Article
Cardiac & Cardiovascular Systems
Mi Chen, Wangli Xu, Yan Ding, Honglei Zhao, Pei Wang, Bo Yang, Huanyu Qiao, Wei Zhang, Chenyang Zhou, Junnan Jia, Tao Bai, Jinrong Xue, Junming Zhu, Yongmin Liu, Weimin Li, Lizhong Sun
Summary: Long-term mortality and reoperation benefits associated with integrated aortic-valve and ascending-aortic replacement (IR) compared to partial replacement (PR) were found to be significant for patients with bicuspid aortic valve (BAV)-related aortopathy, with differences seen for different aortic diameter groups based on valve or aorta type.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Health Care Sciences & Services
Olga Irtyuga, Georgy Kopanitsa, Anna Kostareva, Oleg Metsker, Vladimir Uspensky, Gordeev Mikhail, Giuseppe Faggian, Giunai Sefieva, Ilia Derevitskii, Anna Malashicheva, Evgeny Shlyakhto
Summary: This study evaluated the frequency of ascending aortic aneurysm and aortic dilation in patients with cardiovascular diseases, identifying main risk factors depending on aortic valve morphology. Despite a high prevalence of aortic dilation, many patients were unaware of their condition prior to examination. Factors such as age, male sex, aortic valve parameters, blood pressure, and heart conditions were found to be significant in the formation of aortic dilation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jose M. Siurana, Anna Sabate-Rotes, Ariadna Ayerza, Lorenzo Jimenez, Marc Figueras-Coll, Maria Aranzazu Gonzalez
Summary: This study aimed to find the best reference tool to define dilation of the aortic root and the ascending aorta in BAV adolescents with an adult body surface area (BSA). The results indicate that in the ascending aorta, it is advisable to switch to BSA-IV when children are older than 10 years old and have a BSA >= 1.5 m2.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Borja Antequera-Gonzalez, Marta Faiges, Neus Martinez-Micaelo, Laura Galian-Gay, Carmen Ligero, Maria Ferre-Vallverdu, Lluis Masana, Nuria Amigo, Arturo Evangelista, Josep M. Alegret
Summary: This study analyzed and compared the lipoprotein and glycoprotein profiles in 152 patients with bicuspid aortic valve (BAV) and ascending aorta dilatation (AAoD), and found that parameters related to lipoprotein profile and a novel inflammation biomarker were significantly increased in the dilated group. In long-term follow-up, proatherogenic lipoprotein parameters were associated with ascending aorta dilation velocity. Therefore, BAV patients with AAoD have a more pro-atherogenic profile, which appears to contribute to the increased growth rate of ascending aorta diameter.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Brittany Balint, Jan Federspiel, Catherine Kollmann, Paul Teping, Tanja Schwab, Hans-Joachim Schaefers
Summary: This study aimed to compare the differences in transforming growth factor-beta (TGFss) signaling between aneurysms associated with bicuspid (BAV) and unicuspid (UAV) aortic valves and normal aortic valves. The findings showed that TGFss1 concentration increases with dilatation in normal aortic valve aneurysms, but decreases in BAV and UAV aneurysms. Additionally, the activation of TGFss signaling pathway differs in BAV and UAV aneurysms compared to normal aortic valve aneurysms. These results are important for understanding and treating ascending aortic dilatation.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Laura Galian-Gay, Antonia Pijuan-Domenech, Javier Cantalapiedra-Romero, Berta Serrano, Maria Goya, Nerea Maiz, Manel Casellas, Susana Manrique, Elena Suarez-Edo, Berta Miranda-Barrio, Blanca Gordon Ramirez, Gisela Teixido-Tura, Laura Gutierrez-Moreno, Victor Gonzalez-Fernandez, Lydia Dux-Santoy, Andrea Guala, Arturo Evangelista, Laura Dos-Subira, Jose F. Rodriguez-Palomares, Ignacio Ferreira-Gonzalez
Summary: This study investigates the aortic-related risks associated with pregnancy in women with bicuspid aortic valve (BAV) and evaluates changes in aortic diameter during pregnancy. The results show that pregnant women with BAV have a low rate of cardiac complications and aortic complications are rare. However, there is a small but significant increase in aortic diameter during pregnancy.
Review
Pediatrics
Emma C. Dunne, Ronald V. Lacro, Jonathan N. Flyer
Summary: The purpose of this review is to summarize and critically evaluate recent clinical and research advancements in pediatric BAV and its associated aortopathy. Recent findings show that progressive aortic dilation is commonly present in pediatric patients with BAV and is associated with increased risk for aortic aneurysm, dissection, and surgery in adulthood. Ongoing research aims to explore the cause, incidence, and progression of bicuspid aortopathy to improve early diagnosis and preventive management.
CURRENT OPINION IN PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Lars G. Svensson, Brad F. Rosinski, Kyle Miletic, Kevin Hodges, Jeevanantham Rajeswaran, Brian Griffin, Milind Y. Desai, Vidyasagar Kalahasti, Zackary Goff, Douglas R. Johnston, Patrick R. Vargo, Eric E. Roselli, Eugene H. Blackstone
Summary: The objective of this study was to investigate the impact of sinutubular junction stabilization on the long-term outcomes of bicuspid aortic valve repair. The results showed that adding ascending aorta replacement to bicuspid aortic valve repair had minimal effects on severe aortic regurgitation and aortic valve gradient after 10 years.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Medicine, General & Internal
Anne-Sophie Sillesen, Ottilia Vogg, Christian Pihl, Anna Axelsson Raja, Karin Sundberg, Cathrine Vedel, Helle Zingenberg, Finn Stener Jorgensen, Niels Vejlstrup, Kasper Iversen, Henning Bundgaard
Summary: The prevalence of bicuspid aortic valve among newborns in Copenhagen was 0.77%, with aortopathy present in 33% of cases. This suggests that BAV is likely a fetal malformation as indicated by the high rate of aortic disease among affected newborns.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Cardiac & Cardiovascular Systems
Tian-Yuan Xiong, Walid Ben Ali, Yuan Feng, Kentaro Hayashida, Hasan Jilaihawi, Azeem Latib, Michael Kang-Yin Lee, Martin B. Leon, Raj R. Makkar, Thomas Modine, Christoph Naber, Yong Peng, Nicolo Piazza, Michael J. Reardon, Simon Redwood, Ashok Seth, Lars Sondergaard, Edgar Tay, Didier Tchetche, Wei-Hsian Yin, Mao Chen, Bernard Prendergast, Darren Mylotte
Summary: The indications for transcatheter aortic valve implantation (TAVI) have expanded to include low surgical risk and bicuspid aortic valve (BAV) patients, although BAV patients have been excluded from major randomized trials due to anatomical considerations. Despite advances in device design, BAV presents anatomical challenges and geographical variations, making it a challenging cohort for TAVI procedures.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Charles Cheng, Yohann Bohbot, Hector Michelena, Dan Rusinaru, Floriane Fay, Frederic Elmkies, Maurice Enriquez Sarano, Christophe Tribouilloy
Summary: This study describes the clinical history of patients with BAV across different age groups and evaluates the long-term outcomes of patients referred for surgery. The results showed high survival rates in both the surveillance and surgical groups, with low incidences of complications.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Respiratory System
Yuki Yoshioka, Shin Yajima, Ryoto Sakaniwa, Naoki Tadokoro, Satoshi Kainuma, Naonori Kawamoto, Takashi Kakuta, Hitoshi Matsuda, Tomoyuki Fujita, Satsuki Fukushima
Summary: The fate of the residual aorta after aortic valve and ascending aorta surgery in patients with a bicuspid aortic valve (BAV) is unclear. This study found that rapid dilatation of the residual aorta rarely occurred and suggested that aortic valve replacement (AVR) and graft replacement (GR) of the ascending aorta is an effective treatment option for patients with ascending aortic dilatation.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Alexander H. J. Staal, Kimberley R. G. Cortenbach, Mark A. J. Gorris, Lieke L. van der Woude, Mangala Srinivas, Robin H. Heijmen, Guillaume S. C. Geuzebroek, Nimrat Grewal, Konnie M. Hebeda, I. Jolanda M. de Vries, Marco C. DeRuiter, Roland R. J. van Kimmenade
Summary: This study reveals a significant presence of immune cells in dilating aortas of patients with bicuspid aortic valve (BAV). These findings raise the question of whether immune cells in BAV aortopathy are innocent bystanders or contribute to the deterioration of the aortic wall.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Angela Lopez, Ilaria Dentamaro, Laura Galian, Francisco Calvo, Josep M. Alegret, Violeta Sanchez, Rodolfo Citro, Antonella Moreo, Fabio Chirillo, Paolo Colonna, Maria Celeste Carrero, Eduardo Bossone, Sergio Moral, Augusto Sao-Aviles, Laura Gutierrez, Gisela Teixido-Tura, Jose Rodriguez-Palomares, Arturo Evangelista
Summary: The study aimed to assess the progression of aortic dilation and valve dysfunction in BAV patients. Results showed that rapid aortic root dilation was associated with male sex, hypertension, presence of raphe, and aortic regurgitation, while rapid ascending aorta dilation was only related to hypertension.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Vincenza Sciortino, Salvatore Pasta, Tommaso Ingrassia, Donatella Cerniglia
Summary: Finite element modelling of the lumbar spine is challenging but crucial for understanding spinal biomechanics and developing innovative therapies. Patient-specific computational simulations require validation and verification to ensure accurate results.
APPLIED SCIENCES-BASEL
(2023)
Article
Biotechnology & Applied Microbiology
Fabrizio Crasci, Stefano Cannata, Giovanni Gentile, Caterina Gandolfo, Salvatore Pasta
Summary: This study evaluates the structural and hemodynamic performance of the TricValve system implanted percutaneously in the superior and inferior vena cava of patients with severe tricuspid regurgitation and venous congestion. Computational analysis shows that after TricValve implantation, the contact pressure on the vena cava wall decreases and there is a decrease in time-averaged pressure. This study demonstrates the potential of computational tools to improve the biomechanical performance of structural tricuspid valve interventions and aid in the design of next-generation transcatheter therapies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Microbiology
Davide Lo Porto, Andrea Cona, Francesca Todaro, Elena De Carolis, Francesca Cardinale, Neha Hafeez, Giuseppina Di Martino, Pier Giulio Conaldi, Maurizio Sanguinetti, Paolo Antonio Grossi, Alessandra Mularoni
Summary: Phaeohyphomycosis is a diverse infection caused by pigmented fungi, and solid organ transplant recipients are at increased risk due to immunosuppression. In this study, three successful cases of phaeohyphomycosis in transplant recipients were treated with surgery and antifungal therapy. A literature review revealed a wide range of fungal species, with Alternaria being the most common. Early diagnosis and treatment are crucial in preventing disease dissemination.
Article
Engineering, Biomedical
Federica Cosentino, Selda Sherifova, Gerhard Sommer, Giuseppe Raffa, Michele Pilato, Salvatore Pasta, Gerhard A. Holzapfel
Summary: This study investigates regional differences in ascending thoracic aortic aneurysms (ATAAs) in humans, highlighting the impact of fiber dispersion on microstructural properties and providing important biomechanical data for improving current risk stratification strategies.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Multidisciplinary
Francesco Scardulla, Gloria Cosoli, Susanna Spinsante, Angelica Poli, Grazia Iadarola, Riccardo Pernice, Alessandro Busacca, Salvatore Pasta, Lorenzo Scalise, Leonardo D'Acquisto
Summary: Wearable monitoring systems are expected to shift healthcare out of inpatient settings. Photoplethysmography (PPG) is integrated into wrist-worn commercial products, offering advantages in cost and size. However, PPG-based devices are influenced by various factors, hindering objective characterization. Lack of standardization for data collection and processing limits the full potential of this technology. This review aims to summarize influencing parameters of PPG and propose guidelines for standardization.
Review
Cell Biology
Eleonora Russo, Giusi Alberti, Simona Corrao, Cesar V. Borlongan, Vitale Miceli, Pier Giulio Conaldi, Francesca Di Gaudio, Giampiero La Rocca
Summary: The potential of perinatal cells and their secreted EVs in regenerative medicine is well established. They exhibit therapeutic effects such as tissue repair, immune system modulation, and other functions. However, challenges remain in characterizing and utilizing these cells and EVs.
Article
Biotechnology & Applied Microbiology
Roberta Scuoppo, Stefano Cannata, Giovanni Gentile, Caterina Gandolfo, Salvatore Pasta
Summary: This study used finite-element analysis to quantify coronary flow in a patient who underwent TAVR-in-TAVR and found that high implantation depth and device undersize of the second THV can significantly reduce coronary flow. Additionally, a positive correlation was observed between coronary flow and the valve-to-coronary distance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Alessia Gallo, Valentina Agnese, Sergio Sciacca, Cesare Scardulla, Manlio Cipriani, Michele Pilato, Jae K. Oh, Salvatore Pasta, Joseph Maalouf, Pier Giulio Conaldi, Diego Bellavia
Summary: This study aimed to identify circulating miRNAs that are highly expressed in myocardial tissue and significantly associated with echocardiographic and hemodynamic measures in patients with heart failure. miR-30d was correlated with left ventricular volumes, miR-126-3p was associated with pulmonary artery pressure and pulmonary capillary wedge pressure, and miR-483-3p had an association with right ventricular end diastolic diameter and central venous pressure.
Article
Materials Science, Biomaterials
Salvatore Pasta
Summary: This study assessed the structural and hemodynamic performance of the MitraClip device in a high-fidelity model of the human heart with a healthy mitral valve geometry. The results showed that MitraClip implantation induced geometrical changes in the mitral valve and abnormal hemodynamic conditions, but computational modeling could predict potential adverse events and complications, enhancing the safety and effectiveness of transcatheter mitral valve repairs.
Article
Biochemistry & Molecular Biology
Alessia Gallo, Nicola Cuscino, Claudia Carcione, Rosalia Busa, Pier Giulio Conaldi, Matteo Bulati
Summary: SARS-CoV-2, the virus responsible for COVID-19, has become a global public health hazard and despite vaccination efforts, it continues to pose a threat. Studies have shown that COVID-19 patients with ARDS treated with ECMO have a similar survival rate to those with non-COVID-19-related ARDS. This study examined the changes in the transcriptomic BCR repertoire in COVID-19 patients at different stages using single-cell V(D)J and gene expression sequencing.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chiara Catalano, Tahir Turgut, Omar Zahalka, Nils Goetzen, Stefano Cannata, Giovanni Gentile, Valentina Agnese, Caterina Gandolfo, Salvatore Pasta
Summary: This study developed a non-invasive inverse approach to estimate reliable material constituents for the aortic root and calcified valve leaflets in TAVI patients. The identification of material parameters was based on minimizing the difference between model predictions and cardiac-gated CT measurements. The results demonstrated the feasibility and potential benefits of using non-invasive imaging techniques and computational modeling in estimating material properties for TAVI patients.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Salvatore Pasta, Chiara Catalano, Fabrizio Crasci, Roberta Scuoppo
Summary: This study developed a low-cost custom biaxial system capable of accurately characterizing the mechanical behavior of soft tissues. The system's performance was evaluated through tests on a calibration spring and frozen porcine aorta samples, demonstrating its ability to accurately test materials. The system provides researchers with a valuable tool for cardiovascular disease research and tissue engineering applications.
Proceedings Paper
Engineering, Civil
Vincenza Sciortino, Donatella Cerniglia, Salvatore Pasta, Tommaso Ingrassia
Summary: This article introduces the current research on the biomechanics of the spinal column and intervertebral disc, and presents a new approach using fractional calculus to fully describe the viscoelastic behavior of the disc. This new approach could lead to a breakthrough in understanding herniated disc pathologies and identifying strategies to deal with them.
EUROPEAN WORKSHOP ON STRUCTURAL HEALTH MONITORING (EWSHM 2022), VOL 1
(2023)
Proceedings Paper
Engineering, Biomedical
Chiara Catalano, Stefano Cannata, Valentina Agnese, Gianluca Buffa, Livan Fratini, Salvatore Pasta, Caterina Gandolfo
Summary: Transcatheter mitral valve replacement (TMVR) is a promising alternative treatment for patients who are not eligible for surgery. This study developed patient-specific simulations and 3D printed models to predict and assess the obstructive complications of TMVR. The results showed good agreement between numerical predictions, 3D printed model measurements, and post-TMVR diagnostic images. This approach provides a comprehensive and efficient tool for evaluating the feasibility of TMVR.
V CIRP CONFERENCE ON BIOMANUFACTURING
(2022)
Article
Biotechnology & Applied Microbiology
Vincenza Sciortino, Salvatore Pasta, Tommaso Ingrassia, Donatella Cerniglia
Summary: This study aimed to develop a probabilistic atlas of the lumbar spine segment using statistical shape modeling and explore the variability of spine geometry using principal component analysis. The results showed that the principal shape modes were associated with specific morphological features of the spine segment, which can contribute to the development of new treatments for spine disorders.
BIOENGINEERING-BASEL
(2022)
