Journal
IMMUNOLOGICAL REVIEWS
Volume 286, Issue 1, Pages 137-147Publisher
WILEY
DOI: 10.1111/imr.12703
Keywords
innate lymphoid cells; metabolism; natural killer cells; Th1/Th2/Th17 cells
Categories
Funding
- National Institutes of Health [DP5OD012116, R01AI123368, R21DK110262, U01AI095608, F32AI134018]
- NIAID Mucosal Immunology Studies Team (MIST)
- Crohn's and Colitis Foundation of America
- Searle Scholars Program
- American Asthma Foundation Scholar Award
- Center for Advanced Digestive Care (CADC)
- Burroughs Wellcome Fund
- Cancer Research Institute CLIP grant
- Meyer Cancer Center Collaborative Research Initiative
- Roberts Institute for Research in IBD
- Weill Cornell Medicine Pre-Career Award
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Innate and adaptive lymphocytes employ diverse effector programs that provide optimal immunity to pathogens and orchestrate tissue homeostasis, or conversely can become dysregulated to drive progression of chronic inflammatory diseases. Emerging evidence suggests that CD4(+) T helper cell subsets and their innate counterparts, the innate lymphoid cell family, accomplish these complex biological roles by selectively programming their cellular metabolism in order to instruct distinct modules of lymphocyte differentiation, proliferation, and cytokine production. Further, these metabolic pathways are significantly influenced by tissue microenvironments and disease states. Here, we summarize our current knowledge on how cell-intrinsic metabolic factors modulate the context-dependent bioenergetic pathways that govern innate and adaptive lymphocytes. Further, we propose that a greater understanding of these pathways may lead to the identification of unique features in each population and provoke the development of novel therapeutic strategies to modulate lymphocytes in health and disease.
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