Respiratory syncytial virus vaccine: where are we now and what comes next?

Live Respiratory Syncytial Virus (RSV) Vaccine Candidate Containing Stabilized Temperature-Sensitivity Mutations Is Highly Attenuated in RSV-Seronegative Infants and Children

(2018) Ursula J Buchholz et al.   JOURNAL OF INFECTIOUS DISEASES

Live-Attenuated Respiratory Syncytial Virus Vaccine Candidate With Deletion of RNA Synthesis Regulatory Protein M2-2 is Highly Immunogenic in Children

(2018) Elizabeth J McFarland et al.   JOURNAL OF INFECTIOUS DISEASES

Pre-fusion RSV F strongly boosts pre-fusion specific neutralizing responses in cattle pre-exposed to bovine RSV

(2017) Ann-Muriel Steff et al.   Nature Communications

Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

(2017) Iebe Rossey et al.   Nature Communications

Hospitalizations for respiratory syncytial virus (RSV) among adults in the United States, 1997 - 2012

(2017) Susan T. Pastula et al.   Open Forum Infectious Diseases

A Randomized, Controlled, Observer-Blinded Phase 1 Study of the Safety and Immunogenicity of a Respiratory Syncytial Virus Vaccine With or Without Alum Adjuvant

(2016) Joanne M. Langley et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of Respiratory Syncytial Virus Nonstructural Protein 2 Residues Essential for Exploitation of the Host Ubiquitin System and Inhibition of Innate Immune Responses

(2016) Jillian N. Whelan et al.   JOURNAL OF VIROLOGY

Vaccination strategies against respiratory syncytial virus

(2016) Dan Yamin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Report from the World Health Organization's Product Development for Vaccines Advisory Committee (PDVAC) meeting, Geneva, 7–9th Sep 2015

(2016) Birgitte K. Giersing et al.   VACCINE

Evaluating vaccination strategies for reducing infant respiratory syncytial virus infection in low-income settings

(2015) Piero Poletti et al.   BMC Medicine

Small hydrophobic protein of respiratory syncytial virus as a novel vaccine antigen

(2015) Bert Schepens et al.   Immunotherapy

CX3CR1 is an important surface molecule for respiratory syncytial virus infection in human airway epithelial cells

(2015) Tatiana Chirkova et al.   JOURNAL OF GENERAL VIROLOGY

Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera

(2015) Joan O. Ngwuta et al.   Science Translational Medicine

A gene deletion that up-regulates viral gene expression yields an attenuated RSV vaccine with improved antibody responses in children

(2015) Ruth A. Karron et al.   Science Translational Medicine

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein

(2015) Morgan S. A. Gilman et al.   PLoS Pathogens

Surface expression of the hRSV nucleoprotein impairs immunological synapse formation with T cells

(2014) P. F. Cespedes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-neutralization of four paramyxoviruses by a human monoclonal antibody

(2013) Davide Corti et al.   NATURE

Respiratory Syncytial Virus-Associated Hospitalizations Among Children Less Than 24 Months of Age

(2013) C. B. Hall et al.   PEDIATRICS

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Randomized, placebo-controlled trial to assess the safety and immunogenicity of an adenovirus type 35-based circumsporozoite malaria vaccine in healthy adults

(2013) C Buddy Creech et al.   Human Vaccines & Immunotherapeutics

Characterization of Humoral and Cellular Immune Responses Elicited by a Recombinant Adenovirus Serotype 26 HIV-1 Env Vaccine in Healthy Adults (IPCAVD 001)

(2012) Dan H. Barouch et al.   JOURNAL OF INFECTIOUS DISEASES

Respiratory Syncytial Virus NS1 Protein Colocalizes with Mitochondrial Antiviral Signaling Protein MAVS following Infection

(2012) Sandhya Boyapalle et al.   PLoS One

Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention

(2012) M. Magro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human respiratory syncytial virus viroporin SH: a viral recognition pathway used by the host to signal inflammasome activation

(2012) Kathy Triantafilou et al.   THORAX

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

(2011) Jason S. McLellan et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

(2011) J. S. McLellan et al.   JOURNAL OF VIROLOGY

A Novel Inactivated Intranasal Respiratory Syncytial Virus Vaccine Promotes Viral Clearance without Th2 Associated Vaccine-Enhanced Disease

(2011) Dennis M. Lindell et al.   PLoS One

Progress in understanding and controlling respiratory syncytial virus: Still crazy after all these years

(2011) Peter L. Collins et al.   VIRUS RESEARCH

Respiratory Syncytial Virus Interferon Antagonist NS1 Protein Suppresses and Skews the Human T Lymphocyte Response

(2011) Shirin Munir et al.   PLoS Pathogens

Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

(2010) Harish Nair et al.   LANCET

Respiratory viruses and eosinophils: Exploring the connections

(2009) Helene F. Rosenberg et al.   ANTIVIRAL RESEARCH

Therapeutic Monoclonal Antibody Treatment Targeting Respiratory Syncytial Virus (RSV) G Protein Mediates Viral Clearance and Reduces the Pathogenesis of RSV Infection in BALB/c Mice

(2009) Lia M. Haynes et al.   JOURNAL OF INFECTIOUS DISEASES

The Burden of Respiratory Syncytial Virus Infection in Young Children

(2009) Caroline Breese Hall et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Role of Neutralizing Antibodies in Protection of American Indian Infants Against Respiratory Syncytial Virus Disease

(2009) Angelia Eick et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells

(2008) P. A. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA