Journal
IMMUNOLOGIC RESEARCH
Volume 67, Issue 1, Pages 1-11Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-019-9066-3
Keywords
Macrophage; RhoA; Actin; Magnetic field; Transplantation; Cancer
Categories
Funding
- William and Ella Owens Medical Research Foundation
- William Stamps Farish Fund
- State of Texas through the Texas Center for Superconductivity at the University of Houston
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In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe how mechanical/magnetic, genetic, or pharmacologic interference with the actin cytoskeleton enforces changes in cell shape and function and how such techniques can be used to control the phenotype and functions of immune cells such as macrophages and to develop novel anti-cancer and anti-rejection clinical therapies.
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