Article
Environmental Sciences
Kristin J. Marks, Penelope P. Howards, Melissa M. Smarr, W. Dana Flanders, Kate Northstone, Johnni H. Daniel, Antonia M. Calafat, Andreas Sjodin, Michele Marcus, Terryl J. Hartman
Summary: The study found that prenatal exposure to mixtures of persistent EDCs is not significantly associated with early menarche in female offspring.
ENVIRONMENTAL POLLUTION
(2021)
Review
Nutrition & Dietetics
Anastasia Konstantina Sakali, Alexandra Bargiota, Ioannis G. Fatouros, Athanasios Jamurtas, Djuro Macut, George Mastorakos, Maria Papagianni
Summary: This article summarizes the impact of pesticide residues on the timing of puberty landmarks and their potential effects on the human reproductive system.
Review
Biochemistry & Molecular Biology
Sara Trova, Serena Bovetti, Sara Bonzano, Silvia De Marchis, Paolo Peretto
Summary: Steroid hormones play important roles in vertebrates, especially in mammalian sexual development and brain neural circuits. Studies in recent decades have shown that sex steroids influence the organization of the brain structure during puberty, a critical period characterized by high sensitivity to external stimuli and significant remodeling of the organism's structure and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Albrecht Benzing, Hans-Peter Piepho, Waqas Ahmed Malik, Maria R. Finckh, Manuel Mittelhammer, Dominic Strempel, Johannes Jaschik, Jochen Neuendorff, Liliana Guaman, Jose Mancheno, Luis Melo, Omar Pavon, Roberto Cangahuamin, Juan-Carlos Ullauri
Summary: Pesticide residues are lower in organic food compared to conventional food; differences in sample sources can lead to mislabeling of organic products as conventional; sampling methods focusing on short-range drift can differentiate intentional pesticide usage by organic farmers from drift.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Jessica M. Madrigal, Robert M. Sargis, Victoria Persky, Mary E. Turyk
Summary: The study suggests that certain organochlorine pesticides may alter male estradiol levels. The positive associations with estradiol may implicate sex hormones as a possible mechanism for disease risk among those with organochlorine pesticide exposure.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Liu Qiang, Zheng Jinping, Guo Zhongling, Fan Chunnan
Summary: The study analyzed the residues of organochlorine pesticides in two rivers, revealing different pollution levels in each river and assessing the impact of human activities on the residues of organochlorines in the environment, highlighting potential health risks and environmental risks.
WATER AIR AND SOIL POLLUTION
(2021)
Article
Environmental Sciences
Li Zhang, Jiaxin Ma, Peipei Liu, Anxiang Qi, Haiyan Jin, Renming Jia, Zhenming Zheng, Cheng Yan, Minghong Cai
Summary: With the prohibition of conventional organochlorine pesticides, the use of current-use pesticides such as organic amine pesticides and organophosphate pesticides in agriculture and mariculture activities has become a global concern. A study in the Beibu Gulf, a subtropical agricultural and maricultural zone, found that pesticides were widely present in seawater and sediment, with the most abundant categories being organic amine pesticides and organophosphate pesticides. The spatial distribution of pesticides showed a decrease from coastal areas to the sea, indicating the impact of anthropogenic activities on pesticides pollution.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Environmental Sciences
Tania Pelamatti, Lorena M. Rios-Mendoza, Edgar M. Hoyos-Padilla, Felipe Galvan-Magana, Roberto De Camillis, Ana J. Marmolejo-Rodriguez, Rogelio Gonzalez-Armas
Summary: A study on plastic pollution conducted in the remote Revillagigedo Archipelago in the Mexican Pacific Ocean revealed the potential threat of plastics to animals. Aside from marine animals, plastics also pose a threat to terrestrial animals, including endangered endemic species.
MARINE POLLUTION BULLETIN
(2021)
Article
Environmental Sciences
Sophie E. Bresson, Scott Isom, Elizabeth T. Jensen, Sandra Huber, Youssef Oulhote, Joseph Rigdon, James Lovato, Angela D. Liese, Catherine Pihoker, Dana Dabelea, Shelley Ehrlich, Jerome Ruzzin
Summary: This study investigated the association between persistent organic pollutants (POPs) and type 1 diabetes (T1D) in youth. The results suggest that certain POPs may be associated with an increased risk of T1D and can negatively impact the function and viability of pancreatic beta-cells.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Pannipa Janta, Bussaba Wongla, Wilai Phayoonhong, Oraphan Intarapanich, Sirirat Kokpol, Sugunya Mahatheeranont, Chadin Kulsing
Summary: A high-temperature comprehensive two-dimensional gas chromatography method using a longitudinally modulated cryogenic system was developed for analyzing low-volatility pesticides in cabbage. The method achieved efficient separation of target pesticides and matrix and yielded satisfactory analytical results by optimizing experimental conditions.
ANALYTICAL METHODS
(2022)
Article
Environmental Sciences
Danial Abdollahdokht, Gholamreza Asadikaram, Moslem Abolhassani, Hossein Pourghadamyari, Mojtaba Abbasi-Jorjandi, Sanaz Faramarz, Mohammad Hadi Nematollahi
Summary: The study evaluated the exposure of organophosphate pesticides (OPPs) and organochlorine pesticides (OCPs) in farmworkers' children aged 6 to 11 years in Jiroft city in southeastern Iran, finding harmful effects on the participants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Neurosciences
Madison H. Fung, Elizabeth Heinrichs-Graham, Brittany K. Taylor, Michaela R. Frenzel, Jacob A. Eastman, Yu-Ping Wang, Vince D. Calhoun, Julia M. Stephen, Tony W. Wilson
Summary: Puberty is a period of significant hormonal fluctuations that can influence the structural and functional changes in the developing brain. This study used MEG technology to investigate the impact of pubertal hormones on motor-related oscillations in 69 youths. The findings revealed that pubertal hormones have complex effects on beta event-related desynchronization and highlight the continued development of motor cortical dynamics during puberty.
Article
Environmental Sciences
Yun Liu, Antonia M. Calafat, Aimin Chen, Bruce P. Lanphear, Nana-Hawa Yayah Jones, Kim M. Cecil, Susan R. Rose, Kimberly Yolton, Jessie P. Buckley, Joseph M. Braun
Summary: This study examined the associations of prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFAS) with pubertal development and reproductive hormones. The results showed that adolescent PFAS concentrations were associated with later pubic hair growth, breast maturation, and age at menarche in females, but there was no pattern for prenatal or other postnatal concentrations. No associations were observed between PFAS concentrations and pubic hair growth or reproductive hormones in males.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yun Ma, Tianwei Xu, Qiao Mao, Xinmei Zhou, Rui Wang, Jianqiang Sun, Anping Zhang, Shanshan Zhou
Summary: The study on the distribution patterns of OCPs in the surface sediments collected from Prydz Bay, Antarctica revealed that concentrations were mainly influenced by HCHs and DDTs, with a distinct quasiconcentric circle pattern controlled by total organic carbon and local hydrodynamic conditions. Source apportionment indicated that HCHs and chlordanes were primarily derived from long range atmospheric transport. Annual sedimentary fluxes of OCPs in Antarctica were one to three orders of magnitude lower than some data from the Arctic areas, implying a long active lifetime of OCPs in the Antarctic environment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Gastroenterology & Hepatology
Tusha Sharma, Nagabhishek Sirpu Natesh, Ramesh Pothuraju, Surinder K. Batra, Satyanarayana Rachagani
Summary: The human gut microbiota can be disrupted by environmental contaminants such as pesticides, posing potential health risks. The metabolites produced by gut microbiota play a significant role in maintaining host health, and an imbalance in this system can lead to various diseases. Recent studies have shown that pesticides have harmful effects on the host's gut microbiota. Therefore, further research is needed to understand the impact of pesticides on gut microbiota-mediated metabolic changes, which may provide insights into pesticide-induced toxicity.
Review
Biochemistry & Molecular Biology
Antonio Simone Lagana, Gianpiero Forte, Mariano Bizzarri, Zdravko A. Kamenov, Bianca Bianco, Cihan Kaya, Georgios Gitas, Ibrahim Alkatout, Milan Terzic, Vittorio Unfer
Summary: MI and DCI play key roles in ovarian physiology and steroid biosynthesis. Imbalance of MI-to-DCI ratio may lead to gynecological disorders. Proper evaluation of inositol treatments and their effects on different PCOS phenotypes are important.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)
Review
Public, Environmental & Occupational Health
Madina Yerezhepbayeva, Milan Terzic, Gulzhanat Aimagambetova, Byron Crape
Summary: This systematic review analyzed the effectiveness and complications of Uterine Artery Embolization (UAE) and Magnetic Resonance guided High Intensity Focused Ultrasound (MRgHIFU) for uterine leiomyoma. The results showed that UAE had a significantly higher percentage of fibroid volume shrinkage than MRgHIFU at 6, 12, and 24 months follow-up, but had more complications.
Article
Health Care Sciences & Services
Milan Terzic, Gulzhanat Aimagambetova, Talshyn Ukybassova, Gauri Bapayeva, Aiym Kaiyrlykyzy, Faye Foster, Faina Linkov
Summary: This study assessed factors influencing pain in women undergoing endometrial biopsy. The study found that the type of doctor performing the procedure was strongly associated with pain, suggesting the need for personalized approaches and interventions to reduce pain.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Nutrition & Dietetics
Dimitri Poddighe, Kuanysh Dossybayeva, Diyora Abdukhakimova, Lyudmila Akhmaltdinova, Aigul Ibrayeva
Summary: This review analyzes the pathophysiological aspects and clinical evidence of gallbladder dysfunction in CD patients, highlighting the potential medical complications and research gaps. CD patients may develop gallbladder dysmotility, leading to impaired emptying during digestion. Although CD patients do not seem to be more susceptible to gallbladder complications, further clinical studies are needed to fully understand the clinical implications of gallbladder alterations in CD patients.
Editorial Material
Pediatrics
Dimitri Poddighe, Vahid Ziaee, Ozgur Kasapcopur
FRONTIERS IN PEDIATRICS
(2022)
Review
Oncology
Akzhol Karim, Kundyz Shaikhyzada, Assel Suleimenova, Bakytkali Ibraimov, Dair Nurgaliev, Dimitri Poddighe
Summary: Atypical teratoid/rhabdoid tumor (AT/RT) is a rare and highly malignant embryonal neoplasm that occurs mainly in infants and young children. It is characterized by rapid growth and poor prognosis. The diagnosis of this tumor is based on immunohistochemical staining for loss of nuclear integrase interactor 1 (INI1) expression. There is currently no validated treatment protocol, and multimodality treatment is commonly used.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Diana Talipova, Aiganym Smagulova, Dimitri Poddighe
Summary: This review discusses the potential role of Toll-like receptors (TLRs) in the immunopathogenesis of CD. Although evidence from basic research is limited, differences in TLR expression and activation have been observed between active CD patients and controls or treated CD patients in some clinical studies. Therefore, TLRs may be part of the non-HLA-related genetic factors implicated in CD pathogenesis, considering their potential role in the interaction between the host immune system and environmental factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Green & Sustainable Science & Technology
Dimitri Poddighe, Massimo Pignatelli
Summary: This article presents the first experience of implementing an ACGME-oriented Pediatric Residency Program in Central Asia. The vision, general project, main organizational aspects, and challenges of this program are described and discussed in this article.
Review
Medicine, General & Internal
Milan Terzic, Dinara Makhadiyeva, Jovan Bila, Mladen Andjic, Jelena Dotlic, Gulzhanat Aimagambetova, Antonio Sarria-Santamera, Antonio Simone Lagana, Vito Chiantera, Ivana Vukovic, Dusica Kocijancic Belovic, Slavica Aksam, Gauri Bapayeva, Sanja Terzic
Summary: Cervical cancer is a major cause of cancer-related death in women of reproductive age. Fertility-sparing procedures such as LEEP, cold-knife conization, and trachelectomy can be considered safe and effective treatments for preserving reproductive potential. However, careful monitoring of pregnancies obtained after fertility-preserving procedures is recommended, as these patients are at a higher risk.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Akzhol Karim, Kundyz Shaikhyzada, Nazgul Abulkhanova, Akzhunis Altyn, Bakytkali Ibraimov, Dair Nurgaliyev, Dimitri Poddighe
Summary: Wilms tumor (WT) is a rare form of cancer that typically affects children and is usually confined to the kidneys. Extra-renal Wilms tumor (ERWT) is even rarer and develops in other areas of the body, such as the retroperitoneum and inguinal regions, and occasionally at the level of the spinal cord. Our research emphasizes the importance of timely diagnosis and treatment and, possibly, standardized medical approach, in order to improve the outcome of these very rare pediatric malignancies, whose clinical management is even more problematic in developing countries.
Article
Medicine, General & Internal
Altinoy T. Kamilova, Gulnoza K. Azizova, Dimitri Poddighe, Zulkhumar E. Umarnazarova, Dilrabo A. Abdullaeva, Svetlana I. Geller, Noiba D. Azimova
Summary: This study investigates the prevalence and clinical characteristics of Celiac Disease (CD) in symptomatic children in Uzbekistan. Among the 206 children studied, 5.3% were diagnosed with CD. Watery diarrhea was more frequently observed in CD patients. A full diagnostic work-up for CD in the local clinical setting is recommended.
Article
Biochemistry & Molecular Biology
Antonio Sarria-Santamera, Yerden Yemenkhan, Milan Terzic, Miguel A. Ortega, Angel Asunsolo del Barco
Summary: Endometriosis is a complex and challenging disease with variability in classification and effectiveness of therapies. This study identifies six clusters of women with endometriosis based on comorbidity, providing insight into the multidimensionality of the disease and its association with specific molecular mechanisms.
Review
Obstetrics & Gynecology
Marina Sprem Goldstajn, Mislav Mikus, Filippo Alberto Ferrari, Mariachiara Bosco, Stefano Uccella, Marco Noventa, Peter Torok, Sanja Terzic, Antonio Simone Lagana, Simone Garzon
Summary: This article summarizes the available evidence comparing the transdermal and oral administration routes of hormone replacement therapy (HRT) in postmenopausal women. The findings indicate that there is no significant difference between the two routes in terms of bone mineral density, glucose metabolism, lipid profile improvements, breast cancer, endometrial disease, and cardiovascular risk. However, the risk of venous thromboembolism (VTE) is higher with the oral administration route.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Gauri Bapayeva, Sanja Terzic, Jelena Dotlic, Karlygash Togyzbayeva, Ulzhan Bugibaeva, Madina Mustafinova, Asem Alisheva, Erbil Karaman, Milan Terzic, Antonio Simone Lagana
Summary: Advanced age and increased BMI prior to pregnancy are risk factors for pregnancy complications in women with diabetes mellitus. Maternal obesity is the most important predictor of pregnancy complications in women with diabetes mellitus.
MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY
(2022)
