Article
Oncology
Devin N. Patel, Fady Ghali, Margaret F. Meagher, Juan Javier-Desloges, Sunil H. Patel, Shady Soliman, Kevin Hakimi, Julia Yuan, James Murphy, Ithaar H. Derweesh
Summary: The study found an increasing trend in the use of renal mass biopsy (RMB) for localized Renal Cell Carcinoma in the United States, particularly in cases of ablation. However, underutilization of RMB persists, with a significant portion of patients not undergoing the biopsy. RMB utilization remains relatively low for smaller tumors and patients who receive no treatment.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Felix Couture, Tony Finelli, Rodney H. Breau, Ranjeeta Mallick, Bimal Bhindi, Simon Tanguay, Anil Kapoor, Ricardo A. Rendon, Frederic Pouliot, Luke Lavallee, Adrian S. Fairey, Alan So, Patrick O. Richard
Summary: The study aims to identify factors associated with the use of RTB for localized SRMs within multiple centers contributing data to the Canadian Kidney Cancer information system. The results show an increasing adoption and overall use of RTB among Canadian urologists, with factors such as tumor size, hospital volume, and treatment modality influencing the decision to perform RTB.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Urology & Nephrology
Steven C. Campbell, Peter E. Clark, Sam S. Chang, Jose A. Karam, Lesley Souter, Robert G. Uzzo
Summary: Significant progress has been made in the evaluation and management of clinically-localized renal masses. These guidelines offer updated, evidence-based recommendations on evaluation and counseling, highlighting the evolving role of renal-mass-biopsy (RMB).
JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Algirdas Zalimas, Raimonda Kubiliute, Kristina Zukauskaite, Rasa Sabaliauskaite, Mantas Trakymas, Simona Letautiene, Edita Miseikyte Kaubriene, Jurgita Usinskiene, Albertas Ulys, Sonata Jarmalaite
Summary: Active surveillance is the best strategy for managing small renal masses, but reliable methods for early detection and disease aggressiveness prediction are urgently needed. This study validates DNA methylation biomarkers for non-invasive detection and prognosis of small renal masses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Michael R. Harrison, Brian A. Costello, Nrupen A. Bhavsar, Ulka Vaishampayan, Sumanta K. Pal, Yousef Zakharia, Heather S. L. Jim, Mayer N. Fishman, Ana M. Molina, Christos E. Kyriakopoulos, Che-Kai Tsao, Leonard J. Appleman, Benjamin A. Gartrell, Arif Hussain, Walter M. Stadler, Neeraj Agarwal, Russell K. Pachynski, Thomas E. Hutson, Hans J. Hammers, Christopher W. Ryan, Brant A. Inman, Jack Mardekian, Azah Borham, Daniel J. George
Summary: Systemic therapy can be deferred in patients with metastatic renal cell carcinoma and slow-growing metastases. Active surveillance is a common and safe alternative to immediate systemic therapy for selected patients, leading to better quality of life outcomes compared to those who receive systemic therapy.
Article
Urology & Nephrology
Steven C. Campbell, Robert G. Uzzo, Jose A. Karam, Sam S. Chang, Peter E. Clark, Lesley Souter
Summary: The guideline focuses on active surveillance and follow-up after intervention for adult patients with clinically-localized renal masses suspicious for cancer. Recommendations include consideration of AS for solid enhancing tumors and complex cystic lesions. Follow-up should prioritize risk-based surveillance for local/systemic recurrences and potential treatment-related sequelae.
JOURNAL OF UROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christiaan V. Widdershoven, Brigitte M. Aarts, Patricia J. Zondervan, Michael M. E. L. Henderickx, Elisabeth G. Klompenhouwer, Otto M. van Delden, Warner Prevoo, Alexander D. Montauban van Swijndregt, Reindert J. A. van Moorselaar, Axel Bex, Brunolf W. Lagerveld
Summary: This study highlights the importance of obtaining a biopsy prior to the ablation procedure in a separate session to reduce the rate of potentially unnecessary ablations.
ABDOMINAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Raphael Lehrer, Francois Cornelis, Jean-Christophe Bernhard, Pierre Bigot, Cecile Champy, Franck Bruyere, Morgan Roupret, Nicolas Doumerc, Charles-Karim Bensalah, Jonathan Olivier, Francois Audenet, Thibault Tricard, Bastien Parier, Xavier Durand, Matthieu Durand, Thomas Charles, Nicolas Branger, Louis Surlemont, Evanguelos Xylinas, Jean-Baptiste Beauval, Matthias Barral
Summary: This study compared the oncological and perioperative outcomes of robot-assisted partial nephrectomy (RPN) and percutaneous thermal ablation (PTA) for T1 renal cell cancer (RCC) in elderly patients. The results showed similar oncological outcomes between PTA and RPN in elderly patients.
EUROPEAN RADIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Milena Matuszczak, Adam Kiljanczyk, Maciej Salagierski
Summary: The choice of treatment for small renal masses remains debatable, with surgery being the main approach but focal therapy being advocated by some clinicians.
Article
Medicine, General & Internal
Gaetano Aurilio, Giovanni Mauri, Duccio Rossi, Paolo Della Vigna, Guido Bonomo, Gianluca Maria Varano, Daniele Maiettini, Maria Cossu Rocca, Elena Verri, Daniela Cullura, Franco Nole, Franco Orsi
Summary: Renal cell carcinoma is a common tumor with high recurrence and metastasis rates. Image-guided ablation techniques, such as microwave, radiofrequency, cryo, and laser, can effectively control tumor progression. Systemic treatment can be initiated at a certain time after the ablation. The primary success and efficacy rates were high, and no significant complications occurred.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Urology & Nephrology
Thenappan Chandrasekar, Stephen A. Boorjian, Umberto Capitanio, Boris Gershman, Maria Carmen Mir, Alexander Kutikov
Summary: This critical review examines treatment options for localized non-recurrent RCC, emphasizing factors influencing treatment decisions and providing a framework for conceptualizing the decision-making process.
Article
Radiology, Nuclear Medicine & Medical Imaging
Fatma Eldihimi, Cynthia Walsh, Rebecca M. Hibbert, Khalid Al Nasibi, Jana Sheinis Pickovsky, Nicola Schieda
Summary: A CT scoring system can be used to diagnose ccRCC among small solid renal masses and guide renal mass biopsy decisions in clinical practice.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Lorenzo Bertolotti, Federica Segato, Francesco Pagnini, Sebastiano Buti, Andrea Casarin, Antonio Celia, Francesco Ziglioli, Umberto Maestroni, Giuseppe Pedrazzi, Velio Ascenti, Chiara Martini, Calogero Cicero, Massimo De Filippo
Summary: The efficacy and complication rates of percutaneous radiofrequency ablation (RFA) and cryoablation (CA) in the treatment of T1 renal masses were retrospectively investigated. The results showed that both RFA and CA were effective in treating renal masses, with rare major complications.
Article
Pathology
Chen Yang, Brian Shuch, Harriet M. Kluger, Maria Serrano, Adam S. Kibel, Peter A. Humphrey, Adebowale J. Adeniran
Summary: This study found a significant relationship between adverse tumor histopathologic characteristics and tumor size in papillary renal cell carcinoma (PRCC). Adverse histologic features are less commonly seen in small PRCC and are not associated with lower disease-free survival or disease-specific survival.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert G. Rasmussen, Yin Xi, R. Carson Sibley, Christopher J. Lee, Jeffrey A. Cadeddu, Ivan Pedrosa
Summary: This study explores the association of the clear cell likelihood score (ccLS) on MRI with the growth rates and progression of small renal masses (SRMs). The results show that there is a positive correlation between ccLS and the growth rates of SRMs.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Urology & Nephrology
Brittney H. Cotta, Jill C. Buckley
UROLOGIC CLINICS OF NORTH AMERICA
(2017)
Article
Oncology
Charles A. Field, Brittney H. Cotta, Juan Jimenez, Brian R. Lane, Kendrick Yim, Hak J. Lee, Stephen T. Ryan, Zachary A. Hamilton, Sunil Patel, Song Wang, Christokher J. Kane, Sumi Dey, Rana R. Mckay, Sabrina Noyes, Frederick E. Millard, Brian Rini, Steven C. Campbell, Ithaar H. Derweesh
CLINICAL GENITOURINARY CANCER
(2019)
Article
Urology & Nephrology
Zachary A. Hamilton, Umberto Capitanio, Brian R. Lane, Alessandro Larcher, Kendrick Yim, Sumi Dey, Brittney H. Cotta, Margaret F. Meagher, Samer Kirmiz, Adam Bezinque, Ahmed Eldefrawy, Aaron Bradshaw, Stephen Ryan, Cristina Carenzi, Fang Wan, James Proudfoot, Francesco Montorsi, Ithaar H. Derweesh
WORLD JOURNAL OF UROLOGY
(2019)
Review
Urology & Nephrology
Sean W. Berquist, Kendrick Yim, Stephen T. Ryan, Sunil H. Patel, Ahmed Eldefrawy, Brittney H. Cotta, Aaron W. Bradshaw, Margaret F. Meagher, Ahmet Bindayi, Rana R. McKay, Riccardo Autorino, Michael Staehler, Ithaar H. Derweesh
INTERNATIONAL JOURNAL OF UROLOGY
(2019)
Article
Urology & Nephrology
Brittney H. Cotta, Kurt A. McCammon, Keith Rourke, Daniel Rosenstein, Jill C. Buckley
Article
Urology & Nephrology
Zachary A. Hamilton, Umberto Capitanio, Deepak Pruthi, Fady Ghali, Alessandro Larcher, Devin N. Patel, Ahmed Eldefrawy, Sunil Patel, Brittney H. Cotta, Aaron W. Bradshaw, Margaret F. Meagher, Nathan S. Miller, Cristina Carenzi, Fang Wan, Michael A. Liss, Thomas McGregor, Francesco Montorsi, Ithaar H. Derweesh
Article
Urology & Nephrology
Brittney H. Cotta, Margaret F. Meagher, Dattatraya Patil, Kazutaka Saito, Sunil H. Patel, Devin N. Patel, Nathan Miller, Raksha Dutt, Cathrine Keiner, Aaron W. Bradshaw, Fang Wan, Ahmed Eldefrawy, Yosuke Yasuda, Yasuhisa Fujii, Viraj Master, Ithaar H. Derweesh
Summary: The study found that elevated preoperative CRP levels were associated with non-cancer mortality and progressive renal functional decline in patients undergoing surgery for localised RCC. Age, CRP levels, and renal function were identified as independent factors associated with non-cancer mortality risk.
Article
Urology & Nephrology
Brittney H. Cotta, Vi Nguyen, Roger L. Sur, Seth K. Bechis
Summary: The study analyzed prescribing patterns and risk factors associated with prolonged opiate use in patients with acute renal colic. Larger stone size, need for surgery, existing opiate prescription, new opiate prescription, and greater initial number of pills prescribed were identified as factors increasing the risk of requiring a refill prior to stone resolution. Timely treatment and initial non-narcotic treatment may reduce the risk of prolonged opiate use in these patients.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Margaret F. Meagher, Dattatraya Patil, Kazutaka Saito, Juan F. Javier-Desloges, Aaron W. Bradshaw, Sunil H. Patel, Brittney H. Cotta, Yosuke Yasuda, Ahmed Eldefrawy, Fady Ghali, Ryan Nasseri, Fang Wan, Yasuhisa Fujii, Viraj Master, Ithaar H. Derweesh
Summary: This study investigated the association between African-American race and survival in patients with Renal Cell Carcinoma (RCC). The results showed that despite having more indolent histology and lower stage, African-Americans had a greater risk of diminished survival. They had worse overall survival for all stages and worse cancer-specific survival for stage III/IV RCC.
Article
Oncology
Masahiro Toide, Kazutaka Saito, Yosuke Yasuda, Hajime Tanaka, Shohei Fukuda, Dattatraya Patil, Brittney H. Cotta, Sunil H. Patel, Viraj A. Master, Ithaar H. Derweesh, Yasuhisa Fujii
Summary: This study evaluated the prognostic value of C-reactive protein in patients with non-metastatic papillary renal cell carcinoma and found a significant association between C-reactive protein and poor recurrence-free survival. C-reactive protein can serve as a useful adjunct biomarker for screening patients at high risk of recurrence.
CLINICAL GENITOURINARY CANCER
(2022)
Review
Oncology
Hannah Bell, Brittney H. Cotta, Simpa S. Salami, Hyung Kim, Ulka Vaishampayan
Summary: The SWOG 1931 trial aims to evaluate the role of cytoreductive nephrectomy in metastatic renal cell cancer, particularly in patients receiving immune checkpoint-based combination therapy. The study will investigate the impact of nephrectomy on overall survival outcomes and explore the correlation with tumor genomics, microbiome, and other factors.
Article
Urology & Nephrology
Stephen T. Ryan, Devin N. Patel, Fady Ghali, Sunil H. Patel, Reith Sarkar, Kendrick Yim, Ahmed Eldefrawy, Brittney H. Cotta, Aaron W. Bradshaw, Margaret F. Meagher, Zachary A. Hamilton, James D. Murphy, Ithaar H. Derweesh
Summary: The study found that positive surgical margins (PSM) were associated with decreased overall survival (OS) in patients undergoing partial nephrectomy, especially in pT3a disease.
MINERVA UROLOGY AND NEPHROLOGY
(2021)
Article
Oncology
Mina S. Sedrak, Meghan M. Salgia, Cristiane Decat Bergerot, Kemi Ashing-Giwa, Brendan N. Cotta, Jacob J. Adashek, Nazli Dizman, Andrew R. Wong, Sumanta K. Pal, Paulo Gustavo Bergerot
JCO CLINICAL CANCER INFORMATICS
(2019)
Article
Oncology
Paulo G. Bergerot, Cristiane D. Bergerot, Nazli Dizman, Stenio Zequi, Andre Fay, Yash Dara, Manuel Caitano Maia, Brendan N. Cotta, Edna Prado Goncalves, Maria Nirvana Formiga, Milena Shizue Tariki, Diego Abreu Clavijo, Toni K. Choueiri, Gilberto Lopes, Sumanta K. Pal
JOURNAL OF GLOBAL ONCOLOGY
(2017)