Article
Pharmacology & Pharmacy
Ahmad Alshehri, Afza Ahmad, Rohit Kumar Tiwari, Irfan Ahmad, Ali G. Alkhathami, Mohammad Y. Alshahrani, Mohammed A. Asiri, Tahani M. Almeleebia, Mohd Saeed, Dharmendra Kumar Yadav, Irfan Ahmad Ansari
Summary: The study revealed the antioxidant, anticancer, and anti-inflammatory activities of Adenium obesum, commonly known as desert rose, suggesting its potential as a herbal-based medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Mariam Sharif, Irfan Anjum, Arham Shabbir, Muhammad Naveed Mushtaq
Summary: The study found that A. lanata herbal extract has immunomodulatory and anti-inflammatory effects on allergic asthmatic mice, reducing the number of inflammatory cells, lowering the level of inflammatory mediators, and increasing the expression levels of aquaporin.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Takaki Hiwasa, Hao Wang, Ken-ichiro Goto, Seiichiro Mine, Toshio Machida, Eiichi Kobayashi, Yoichi Yoshida, Akihiko Adachi, Tomoo Matsutani, Mizuki Sata, Kazumasa Yamagishi, Hiroyasu Iso, Norie Sawada, Shoichiro Tsugane, Mitoshi Kunimatsu, Ikuo Kamitsukasa, Masahiro Mori, Kazuo Sugimoto, Akiyuki Uzawa, Mayumi Muto, Satoshi Kuwabara, Yoshio Kobayashi, Mikiko Ohno, Eiichiro Nishi, Akiko Hattori, Masashi Yamamoto, Yoshiro Maezawa, Kazuki Kobayashi, Ryoichi Ishibashi, Minoru Takemoto, Koutaro Yokote, Hirotaka Takizawa, Takashi Kishimoto, Kazuyuki Matsushita, Sohei Kobayashi, Fumio Nomura, Takahiro Arasawa, Akiko Kagaya, Tetsuro Maruyama, Hisahiro Matsubara, Minako Tomiita, Shinsaku Hamanaka, Yushi Imai, Tomoo Nakagawa, Naoya Kato, Jiro Terada, Takuma Matsumura, Yusuke Katsumata, Akira Naito, Nobuhiro Tanabe, Seiichiro Sakao, Koichiro Tatsumi, Masaaki Ito, Fumiaki Shiratori, Makoto Sumazaki, Satoshi Yajima, Hideaki Shimada, Mikako Shirouzu, Shigeyuki Yokoyama, Takashi Kudo, Hirofumi Doi, Katsuro Iwase, Hiromi Ashino, Shu-Yang Li, Masaaki Kubota, Go Tomiyoshi, Natsuko Shinmen, Rika Nakamura, Hideyuki Kuroda, Yasuo Iwadate
Summary: The study identified antigens related to atherosclerosis through serum antibody levels, which can help predict the onset of AIS and provide significantly increased risk signals.
Article
Cell Biology
Jiajia Fu, Sihui Chen, Jiao Liu, Jing Yang, Ruwei Ou, Lingyu Zhang, Xueping Chen, Huifang Shang
Summary: This study investigated the serum levels of inflammatory cytokines and their correlations with clinical symptoms in Parkinson's disease (PD) patients. The results showed that PD patients had higher levels of IL-6 and TNF-alpha compared to healthy controls, and IL-6 was associated with non-motor symptoms and cognitive dysfunction, while TNF-alpha had diagnostic value for PD despite its irrelevance to clinical symptoms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Sirikul Soontararak, Piyathida Ardaum, Napaporn Senarat, Sarawut Yangtara, Chalermpol Lekcharoensuk, Iyarath Putchong, Narudee Kashemsant, Monchanok Vijarnsorn, Lyndah Chow, Steven Dow, Porntippa Lekcharoensuk
Summary: Autologous conditioned serum (ACS) generated from dogs with osteoarthritis (OA) has therapeutic potential in reducing inflammation and promoting joint regeneration. ACS was shown to suppress T cell activity and promote the proliferation of joint cells and gene expression in chondrocytes. These effects are likely due to the presence of mediators such as transforming growth factor and IL-1RA in ACS.
Article
Oncology
Rita Godinho, Alessandra Noto, Craig Fenwick, Athina Stravodimou, Sarah Hugelshofer, Solange Peters, Roger Hullin, Michel Obeid
Summary: We report a case of severe biventricular dysfunction and cardiogenic shock induced by anti-HER2 therapies in a breast cancer patient. The patient showed severe systemic inflammation, with structural changes in the heart indicative of myocardial inflammation. The immune-inflammatory profile revealed increased complement activation, elevated levels of proinflammatory cytokines, and increased activity of specific immune cell subsets.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Multidisciplinary Sciences
Jessica Feldt, Anna-Jasmina Donaubauer, Jessica Welss, Ulrich Schneider, Udo S. Gaipl, Friedrich Paulsen
Summary: A gold-based autologous serum therapy for osteoarthritis patients was investigated, which showed modulatory effects on immune cell activation and cytokine levels. The therapy downregulated CD4(+) T cells and B cells, and upregulated monocytes in patients. Serum levels of IL-9 and TNF-alpha were also decreased after therapy.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Masahiro Kogami, Yoshiyuki Abe, Taiki Ando, Ayako Makiyama, Ken Yamaji, Naoto Tamura
Summary: The anti-MDA5 antibody titre at diagnosis may predict the clinical course of anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis. Levels of macrophage-associated cytokines significantly decline at 6 months post-treatment, and they may increase after anti-MDA5 antibody titre positivity.
Article
Gastroenterology & Hepatology
Marina Liso, Giulio Verna, Elisabetta Cavalcanti, Stefania De Santis, Raffaele Armentano, Angela Tafaro, Antonio Lippolis, Pietro Campiglia, Antonio Gasbarrini, Mauro Mastronardi, Theresa Torres Pizarro, Fabio Cominelli, Loris Riccardo Lopetuso, Marcello Chieppa
Summary: This study provides new insights and alternative approaches to treat ulcerative colitis (UC) patients. It suggests that anti-interleukin (IL)1 strategies, such as anakinra, may be a more effective therapeutic option for primary nonresponders to anti-tumor necrosis factor (TNF) therapy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
Mathieu Ferrari, Shimobi C. Onuoha, Liliane Fossati-Jimack, Alessandra Nerviani, Pedro L. Alves, Sara Pagani, Cecilia Deantonio, Federico Colombo, Claudio Santoro, Daniele Sblattero, Costantino Pitzalis
Summary: Novel tissue-specific agent BsAb shows improved therapeutic effect by targeting the arthritic synovium, providing better efficacy compared to standard treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Juliette Brenner, Sara Mariotto, Anna E. M. Bastiaansen, Manuela Paunovic, Sergio Ferrari, Daniela Alberti, Marienke A. A. M. de Bruijn, Yvette S. Crijnen, Marco W. J. Schreurs, Rinze F. Neuteboom, Jan G. M. C. Damoiseaux, Juna M. de Vries, Maarten J. Titulaer
Summary: This study aimed to investigate the value of serum NfL levels as a biomarker for disease severity and prognosis in patients with anti-NMDA receptor encephalitis. The results showed that increased NfL levels were associated with neuroaxonal damage in patients, but not with disease severity. However, the association with outcome was confounded by age. Therefore, the applicability of NfL as a prognostic marker is limited.
Article
Multidisciplinary Sciences
Fatemeh Bahram Yazdroudi, Alaeddin Malek
Summary: This article proposes an optimal regulator control problem to simulate how to prevent pulmonary fibrosis by controlling the proliferation and apoptosis of myofibroblasts with anti-TGF-beta and anti-PDGF medicines. The problem is solved using the weighted Galerkin method and the calculus of variations. Numerical results show that the myofibroblast population decreases and eventually vanishes over time by prescribing the controller medicines.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Marcin Sochal, Jakub Fichna, Agata Gabryelska, Renata Talar-Wojnarowska, Piotr Bialasiewicz, Ewa Malecka-Wojciesko
Summary: This study evaluated serum levels of chemerin in patients with inflammatory bowel disease (IBD), finding that chemerin levels were significantly higher during exacerbation of the disease and correlated with severity of Crohn's disease (CD). Anti-TNF therapy significantly decreased chemerin levels, suggesting its potential relationship with disease activity in IBD and potential clinical utility as a monitoring tool.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Miriam Bobadilla, Ana Pariente, Ana Oca, Rafael Pelaez, Alvaro Perez-Sala, Ignacio M. Larrayoz
Summary: Researchers propose combining genomic, proteomic, and metabolomic markers with specific clinical characteristics to identify patients with poor response to anti-VEGF treatment and establish personalized treatment plans.
Article
Immunology
Maria de la Luz Garcia-Hernandez, Javier Rangel-Moreno, Maricela Garcia-Castaneda, H. Mark Kenney, Ananta Paine, Michael Thullen, Allen P. Anandarajah, Edward M. Schwarz, Robert T. Dirksen, Christopher T. Ritchlin
Summary: DC-STAMP modulates both bone resorption and inflammation, and may serve as a therapeutic target in inflammatory arthritis and metabolic bone disease.
FRONTIERS IN IMMUNOLOGY
(2022)