Article
Oncology
Jung-Sun Sim, Hwa-Yeong Lee, Mijung Yim
Summary: The ethanol extract of Coriandrum sativum L. inhibits osteoclast formation and function by downregulating the NF-kappa B and ERK/c-Fos/NFATc1 signaling pathways. This study suggests that Coriandrum sativum L. could be a potential candidate for the prevention and treatment of osteolytic diseases.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Environmental Sciences
Hui Zhao, Lin Fu, Hui-Xian Xiang, Ying Xiang, Meng-Die Li, Bian-Bian Lv, Zhu-Xia Tan, Lan Gao, Cheng Zhang, De-Xiang Xu
Summary: The study found that Benzo[a]pyrene can cause acute lung injury and inflammation, while the antioxidant N-acetylcysteine (NAC) can alleviate the pulmonary inflammatory response induced by Benzo[a]pyrene.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li
Summary: The study demonstrates that SVHRP can inhibit neuroinflammation and microglia activation, potentially explaining the therapeutic effects of BmK-derived materials and suggesting that BmK venom could be a potential source for CNS drug development.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Bingfeng Lin, Pingcui Xu, Juan Zheng, Xuehui Deng, Qitao Ye, Zhongping Huang, Nani Wang
Summary: This review discusses the use of natural alkaloids in the prevention and treatment of osteoporosis. Anti-osteoporosis alkaloids can promote mesenchymal stem cells differentiation, improve osteoblast proliferation, suppress osteoclast formation, and regulate multiple signaling pathways. These findings provide evidence and support for the development of novel drugs and clinical treatment of osteoporosis using natural alkaloids.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Fang He, Xiaoyan Wu, Qingzhuo Zhang, Yikun Li, Yuyi Ye, Pan Li, Shuai Chen, Yuanyi Peng, Rudiger Hardeland, Yaoyao Xia
Summary: Melatonin exhibits antibacterial effects on various pathogenic bacteria in animals and plants, acting through multiple mechanisms such as direct actions at high concentrations, activation of hosts' defense mechanisms, attenuation of inflammation, and modulation of signaling pathways. Its protective functions involve inhibition of reactive oxygen and nitrogen species, detoxification, and protection against mitochondrial damage, suggesting melatonin as a potential effective approach against bacterial infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Linjie Ju, Peipei Hu, Ping Chen, Jiejie Wu, Zhuoqun Li, Zhixia Qiu, Jun Cheng, Fang Huang
Summary: The study showed that CSBTA can alleviate cancer-induced bone pain and inhibit osteoclastogenesis, possibly through suppressing RANKL-induced NF-kappa B and c-Fos/NFATc1 pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Zhuangwei Zhang, Shuoqi Jiang, Hengqun Tian, Yu Zeng, Kang He, Lin Lin, Fangmiao Yu
Summary: The study aimed to investigate the anti-inflammatory effects of Nymphaea hybrida ethanol extract and its polar fractions. The results showed that the ethyl acetate fraction of NHE exhibited significant inhibitory effects on inflammation by suppressing the activation of NF-kappa B and MAPK pathways in LPS-induced inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Hyun Ji Eo, Jun Hyuk Jang, Gwang Hun Park
Summary: Berchemia floribunda (BF), a plant from Rhamnaceae, known for its antioxidant and whitening effects, was studied for its anti-inflammatory properties in this research. The leaves extract (BR-L) showed strong anti-inflammatory activity by inhibiting NO production and suppressing pro-inflammatory mediators in LPS-induced cells. BR-L also demonstrated potential in inhibiting NF-kappa B activation and MAPKs phosphorylation. These findings suggest the potential of BR-L as a candidate for new anti-inflammatory drugs against acute and chronic inflammatory disorders.
Article
Biochemistry & Molecular Biology
Yingjie Liu, Haojie Shan, Yang Zong, Yiwei Lin, Wenyang Xia, Nan Wang, Lihui Zhou, Youshui Gao, Xin Ma, Chaolai Jiang, Xiaowei Yu
Summary: The study showed that IKKe interacts with NIK in the NF-kappa B pathway to suppress osteoclastogenesis in methylprednisolone-induced ONFH. Knockout of IKKe promotes osteoclastogenesis and suppresses ONFH progression by inhibiting the NIK/NF-kappa B pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Plant Sciences
Ying Li, Jin-gang Hou, Zhi Liu, Xiao-jie Gong, Jun-nan Hu, Ying-ping Wang, Wen-cong Liu, Xiang-hui Lin, Zi Wang, Wei Li
Summary: In this study, treatment with 20(R)-Rg3 for 8 weeks in T2D mice not only decreased FBG and AGEs levels, but also improved insulin, blood lipids, oxidative stress, and renal function by regulating MAPKs and NF kappa B signal pathways, showing significant ameliorative effects on DN mice.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Inyoung Kim, Jung Ha Kim, Kabsun Kim, Semun Seong, Keun-Bae Lee, Nacksung Kim
Summary: IRF2 plays a crucial role in RANKL-induced osteoclast differentiation by enhancing NFATc1 expression and promoting the translocation of NF-kappa B subunit p65 to the nucleus. It regulates the NF-kappa B/NFATc1 signaling pathway, providing insights into potential therapeutic targets for bone diseases characterized by excessive bone resorption.
Article
Biochemistry & Molecular Biology
Ahmed M. Sayed, Maha M. Abdel-Fattah, Hany H. Arab, Wafaa R. Mohamed, Emad H. M. Hassanein
Summary: Perindopril attenuated MTX-induced intestinal injury by suppressing TLR4/NF-kappa B and c-Fos/c-Jun pathways, enhancing PPAR-gamma/SIRT1 cytoprotective signals, decreasing expression of inflammatory cytokines, and increasing anti-inflammatory factors.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Medicinal
Xinxin Zhang, Yating Qin, Weibin Ruan, Xiaoning Wan, Chao Lv, Lin He, Li Lu, Xiaomei Guo
Summary: Baicalein, a flavonoid phytochemical, demonstrates anti-inflammatory properties in macrophages, endothelial cells, and vascular smooth muscle cells by activating the AMPK/Mfn-2 axis and inhibiting MAPKs/NF-kappa B signaling transduction pathway. Baicalein effectively reduces proinflammatory cytokine levels, suggesting its potential role in atherosclerosis treatment. Further studies may be needed to fully understand the mechanisms of baicalein's anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sakawrat Janpaijit, Pattawika Lertpatipanpong, Chanin Sillapachaiyaporn, Seung Joon Baek, Somsri Charoenkiatkul, Tewin Tencomnao, Monruedee Sukprasansap
Summary: The seed extract of Cleistocalyx nervosum var. paniala (CNSE) has anti-neuroinflammatory effects and can inhibit LPS-induced inflammation through the MAPKs/NF-kappa B pathway.
Article
Biochemical Research Methods
Wang Yang, Jian Shi, Yan Zhou, Tongjun Liu, Jiannan Li, Feng Hong, Kai Zhang, Ning Liu
PROTEOMICS CLINICAL APPLICATIONS
(2019)
Article
Pharmacology & Pharmacy
Huanhuan Hou, Qisheng Peng, Shaoming Wang, Yuxin Zhang, Jinjin Cao, Yuming Deng, Yingjian Wang, Wan-chun Sun, Hong-bing Wang
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Chemistry, Analytical
Ningning Sun, Yong Wang, Jun Wang, Wanchun Sun, Jingbo Yang, Ning Liu
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Chi-Kong Chan, Kwan-Kit Jason Chan, Ning Liu, Wan Chan
Summary: This study developed a highly sensitive and selective method for quantifying protein adducts of aristolochic acid I (AAI) as a biomarker of AA exposure, which can accurately and precisely detect AAI exposure in human and animal samples. This method is expected to fill the technical gap in diagnosing AA intoxication.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Immunology
Jinjin Cao, Shaoming Wang, Congmin Wei, Hongru Lin, Chen Zhang, Yehui Gao, Zixian Xu, Zhou Cheng, Wan-chun Sun, Hong-bing Wang
Summary: In this study, Agrimophol (AGR) was found to inhibit RANKL-induced osteoclastogenesis through various mechanisms, suggesting its potential as a therapeutic agent against bone lysis diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemical Research Methods
Jinming Zhang, Qisheng Peng, Weizheng Zhao, Wanchun Sun, Jingbo Yang, Ning Liu
Summary: Studying PTMs is crucial for understanding the pathogenesis of influenza viruses and finding new treatment methods. Proteomics has made significant contributions in describing the dynamic interaction between influenza viruses and their hosts. PTMs play a critical role in regulating the structure, function, and localization of proteins.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Gengjun Zhu, Lifang Jin, Wanchun Sun, Shuang Wang, Ning Liu
Summary: This review highlights the importance of post-translational modifications (PTMs) in colorectal cancer (CRC) and discusses their role in diagnosis, prognosis, and treatment. The review summarizes the proteomic profiling strategies for key PTMs and describes the methods used to delineate the global landscapes of each PTM. The review also discusses the current status of PTM research in CRC and provides future perspectives on the role of PTM regulation in translational medicine for CRC.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Engineering, Biomedical
Jingyao Liu, Wanchun Sun, Xuehua Zhao, Jiashi Zhao, Zhengang Jiang
Summary: This study proposes an efficient method based on deep learning, called the deep feature fusion classification network (DFFCNet), to improve the overall accuracy of diagnosing highly infectious diseases such as COVID-19. The method consists of two modules, the deep feature fusion module (DFFM) and multi-disease classification module (MDCM). The DFFM combines different network advantages for feature fusion, while the MDCM uses support vector machine (SVM) as a classifier to enhance classification performance. Spatial attention and channel attention modules are introduced to improve feature extraction capability. The method also performs multiple-way data augmentation on chest X-ray images to increase sample diversity. Results show that the proposed method achieves a high accuracy rate of 99.89% in classifying COVID-19, pneumonia, and health X-ray images, outperforming other classification techniques.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Engineering, Biomedical
Wanchun Sun, Xin Feng, Jingyao Liu, Hui Ma
Summary: This article introduces a weakly supervised learning strategy called LLC-Net for COVID-19 CT image segmentation. The method utilizes a local self-coherence mechanism for label propagation, a scale transform for self-correlation to optimize model robustness, and a lesion infection edge attention module to improve segmentation accuracy. Experiments demonstrate that this method achieves state-of-the-art performance on public datasets.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Computer Science, Hardware & Architecture
Wanchun Sun, Xin Feng, Jingyao Liu
Summary: This paper proposes a new weakly supervised semantic segmentation method, which improves the sparsity issue of seed by designing a non-bias layer and introducing an information enhancement module, thus enhancing the accuracy and generalization ability of the model.
COMPUTERS & ELECTRICAL ENGINEERING
(2023)
Article
Engineering, Multidisciplinary
Wanchun Sun, Xin Feng, Jingyao Liu, Hui Ma
Summary: This paper proposes a self-progress aggregate learning method named SPAL for weakly supervised salient object detection. By optimizing the edge information module and complementing slight-level edge information with high-level affinity information, along with guiding the network with the scale attention module, our method achieved better experimental results compared to other competitive models.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Wanchun Sun, Xin Feng, Hui Ma, Jingyao Liu
Summary: This paper proposes a method that learns the semantic relationships between different blocks using a graph structure to address the issue of determining semantic association in transformer-based weakly supervised semantic segmentation. Experimental results on the PASCAL VOC2012 dataset demonstrate the significant performance improvement of the proposed method in the WSSS task, outperforming other state-of-the-art transformer-based methods.
COMPLEX & INTELLIGENT SYSTEMS
(2023)
Article
Engineering, Electrical & Electronic
Wanchun Sun, Xin Feng, Hui Ma, Jingyao Liu
Summary: This article introduces a weakly supervised object localization method based on transformers, which addresses the limitations of traditional methods by introducing hierarchical comprehension of transformers (HiCT), discriminative-based attention layer (DAL), and spatial aware digging module (SADM), and its effectiveness is proven through experiments.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Immunology
Chen Li, Jingyu Wang, Wanchun Sun, Xiaofeng Liu, Jun Wang, Qisheng Peng
Summary: BspI, a Brucella T4SS effector protein, negatively regulates immune responses in mice to Brucella infection by inhibiting IRE1 kinase activity, thus preventing proinflammatory cytokine production. BspI interacts with IRE1 in HeLa cells and its inhibitory function depends on the GAP domain, not on interaction with small GTPase RAB1B.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuxin Zhang, Jing Wang, Chenxu Jing, Ming-Xue Zhou, Wenqi Jin, Xiuci Yan, Huanhuan Hou, Kai Shi, Wan-Chun Sun, Liwei Sun
Summary: Purple tea extract (PTE) was found to suppress osteoclast formation in bone marrow macrophages (BMMs) stimulated by RANKL, possibly through modulation of the Blimp1-Irf8 and Akt/GSK3 beta signaling pathways. In addition, PTE administration showed improvement in bone loss in LPS-treated mice.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)