Article
Dermatology
Wen-Yen Huang, Jin-Bon Hong, Michael Chang, Shih-Yi Wang, Shih-Fan Lai, Hsiung-Fei Chien, Sung-Jan Lin
Summary: The effects of cyclophosphamide on anagen hair follicles depend on dosage, with low dosages leading to dystrophy that can be self-repaired, while high dosages prematurely induce other growth stages. Analysis of cell dynamics revealed that apoptosis of central cells in hair bulbs is repairable, bulge stem cells remain unaffected, and basal cup cells can quickly replenish damaged cells and reconstruct structures.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiali Li, Bohao Zhao, Shuyu Yao, Yingying Dai, Xiyu Zhang, Naisu Yang, Zhiyuan Bao, Jiawei Cai, Yang Chen, Xinsheng Wu
Summary: This study found that exosomes derived from dermal papilla cells regulate hair follicle stem cell proliferation by stimulating LEF1, providing new insights into the regulatory mechanisms of hair follicle growth and development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jingjing Wang, Yuheng Fu, Wenmao Huang, Ritusree Biswas, Avinanda Banerjee, Joshua A. Broussard, Zhihai Zhao, Dongmei Wang, Glen Bjerke, Srikala Raghavan, Jie Yan, Kathleen J. Green, Rui Yi
Summary: This study reveals that hair follicle stem cells (SCs) and hair germ (HG) progenitors have different mechanical properties, with SCs being stiff and resistant to size change, while HG progenitors are soft and periodically enlarge and contract. During hair follicle growth, HGs reduce contraction and more frequently enlarge, which is associated with weakening of the actomyosin network and nuclear YAP accumulation. miR-205 can reduce actomyosin contractility and activate hair regeneration in mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Chinnavuth Vatanashevanopakorn, Thanutchaporn Sartyoungkul
Summary: Hair follicles are involved in a variety of functions and their formation and cycling require interaction between different cell types. Despite extensive research, generating functional human hair follicles for clinical use remains a challenge. Human pluripotent stem cells offer a promising unlimited cell source for generating hair follicle cells. This review discusses hair follicle morphogenesis, different cell sources for regeneration, and potential strategies using induced pluripotent stem cells for hair follicle bioengineering. Challenges and perspectives for using bioengineered hair follicles in treating hair loss disorders are also discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chao Zhang, YuanHong Li, Jie Qin, ChengQian Yu, Gang Ma, HongDuo Chen, XueGang Xu
Summary: In this study, it was found that injection of BMSC and MSC-CM led to the transition of telogen hair follicles to anagen hair follicles, and enhanced proliferation of HFSCs positive for Krt15 and Sox9 was observed. Proteomics analyses identified Krt25, Cpm, Stmn1, and Mb as potentially central players in hair follicle transition, suggesting they could be viable clinical targets for HL treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Xiaojiao Fan, Jing Chen, Yajun Zhang, Siyi Wang, Wenqian Zhong, Huipu Yuan, Xia Wu, Chaochen Wang, Yixin Zheng, Yuan Wei, Ying Xiao
Summary: This study clarified the mechanism by which Alpinetin (AP) promotes hair regeneration by activating HFSCs via Wnt signaling. These findings may contribute to the development of a new generation of pilatory that is more efficient and less cytotoxic for treating alopecia.
Article
Dermatology
Jiyoon Lee, Karl R. Koehler
Summary: Culturing skin cells outside the body has long been essential to dermatological research, but artificial skin equivalents often lack the full complexity of native skin, especially in generating and maintaining skin appendages such as hair follicles and sweat glands.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Engineering, Biomedical
Mafalda Correia, Joana Lopes, Daniela Lopes, Ana Melero, Pooyan Makvandi, Francisco Veiga, Jorge F. J. Coelho, Ana C. Fonseca, Ana Claudia Paiva-Santos
Summary: This review discusses nanotechnology-based strategies for hair follicle (HF) regeneration, including controlled drug release and HF-specific targeting. In addition to traditional hair repair methods, wound-induced hair neogenesis (WIHN) has gained attention as a research focus. HF regeneration involves various modalities and technologies, including modulation of the hair cycle, stimulation of progenitor cells and signaling pathways, tissue engineering, WIHN, and gene therapy.
Review
Cell Biology
Min Yang, Tingting Weng, Wei Zhang, Manjia Zhang, Xiaojie He, Chunmao Han, Xingang Wang
Summary: Alopecia is a commonly seen issue affecting various age groups, with hair follicle regeneration considered as a strategy to address this problem. Non-coding RNAs, particularly microRNAs and long ncRNAs, play crucial regulatory roles in hair follicle development and regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Eva Maria Rico-Leo, Luis Francisco Lorenzo-Martin, Angel Carlos Roman, Xose Ramon Bustelo, Jaime Maria Merino, Pedro Maria Fernandez-Salguero
Summary: The aryl hydrocarbon receptor (AhR) plays a crucial role in skin regeneration and homeostasis by maintaining the identity of epidermal stem cells, making it a potential target for treating cutaneous pathologies.
Article
Cell Biology
Masahiro Fukuyama, Aki Tsukashima, Momoko Kimishima, Yoshimi Yamazaki, Hideyuki Okano, Manabu Ohyama
Summary: This study attempted to reproduce the anatomical relationship between the epithelial main body and the dermal papilla within hair follicles in vitro and evaluated how follicle characteristics were reproduced in constructs. Using hiPSC-derived cell composites, the study showed promising potential for regenerating hair follicle equivalents with in vitro hair inductive capacity, reducing the reliance on human tissue-derived trichogenic cell subsets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Sangbum Park
Summary: Hair follicles undergo continuous growth and regression cycles driven by the regulation of stem cells and niche components. Complex morphogenesis is required to build the structure of hair follicles during embryonic development. Understanding the formation and maintenance of hair follicles, as well as the mechanisms for hair follicle generation and skin regeneration, is crucial.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Carla M. Abreu, Mariana T. Cerqueira, Rogerio P. Pirraco, Luca Gasperini, Rui L. Reis, Alexandra P. Marques
Summary: The conditioned medium from interfollicular keratinocytes (KCs-CM) has been shown to improve the hair inductive ability of DP cells, with significant effects on DP cell growth and restoration of activity. Additionally, DP cells cultured with KCs-CM in spheroids demonstrated superior activity and supported the formation of hair follicle- and sebaceous gland-like structures in mice when co-grafted with human keratinocytes.
JOURNAL OF ADVANCED RESEARCH
(2021)
Article
Cell Biology
Weiming Qiu, Pei-Rong Gu, Cheng-Ming Chuong, Mingxing Lei
Summary: A cyst is a closed sac-like structure that can contain various substances, its formation can be caused by different factors. In skin pathology, cysts are commonly used as a sign for diagnosis, impacting patients' appearance and adjacent tissue function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Veterinary Sciences
Wei Yan, Fei Hao, Xiaoshu Zhe, Yingmin Wang, Dongjun Liu
Summary: This study confirmed the biological characteristics and differentiation potential of PHFSCs and SHFSCs from Arbas Cashmere goats, expanding and refining our knowledge of adult stem cell types and characteristics.
BMC VETERINARY RESEARCH
(2022)
Article
Dermatology
Lo-Yu Chang, Sabrina Mai-Yi Fan, Yen-Chen Liao, Wei-Hung Wang, Yu-Ju Chen, Sung-Jan Lin
LASERS IN SURGERY AND MEDICINE
(2020)
Article
Dermatology
Wen-Yen Huang, Jin-Bon Hong, Michael Chang, Shih-Yi Wang, Shih-Fan Lai, Hsiung-Fei Chien, Sung-Jan Lin
Summary: The effects of cyclophosphamide on anagen hair follicles depend on dosage, with low dosages leading to dystrophy that can be self-repaired, while high dosages prematurely induce other growth stages. Analysis of cell dynamics revealed that apoptosis of central cells in hair bulbs is repairable, bulge stem cells remain unaffected, and basal cup cells can quickly replenish damaged cells and reconstruct structures.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tse-En Wang, Yu-Hua Lai, Kai-Chien Yang, Sung-Jan Lin, Chih-Lin Chen, Pei-Shiue Tsai
Article
Medicine, Research & Experimental
Yen-Ting Chen, Pei-Yu Jhao, Chen-Ting Hung, Yueh-Feng Wu, Sung-Jan Lin, Wen-Chih Chiang, Shuei-Liong Lin, Kai-Chien Yang
Summary: Renal fibrosis is a common pathological manifestation of chronic kidney disease without effective therapy. TXNDC5, identified as a critical mediator of cardiac fibrosis, is upregulated in fibrotic kidneys and may play a potential role in renal fibrosis.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Letter
Dermatology
Jen-Ping Chao, Jing-Yi Lin, Cheng-Ying Chiang, Tyng-Shiuan Hsieh, Sung-Jan Lin, Jin-Bon Hong
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Hsien-Yi Chiu, Wei-Hung Wang, Chen-Hsiang Kuan, Yueh-Feng Wu, Chung-Jen Tseng, Wen-Yen Huang, Shiou-Han Wang, Sung-Jan Lin
Summary: This study investigates the mechanism of permanent hair loss induced by depilatory laser and reveals the role of thermal diffusion. The results showed that laser treatment leads to hair miniaturization due to thermal necrosis of dermal papilla cells caused by thermal diffusion from melanin-containing cells.
LASERS IN SURGERY AND MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Ching-Wen Lin, Chien-Min Hung, Wan-Jiun Chen, Jui-Ching Chen, Wen-Yen Huang, Chia-Sing Lu, Ming-Liang Kuo, Shyi-Gen Chen
Summary: Diabetic foot ulcers are costly and problematic complications of diabetes. The chronicity of these ulcers presents a challenge in treatment. Modulating the activity of M1 and M2 macrophages seems to be an effective approach in improving the healing process of DFUs.
Article
Dermatology
Shih-Fan Lai, Wen-Yen Huang, Wei-Hung Wang, Jin-Bon Hong, Sung-Hsin Kuo, Sung-Jan Lin
Summary: This study found that local administration of prostaglandin E2 (PGE2) can effectively reduce radiotherapy-induced alopecia (RIA) and promote hair follicle (HF) self-repair. It was discovered that PGE2 can transiently arrest transit amplifying cells (TACs) in the G1 phase, thereby reducing apoptosis and dystrophy of HFs, and accelerating their regeneration. This study provides a new treatment option for the prevention of RIA.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Review
Dermatology
Sung-Jan Lin, Zhicao Yue, Ralf Paus
Summary: This article describes the clinical manifestation and pathobiology of radiotherapy-induced alopecia (RIA), emphasizing the importance of studying the principles of human organ and stem cell repair, regeneration, and loss. The article discusses the response of different hair follicle and extrafollicular cell populations to radiation, their roles in hair follicle repair and regeneration, and how they contribute to hair follicle miniaturization or even loss in persistent RIA. Finally, the article highlights the potential of targeting various pathways in future RIA management.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Wei-Hung Wang, Raul Ramos, Kang-Yu Tai, Yun-Shan Wu, Tso-Yu Chang, Jia-Yu Yan, Maksim V. Plikus, Ji Won Oh, Sung-Jan Lin
Summary: Researchers should take into account the impact of the hair growth cycle on the interpretation of dermatological studies. Hair growth in mice is not synchronized and occurs in waves, resulting in different stages of hair follicles being present in close proximity. The stochasticity of hair growth waves in mice can lead to misconceptions in mutant or drug-treated mice. This article provides guidelines for designing reliable murine hair growth studies and highlights experimental caveats to be avoided.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Cell Biology
Chih-Lung Chen, Wen-Yen Huang, Eddy Hsi Chun Wang, Kang-Yu Tai, Sung-Jan Lin
JOURNAL OF BIOMEDICAL SCIENCE
(2020)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)