEROSCLEROSIS REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Gregory Ducrocq, Deepak L. Bhatt, Jane J. Lee, Naishu Kui, Kim M. Fox, Robert A. Harrington, Lawrence A. Leiter, Shamir R. Mehta, Robert Gabor Kiss, Stefan James, Dragos Vinereanu, Kurt Huber, Marielle Andersson, Anders Himmelmann, Tabassome Simon, Ph Gabriel Steg
Summary: In patients with diabetes and stable coronary artery disease, only those with lower bleeding risk derived net benefit from ticagrelor.
AMERICAN HEART JOURNAL
(2022)
Review
Peripheral Vascular Disease
Gerald Chi, Jane J. Lee, Sahar Memar Montazerin, Jolanta Marszalek
Summary: Elevated D-dimer levels are predictive of VTE occurrence within 90 days in acutely ill medical patients.
Review
Health Care Sciences & Services
Jane J. Lee, Sahar Memar Montazerin, Fahimehalsadat Shojaei, Gerald Chi
Summary: VTE is a known cause of morbidity and mortality in acutely ill medical patients and there is controversy regarding its prophylaxis in this population. Recent clinical trials have compared the safety and efficacy of direct oral anticoagulants with traditional treatment options, and guidelines have been updated accordingly. Discussions also include potential barriers, cost-effectiveness, and the impact of COVID-19 on extended-duration or post-discharge usage of anticoagulants.
THERAPEUTICS AND CLINICAL RISK MANAGEMENT
(2021)
Article
Engineering, Multidisciplinary
Jingjing Sun, Bugao Xu, Jane Lee, Jeanne H. Freeland-Graves
Summary: This study explores new categorization of visceral and subcutaneous adipose tissue distribution using MRI. It found that body shape descriptors (BSDs) are effective in predicting abdominal fat distributions.
CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES
(2021)