Review
Environmental Sciences
Shimeng Li, Qinbo Wang, Wenting Luo, Shanshan Jia, Dan Liu, Wei Ma, Hui Gu, Xiaowei Wei, Yiwen He, Songying Cao, Zhengwei Yuan
Summary: This meta-analysis found a positive association between maternal exposure to heavy metals during pregnancy and congenital heart defects (CHDs), particularly with arsenic, cadmium, mercury, and lead. Different measurement methods led to heterogeneous relationships, mainly due to differences in actual exposure levels to heavy metals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Xuelian Yuan, Fengchao Liang, Jun Zhu, Keyong Huang, Li Dai, Xiaohong Li, Yanping Wang, Qi Li, Xiangfeng Lu, Jianfeng Huang, Lihui Liao, Yang Liu, Dongfeng Gu, Hanmin Liu, Fangchao Liu
Summary: This study investigated the association between maternal exposure to fine particulate matter (PM2.5) and fetal congenital heart defects (CHDs) in China. The results showed that higher maternal PM2.5 exposure, especially during the preconception period, increased the risk of certain types of CHDs in offspring. The findings highlight the importance of improving air quality in China and other highly polluted regions for CHD prevention.
Review
Medicine, General & Internal
Jevan Cevik, Omar Salehi, James Gaston, Warren M. M. Rozen
Summary: This systematic review examined the association between maternal smoking during pregnancy and the risk of congenital limb anomalies. The analysis indicated a significant increased risk of these anomalies in infants born to mothers who smoked during pregnancy. These findings underscore the importance of smoking cessation interventions for pregnant women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Jiaomei Yang, Yijun Kang, Qianqian Chang, Binyan Zhang, Xin Liu, Lingxia Zeng, Hong Yan, Shaonong Dang
Summary: This study investigated the associations between maternal total, dietary, and supplemental intakes of zinc, copper, and selenium during pregnancy and congenital heart defects (CHDs). The results showed that higher intakes of zinc and selenium during pregnancy were associated with a reduced risk of CHDs, highlighting the importance of promoting zinc and selenium intakes in reducing the incidence of CHDs in the Chinese population.
Article
Medicine, General & Internal
Lizhu Chen, Yun Xiu, Qijun Wu, Yu Wang, Yixin Zhang, Jia Xue, Qinbo Wang, Zhengwei Yuan
Summary: This study found that maternal serum LMNA may serve as a potential biomarker for prenatal diagnosis of fetal CHD, NTD, and PE.
Review
Cardiac & Cardiovascular Systems
Amalia Baroutidou, Alexandra Arvanitaki, Ioannis T. Farmakis, Vasiliki Patsiou, Andreas Giannopoulos, Georgios Efthimiadis, Antonios Ziakas, George Giannakoulas
Summary: Transcatheter closure is effective for secundum atrial septal defects in elderly patients, improving functional capacity, biventricular dimensions, pulmonary pressures, tricuspid regurgitation severity and brain natriuretic peptide levels. However, it does not significantly affect the incidence of atrial arrhythmias.
Article
Biochemistry & Molecular Biology
Ping-Ching Hsu, Suman Maity, Jenil Patel, Philip J. Lupo, Wendy N. Nembhard
Summary: This study is important in understanding the impact of pregnancies affected by congenital heart defects (CHDs) on maternal metabolism. The study found significant metabolic alterations in mothers of infants with hypoplastic left heart syndrome (HLHS) and tetralogy of Fallot (ToF), suggesting the need for postpartum dietary supplementation for women giving birth to CHD offspring.
Article
Public, Environmental & Occupational Health
Jianhao Sun, Baohong Mao, Zhenzhen Wu, Xinjuan Jiao, Yanxia Wang, Yongli Lu, Xuejing Ma, Xiaohui Liu, Xiaoying Xu, Hongmei Cui, Xiaojuan Lin, Bin Yi, Jie Qiu, Qing Liu
Summary: This study aimed to investigate the relationship between prenatal titanium exposure and the risk of congenital heart defects (CHDs) in offspring. The results showed that higher concentrations of titanium in maternal blood were associated with an increased risk of CHDs, as well as multiple CHDs, atrial septal defects, and patent ductus arteriosus. Higher concentrations of titanium in umbilical cord blood were also associated with an increased risk of CHDs and different heart defects. Therefore, titanium exposure may cross the placental barrier and contribute to the occurrence of CHDs.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Li Sun, Qianlan Wu, Huiying Wang, Juning Liu, Yan Shao, Rong Xu, Tian Gong, Xiaoju Peng, Baoli Zhang
Summary: This study investigates the association between maternal exposure to air pollutants and the risk of congenital heart defects in Suzhou, China. The results suggest that exposure to PM2.5 and NO2 is associated with an increased risk of CHDs.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Stephanie Ibrahim, Benedicte Gaborit, Marien Lenoir, Gwenaelle Collod-Beroud, Sonia Stefanovic
Summary: Congenital heart defects (CHDs), the most common form of birth defects in humans, are complex and difficult to understand. While genetic factors can explain only a minority of cases, environmental risk factors also contribute to the development of CHDs. Maternal pregestational diabetes is associated with an increased risk, but the specific molecular mechanisms remain unclear. This review summarizes key findings on the molecular mechanisms altered in cardiac development under hyperglycemic conditions, presents experimental modeling techniques, and suggests new approaches for understanding and prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Isabel Hardee, Lydia Wright, Courtney McCracken, Emily Lawson, Matthew E. Oster
Summary: This study evaluated maternal and neonatal outcomes of pregnancies among women with congenital heart disease (CHD) in the modern era, finding that pregnancy in women with CHD typically has a successful outcome in both mother and child. However, as maternal CHD severity increases, the risk of numerous morbidities and neonatal mortality also increases. These findings may be helpful in counseling women with CHD, especially those with severe lesions, who plan to become pregnant.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Environmental Sciences
Bo-Yi Yang, Yanji Qu, Yuming Guo, Iana Markevych, Joachim Heinrich, Michael S. Bloom, Zhipeng Bai, Luke C. Knibbs, Shanshan Li, Gongbo Chen, Bin Jalaludin, Lidia Morawska, Meng Gao, Bin Han, Yunjiang Yu, Xiao-Xuan Liu, Yanqiu Ou, Jinzhuang Mai, Xiangmin Gao, Yong Wu, Zhiqiang Nie, Xiao-Wen Zeng, Li-Wen Hu, Xubo Shen, Yuanzhong Zhou, Shao Lin, Xiaoqing Liu, Guang-Hui Dong
Summary: The study found that maternal exposure to air pollution during pregnancy, particularly in the first trimester, is associated with an increased risk of CHD in offspring. No significant associations were observed for exposure to air pollutants during the second and third trimesters. The associations between air pollutants and different CHD subtypes varied.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Clinical Neurology
Jing Gu, Hong-Bo Guan
Summary: Maternal stress and stressful life events during pregnancy may be associated with a higher risk of CHD in offspring, but there is no observed association for maternal anxiety and depression during pregnancy. Residual confounding, heterogeneity, and publication bias may exist as limitations in the interpretation of the results.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Nursing
Katie C. Hall, Jennifer C. Robinson, William H. Cooke, Aimee S. Parnell, Lei Zhang, Ladonna Northington
Summary: This study examined the relationship between maternal exposure to PM2.5 and O-3 air pollutants during the first trimester and a critical CHD diagnosis. While no overall association was found, vulnerability during certain weeks of gestation was suggested, calling for further surveillance and study.
Review
Pediatrics
Ping Ni, XiuLi Wang, ZhuoMing Xu, Wenyi Luo
Summary: High-energy and/or high-protein feeding may be safe and effective in improving nutrition and reducing the duration of mechanical ventilation, ICU stay, and hospital stay in children after congenital heart surgery. However, further studies are needed to confirm these findings in patient cohorts with different cardiac physiologies.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Peripheral Vascular Disease
Ziqi Yang, Xuan Zhou, Ziqiang Gong, Senmao Zhang, Xiaoling Liu, Yan Chen, Changxiang Ye, Lizhang Chen, Tingting Wang
Summary: Hypertensive disorders of pregnancy (HDP) may affect pubertal development in offspring, particularly in terms of body mass index (BMI) and waist circumference, highlighting the importance of focusing on developmental abnormalities during adolescence in offspring exposed to HDP.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Obstetrics & Gynecology
Manjun Luo, Tingting Wang, Peng Huang, Senmao Zhang, Xinli Song, Mengting Sun, Yiping Liu, Jianhui Wei, Jing Shu, Taowei Zhong, Qian Chen, Ping Zhu, Jiabi Qin
Summary: By conducting a case-control study, it was found that maternal BHMT gene polymorphisms at rs1316753 and rs1915706 are significantly associated with increased risk of congenital heart disease (CHD) in offspring. Furthermore, significant interactions between different SNPs also exist on the risk of CHD.
REPRODUCTIVE SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Yuhang Wu, Fan Xia, Mengshi Chen, Senmao Zhang, Ziqi Yang, Ziqiang Gong, Xuan Zhou, Lizhang Chen, Tingting Wang
Summary: This study estimated the burden of neonatal disorders in China from 1990 to 2019 and predicted the trends from 2020 to 2024. The results showed a decline in mortality, incidence, disability-adjusted life years, and years of life lost, but an increase in prevalence and years lived with disability. The specific causes of neonatal disorders included preterm birth, birth asphyxia and trauma, sepsis and other infections, and jaundice, with low birth weight, short gestation, particulate matter pollution, and household air pollution from solid fuels identified as leading risk factors.
Article
Endocrinology & Metabolism
Xinli Song, Cheng Wang, Tingting Wang, Senmao Zhang, Jiabi Qin
Summary: Genetically predicted causal associations were found between general and central obesity and GDM, with circulating lipids acting as potential mediators. The results indicated a direct effect of obesity on GDM risk, with lipid metabolism playing a role in the relationship.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Correction
Pharmacology & Pharmacy
Jiehua Wei, Fan Xia, Junxiang Miao, Tingting Wang, Lizhang Chen, Xuemei Yan
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jiehua Wei, Fan Xia, Junxiang Miao, Tingting Wang, Lizhang Chen, Xuemei Yan
Summary: This study did not find an association between maternal corticosteroids exposure during the first trimester and offspring congenital heart defects. However, the existing evidence is of low quality, and further research is needed to confirm these findings.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Chemistry, Physical
Liu Lin, Ruiyun Xin, Mengwei Yuan, Tongyue Wang, Jie Li, Yunming Xu, Xuhui Xu, Mingxuan Li, Yu Du, Jianing Wang, Shuyi Wang, Fubin Jiang, Wenxin Wu, Caicai Lu, Binbin Huang, Zemin Sun, Jian Liu, Jinlu He, Genban Sun
Summary: Based on experimental and theoretical studies, the spin-magnetic effect of iron group layered double hydroxides (LDHs) was found to enhance the oxygen evolution reaction (OER) process. The saturation magnetization of iron group LDHs positively correlates with their OER performance under different magnetic fields. Among the tested LDHs, NiCoFe-LDHs show the strongest OER activity and saturation magnetization.
Article
Obstetrics & Gynecology
Jianhui Wei, Tingting Wang, Xinli Song, Yiping Liu, Jing Shu, Mengting Sun, Jingyi Diao, Jingqi Li, Yihuan Li, Letao Chen, Senmao Zhang, Peng Huang, Jiabi Qin
Summary: This study found that maternal MTRR gene polymorphisms are associated with the risk of CHD in offspring. Specifically, certain SNPs (such as rs1532268 and rs1802059) are associated with increased risk, while other SNPs (such as rs2287779 and rs2303080) are associated with decreased risk. Additionally, certain haplotypes of the MTRR gene are also linked to CHD risk. However, the mechanisms by which these factors influence fetal cardiac development remain unknown, and further studies in larger and more diverse populations are needed.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Junxiang Miao, Yan Chen, Xiaoling Liu, Changxiang Ye, Xuan Zhou, Ziqi Yang, Ziqiang Gong, Lizhang Chen, Tingting Wang
Summary: This research conducted a systematic and comprehensive meta-analysis to determine the association between maternal body mass index (BMI) and gestational weight gain (GWG) and the risk of cancer in offspring. The results suggest that high GWG may increase the risk of total cancer in offspring, while low GWG is not associated with the risk. There is no significant association between maternal underweight, overweight/obesity, and the risk of total cancer in offspring. Further research is needed to clarify the potential relevance of maternal BMI and GWG on offspring cancer, especially for specific cancers.
Article
Multidisciplinary Sciences
Yiping Liu, Taowei Zhong, Xinli Song, Senmao Zhang, Mengting Sun, Jianhui Wei, Jing Shu, Tubao Yang, Tingting Wang, Jiabi Qin
Summary: In this hospital-based case-control study, we found significant associations between genetic polymorphisms of the methionine synthase (MTR) gene at rs1805087 and rs2275565 and the risk of non-syndromic congenital heart disease (CHD). Additionally, we observed significant associations between three haplotypes and CHD risk.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Manjun Luo, Mengting Sun, Tingting Wang, Senmao Zhang, Xinli Song, Xiaoying Liu, Jianhui Wei, Qian Chen, Taowei Zhong, Jiabi Qin
Summary: This study used two-sample bidirectional mendelian randomization to evaluate the causal relationship between gut microbiota and T1D. The results showed that the Bacteroidetes phylum, Bacteroidia class, and Bacteroidales order of gut microbiota increase the risk of T1D, while the Eubacterium eligens group genus belonging to the Firmicutes phylum decreases the risk of T1D.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Mengting Sun, Manjun Luo, Tingting Wang, Jianhui Wei, Senmao Zhang, Jing Shu, Taowei Zhong, Yiping Liu, Qian Chen, Ping Zhu, Jiabi Qin
Summary: This study investigated the independent and combined effects of advanced maternal age and pre-pregnancy body mass index (BMI) on the risk of pre-eclampsia and gestational diabetes mellitus (GDM). The results showed that both advanced maternal age and pre-pregnancy overweight/obesity were associated with an increased risk of pre-eclampsia and GDM. Furthermore, pre-pregnancy BMI mediated the associations between maternal age and the development of pre-eclampsia and GDM.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
Article
Public, Environmental & Occupational Health
Jiehua Wei, Peiwen Wang, Fan Xia, Junxiang Miao, Xuan Zhou, Ziqi Yang, Ziqiang Gong, Lizhang Chen, Tingting Wang
Summary: This study analyzed the effects of non-optimal temperatures on cardiovascular disease mortality risk in China. The results showed that from 1990 to 2019, the mortality rate of cardiovascular disease attributable to non-optimal temperatures generally declined, but ischemic heart disease showed a slight increase. Low temperatures had a higher death burden than high temperatures, but the death burden from high temperatures showed steady increases.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Chemistry, Multidisciplinary
Baochang Zhang, Yupeng Zheng, Guochao Chu, Xiangyu Deng, Tongyue Wang, Weiwei Shi, Yongkang Zhou, Shan Tang, Ji-Shen Zheng, Lei Liu
Summary: This article presents a new method called Backbone-Installed Split Intein-Assisted Ligation (BISIAL) for the synthesis of membrane-associated D-proteins. The BISIAL method allows smooth ligation under strongly chaotropic conditions and the removal of ligation scars on the products, enabling the synthesis of challenging Dprotein targets.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Clinical Neurology
Luying Fan, Yuhang Wu, Jiehua Wei, Fan Xia, Yufeng Cai, Senmao Zhang, Junxiang Miao, Yunzhe Zhou, Chu Liu, Wei Yan, Dan Liu, Lizhang Chen, Tingting Wang
Summary: This study examined global trends in migraine incidence using data from the Global Burden of Disease 2019. The results showed that the global incidence of migraine increased to 87.6 million in 2019, with a 40.1% increase compared to 1990. India, China, United States of America, and Indonesia had the highest number of incidences. Females had a higher incidence rate than males, with the highest incidence observed in the 10-14 age group. There were also variations in incidence trends and age distribution across different countries.
JOURNAL OF HEADACHE AND PAIN
(2023)
