Journal
GENE
Volume 683, Issue -, Pages 61-71Publisher
ELSEVIER
DOI: 10.1016/j.gene.2018.09.042
Keywords
Genetic triggers; Keratinocytes; Autoimmunity; IL23/Type 17 T cell axis; PSORS
Categories
Funding
- Indian Council of Medical Research [BIC/NTF/1/2013-2014]
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Psoriasis is an immune mediated inflammatory skin disease with complex etiology involving interplay between environmental and genetic risk factors as disease initiating event. Enhanced understanding on genetic risk factors, differentially expressed genes, deregulated proteins and pathway-targeted therapeutics have established multiple axis of psoriasis pathogenesis. So far, loci in 424 genes are reported to be associated with psoriasis alongside copy number variations and epigenetic alterations. From clinical perspective, presence of specific genetic trigger(s) in individual psoriasis patient could aid in devising a personalized therapeutic strategy. Therefore, the review presents an updates on reported genomic alterations and their subsequent course of cutaneous inflammations that potentially drive to psoriasis.
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