Article
Biotechnology & Applied Microbiology
Haowen Dai, Yang Liu, Qing Han, Aobo Zhang, Hao Chen, Yang Qu, Jincheng Wang, Jianwu Zhao
Summary: This study compared the biomechanical differences between unilateral percutaneous vertebroplasty (UPVP) and bilateral percutaneous vertebroplasty (BPVP) using finite element analysis. The results showed that BPVP could balance vertebral body stress, reduce intervertebral disc stress, and offer stability advantages compared to UPVP. Therefore, BPVP has the potential to reduce postoperative complications and provide promising clinical effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Rajdeep Ghosh, Souptick Chanda, Debabrata Chakraborty
Summary: This article provides a comprehensive review of the development of mathematical models of tissue-differentiation and bone adaptation for orthopaedic implant design optimization. Despite the existence of various mechanoregulatory models, none of them has been widely accepted. The lack of research involving clinically relevant animal models has hindered the development of mathematical formulations in this field.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandre J. Prestat, Pedro-Augusto Gondim Teixeira, Aymeric Rauch, Damien Loeuille, Pierre-Henri Pretat, Matthias Louis, Alain Blum
Summary: Percutaneous vertebral cementoplasty (PVC) is an effective treatment with high success rates for vertebral fractures within ankylosed spine segments, providing pain relief and stable fracture consolidation.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2021)
Article
Biotechnology & Applied Microbiology
Cunheng Yang, Fumin Wang, Xingxing Huang, Hao Zhang, Meng Zhang, Junxiao Gao, Shengbo Shi, Fuyang Wang, Fangjun Yang, Xiaobing Yu
Summary: Investigation showed that mineralized collagen modified PMMA bone cement has similar stress distribution to common bone cement and has advantages of promoting bone regeneration, good biocompatibility, and improved properties. It has comparable support strength and has great potential for development.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Conall Quinn, Alexander Kopp, Ted J. Vaughan
Summary: This study presents a computational modelling framework for bone fracture repair that predicts healing and remodelling phases. It investigates the impact of an internal fixation plate on the long-term healing performance of a fractured tibia under different conditions. The introduction of a titanium plate allows for successful healing at higher loading conditions and fracture gaps, but substantial stress shielding is predicted in the remodelling phase.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Article
Mathematics, Interdisciplinary Applications
Fynn Bensel, Marlis Reiber, Elise Foulatier, Philipp Junker, Udo Nackenhorst
Summary: Numerical simulation of bone remodelling is a crucial tool for investigating the stability of bone implants and can aid in surgical planning. This paper introduces a numerical approach using gradient enhancement technique to regularize the internal variables in the bone density evolution model. The method's robustness is demonstrated through parametric studies on benchmark examples, and its effectiveness is further validated through a detailed femur model simulation.
COMPUTATIONAL MECHANICS
(2023)
Article
Biology
Rahul Gautam Talukdar, Ceby Mullakkara Saviour, Santanu Dhara, Sanjay Gupta
Summary: Functionally graded porous interbody cage can balance between the reduction of stiffness and maintenance of mechanical properties. This study used finite element models to investigate the load transfer and bone density changes around FGP interbody cages. The results showed that FGP cages had lower strain distribution and higher bone apposition compared to solid-Ti cages. The FGP cage also resulted in reduced micromotion for physiologic movements.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Clinical Neurology
Ryan Mattie, Nick Brar, Jennifer T. Tram, Zachary L. McCormick, Douglas P. Beall, Andrew Fox, Mikhail Saltychev
Summary: This study compared vertebral augmentation surgeries with other therapies for cancer-related vertebral compression fractures through meta-analysis of randomized controlled trials, demonstrating a statistically significant pain relief effect. Vertebral augmentation surgeries, such as vertebroplasty and kyphoplasty, showed better outcomes compared to nonsurgical management, radiofrequency ablation, or chemotherapy alone.
Article
Engineering, Biomedical
Anneke S. K. Verbruggen, Laoise M. McNamara
Summary: Metastatic bone disease is common in advanced breast cancer patients, and understanding the mechanical environment within bone tissue during bone metastasis is crucial. This study used finite element analysis to quantify changes in the mechanical stimuli within bone tissue during early metastasis and found that there was a decrease in strain distribution before extensive osteolytic destruction occurred. These findings suggest that early changes in the mechanical environment may contribute to the development of osteolysis in bone metastasis.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biophysics
Yogesh Deepak Bansod, Maeruan Kebbach, Daniel Kluess, Rainer Bader, Ursula van Rienen
Summary: Bone tissue exhibits piezoelectric properties, transforming mechanical stress into electrical potential, playing a vital role in bone adaptation and remodelling. Simulation results show that electrically stimulated bone surface enhances bone deposition, and the effect of initial bone density on density distribution was investigated.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Biophysics
Basil Mathai, Santanu Dhara, Sanjay Gupta
Summary: This study aimed to develop an orthotropic bone remodelling algorithm for evaluating peri-prosthetic bone adaptation in uncemented implanted femur. The orthotropic directionality, based on principal stress directions, was found to be consistent with trabecular orientation. Despite reasonable agreement in peri-prosthetic bone density distributions, there were quantitative differences between the isotropic and orthotropic models.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Biophysics
Basil Mathai, Santanu Dhara, Sanjay Gupta
Summary: This study aimed to develop an orthotropic bone remodelling algorithm for evaluation of peri-prosthetic bone adaptation in the uncemented implanted femur. The algorithm was tested on intact femur models to verify predicted results, and compared with an isotropic formulation. Results showed differences in bone directionality and density predictions between the two models, highlighting the influences of bone orthotropy and mechanical stimulus in the adaptation process.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Medicine, General & Internal
Yuanzheng Song, Xia Pang, Fahao Zhu
Summary: Burst fractures of the thoracolumbar spine often result in damage to the spinal column and posterior structures, leading to compression of the spinal cord or cauda equina and neurological dysfunction. The use of positioning and distraction techniques can effectively restore the injured vertebrae to their normal height and alignment. Decompression of the posterior longitudinal ligament can help push the bone block in the spinal canal back into place, achieving a successful reduction.
Article
Engineering, Biomedical
Juan Du, Simin Li, Vadim V. Silberschmidt
Summary: This study developed and validated a finite-element model based on a 6-month longitudinal in-vivo HR-pQCT study to investigate the effect of mechanical stimuli on bone remodelling. The density distribution varied with mechanical signals, and some parameters showed significant correlation with experimental data. The developed model lays a good foundation for further exploration of the relationships between mechanical loading and human-bone microarchitecture.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Oncology
Biao Wang, Yi Zhan, Yesheng Bai, Lingbo Kong, Liang Li, Haiping Zhang, Simin He, Dingjun Hao
Summary: This study developed a novel bone cement bridging screw system for strengthening the vertebrae in patients with Kummell disease. The results showed that the bridging screw system combined with vertebroplasty has better stability and safety compared to single vertebroplasty and vertebroplasty combined with pediculoplasty.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Engineering, Biomedical
Jenny Gehlen, Wanwan Qiu, Gian Nutal Schadli, Ralph Mueller, Xiao-Hua Qin
Summary: Tomographic volumetric bioprinting (VBP) is a powerful tool for rapid solidification of cell-laden hydrogel constructs. This study explores the application of VBP in bone tissue engineering by merging GelMA bioresin with 3D endothelial co-culture. The optimal formulation for VBP of complex perfusable constructs with high cell viability was identified.
ACTA BIOMATERIALIA
(2023)
Article
Endocrinology & Metabolism
Kenneth Guangpu Yang, Elliott Goff, Ka-lo Cheng, Gisela A. Kuhn, Yujia Wang, Jack Chun-yiu Cheng, Yong Qiu, Ralph Muller, Wayne Yuk-wai Lee
Summary: The study aimed to validate abnormal osteocyte lacunar morphology in adolescent idiopathic scoliosis (AIS) through a large-scale comparison of morphological features between AIS patients and controls in spine and ilium. Results showed that AIS patients had more oblate osteocyte lacunae in the iliac bone, which is less affected by asymmetric loading of the deformed spine, and the shape of osteocyte lacunae in the iliac bone was associated with the radiological Cobb angle in AIS patients. Osteocyte lacunae on the concave side of scoliotic curves were more stretched in both AIS and congenital scoliosis (CS) groups, likely due to asymmetric mechanical loading.
Article
Clinical Neurology
Dominika Ignasiak, Pascal Behm, Anne F. Mannion, Fabio Galbusera, Frank Kleinstuck, Tamas F. Fekete, Daniel Haschtmann, Dezso Jeszenszky, Laura Zimmermann, Sarah Richner-Wunderlin, Alba Vila-Casademunt, Ferran Pellise, Ibrahim Obeid, Javier Pizones, Francisco J. Sanchez Perez-Grueso, Muhammed Ilkay Karaman, Ahmet Alanay, Caglar Yilgor, Stephen J. Ferguson, Markus Loibl
Summary: Sagittal malalignment is a risk factor for mechanical complications after surgery for adult spinal deformity. This study aimed to investigate the relationships between postoperative changes in loads at the proximal segment and realignment, as well as the relationships between absolute postoperative loads and postoperative alignment measures. Patient-specific alignments were simulated based on clinical and radiographic data to predict loads at the proximal segment adjacent to the spinal fusion.
EUROPEAN SPINE JOURNAL
(2023)
Article
Biotechnology & Applied Microbiology
Anita Fung, Ingmar Fleps, Peter A. Cripton, Pierre Guy, Stephen J. Ferguson, Benedikt Helgason
Summary: Sideways falls causing femoral fractures are a major concern for the elderly, and current prevention methods are not very effective. Prophylactic femoral augmentation systems involving ceramic-based bone cements are gaining attention as a potential alternative. This study evaluated the mechanical effectiveness of different bone cement injection patterns and found that supporting the femoral neck cortex is crucial in preventing fractures.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Wanwan Qiu, Jenny Gehlen, Margherita Bernero, Christian Gehre, Gian Nutal Schaedli, Ralph Mueller, Xiao-Hua Qin
Summary: Tomographic volumetric bioprinting (VBP) allows fast fabrication of cell-laden hydrogel constructs using a dynamic resin based on thiol-ene photo-clickable polyvinyl alcohol (PVA) and thermo-sensitive sacrificial gelatin. This technique enables rapid cell spreading, 3D osteogenic differentiation, and matrix mineralization. It also allows site-specific immobilization of molecules-of-interest inside a PVA hydrogel. Overall, this study introduces a synthetic dynamic photoresin that enables fast fabrication of functional ultrasoft hydrogel constructs with well-defined physicochemical properties.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Jenny Carlsson, Anna Braesch-Andersen, Stephen J. Ferguson, Per Isaksson
Summary: A dynamic phase-field fracture finite element model is used to investigate rapid bone fracture in human trabecular bone based on high-resolution three-dimensional computed tomography images. The model is compared to quasi-static experimental results and a quasi-static phase-field finite element model. The experiment shows complex crack evolution with multiple crack fronts and crack arrests, while the quasi-static phase-field fracture model can reasonably capture the fractures in the experiment. At higher load rates, inertia effects significantly contribute to increased stiffness, higher peak forces, and more cracks spread over a larger volume. The study concludes that dynamic fracture models are necessary for simulating rapid bone fracture.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Orthopedics
Salim E. E. Darwiche, Anna Kaczmarek, Peter Schwarzenberg, Brendan J. J. Inglis, Beat Lechmann, Peter Kronen, Stephen J. J. Ferguson, Hannah Dailey, Brigitte von Rechenberg, Karina Klein
Summary: Therapies using electromagnetic field technology show evidence of enhanced bone regeneration, resulting in improved new bone structure and biomechanical properties. The study suggests that combining electric and magnetic field treatment can accelerate bone healing and transform orthopedic implants into active devices for stimulating bone tissue.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Fabio D'Isidoro, Clara Brockmann, Bernd Friesenbichler, Thomas Zumbrunn, Michael Leunig, Stephen J. Ferguson
Summary: This study used a moving fluoroscopic robot to measure the hip joint motion of 15 patients with total hip arthroplasty (THA) during unrestricted activities of daily living. The results showed that current pre-clinical wear testing procedures do not accurately reflect the in-vivo daily motions of THA patients. The patient-specific kinematics measured can be used for in vitro and computational simulations to investigate the impact of individual motion patterns on predicted wear or impingement.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Correction
Engineering, Biomedical
Jianhua Zhang, Esther Wehrle, Jolanda R. Vetsch, Graeme R. Paul, Marina Rubert, Ralph Mueller
BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Aapo Ristaniemi, Amra Secerovic, Vincent Dischl, Francesco Crivelli, Sarah Heub, Diane Ledroit, Gilles Weder, Sibylle Grad, Stephen J. Ferguson
Summary: The physiological and degenerative levels of maximum principal strains and stresses in bovine intervertebral disc tissue were determined through finite element analysis. It was found that when applying 0.1 MPa of compression and +/- 2-3 degrees of flexion and +/- 1-2 degrees of torsion, the mechanical parameters remained at physiological levels. However, with +/- 6-8 degrees of flexion in combination with +/- 2-4 degrees of torsion, the stresses in the outer annulus fibrosus exceeded degenerative levels. These findings provide important guidelines for bioreactor experiments with bovine intervertebral discs.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Andre M. Souza Plath, Stephanie Huber, Serena R. R. Alfarano, Daniel F. F. Abbott, Minghan Hu, Victor Mougel, Lucio Isa, Stephen J. J. Ferguson
Summary: To improve the integration of osteoarthritis scaffold-based grafts, electrospun poly(& epsilon;-caprolactone)/zein-based scaffolds were proposed. The zein surface segregation in the membranes changed the hydrophobic behavior of the materials and increased the cell yield and metabolic activity. The co-electrospun PCL/zein scaffolds showed promising surface and biocompatibility properties for articular-tissue-engineering applications.
BIOENGINEERING-BASEL
(2023)
Article
Nanoscience & Nanotechnology
Xiaoyu Du, Sean Ronayne, Seunghun S. Lee, Jackson Hendry, Douglas Hoxworth, Ryan Bock, Stephen J. Ferguson
Summary: This study focused on the fabrication of 3D-printed polyether ether ketone/silicon nitride (PEEK/SiN) scaffolds with a triply periodic minimal surface (TPMS) structure. The scaffolds demonstrated similar mechanical properties to trabecular bone and stimulated osteogenic differentiation. As a result, PEEK/SiN TPMS scaffolds show significant potential for bone tissue engineering and as candidates for spinal fusion implants.
ACS APPLIED BIO MATERIALS
(2023)
Article
Sport Sciences
Basil Achermann, Katja Oberhofer, Stephen J. Ferguson, Silvio R. Lorenzetti
Summary: Velocity-based training (VBT) is monitored using kinematics measured by expensive devices. This study evaluates the accuracy and precision of the Apple Watch 7 and Enode Pro device for measuring velocity during the back squat exercise. The results show that the barbell-mounted Apple Watch is the most valid for assessing propulsive and peak lifting velocity.
Article
Chemistry, Multidisciplinary
Jean Schoeller, Karin Wuertz-Kozak, Stephen J. J. Ferguson, Markus Rottmar, Jonathan Avaro, Yvonne Elbs-Glatz, Michael Chung, Rene M. Rossi
Summary: The ability of poly(ethylene-co-vinyl alcohol) nanofibers to release ibuprofen for the treatment of chronic wounds was evaluated. The electrospinning of different compositions of poly(ethylene-co-vinyl alcohol) copolymers was optimized, and the release kinetics of ibuprofen from the nanofibers at different temperatures were studied. The scaffolds also showed no cytotoxicity to normal human fibroblasts, indicating their potential for use in chronic wound treatment.
NANOSCALE ADVANCES
(2023)
Article
Mathematical & Computational Biology
Xiaoyu Du, Yijun Zhou, Lingzhe Li, Cecilia Persson, Stephen J. Ferguson
Summary: Investigating the dynamic properties of implants is crucial for their safety and compatibility with natural spinal tissue. This study presents a simplified model of a cantilever beam to explore the effects of holes/pores on the structures. The natural frequencies and damping ratios of cantilever beams with open holes made of polycarbonate (PC) were investigated numerically, analytically, and experimentally. Finite element analysis accurately simulated the damped vibration behavior of cantilever beams with open holes, highlighting the potential of this method for analyzing the dynamic response of complex structures and improving implant design.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
