Journal
FETAL AND PEDIATRIC PATHOLOGY
Volume 38, Issue 1, Pages 85-90Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15513815.2018.1547337
Keywords
Congenital hemangioma; congestive heart failure; hydrops fetalis; vascular malformation
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Background: Congenital cutaneous hemangioma is a benign vascular lesion that is a leading cause of severe hemodynamic compromise in a fetus when it is of significant size and especially in association with arteriovenous malformation. Case report: A large cutaneous hemangioma involving the right arm of a 32-week-old male fetus was complicated by fetal hypotrophy, hydrops fetalis and neonatal death. Axillary arteriovenous fistulas and bilateral arterial carotid-subclavian anastomosis were demonstrated at autopsy. Microscopically, the main tumor was a mixed capillary-cavernous hemangioma with vascular channels lined by CD31-positive and GLUT1/Ki-67-negative endothelial cells. Conclusion: Congenital hemangioma can be associated with vascular malformations, and that associations with other vascular malformations may increase the morbidity/mortality.
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