Diabetic retinopathy: a complex pathophysiology requiring novel therapeutic strategies

AAV-mediated gene delivery of the calreticulin anti-angiogenic domain inhibits ocular neovascularization

(2018) Leilei Tu et al.   ANGIOGENESIS

Neurodegeneration in diabetic retinopathy: does it really matter?

(2018) Rafael Simó et al.   DIABETOLOGIA

Gene therapy for diabetic retinopathy: Are we ready to make the leap from bench to bedside?

(2017) Jiang-Hui Wang et al.   PHARMACOLOGY & THERAPEUTICS

Genome editing abrogates angiogenesis in vivo

(2017) Xionggao Huang et al.   Nature Communications

The neurovascular unit and the pathophysiologic basis of diabetic retinopathy

(2016) Thomas W. Gardner et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Neuroprotection as a Therapeutic Target for Diabetic Retinopathy

(2016) Cristina Hernández et al.   Journal of Diabetes Research

Pharmacologic Vitreolysis with Ocriplasmin: Rationale for Use and Therapeutic Potential in Vitreo-Retinal Disorders

(2015) Matin Khoshnevis et al.   BIODRUGS

The Diabetes Visual Function Supplement Study (DiVFuSS)

(2015) A Paul Chous et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Role of Complement and Complement Regulatory Proteins in the Complications of Diabetes

(2015) Pamela Ghosh et al.   ENDOCRINE REVIEWS

Treatment of ocular disorders by gene therapy

(2015) M. Ángeles Solinís et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Diabetes enhances the efficacy of AAV2 vectors in the retina: therapeutic effect of AAV2 encoding vasoinhibin and soluble VEGF receptor 1

(2015) Nundehui Díaz-Lezama et al.   LABORATORY INVESTIGATION

Minocycline inhibits PARP-1 expression and decreases apoptosis in diabetic retinopathy

(2015) YING WU et al.   Molecular Medicine Reports

Efficacy of Intravitreal Ocriplasmin for Treatment of Vitreomacular Adhesion

(2015) Julia A. Haller et al.   OPHTHALMOLOGY

TOPICAL NEPAFENEC IN EYES WITH NONCENTRAL DIABETIC MACULAR EDEMA

(2015) Scott M. Friedman et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

Improvement in Patient-Reported Visual Function After Ocriplasmin for Vitreomacular Adhesion

(2015) Rohit Varma et al.   JAMA Ophthalmology

Anti-angiogenic Effects of Mammalian Target of Rapamycin Inhibitors in a Mouse Model of Oxygen-Induced Retinopathy

(2014) Rina Yagasaki et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Therapeutic efficacy of a novel non-peptide αvβ3 integrin antagonist for pathological retinal angiogenesis in mice

(2014) Yong-Jie Li et al.   EXPERIMENTAL EYE RESEARCH

Effects of antioxidant gene therapy on the development of diabetic retinopathy and the metabolic memory phenomenon

(2014) Liwei Zhang et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Intravitreal Injection of Ranibizumab and CTGF shRNA Improves Retinal Gene Expression and Microvessel Ultrastructure in a Rodent Model of Diabetes

(2014) Bojie Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Hypoxia-Responsive Glial Cell-Specific Gene Therapy Vector for Targeting Retinal Neovascularization

(2014) M. R. Biswal et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Temsirolimus Inhibits Proliferation and Migration in Retinal Pigment Epithelial and Endothelial Cells via mTOR Inhibition and Decreases VEGF and PDGF Expression

(2014) Raffael Liegl et al.   PLoS One

Relative Cardiovascular and Gastrointestinal Safety of Non-selective Non-steroidal Anti-inflammatory Drugs Versus Cyclo-oxygenase-2 Inhibitors

(2013) José Pedro Henriques Patrício et al.   CLINICAL DRUG INVESTIGATION

Adeno-Associated Virus Mediated Delivery of a Non-Membrane Targeted Human Soluble CD59 Attenuates Some Aspects of Diabetic Retinopathy in Mice

(2013) Mehreen Adhi et al.   PLoS One

Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives

(2013) Rafael Simó et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Reduction of Interleukin 8 and Platelet-Derived Growth Factor Levels by Topical Ketorolac, 0.45%, in Patients With Diabetic Retinopathy

(2013) Scott. D. Schoenberger et al.   JAMA Ophthalmology

Pathophysiology and treatment of diabetic retinopathy

(2012) Francesco Bandello et al.   ACTA DIABETOLOGICA

Protective Effects of Adeno-associated Virus Mediated Brain-derived Neurotrophic Factor Expression on Retinal Ganglion Cells in Diabetic Rats

(2012) Yan Gong et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Intravitreal Injection of Commercially Available Ketorolac Tromethamine in Eyes with Diabetic Macular Edema Refractory to Laser Photocoagulation

(2012) Renata Malvezzi Maldonado et al.   CURRENT EYE RESEARCH

Global Prevalence and Major Risk Factors of Diabetic Retinopathy

(2012) J. W. Y. Yau et al.   DIABETES CARE

High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina

(2012) Ghulam Mohammad et al.   EXPERIMENTAL EYE RESEARCH

Diabetic Retinopathy

(2012) David A. Antonetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Retinal PEDF Overexpression Prevents Neovascularization in a Murine Adult Model of Retinopathy

(2012) Virginia Haurigot et al.   PLoS One

AGEs, RAGE, and Diabetic Retinopathy

(2011) Hongliang Zong et al.   Current Diabetes Reports

Ketorolac 0.45% Ophthalmic Solution

(2011) Paul L. McCormack   DRUGS & AGING

Inhibition of pathological retinal angiogenesis by the integrin αvβ3 antagonist tetraiodothyroacetic acid (tetrac)

(2011) Takeshi Yoshida et al.   EXPERIMENTAL EYE RESEARCH

ACE2 and Ang-(1-7) Confer Protection Against Development of Diabetic Retinopathy

(2011) Amrisha Verma et al.   MOLECULAR THERAPY

A Randomized, Dose-Escalation Study of Subconjunctival and Intravitreal Injections of Sirolimus in Patients with Diabetic Macular Edema

(2011) Pravin U. Dugel et al.   OPHTHALMOLOGY

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Effect of Prior Intensive Therapy in Type 1 Diabetes on 10-Year Progression of Retinopathy in the DCCT/EDIC: Comparison of Adults and Adolescents

(2010) N. H. White et al.   DIABETES

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

PKC and the control of localized signal dynamics

(2010) Carine Rosse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effects of Medical Therapies on Retinopathy Progression in Type 2 Diabetes

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells

(2009) Orisha K. Yacyshyn et al.   ANGIOGENESIS

Vascular endothelial growth factor-A: A multifunctional molecular player in diabetic retinopathy

(2009) Xinyuan Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Renal and Retinal Effects of Enalapril and Losartan in Type 1 Diabetes

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Glycemic Exposure on the Risk of Microvascular Complications in the Diabetes Control and Complications Trial--Revisited

(2008) J. M. Lachin et al.   DIABETES

High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study

(2008) N. Rabbani et al.   DIABETOLOGIA

Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization

(2008) P Pechan et al.   GENE THERAPY

Inhibition of retinal neovascularization by gene transfer of small interfering RNA targeting HIF-1α and VEGF

(2008) Jian Jiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials

(2008) Nish Chaturvedi et al.   LANCET

Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial

(2008) Anne Katrin Sjølie et al.   LANCET

Activation of the renal renin-angiotensin system in diabetes--new concepts

(2008) J. Peti-Peterdi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Vascular endothelial growth factor and diabetic complications

(2008) B WIROSTKO et al.   PROGRESS IN RETINAL AND EYE RESEARCH