Article
Oncology
Jie-Ru Yang, Ju Wang, Hai-Ming Li, Shuai Gao, Yu-Chen Fan, Kai Wang
Summary: The study found that the IL-6 promoter methylation level is significantly lower in patients with HBV-associated hepatocellular carcinoma, and it is independently associated with the development of liver cancer. The combined use of IL-6 methylation level and AFP can improve the diagnostic accuracy of liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Eun Young Lee, Jae Min Song, Hye Jung Kim, Hae Ryoun Park
Summary: This study found that lncRNA H19 was highly expressed and the promoter region was hypomethylated in OSCC cell lines; most OSCC patient tissues showed hypomethylation of lncRNA H19, which was significantly correlated with tumor histopathologic grade; OSCC patients with hypomethylation of lncRNA H19 had a significantly lower 5-year survival rate.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shanting Ye, Yong Ni
Summary: The study revealed that upregulated SNHG9 in HCC is associated with shorter disease-free survival, and knocking down SNHG9 can inhibit cell proliferation, block cell cycle progression, and suppress cell migration and invasion by upregulating GSTP1.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Medicine, Research & Experimental
Ru-ting Xie, Qian-yu Li, Xue-chen Sun, Qing-jun Zhi, Xiang-xiang Huang, Xing-chen Zhu, Qi-zeng Miao, Dai-zhan Zhou, Dong-yan Han
Summary: The methylation levels of TPO promoter were downregulated in HCC tissues, and could potentially serve as a biomarker for tumor thrombosis in HCC patients.
CURRENT MEDICAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Donghyun D. Lee, Martin Komosa, Sumedha Sudhaman, Ricardo Leao, Cindy H. Zhang, Joana D. Apolonio, Thomas Hermanns, Peter J. Wild, Helmut Klocker, Farshad Nassiri, Gelareh Zadeh, Bill H. Diplas, Hai Yan, Steven Gallinger, Trevor J. Pugh, Vijay Ramaswamy, Michael D. Taylor, Pedro Castelo-Branco, Nuno Miguel Nunes, Uri Tabori
Summary: The research found that allele-specific DNA methylation within the TERT promoter plays a significant regulatory role in cancer, especially more common in adult cancers and enriched in tumors with TERT promoter mutations. This allele-specific DNA methylation is essential for the regulation of TERT expression in cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Sangkyun Jeong, Sunwha Cho, Seung Kyoung Yang, Soo A. Oh, Yong-Kook Kang
Summary: Age-associated DNA-methylation drift (AMD) in mammals includes both global decrease (hypomethylation) and local increase of DNA methylation (hypermethylation). This study used reduced-representation-bisulfite-sequencing (RRBS) to analyze the methylation states of CpG dinucleotides in mouse splenic DNA and found that methylation levels of CpGs decreased with age. Promoter-resident CpGs became hypermethylated in old mice, while CpGs in gene-body and intergenic regions became hypomethylated. Methylation heterogeneities increased with age. Higher methylation density was observed in CpG-rich regions and lower methylation density in CpG-poor regions. The study also revealed a correlation between changes in gene expression and methylation patterns, suggesting a potential link between the two age-associated changes.
Article
Biochemistry & Molecular Biology
Chalermsin Permtermsin, H. Lalchungnunga, Sirintra Nakjang, John Casement, Laura Frances Ogle, Helen L. L. Reeves, Gordon Strathdee, Ruchi Shukla
Summary: Hepatocellular carcinoma (HCC) is a common and deadly form of liver cancer. Current treatments are not effective and have significant side effects. A new method using bioinformatics has been developed to identify genes that are necessary for the survival of specific molecular subgroups of HCC but not normal cells. By targeting these genes, it may be possible to induce synthetic lethality in cancer cells. One gene, TIAM1, has been identified as a potential therapeutic target in a specific subgroup of HCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Ryan H. Miller, Chad A. Pollard, Kristin R. Brogaard, Andrew C. Olson, Ryan C. Barney, Larry I. Lipshultz, Erica B. Johnstone, Yetunde O. Ibrahim, James M. Hotaling, Enrique F. Schisterman, Sunni L. Mumford, Kenneth I. Aston, Tim G. Jenkins
Summary: Complex diseases are challenging to diagnose due to their multifactorial etiologies. This study developed a diagnostic tool that analyzes a comprehensive network of epigenetic profiles to identify global shifts associated with complex diseases. The tool was validated by assessing tissue-specific epigenetic variability, differences between diseased and normal tissue, and its utility in male infertility, showing potential for clinical use. This approach expands diagnostic research beyond single genetic targets and provides insights into the role of epigenetic variability in complex diseases.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Peng Huang, Mengxiang Xu, Haijun Han, Xinyi Zhao, Ming D. Li, Zhongli Yang
Summary: DNA methylation plays a crucial role in regulating gene expression in hepatocellular carcinoma (HCC). This study identified a large number of differentially methylated CpG sites in HCC and highlighted the activation of cell cycle-related pathways and repression of metabolic pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ganji Purnachandra Nagaraju, Begum Dariya, Prameswari Kasa, Sujatha Peela, Sujatha Peela Bassel F. El-Rayes
Summary: HCC is the most common primary malignancy of the liver, with a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC, including chromatin remodeling, histone alterations, DNA methylation, and ncRNA expression. In-depth understanding of the epigenetics of HCC is critical for developing rational clinical strategies, improving overall survival, and predicting therapeutic outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jie Zhao, Li Li, Liying Guo, Rui Wang, Yan Zhao, Wei Li, Yupei Liu, Yanhong Ma, Jianwei Jia
Summary: This study introduced nano-gold PCR for detecting TERT methylation and found that TERT methylation is associated with poor prognosis in hepatocellular carcinoma patients. Nano-gold PCR showed higher sensitivity in detecting TERT methylation compared to conventional PCR. Moreover, as chronic hepatitis B progresses, TERT methylation increases, indicating a worsening prognosis in HCC patients.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2021)
Review
Oncology
Yan Li, Yuanyuan Zheng, Liwei Wu, Jingjing Li, Jie Ji, Qiang Yu, Weiqi Dai, Jiao Feng, Jianye Wu, Chuanyong Guo
Summary: The traditional method of tumor biopsy for hepatocellular carcinoma is limited and there is a need for a novel non-invasive diagnostic technique; circulating tumor DNA technology provides an important method for cancer screening, diagnosis, treatment selection, and prognosis prediction in hepatocellular carcinoma.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Wu Xing, Peng-Cheng Zhou, Hao-Ye Zhang, Li-Min Chen, Yang-Mei Zhou, Xue-Fei Cui, Zhen-Guo Liu
Summary: The study revealed that circ_GLIS2 suppresses the growth and metastasis of HCC by inhibiting cell proliferation, migration, and invasion, while promoting cell apoptosis. This suggests that circ_GLIS2 could potentially serve as a diagnostic marker or therapeutic target for HCC.
LIVER INTERNATIONAL
(2022)
Article
Medical Laboratory Technology
Guillaume Beinse, Bruno Borghese, Marie Metairie, Pierre-Alexandre Just, Geoffroy Poulet, Simon Garinet, Beatrice Parfait, Audrey Didelot, Camille Bourreau, Natacha Agueeff, Alexandre Lavolle, Benoit Terris, Charles Chapron, Francois Goldwasser, Karen Leroy, Helene Blons, Pierre Laurent-Puig, Valerie Taly, Jerome Alexandre
Summary: This study aimed to identify DNA positions universally hypermethylated in endometrial carcinoma (EC) and develop a digital droplet PCR (ddPCR) assay for detection of hypermethylated circulating tumor DNA (meth-ctDNA) in plasma from EC patients. The study found that methylation of ZSCAN12/OXT can be highly specific and sensitive in detecting ctDNA in plasma, providing promise for personalized approaches for EC patients.
CLINICAL CHEMISTRY
(2022)
Article
Cell Biology
Aurelie Beaufrere, Sarah Paisley, Ibrahima Ba, Samira Laouirem, Victoria Priori, Helene Cazier, Loetitia Favre, Francois Cauchy, Mickael Lesurtel, Julien Calderaro, Caroline Kannengiesser, Valerie Paradis
Summary: This study aims to identify histological criteria associated with TERT promoter mutations in small hepatocellular nodules arising in cirrhosis. The study found that increased cell density, stromal invasion, and plate-thickening anomalies were histological criteria associated with TERT promoter mutations. The combination of at least two of these criteria can predict TERT promoter mutations.
Article
Computer Science, Information Systems
Shumei Miao, Tingyu Xu, Yonghui Wu, Hui Xie, Jingqi Wang, Shenqi Jing, Yaoyun Zhang, Xiaoliang Zhang, Yinshuang Yang, Xin Zhang, Tao Shan, Li Wang, Hua Xu, Shui Wang, Yun Liu
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2018)
Article
Endocrinology & Metabolism
Shumei Miao, Xiao Dong, Xin Zhang, Shenqi Jing, Xiaoliang Zhang, Tingyu Xu, Li Wang, Xianglin Du, Hua Xu, Yun Liu
JOURNAL OF DIABETES
(2019)
Article
Oncology
Wenjie Zheng, Junling Yang, Zhizhen Dong, Li Wang, Miao Fang, Wei Wu, Dengfu Yao, Min Yao
CANCER MANAGEMENT AND RESEARCH
(2018)
Review
Chemistry, Medicinal
Li Wang, Min Yao, Wenjie Zheng, Miao Fang, Mengna Wu, Jianying Sun, Zhizhen Dong, Dengfu Yao
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2019)
Editorial Material
Gastroenterology & Hepatology
Miao Fang, Min Yao, Li Wang, Deng-Fu Yao
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2019)
Article
Gastroenterology & Hepatology
Wen-Li Sai, Min Yao, Shui-Jie Shen, Wen-Jie Zheng, Jian-Ying Sun, Meng-Na Wu, Li Wang, Deng-Fu Yao
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2020)
Article
Computer Science, Information Systems
Yanqiu Ge, Qinghua Wang, Li Wang, Honghu Wu, Chen Peng, Jiajing Wang, Yuan Xu, Gang Xiong, Yaoyun Zhang, Yingping Yi
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2019)
Article
Medicine, Research & Experimental
Wenjie Zheng, Min Yao, Mengna Wu, Junling Yang, Dengfu Yao, Li Wang
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Oncology
Miao Fang, Min Yao, Jie Yang, Wen-Jie Zheng, Li Wang, Deng-Fu Yao
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2020)
Article
Mathematical & Computational Biology
Li Wang, Wenjie Pan, QingHua Wang, Heming Bai, Wei Liu, Lei Jiang, Yuanpeng Zhang
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2020)
Article
Neurosciences
Yuanpeng Zhang, Ziyuan Zhou, Heming Bai, Wei Liu, Li Wang
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Genetics & Heredity
Li Wang, Qinghua Wang, Heming Bai, Cong Liu, Wei Liu, Yuanpeng Zhang, Lei Jiang, Huji Xu, Kai Wang, Yunyun Zhou
FRONTIERS IN GENETICS
(2020)
Review
Biochemistry & Molecular Biology
Min Yao, Wenli Sai, Wenjie Zheng, Li Wang, Zhizhen Dong, Dengfu Yao
CURRENT MEDICINAL CHEMISTRY
(2020)
Article
Oncology
Wenjie Zheng, Min Yao, Miao Fang, Liuhong Pan, Li Wang, Junling Yang, Zhizhen Dong, Dengfu Yao