Article
Oncology
Ingunn M. Stromnes, Ayaka Hulbert, Meagan R. Rollins, Ryan S. Basom, Jeffrey Delrow, Patrick Bonson, Adam L. Burrack, Sunil R. Hingorani, Philip D. Greenberg
Summary: This study investigates the role of immune checkpoints in mediating functional dysfunction of engineered T cells in pancreatic ductal adenocarcinoma (PDA). The findings suggest that blockade of PD-1 signaling alone is not enough to overcome the dysfunction of TCR engineered T cells in PDA. Contributions from both the differentiation pathways induced during the T cell engineering process and intratumoral suppressive mechanisms render engineered T cells dysfunctional.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Yukiko Yamaguchi, Jackson Gibson, Kevin Ou, Lupita S. Lopez, Rachel H. Ng, Neena Leggett, Vanessa D. Jonsson, Jelani C. Zarif, Peter P. Lee, Xiuli Wang, Catalina Martinez, Tanya B. Dorff, Stephen J. Forman, Saul J. Priceman
Summary: This study reveals an alternative mechanism by which the combination of CAR T cells and immune checkpoint blockade modulates the immune landscape of solid tumors to enhance therapeutic efficacy of CAR T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Jessica Waibl Polania, Emily C. Lerner, Daniel S. Wilkinson, Alexandra Hoyt-Miggelbrink, Peter E. Fecci
Summary: Tumors often develop mechanisms to evade T cell killing, leading to the failure of T cell-based immunotherapies in solid tumors. New approaches are necessary to overcome these barriers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Anders Handrup Kverneland, Christopher Aled Chamberlain, Troels Holz Borch, Morten Nielsen, Sofie Kirial Mork, Julie Westerlin Kjeldsen, Cathrine Lund Lorentzen, Lise Pyndt Jorgensen, Lene Buhl Riis, Christina Westmose Yde, Ozcan Met, Marco Donia, Inge Marie Svane
Summary: This study demonstrated high success rates of TIL expansion and tumor regressions in multiple solid cancer types when combining TIL ACT with CPIs. In vitro tumor reactivity was positively associated with treatment outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Chen Chen, Zehua Wang, Yi Ding, Yanru Qin
Summary: Cellular metabolism plays a critical role in tumor cells and T cells. Dysregulated metabolism is a hallmark of cancer and impacts the function of T cells. The interaction between tumor and T cell metabolism can affect T cell responses. Metabolic competition in the tumor ecosystem suppresses effector T cells. Targeting metabolic reprogramming shows promise in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
John S. Davies, Farrah Karimipour, Ling Zhang, Nisha Nagarsheth, Scott Norberg, Carylinda Serna, Julius Strauss, Shinheng Chiou, James L. Gulley, Christian S. Hinrichs
Summary: PD-1 blockade primarily acts through endogenous T cells rather than transferred T cells to mediate a non-synergistic antitumor effect in solid tumor cell therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Cell Biology
Shuyang S. Qin, Alexa D. Melucci, Alexander C. Chacon, Peter A. Prieto
Summary: Adoptive cell therapy with tumor-infiltrating T cells has emerged as a promising treatment for unresectable or metastatic solid tumors. Despite its ability to induce complete tumor regression, many patients do not respond well. Recent research has focused on refining the TIL protocol to increase therapeutic efficacy.
Review
Medicine, Research & Experimental
Jingtao Zhang, Shuai Liu, Xiubao Chen, Xiangdong Xu, Fei Xu
Summary: Lung cancer is a major cause of cancer-related deaths worldwide. Immunotherapies have revolutionized cancer treatment strategies and have the potential to improve immune responses, response rates, and survival rates. However, a deeper understanding of the complex immunological networks in lung cancer is necessary to enhance the efficacy of immunotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Guillermo O. Rangel Rivera, Hannah M. Knochelmann, Connor J. Dwyer, Aubrey S. Smith, Megan M. Wyatt, Amalia M. Rivera-Reyes, Jessica E. Thaxton, Chrystal M. Paulos
Summary: The review discusses how targeting metabolic pathways can enhance the immune response of T cells to tumors, as tumors consume key metabolites in the host, depriving T cells of essential nutrients for growth and function. Furthermore, immunosuppressive molecules and checkpoint receptors further compromise the activity of T cells within tumors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Laura K. Fogli, Rosemarie Aurigemma, Connie L. Sommers, Anju Singh, Kasia Bourcier, Marc S. Ernstoff
Summary: Cell-based immunotherapies have shown remarkable success in treating hematologic malignancies, but have limited efficacy in solid tumor patients. Key challenges in developing cell-based immunotherapy for solid tumors include scientific, technical, clinical, and regulatory barriers. The research community may benefit from NCI support in areas such as tumor target selection, clinical trial harmonization, manufacturing support, and standard operating procedures.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Materials Science, Multidisciplinary
Xin Li, Yu Zhen, Shanshan Li
Summary: This article reviews the significance of immune checkpoint blockade, photodynamic therapy, and nanotechnology in cancer treatment, highlighting the promising results of their combination in preclinical models and potential clinical applications.
MATERIALS & DESIGN
(2021)
Article
Oncology
Fengguang Guo, Jugal K. Das, Koichi S. Kobayashi, Qing-Ming Qin, Thomas A. Ficht, Robert C. Alaniz, Jianxun Song, Paul De Figueiredo
Summary: This study demonstrates that live attenuated bacterial treatment can improve antitumor immunity by remodeling the tumor microenvironment, overcoming cancer resistance to chimeric antigen receptor T-cell therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Nanoscience & Nanotechnology
Xingye Chen, Mengqian Gao, Shan An, Lei Zhao, Wenqing Han, Wenjun Wan, Jin Chen, Siqi Ma, Wenhua Cai, Yanni Cao, Dawei Ding, Yi Yan Yang, Lifang Cheng, Yiran Zheng
Summary: In this study, we demonstrate an innovative approach to enhance the treatment outcome of Adoptive Cell Therapy (ACT) for solid tumors by safely anchoring immune checkpoint inhibitors onto T cell surface using bio-orthogonal click chemistry.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Xuhui Dong, Jiqiang Fan, Wangxu Xie, Xiang Wu, Jia Wei, Zhonglei He, Wenxin Wang, Xueting Wang, Pingping Shen, Yuncheng Bei
Summary: Researchers have developed a novel macrophage-based therapy for gastric cancer and investigated its anti-tumoral effects. The therapy specifically targeted HER2-expressed gastric cancer in vitro and in vivo. The combination of this therapy with oxaliplatin showed enhanced efficacy.
BRITISH JOURNAL OF CANCER
(2023)
Review
Immunology
Sijia Ren, Xinxin Xiong, Hua You, Jianfei Shen, Penghui Zhou
Summary: Combining immunotherapy with anti-angiogenesis can transform the tumor microenvironment from immunosuppressive to immune-supportive, increasing the infiltration and activation of immune cells. Therefore, this combination is a promising strategy for cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)