Journal
GENOMICS
Volume 111, Issue 6, Pages 1668-1675Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2018.11.017
Keywords
LncRNAs; sRNA trigger; ta-siRNA; Conserved pathway; Arabidopsis
Funding
- Zhejiang Provincial Natural Science Foundation of China [LQ16C060001, LY17C190001]
- National Natural Science Foundation of China [31801102, 31771457, 31571349]
- Public Welfare Technology Application Research Project of Zhejiang Province [2016C33193]
- Scientific Research Fund of Zhejiang Provincial Education Department [Y201533314]
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Long non-coding RNAs (lncRNAs) are the dark mattersinvolved in gene regulation with complex mechanisms. However, the functions of most lncRNAs remain to be determined. Our previous work revealed a massive number of degradome-supported cleavage signatures on Arabidopsis lncRNAs. Some of them have been confirmed associated with miRNAs-like sRNAs production, while others without long stem structure remain unexplored. A systematical search for phasiRNAs generating ability of these lncRNAs was conducted. Eight novel small RNA triggered lncRNA-phasiRNA pathways were discovered and three of them were found to be conserved in Arabidopsis, Oryza saliva, Glycine max and Gossypium hirsutum. Besides, Five novel ta-siRNAs derived from these lncRNAs were further identified to be involved in the regulation of plant development, stress responses and aromatic amino acids synthesis. These results substantially expanded the gene regulation mechanisms of lncRNAs.
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