Journal
VIROLOGICA SINICA
Volume 30, Issue 5, Pages 326-343Publisher
SPRINGER
DOI: 10.1007/s12250-015-3624-1
Keywords
dengue; epidemiology; pathogenesis; dengue vaccine; vector control; anti-viral; animal model
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Every year, millions of individuals throughout the world are seriously affected by dengue virus. The unavailability of a vaccine and of anti-viral drugs has made this mosquito-borne disease a serious health concern. Not only does dengue cause fatalities but it also has a profoundly negative economic impact. In recent decades, extensive research has been performed on epidemiology, vector biology, life cycle, pathogenesis, vaccine development and prevention. Although dengue research is still not at a stage to suggest definite hopes of a cure, encouraging significant advances have provided remarkable progress in the fight against infection. Recent developments indicate that both anti-viral drug and vaccine research should be pursued, in parallel with vector control programs.
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