Review
Medicine, General & Internal
Puneet Agarwal, Snehal Balvant Lunge, Nandini Sundar Shetty, Priyanka Karagaiah, Steven Daveluy, Alex G. Ortega-Loayza, Thrasyvoulos Tzellos, Jacek C. Szepietowski, Christos C. Zouboulis, Stephan Grabbe, Mohamad Goldust
Summary: Hidradenitis suppurativa/acne inversa (HS) is a chronic inflammatory disease that causes painful, inflammatory nodules, abscesses, and tunnels in the apocrine gland-bearing areas of the skin. Pain and drainage are the main symptoms that affect the quality of life in HS patients. Itch, which is often overlooked in quality of life studies, is also an important symptom and is associated with reduced quality of life, depression, and impairment of social life. Mast cells and mTor signaling are elevated in both lesional and perilesional skin. Brodalumab, a monoclonal antibody against IL-17A receptor, has shown significant improvements in itch, pain, quality of life, and depression in patients with moderate to severe HS. Statins have shown some reduction in itch intensity score. Further studies are needed to better understand the etiopathogenesis and optimal therapeutic modalities for itch in HS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dermatology
Surav Man Sakya, David R. Hallan, Steven A. Maczuga, Joslyn S. Kirby
Summary: Pregnant women with Hidradenitis Suppurativa (HS) have lower odds of live birth, higher odds of elective terminations, gestational hypertension, and cesarean deliveries compared to those without HS. They also have greater odds of receiving designated HS treatment during pregnancy. Coordinated care by dermatologists and obstetric providers may benefit women planning for or currently pregnant.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Medicine, General & Internal
Lennart Ocker, Nessr Abu Rached, Caroline Seifert, Christina Scheel, Falk G. Bechara
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease that significantly impacts patients' quality of life and is associated with comorbidities. Treatment is complex, requiring personalized medical and surgical approaches. There is a need for new treatment options, and recent research has identified potential therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Allergy
Kelsey R. van Straalen, Errol P. Prens, Johann E. Gudjonsson
Summary: Hidradenitis suppurativa is a chronic, inflammatory skin disorder that affects around 1% of the population and significantly impacts patients' quality of life. It is characterized by inflammatory lesions such as nodules, abscesses, and sinus tracts in areas like the armpits, groin, and buttocks, typically appearing during or after puberty. The development and maintenance of the disease involve a complex interplay of genetic predisposition, hormonal factors, obesity, and smoking. It is believed to stem from a defect in the hair follicle, leading to follicular plugging, cyst formation, and subsequent acute inflammation. Over time, acute lesions progress to a chronic condition with draining sinus tracts and extensive fibrosis. Hidradenitis suppurativa is associated with other immune-mediated inflammatory diseases, metabolic and cardiovascular disorders, and psychiatric comorbidities.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Dermatology
Milosz Lewandowski, Zuzanna Swierczewska, Wioletta Baranska-Rybak
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease that severely affects patients' quality of life. While there are multiple treatment options, no uniformly effective therapy has been found. A multidisciplinary approach is needed for the management of this disease.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Nutrition & Dietetics
Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Giulia de Alteriis, Maria Maisto, Marianna Donnarumma, Gian Carlo Tenore, Annamaria Colao, Gabriella Fabbrocini, Silvia Savastano
Summary: In this study, circulating TMAO levels were higher and adherence to the Mediterranean diet was lower in HS patients, with HS patients of higher severity showing higher BMI, waist circumference, and energy intake but lower PhA and MD adherence. Circulating TMAO levels were positively correlated with HS severity, and both circulating TMAO levels and PhA were main predictors of HS clinical severity.
Review
Biochemistry & Molecular Biology
Roberta Giuffrida, Serafinella Patrizia Cannavo, Marialorena Coppola, Claudio Guarneri
Summary: Research on newer therapeutic approaches targeting specific molecular or cellular targets, such as tumor necrosis factor-alpha, IL-1 beta, IL-10, and the IL-23/T-helper (Th) 17 and IL12/Th1 axes, has shown promising results in the management of HS. Inhibitors of phosphodiesterase 4 and laser treatments have demonstrated good short-term safety and effectiveness. Target therapy has revolutionized the treatment of moderate to severe HS by directly inhibiting the pathogenesis of the condition.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zuzanna Swierczewska, Milosz Lewandowski, Agnieszka Surowiecka, Wioletta Baranska-Rybak
Summary: Hidradenitis suppurativa, also known as acne inversa, is a debilitating skin disease characterized by severe inflammation and the formation of painful nodules, abscesses, and fistulas. Current treatment options are limited and ineffective, leading to the search for new biologics and target treatments. This article discusses the current and future targets for acne inversa treatment and provides insights into the molecular pathomechanisms of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Christopher J. Sayed, Jennifer L. Hsiao, Martin M. Okun
Summary: Hidradenitis suppurativa is a chronic inflammatory skin disease that is more prevalent in women and individuals aged 18-40 years. Obstetrician-gynecologists have the opportunity to reduce morbidity by diagnosing and optimizing treatment early.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medicine, General & Internal
Massimo Dell'Antonia, Jasmine Anedda, Alice Tatti, Alessandro Falco, Silvia Sanna, Caterina Ferreli, Laura Atzori
Summary: This study evaluated the effectiveness of cryotherapy in treating persistent nodules of hidradenitis suppurativa. The results showed that cryotherapy was effective in the majority of patients and they highly recommended the treatment.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Elisa Molinelli, Helena Gioacchini, Claudia Sapigni, Federico Diotallevi, Valerio Brisigotti, Giulio Rizzetto, Annamaria Offidani, Oriana Simonetti
Summary: Hidradenitis suppurativa (HS) is an immune-mediated inflammatory disorder characterized by nodules, abscesses, sinus tracts, and scars in intertriginous areas. It causes pain, malodorous secretion, and significantly decreases the quality of life. The pathogenesis is not fully understood, but follicular hyperkeratosis of the pilosebaceous apocrine unit is considered the primary event. Since the registration of Adalimumab in 2015, several cytokines have been implicated in the pathomechanism of HS, leading to intensified research on novel therapeutic targets for HS management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Devea R. De, Terri Shih, Denise Fixsen, Brindley Brooks, Jennifer L. Hsiao, Vivian Y. Shi
Summary: This study aimed to explore the perspectives and barriers of Hidradenitis suppurativa (HS) patients on biologics. The survey results revealed that fear of side effects, high cost/lack of insurance coverage, and frequency of weekly injections were the main barriers to using biologics. It was also found that patients whose primary healthcare provider was a non-dermatologist and who were not seen at an HS specialty clinic were less knowledgeable about how biologics work.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Review
Pediatrics
Nicholas Chiang, Cathryn Sibbald, Rebecca Levy, Irene Lara-Corrales
Summary: Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin condition that significantly impacts the quality of life and psychosocial well-being of affected individuals. Limited data on treatment for children and adolescents with HS call for further research.
Article
Dermatology
Emily K. Kozera, Martina Porter, So Yeon Paek, Dillon Mintoff, Erin Mcmeniman, Hazel H. Oon, Nisha Suyien Chandran, Katalin Glasenhardt, Hans Christian Ring, John W. Frew
Summary: This study aimed to establish expert consensus on infectious disease screening prior to systemic immunomodulatory therapy in Hidradenitis Suppurativa (HS) through a Delphi method. The study recommended screening for hepatitis B, hepatitis C, and tuberculosis in all HS patients prior to therapy, as well as considering endemic local diseases and high-risk activities and occupations.
Review
Dermatology
Tiffany Y. Loh, Aleksi J. Hendricks, Jennifer L. Hsiao, Vivian Yan Shi
Summary: HS, a chronic inflammatory disease, is worsened by factors like friction, obesity, and sweating. Choosing breathable, absorbent fabrics can help reduce microbial colonization, sweat retention, and odor.
Article
Dermatology
Pavel Chernyshov, Lucia Tomas-Aragones, Liana Manolache, Nives Pustisek, Carmen Maria Salavastru, Servando E. Marron, Anthony Bewley, Ake Svensson, Francoise Poot, Alina Suru, Sam S. Salek, Matthias Augustin, Jacek C. Szepietowski, Dimitra Koumaki, Alexander C. Katoulis, Francesca Sampogna, Damiano Abeni, Dennis Michael Linder, Reinhart Speeckaert, Nanja van Geel, Julien Seneschal, Khaled Ezzedine, Andrew Y. Finlay
Summary: The European Academy of Dermatology and Venereology (EADV) task force reviewed available assessment tools for health-related quality of life (HR QoL) in vitiligo and made recommendations for its assessment. They found that the Dermatology Life Quality Index (DLQI) was the most commonly used instrument for HR QoL assessment, and identified several vitiligo-specific instruments. They recommended the use of DLQI and Children's Dermatology Life Quality Index (CDLQI) in vitiligo.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Andrew Blauvelt, Leon Kircik, Kim A. Papp, Eric L. Simpson, Jonathan Silverberg, Brian S. Kim, Shawn G. Kwatra, Michael E. Kuligowski, May E. Venturanza, Shaoceng Wei, Jacek C. Szepietowski
Summary: Ruxolitinib cream showed rapid and sustained improvement in itch in patients with mild to moderate AD. More patients who applied Ruxolitinib cream achieved a ≥2-point itch reduction within approximately 12 hours and a ≥4-point itch reduction by Day 2 compared to the vehicle cream group.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Joanna Maj, Kamila Wala, Jacek C. Szepietowski
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Immunology
Piotr K. Krajewski, Jacek C. Szepietowski
Summary: Psoriasis is a chronic skin disorder that significantly affects patients' quality of life. The prevalence of psoriasis among children varies depending on age, ranging from 0.12% at one year to 2% at 18 years. Secukinumab has been approved for the treatment of moderate to severe plaque psoriasis in children aged 6-18, but there is limited information on its efficacy and safety in this population.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Justyna Pajak, Danuta Nowicka, Jacek C. Szepietowski
Summary: Inflammaging and immunosenescence are two aging-related processes in the human body, with the former being a consequence of the latter. While there has been significant research on these processes, our understanding of aging and effective interventions is still insufficient. This review focuses on immunosenescence and inflammaging in the skin, identifying influencing factors and potential anti-aging treatments. It emphasizes the need for further research to better comprehend factors that can either slow down or accelerate inflammaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anatomy & Morphology
Jurand Domanski, Adriana Janczura, Marta Wanat, Katarzyna Wiglusz, Magdalena Grajzer, John E. Simmons, Zygmunt Domagala, Jacek C. Szepietowski
Summary: Anatomical museums hold specimens with historical and scientific value, but often lack documentation on preservation techniques and composition. This presents a challenge for their care and it requires interdisciplinary knowledge. This study aimed to identify preservation substances and assess factors causing deterioration.
JOURNAL OF ANATOMY
(2023)
Review
Allergy
Wasuchon Chaichan, Chidchanok Ruengorn, Kednapa Thavorn, Brian Hutton, Jacek C. Szepietowski, Jonathan A. Bernstein, Mati Chuamanochan, Surapon Nochaiwong
Summary: A systematic review and network meta-analysis were conducted to compare the safety profiles of different second-generation H1-antihistamines in patients with chronic urticaria. The study found variations in safety profiles, with mizolastine, emedastine, and cetirizine associated with unfavorable safety profiles.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Medicine, General & Internal
Karolina Swierczynska-Mroz, Danuta Nowicka-Suszko, Mariusz G. Fleszar, Paulina Fortuna, Piotr K. Krajewski, Magdalena Krajewska, Rafal Bialynicki-Birula, Jacek C. Szepietowski
Summary: This study aimed to investigate the possible contribution of free and total Indoxyl Sulfate (IS) and p-Cresol Sulfate (PCS) to the cause of CKD-aP. The results showed no significant difference in the serum levels of free and total IS, or PCS, between patients with and without CKD-aP, and no correlation between serum IS or PCS levels and the severity of the itch.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Adam Zalewski, Piotr K. Krajewski, Jacek C. Szepietowski
Summary: This study evaluated the characteristics of itch and pain in adults with hand eczema. The results showed that itch and pain are common symptoms and have a negative impact on patients' quality of life and social integration. Understanding the characteristics of itch and pain can help improve the management of hand eczema.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Kamila Wala-Zielinska, Karolina Swierczynska-Mroz, Piotr K. Krajewski, Danuta Nowicka-Suszko, Magdalena Krajewska, Jacek C. Szepietowski
Summary: The concentration of met-enkephalin was higher in dialysis patients with pruritus compared to the control group. Moreover, significantly lower levels of β-endorphin and dynorphin A were observed in dialysis patients compared to the control group. In addition, the β-endorphin/dynorphin A concentration ratio was significantly lower in patients with pruritus compared to patients without pruritus and the control group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Katarzyna Krefft-Trzciniecka, Zuzanna Pietowska, Danuta Nowicka, Jacek C. Szepietowski
Summary: Androgenetic alopecia is a common condition causing hair loss in both men and women, which can significantly affect one's psychological well-being. A systematic review was conducted to assess the efficacy of using stem cells in treating androgenetic alopecia. The review analyzed the results of using different types of stem cells compared to control treatment or other types of treatment for male and female androgenetic alopecia. The use of stem cells shows promise as an alternative or complementary therapy for androgenetic alopecia, but further research is needed for validation in larger and more diverse samples.
Article
Microbiology
Beata Jastrzab, Barbara Pasnik-Chwalik, Katarzyna Debska-Lasut, Tomasz Konopka, Piotr K. Krajewski, Jacek C. Szepietowski, Lukasz Matusiak
Summary: This study aimed to compare the composition of subgingival microbiome between patients with hidradenitis suppurativa (HS) and periodontitis. The results showed that the subgingival microbiome count was significantly higher in HS and periodontitis patients compared to controls. Additionally, there were similarities in the subgingival microbiome composition between HS and periodontitis patients.
Letter
Dermatology
V. A. Zouboulis, A. F. Massa, G. Nikolakis, E. P. Prens, J. C. Szepietowski, T. Tzellos, C. C. Zouboulis
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
Nicole Mastacouris, Rachel Tannenbaum, Andrew Strunk, Jonathan Koptyev, Pim Aarts, Raed Alhusayen, Falk G. Bechara, Farida Benhadou, Vincenzo Bettoli, Alain Brassard, Debra Brown, Siew Eng Choon, Patricia Coutts, Dimitri Luz Felipe da Silva, Steven Daveluy, Robert P. Dellavalle, Veronique del Marmol, Lennart Emtestam, Kurt Gebauer, Ralph George, Evangelos J. Giamarellos-Bourboulis, Noah Goldfarb, Iltefat Hamzavi, Paul G. Hazen, Barbara Horvath, Jennifer Hsiao, John R. Ingram, Gregor B. E. Jemec, Joslyn S. Kirby, Michelle A. Lowes, Angelo V. Marzano, Lukasz Matusiak, Haley B. Naik, Martin M. Okun, Hazel H. Oon, Lauren A. V. Orenstein, So Yeon Paek, Jose C. Pascual, Pablo Fernandez-Penas, Barry I. Resnik, Christopher J. Sayed, Linnea Thorlacius, Hessel H. van der Zee, Kelsey R. van Straalen, Amit Garg
Article
Medicine, General & Internal
Adam Zalewski, Piotr K. Krajewski, Jacek C. Szepietowski
Summary: Hand eczema has a significant psychological burden on patients, impacting their quality of life and potentially leading to depression and anxiety disorders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Xiangye Zhao, Kewei Ma, Xiaobo Ma, Xu Wang, Chao Sun, Shi Qiu, Ye Guo, Zhiguang Yang, Yunpeng Liu, Yinghui Xu
Summary: Immunotherapy may lead to pseudoprogression, where tumors initially grow but shrink with continued treatment. This article reports a case of pseudoprogression in a lung cancer patient receiving immunotherapy, and reviews the mechanisms, clinical manifestations, and prognostic indicators of pseudoprogression.
Article
Immunology
Ling-zhijie Kong, Ying Zheng, Kaichun Li
Summary: Treatment options for metastatic colorectal cancer are limited after second-line chemotherapy failure. In this case report, a 59-year-old male patient achieved remarkable response to fruquintinib and toripalimab combination therapy after multiple lines of chemotherapy failed. The patient had partial response within 3 months and complete response of pulmonary masses within 12 months. The combination of fruquintinib and PD-1 inhibitors improves the prognosis of metastatic colorectal cancer, with a progression-free survival of over 17 months.
