Article
Economics
Ben A. van Hout, James W. Shaw
Summary: This research developed algorithms to map EQ-5D-3L responses to EQ-5D-5L value sets and found that including indicants of problems for other dimensions as regressors in the model improved prediction accuracy. Adding age and gender lowered AIC without improving predictions, while including a latent factor slightly improved predictive accuracy. Models conditioning on problems in other dimensions yielded more accurate predictions than an alternative copula-based approach.
Article
Rehabilitation
Yan Gao, Yulong Wang, Dongxia Li, Jingpu Zhao, Zhiyuan Dong, Jing Zhou, Guanqi Fu, Jing Zhang
Summary: This study explored the correlations and differentiate ability among the Longshi Scale, Barthel Index, and modified Rankin Scale in stroke patients. The results indicate that the Longshi Scale has better ability than the modified Rankin Scale in differentiating disability, especially for patients with higher levels of activities of daily living.
CLINICAL REHABILITATION
(2021)
Article
Oncology
Nasrin Moradi, Thomas G. Poder, Hossein Safari, Mohammad M. Mojahedian, Hosein Ameri
Summary: This study aimed to test the validity and reliability of the EQ-5D-5L (5L) in cancer patients compared to EQ-5D-3L (3L). The results showed that compared to 3L, 5L performed better in terms of ceiling effect, inconsistency, discriminatory power, convergent validity, and relative efficiency.
FRONTIERS IN ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Elena Olariu, Raluca Caplescu, Luke Vale, Ileana Gabriela Niculescu-Aron, Yemi Oluboyede, Marian Sorin Paveliu
Summary: The study aimed to estimate population norms for the Romanian versions of EQ-5D-5L, EQ-5D-3L, their indexes, and EQ VAS. A cross-sectional survey was conducted using a representative sample, and descriptive statistics were used to estimate population norms by age groups and sex. The findings provide reference values for healthcare professionals, researchers, and decision-makers in Romania.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2023)
Article
Health Care Sciences & Services
Juan Zhu, Xin-Xin Yan, Cheng-Cheng Liu, Hong Wang, Le Wang, Su-Mei Cao, Xian-Zhen Liao, Yun-Feng Xi, Yong Ji, Lin Lei, Hai-Fan Xiao, Hai-Jing Guan, Wen-Qiang Wei, Min Dai, Wanqing Chen, Ju-Fang Shi
Summary: The study found that EQ-5D-5L has better discriminatory power and lower ceiling effect in cancer patients, which may be more suitable for assessing HRQoL.
QUALITY OF LIFE RESEARCH
(2021)
Article
Health Care Sciences & Services
Alex Bato, Valentin Brodszky, L. Hunor Gergely, Krisztian Gaspar, Norbert Wikonkal, Agnes Kinyo, Akos Szabo, Zsuzsanna Beretzky, Andrea Szegedi, Eva Remenyik, Norbert Kiss, Miklos Sardy, Fanni Rencz
Summary: The study aimed to compare the measurement properties of two adult versions of EQ-5D in patients with Hidradenitis suppurativa (HS), with EQ-5D-5L outperforming EQ-5D-3L in terms of feasibility, informativity, and validity for important clinical characteristics. EQ-5D-5L was recommended for assessing HS patients across various settings.
QUALITY OF LIFE RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Bo Burstrom, Robert Irestig, Kristina Burstrom
Summary: The study compared the demographic composition, social determinants of health, and self-reported health among homeless people in Stockholm, Sweden in 2006 and 2018. Differences were found in the origin of homeless individuals, social support, exposure to violence, health-seeking behaviors, substance use, and health outcomes between the two years. Efforts are needed to address housing issues and collaborate with public authorities for the health and social welfare of homeless individuals.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Titi Sahidah Fitriana, Fredrick Dermawan Purba, Rina Rahmatika, Riski Muhaimin, Nur Melani Sari, Gouke Bonsel, Elly Stolk, Jan J. Busschbach
Summary: This study compared the measurement properties and responsiveness of EQ-5D-Y-3L and EQ-5D-Y-5L in pediatric patients. The results showed that the feasibility, convergent validity, and disease-specific measures were similar between the two versions, but EQ-5D-Y-5L had better test-retest reliability and sensitivity for detecting health changes.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2021)
Article
Health Care Sciences & Services
Jie Jiang, Yanming Hong, Tiantian Zhang, Zhihao Yang, Tengfei Lin, Zhuoru Liang, Peiyao Lu, Lishun Liu, Binyan Wang, Yongmei Xu, Nan Luo
Summary: This study compared the measurement properties of EQ-5D-3L and EQ-5D-5L in hypertensive patients in rural China. The results showed that the 5L version had a lower ceiling effect and higher informativity compared to the 3L version, with good agreement between the two.
QUALITY OF LIFE RESEARCH
(2021)
Article
Health Care Sciences & Services
Titi Sahidah Fitriana, Fredrick Dermawan Purba, Elly Stolk, Jan J. Busschbach
Summary: Background: Self-report is the standard method for measuring health-related quality of life (HRQoL) in children, but sometimes children are unable to report their own health. This study investigated the agreement between self-report and proxy-report measures of HRQoL in children using the EQ-5D-Y questionnaire. The study also explored the potential benefits of extending the response levels of the proxy questionnaire from 3 to 5.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Health Care Sciences & Services
Ruixuan Jiang, Kim Rand, Maja Kuharic, A. Simon Pickard
Summary: This study compared the measurement properties of the US EQ-5D-3L, EQ-5D-5L, and -5L to -3L crosswalk value sets across the spectrum of health. The results showed that the 5L value set had the broadest range of scale and was more discriminative and responsive than the crosswalk and 3L.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Oncology
Li-Fei Sun, Sheng Huang, Yun-Fen Li, Zhuang-Qing Yang, Xiao-Juan Yang, Jie-Ya Zou, Xiao-Wen Wang, Jian-Yun Nie
Summary: This study explored the factors influencing the health-related quality of life of spouses of breast cancer patients and the suitable questionnaires for assessment. The results showed that social support and cognition of the treatment effect were important factors influencing the health-related quality of life of spouses. The EQ-5D-3L questionnaire demonstrated good reliability and validity in measuring the quality of life of spouses of breast cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Xiangxiang Liu, Mingchao Zhou, Jingpu Zhao, Yan Gao, Yao Wang, Jing Zhou, Li Wan, Guohui Nie, Yulong Wang
Summary: The study aimed to identify the optimal cut-off scores of LS and BI according to the mRS in Chinese stroke patients with different levels of functional disability. Results showed that mRS is more precise to determine mild functional disability, whereas BI provides more specific information on moderate and severe levels in stroke patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Economics
Guizhi Weng, Yanming Hong, Nan Luo, Clara Mukuria, Jie Jiang, Zhihao Yang, Sha Li
Summary: This study compares the measurement properties of EQ-5D-3L and EQ-5D-5L in quantifying health-related quality of life burden for four different health conditions in China. The results showed that EQ-5D-5L demonstrated superior performance in terms of higher sensitivity to mild health problems, better relative efficiency, and responses and index value distributions.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Health Care Sciences & Services
Anders Joelson, Freyr Gauti Sigmundsson, Jan Karlsson
Summary: The study aimed to apply a single large longitudinal EQ-5D-3L dataset to multiple national EQ-5D-3L value sets and investigate differences in EQ-5D-3L index density functions and effect sizes before and after treatment. Analysis of procedures from patients surgically treated for lumbar spinal stenosis or lumbar disk herniation between 2007 and 2017 was conducted, revealing high variability in EQ-5D-3L index density functions and significant differences before and after treatment. However, effect sizes of 2-year change were found to be similar when the 9 value sets were applied, suggesting caution in aggregating international data and recommending against pooling different national EQ-5D-3L index data.
QUALITY OF LIFE RESEARCH
(2021)
Article
Ophthalmology
Mijie Li, Carla Lanca, Chuen-Seng Tan, Li-Lian Foo, Chen-Hsin Sun, Fabian Yap, Raymond P. Najjar, Charumathi Sabanayagam, Seang-Mei Saw
Summary: This study evaluated the association between reported time outdoors and light exposure patterns with myopia in 9-year-old Singaporean children. The findings showed that greater reported time outdoors was associated with a lower risk of myopia, while light levels and specific light measures did not have an impact.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Health Care Sciences & Services
Sungwon Yoon, Pei Shan Hoe, Angelique Chan, Rahul Malhotra, Abhijit Visaria, David Matchar, Hendra Goh, Bridget Seng, Chandrika Ramakrishnan, Mariko S. Koh, Tiew Pei Yee, Gayathri Devi Nadarajan, Yong Mong Bee, Nicholas Graves, Tazeen H. Jafar, Marcus E. H. Ong
Summary: This study examines the impact of COVID-19 measures on wellbeing and self-management in medically vulnerable non-COVID patients. The results indicate that the pandemic has negatively affected patients' subjective wellbeing, particularly in terms of emotional distress and interference in self-care.
Article
Ophthalmology
Li Lian Foo, Lingqian Xu, Charumathi Sabanayagam, Hla M. Htoon, Han Nian Marcus Ang, Jingwen Zhang, Kyoko Ohno-Matsui, Ching Yu Cheng, Quan Hoang, Chuen-Seng Tan, Seang-Mei Saw, Chee Wai Wong
Summary: The purpose of this study was to investigate the predictive factors for myopic macular degeneration (MMD) and progression in adults with myopia. The study found that in adults without MMD, tessellated fundus, age, spherical equivalent (SE), and axial length (AL) were good predictors for incident MMD. In adults with MMD, older age, more severe myopia, and longer AL were independent risk factors for progression.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Engineering, Biomedical
Emily Shu Ting Ng, Ryan Ruiyang Ling, Saikat Mitra, Chuen Seng Tan, Graeme MacLaren, Kollengode Ramanathan
Summary: Burns are a major cause of trauma globally, and acute respiratory distress syndrome (ARDS) is a common cause of death for burn patients. In some cases where conventional therapies fail to improve hypoxemia, extracorporeal membrane oxygenation (ECMO) may be used as a rescue treatment. A meta-analysis of studies on ECMO for burns or inhalation injuries found a pooled survival rate of 53.6% and identified age and the proportion of male patients as significant factors affecting survival. The average duration of ECMO cannulation was 8.4 days, ICU stay was 40.4 days, and hospital length of stay was 45.4 days.
Article
Medical Informatics
Sean Shao Wei Lam, Andrew Hao Sen Fang, Mariko Siyue Koh, Sumitra Shantakumar, See-Hwee Yeo, David Bruce Matchar, Marcus Eng Hock Ong, Ken Mei Ting Poon, Liming Huang, Sudha Harikrishan, Dominique Milea, Des Burke, Dave Webb, Narayanan Ragavendran, Ngiap Chuan Tan, Chian Min Loo
Summary: The SingHealth-Duke-GlaxoSmithKline COPD and Asthma Real-world Evidence (SDG-CARE) collaboration aims to accelerate the use of Singaporean real-world evidence in research and clinical care. A near real-time database, the SingHealth COPD and Asthma Data Mart (SCDM), was developed to inform healthcare decision-making and research studies on asthma and COPD.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Review
Geriatrics & Gerontology
Jie Kie Phang, Yu Heng Kwan, Sungwon Yoon, Hendra Goh, Wan Qi Yee, Chuen Seng Tan, Lian Leng Low
Summary: This realist review analyzed existing digital intergenerational programs that aimed to reduce loneliness or social isolation among older adults. The findings showed that providing digital technology training can increase older adults' self-efficacy and use of digital communication to reduce social isolation. Additionally, digital psychosocial support, educational interventions, and video calls were found to be effective in reducing loneliness in different contexts. The review emphasizes the importance of considering different strategies and contexts when designing and implementing digital intergenerational programs for older adults.
Article
Nutrition & Dietetics
Xiangyuan Huang, Zher Min Tan, Chuen Seng Tan, Yi Lin Ng, Rob M. van Dam, Saima Hilal
Summary: This study examined the association between diet quality and cognitive impairment in middle-aged and older adults of different ethnicities in Singapore. The findings showed that healthier dietary patterns were associated with better cognitive function, which could help promote healthier eating patterns in Asian populations.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Neurosciences
Nicole Shu Ning Teoh, Bibek Gyanwali, Mitchell K. P. Lai, Yuek Ling Chai, Joyce R. Chong, Eddie Jun Yi Chong, Christopher Chen, Chuen Seng Tan, Saima Hilal
Summary: This study investigated the association between baseline IL-6 and IL-8 levels and cognitive function as well as cognitive decline over a five-year follow-up period. The results showed a negative linear trend association between IL-8 levels and baseline cognitive function, particularly in attention, executive function, and visuospatial function domains. However, there was no association between IL-6 levels and cognitive function. These findings suggest the role of neuroinflammation in cognitive impairment and indicate that blood inflammatory biomarkers may be useful in identifying patients at risk of cognitive decline.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Economics
Wenjia Chen, Yi Wang, Yaroslava Zemlyanska, Dimple Butani, Nigel Chong Boon Wong, Suchin Virabhak, David Bruce Matchar, Yot Teerawattananon
Summary: This study comprehensively reviewed the modeling approaches, methodological and policy challenges in the economic evaluation of precision medicine across clinical stages. The findings revealed the challenges in capturing the value of precision medicine, differentiating early evaluations from conventional evaluations, and the importance of budget impact, cost savings, and cost-effectiveness in decision making. It emphasizes the need to modify existing guidelines or develop a new reference case to guide decision making in research and development and market access.
Article
Neurosciences
Reshma Aziz Merchant, Yiong Huak Chan, Denishkrshna Anbarasan, Ivan Aprahamian
Summary: Motoric cognitive risk syndrome (MCR) is associated with slow gait and subjective cognitive decline, and it is considered a prodrome for dementia. This study investigated the link between MCR and body composition, including sarcopenia and systemic inflammation, in pre-frail older adults. The results showed that MCR was associated with higher body fat percentages, sarcopenia prevalence, and levels of inflammatory biomarkers. Sarcopenia, body fat percentage, and the ratio of progranulin to TNF-a were independently associated with MCR. Longitudinal studies are needed to understand the role of body fat indices and IL-10 in the trajectory to dementia in pre-frail older adults with MCR.
Article
Social Sciences, Interdisciplinary
Ashish Kumar, Zhenghong Liu, John Pastor Ansah, Yih Yng Ng, Benjamin Sieu-Hon Leong, David Bruce Matchar, Marcus Eng Hock Ong, Fahad Javaid Siddiqui
Summary: Globally, Emergency Care Systems (ECS) are critical resources that require careful use due to the potential for demand to exceed capacity. In Singapore, policymakers are considering the introduction of Alternate Care Service Pathways (ACSPs) to address overcrowding in Emergency Departments (EDs). However, developing ACSPs is costly and carries the risk of unintended consequences.
Article
Geriatrics & Gerontology
Vanessa Koh, David B. Matchar, Angelique Chan
Summary: This study aimed to investigate the mediating effects of poor physical strength and depression on the association between pain and recurrent and/or injurious falls in older adults. The results showed that pain significantly influenced recurrent and injurious falls, and poor physical strength and depression played a significant mediating role in this association.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Health Care Sciences & Services
Sarah Edney, Claire Marie Goh, Xin Hui Chua, Alicia Low, Janelle Chia, Daphne S. Koek, Karen Cheong, Rob van Dam, Chuen Seng Tan, Falk Mueller-Riemenschneider
Summary: This study aimed to evaluate the effects of study design features on Ecological Momentary Assessments (EMAs) response rates. The results showed that using SMS text messages instead of emails for notifications increased the response rate over time. Changing the available rewards did not lead to a significant difference in the response rate, while increasing the schedule length significantly improved response rates.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Wenjia Chen, Nigel Chong Boon Wong, Yi Wang, Yaroslava Zemlyanska, Dimple Butani, Suchin Virabhak, David Bruce Matchar, Thittaya Prapinvanich, Yot Teerawattananon
Summary: This study aimed to determine the heterogeneity in the value for money of precision medicine (PM) across different application types and contexts. The analysis of cost-effectiveness of PM interventions showed that publicly sponsored studies found genetic testing and gene therapy to be not cost-effective, while studies funded by commercial entities and early stage evaluations had contradictory results. Evidence of cost-effectiveness was found in genetic tests for screening, diagnosis, or companion diagnostics, as well as multigene panel testing, but only in specific disease areas and high-income countries. Incremental effectiveness was a key driver for value in genetic tests but not in gene therapy.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Sean Shao Wei Lam, Jingwei Chen, Jun Tian Wu, Chun Fan Lee, Narayanan Ragavendran, Marcus Eng Hock Ong, Ngiap Chuan Tan, Chian Min Loo, David Bruce Matchar, Mariko Siyue Koh
Summary: This study evaluated the impact of asthma education, asthma control assessment, and spirometry testing on the time to severe exacerbation (TTSE). The results showed that asthma education and asthma control assessment were associated with a decrease in exacerbation frequency and an extended TTSE, highlighting the importance of ensuring quality care in clinical practice.
ANNALS ACADEMY OF MEDICINE SINGAPORE
(2023)
