Journal
INFECTION
Volume 47, Issue 2, Pages 289-292Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s15010-018-1261-y
Keywords
Multi-drug resistance; Respiratory tract infection; Lung transplantation; Cystic fibrosis; Ceftazidime-avibactam; Burkholderia cepacia complex
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We describe two cystic fibrosis patients infected with pandrug-resistant Burkholderia cepacia complex, with the exception of ceftazidime-avibactam, who received prophylaxis with this antibiotic during lung transplantation. Although both patients had a post-operative relapse of respiratory infection, one with positive blood cultures, ceftazidime-avibactam treatment yielded a favourable outcome. 12 months after transplantation, one patient presented an excellent clinical outcome. However, the other patient died 10 months later due to severe B. cepacia sinusitis with intracranial invasion.
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