Article
Biology
Kati A. Turner, Emily E. Spurlin, Patricia T. Jimenez
Summary: With improved cancer therapies, survival rates of adolescent and young adult patients have increased. However, the gonadotoxic nature of many chemotherapeutic agents limit fertility preservation options. Advancements have been made in oncofertility, particularly vitrification of oocytes, but health disparities hinder access to and utilization of fertility preservation.
Article
Genetics & Heredity
Vaidehi Mujumdar, Kavya Shivashankar, Rachel Madding, Ariel T. Levy, Sushmita Gordhandas, Norman G. Rosenblum, Scott Richard, Brent Monseur
Summary: This study assessed the presence of oncofertility content on fertility clinic websites and examined the relationship with clinic characteristics. The majority of clinic websites included oncofertility-related keywords, with large clinics more likely to mention these keywords. Further research is needed to understand the impact of oncofertility content on clinic websites.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Oncology
Sheng-Miauh Huang, Ling-Ming Tseng, Ming-Jeng Yang, Aria Chang, Pei-Ju Lien, Yvonne Hsiung
Summary: The study aimed to develop electronic systems for oncofertility support and examine its comprehensibility, feasibility, usability, and effects on social support and decision-making preparation. The results showed that the oncofertility support website demonstrated acceptable comprehensibility, feasibility, and usability, as well as improvement in informational and instrumental support.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Piotr Pawlowski, Karolina Joanna Zietara, Justyna Michalczyk, Magdalena Fryze, Anna Buchacz, Agnieszka Zaucha-Prazmo, Joanna Zawitkowska, Anna Torres, Marzena Samardakiewicz
Summary: Oncofertility refers to medical interventions aimed at preserving fertility for cancer patients, particularly those undergoing treatments that can harm reproductive cells. This review focuses on oncofertility in pediatric and adolescent populations, analyzing methods used, financing, ethical considerations, and patient perspectives. Funding for these procedures varies by country, and controversies arise regarding decisions, parental beliefs, ethical dilemmas, and healthcare professionals' knowledge and experience. Healthcare professionals must strive to assist young cancer patients in realizing their reproductive plans and desires for a family. The development of systemic solutions is crucial for advancing oncofertility in this population.
Article
Endocrinology & Metabolism
Noelle Ozimek, Mahmoud Salama, Teresa K. Woodruff
Summary: Oncofertility is an emerging field aiming to preserve fertility in young cancer patients. However, very few countries have established official national oncofertility registries. This study emphasizes the urgent need for such registries to monitor oncofertility services effectively.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Robert E. Brannigan, Richard J. Fantus, Joshua A. Halpern
Summary: Cancer and oncologic therapies can adversely impact male reproductive potential, leading to infertility. Fertility preservation has become a key issue in survivorship, but remains a challenge for certain groups such as prepubertal boys and men who cannot produce sperm. Experimental approaches offer hope for additional pathways in successful fertility preservation care for these patients.
FERTILITY AND STERILITY
(2021)
Review
Oncology
Sophia L. Landay, Jamie A. Burns, Madison L. Bickle, Becky Baltich Nelson, Ryan D. Nipp
Summary: This scoping review aimed to assess the frequency and quality of fertility preservation (FP) discussions between oncology clinicians and reproductive-age female patients with colorectal cancer (CRC), in order to identify gaps in care and guide future research, interventions, or practice changes.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Genetics & Heredity
L. M. Ataman, M. M. Laronda, M. Gowett, K. Trotter, H. Anvari, F. Fei, A. Ingram, M. Minette, C. Suebthawinkul, Z. Taghvaei, M. Torres-Velez, K. Velez, S. L. Adiga, A. Anazodo, L. Appiah, M. T. Bourlon, N. Daniels, M. M. Dolmans, C. Finlayson, R. B. Gilchrist, V. Gomez-Lobo, E. Greenblatt, J. A. Halpern, K. Hutt, E. K. Johnson, K. Kawamura, M. Khrouf, D. Kimelman, S. Kristensen, R. T. Mitchell, M. B. Moravek, L. Nahata, K. E. Orwig, M. E. Pavone, D. Pepin, R. Pesce, G. P. Quinn, M. P. Rosen, E. Rowell, K. Smith, C. Venter, S. Whiteside, S. Xiao, M. Zelinski, K. N. Goldman, T. K. Woodruff, F. E. Duncan
Summary: Since 2007, the Oncofertility Consortium has held an annual conference to disseminate emerging research findings in fertility preservation and facilitate scientific communication. In 2020, the pandemic forced a shift to a virtual meeting, which attracted over 700 participants and showcased global advances in oncofertility and fertility preservation.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Editorial Material
Genetics & Heredity
Teresa K. Woodruff, Lauren Ataman-Millhouse, Kelly S. Acharya, Teresa Almeida-Santos, Antoinette Anazodo, Richard A. Anderson, Leslie Appiah, Joy Bader, Kerri Becktell, Robert E. Brannigan, Lesley Breech, Maria T. Bourlon, Zana Bumbuliene, Karen Burns, Lisa Campo-Engelstein, Jacira R. Campos, Grace M. Centola, Mauricio Barbour Chehin, Diane Chen, Michel De Vos, Francesca E. Duncan, Ahmed El-Damen, Douglas Fair, Yemi Famuyiwa, Patricia Y. Fechner, Paula Fontoura, Olivia Frias, Sabrina A. Gerkowicz, Jill Ginsberg, Clarisa R. Gracia, Kara Goldman, Veronica Gomez-Lobo, Brent Hazelrigg, Michael H. Hsieh, Luis R. Hoyos, Alfonso Hoyos-Martinez, Robert Jach, Jacek Jassem, Murid Javed, Yasmin Jayasinghe, Roohi Jeelani, Jacqueline S. Jeruss, Nalini Kaul-Mahajan, Jessica Keim-Malpass, Tyler G. Ketterl, Mohamed Khrouf, Dana Kimelman, Atsuko Kusuhara, William H. Kutteh, Monica M. Laronda, Jung Ryeol Lee, Vicky Lehmann, Joseph M. Letourneau, Lynda K. McGinnis, Eileen McMahon, Lillian R. Meacham, Monserrat Fabiola Velez Mijangos, Molly Moravek, Leena Nahata, George Moses Ogweno, Kyle E. Orwig, Mary Ellen Pavone, Fedro Alessandro Peccatori, Romina Ileana Pesce, Hanna Pulaski, Gwendolyn Quinn, Ramiro Quintana, Tomas Quintana, Bruno Ramalho de Carvalho, Rosalind Ramsey-Goldman, Joyce Reinecke, Fernando M. Reis, Julie Rios, Alice S. Rhoton-Vlasak, Kenny A. Rodriguez-Wallberg, Cassandra Roeca, Seth J. Rotz, Erin Rowell, Mahmoud Salama, Amanda J. Saraf, Anibal Scarella, Tara Schafer-Kalkhoff, Deb Schmidt, Suneeta Senapati, Divya Shah, Ariella Shikanov, Margarett Shnorhavorian, Jodi L. Skiles, James F. Smith, Kristin Smith, Fabio Sobral, Kyle Stimpert, H. Irene Su, Kouhei Sugimoto, Nao Suzuki, Mili Thakur, David Victorson, Luz Viale, Wendy Vitek, W. Hamish Wallace, Ellen A. Wartella, Lynn M. Westphal, Stacy Whiteside, Lea H. Wilcox, Christine Wyns, Shuo Xiao, Jing Xu, Mary Zelinski
Summary: The Oncofertility Consortium is an international initiative addressing the reproductive futures of cancer survivors and individuals undergoing fertility-limiting treatments. Through open information sharing, the community aims to provide the best care for patients and prepare for future challenges in the field.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Ji Young Choi, Tae Jin Kim
Summary: The gender diverse and transgender community is increasingly encountered in clinical settings due to improved awareness and access to medical facilities. Gender-affirming therapy can have an impact on fertility potential, and transgender patients should be counseled on fertility preservation options prior to transitioning. However, there is limited data and clinical information on fertility preservation for transgender individuals. Understanding this clinical agenda and the processes involved is important for providing comprehensive and specific care for transgender individuals who need fertility counseling or treatment options.
Review
Obstetrics & Gynecology
Hajra Khattak, Rosamund Malhas, Laurentiu Craciunas, Yousri Afifi, Christiani A. Amorim, Simon Fishel, Sherman Silber, Debra Gook, Isabelle Demeestere, Olga Bystrova, Alla Lisyanskaya, Georgy Manikhas, Laura Lotz, Ralf Dittrich, Lotte Berdiin Colmorn, Kirsten Tryde Macklon, Ina Marie Dueholm Hjorth, Stine Gry Kristensen, Ioannis Gallos, Arri Coomarasamy
Summary: Ovarian tissue cryopreservation and transplantation techniques have evolved over the past two decades with the aim of restoring fertility and hormonal function in women. Although evidence of success is largely based on case reports, studies demonstrate that this technology can restore reproductive and hormonal functions in women.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Oncology
Stacy L. Whiteside, Olivia Jaworek Frias, Lindsey Clifford, Katie Schultz, Laura Erickson, Mary Caldwell, Olivia Prebus, Megan Pruett, Kristin Smith
Summary: Oncofertility is a new field that brings together various disciplines to care for oncology patients who are at risk of fertility issues due to treatment. However, there is limited research on the provision of this care and the training of healthcare professionals, as well as patient outcomes. The role of the oncofertility patient navigator is to provide timely information and support for fertility risk and preservation options. This paper aims to define the role of the navigator and provide a framework for improving reproductive care for cancer patients.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Biology
Ahmed Al Ghaithi, Eyas Al Rashdi, Maryam Al Shukri, Rahma Al Ghabshi, Halima Albalushi
Summary: Improved treatments for cancer have increased survival rates, but they can also result in infertility for survivors. It is important for healthcare providers to discuss fertility preservation options with young cancer survivors, but in Oman, the lack of knowledge and availability of services hinders these discussions.
Article
Oncology
Eleonora Porcu, Linda Cipriani, Maria Dirodi, Pierandrea De Iaco, Anna Myriam Perrone, Pier Luigi Zinzani, Mario Taffurelli, Claudio Zamagni, Patrizia Maria Ciotti, Leonardo Notarangelo, Nilla Calza, Giuseppe Damiano
Summary: This study demonstrates that oocyte cryopreservation is a feasible and efficient option for fertility preservation in cancer patients, based on the comparison with nononcological patients undergoing in vitro fertilization treatments. The results show that cancer patients who undergo oocyte cryopreservation have a high pregnancy rate and birth rate, indicating the effectiveness of this method in preserving fertility.
Article
Oncology
Alice Hours, Aullene Toussaint, Victoire De Castelbajac, Camille Sautter, Julie Borghese, Sophie Frank, Florence Coussy, Enora Laas, Beatriz Grandal, Elise Dumas, Eric Daoud, Julien Guerin, Thomas Balezeau, Jean-Guillaume Feron, Virginie Fourchotte, Youlia Kirova, Florence Lerebours, Jean-Yves Pierga, Eugenie Guillot, Pietro Santulli, Michael Grynberg, Charlotte Sonigo, Emmanuel Reyrat, Pauline Soibinet-Oudot, Fabien Reyal, Anne-Sophie Hamy
Summary: The study found that only 33% of female breast cancer patients had discussed fertility preservation, and the discussion rate was influenced by factors such as patient age, nulliparity, physician gender, and physician specialty. Interestingly, the probability of discussing fertility preservation has increased over the past few years.
FRONTIERS IN ONCOLOGY
(2021)
Article
Obstetrics & Gynecology
Molly B. Moravek, Laurie J. Legocki, Claudia Kraus Piper, Katie Bernard, Barbara D. Reed, Hope K. Haefner
Summary: This study evaluated the impact of a single session of psychosocial counseling on patients with vulvodynia. Results showed that patients who received the counseling intervention reported improved understanding and lessened emotional impact of their symptoms, compared to the control group.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Correction
Genetics & Heredity
L. M. Ataman, M. M. Laronda, M. Gowett, K. Trotter, H. Anvari, F. Fei, A. Ingram, M. Minette, C. Suebthawinkul, Z. Taghvaei, M. Torres-Velez, K. Velez, S. K. Adiga, A. Anazodo, L. Appiah, M. T. Bourlon, N. Daniels, M. M. Dolmans, C. Finlayson, R. B. Gilchrist, V. Gomez-Lobo, E. Greenblatt, J. A. Halpern, K. Hutt, E. K. Johnson, K. Kawamura, M. Khrouf, D. Kimelman, S. Kristensen, R. T. Mitchell, M. B. Moravek, L. Nahata, K. E. Orwig, M. E. Pavone, D. Pepin, R. Pesce, G. P. Quinn, M. P. Rosen, E. Rowell, K. Smith, C. Venter, S. Whiteside, S. Xiao, M. Zelinski, K. N. Goldman, T. K. Woodruff, F. E. Duncan
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Genetics & Heredity
L. M. Ataman, M. M. Laronda, M. Gowett, K. Trotter, H. Anvari, F. Fei, A. Ingram, M. Minette, C. Suebthawinkul, Z. Taghvaei, M. Torres-Velez, K. Velez, S. L. Adiga, A. Anazodo, L. Appiah, M. T. Bourlon, N. Daniels, M. M. Dolmans, C. Finlayson, R. B. Gilchrist, V. Gomez-Lobo, E. Greenblatt, J. A. Halpern, K. Hutt, E. K. Johnson, K. Kawamura, M. Khrouf, D. Kimelman, S. Kristensen, R. T. Mitchell, M. B. Moravek, L. Nahata, K. E. Orwig, M. E. Pavone, D. Pepin, R. Pesce, G. P. Quinn, M. P. Rosen, E. Rowell, K. Smith, C. Venter, S. Whiteside, S. Xiao, M. Zelinski, K. N. Goldman, T. K. Woodruff, F. E. Duncan
Summary: Since 2007, the Oncofertility Consortium has held an annual conference to disseminate emerging research findings in fertility preservation and facilitate scientific communication. In 2020, the pandemic forced a shift to a virtual meeting, which attracted over 700 participants and showcased global advances in oncofertility and fertility preservation.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Endocrinology & Metabolism
Prianka H. Hashim, Hadrian M. Kinnear, Cynthia Dela Cruz, Vasantha Padmanabhan, Molly B. Moravek, Ariella Shikanov
Summary: In this study, three different modes of testosterone (T) administration (subcutaneous injections, commercially available pellets, and silastic implants) were compared in terms of their release dynamics and pharmacokinetic profiles in mice. The results showed that all three methods were able to increase T levels in plasma, but had different recovery speeds after cessation of treatment. Silastic implants provided sustained elevation of T levels for at least 21 weeks.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Daphna Stroumsa, Leah A. Minadeo, Mariam Maksutova, Molly B. Moravek, Rob Stephenson, Paul N. Pfeiffer, Justine P. Wu
Summary: This qualitative study explored the range of attitudes and approaches to mental health evaluation among providers of gender-affirming hormones (GAH) in the United States. The findings revealed variations in providers' perspectives, with some advocating for universal mental health evaluation and others seeing it as a barrier to care. Providers' views were primarily influenced by their understanding of transgender identity and transition, as well as their interpretation of the risk of significant mental illness associated with being transgender.
Article
Obstetrics & Gynecology
Cynthia Dela Cruz, Hadrian M. Kinnear, Prianka H. Hashim, Abigail Wandoff, Likitha Nimmagadda, Faith L. Chang, Vasantha Padmanabhan, Ariella Shikanov, Molly B. Moravek
Summary: This study successfully developed a mouse model to investigate the reproductive consequences of testosterone therapy in transgender men. The model provides a tool for researchers to study the effects of gender-affirming hormone therapy in peripubertal transmasculine youth.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Molly B. Moravek, Marjorie Dixon, Samantha M. Pena, Juno Obedin-Maliver
Summary: Approximately 50% of transmasculine people use testosterone for gender affirmation, but little is known about its effects on reproductive capacity. The current practice of stopping testosterone prior to ovarian stimulation may have negative effects on mental health. Two case studies are presented to support the continuation of testosterone during stimulation.
HUMAN REPRODUCTION
(2023)
Article
Genetics & Heredity
M. Salama, L. Nahata, Y. Jayasinghe, V Gomez-Lobo, M. M. Laronda, M. B. Moravek, L. R. Meacham, M. S. Christianson, M. Lambertini, A. Anazodo, G. P. Quinn, T. K. Woodruff
Summary: Purpose: To compare the oncofertility practices for childhood cancer in limited resource settings versus optimum resource settings based on data collected in the Repro-Can-OPEN Study Part I & II. Methods: Surveyed 39 oncofertility centers from different regions. Results: Showed higher oncofertility scores in optimum resource settings, frequent utilization of certain techniques, and rare utilization of advanced options. Conclusions: Presented a best practice model to optimize care for children with cancer in different resource settings.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Oncology
Nina Jackson Levin, Chiu Yi Tan, Daria Stelmak, Nicholas T. Iannarino, Anao Zhang, Erin Ellman, Lindsey A. Herrel, Emily B. Walling, Molly B. Moravek, Rashmi Chugh, Megan R. Haymart, Brad Zebrack
Summary: Financial concern is a significant issue for adolescent and young adult cancer patients, especially in terms of oncofertility. The lack of financial support for fertility preservation services has a negative impact on these patients' decision making and experiences.
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2023)
Article
Reproductive Biology
Hadrian M. Kinnear, Prianka H. Hashim, Cynthia Dela Cruz, Faith L. Chang, Gillian Rubenstein, Likitha Nimmagadda, Venkateswaran Ramamoorthi Elangovan, Andrea Jones, Margaret A. Brunette, D. Ford Hannum, Jun Z. Li, Vasantha Padmanabhan, Molly B. Moravek, Ariella Shikanov
Summary: After pausing testosterone in a transgender mouse model, estrous cyclicity resumes but with ovarian stromal aberrations and upregulated inflammation. The impact of taking and pausing testosterone on the ovaries is not fully understood. This study utilized a mouse model to characterize the ovarian dynamics following testosterone cessation and found stromal changes, immune pathway upregulation, and the presence of multinucleated macrophages in the ovaries.
BIOLOGY OF REPRODUCTION
(2023)
Article
Psychology, Clinical
Caleb Haley, Anca Tilea, Daphna Stroumsa, Molly B. Moravek, Vanessa K. Dalton, Halley P. Crissman
Summary: The conflation of sex assigned at birth and gender has made it difficult to identify transgender and nonbinary people in large datasets. This study developed a method using diagnostic and procedural codes to determine the sex assigned at birth of these patients, with the aim of expanding available datasets for exploring sex-specific conditions in this population.
TRANSGENDER HEALTH
(2023)
Meeting Abstract
Obstetrics & Gynecology
Amanda R. Schwartz, Min Xu, Cynthia Dela Cruz, Daniel Pfau, Vasantha Padmanabhan, Ariella Shikanov, Molly B. Moravek
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Amanda R. Schwartz, Min Xu, Nicholas Henderson, Cynthia Dela Cruz, Daniel Pfau, Vasantha Padmanabhan, Ariella Shikanov, Molly B. Moravek
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Health Care Sciences & Services
Laura Taylor, Molly Moravek, Adam Marks
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Psychology, Clinical
Erin Inman, Daria Stelmak, Emily K. Kobernik, Juan J. Andino, Daphna Stroumsa, Molly B. Moravek, John F. Randolph
Summary: Patients prefer specialist care for HT follow-up, but are also willing to transition care to primary care providers and express interest in telemedicine.
TRANSGENDER HEALTH
(2022)
