Article
Multidisciplinary Sciences
Kouji Narita, Krisana Asano, Kyosuke Yamane, Hiroyuki Ohashi, Tatsushi Igarashi, Akio Nakane
Summary: This study reported the germicidal effect of 222 nm UVC and the critical role of bandpass filters in reducing the harmful effects of wavelengths outside of 222 nm on mammalian cells. Mice exposed to UVC emitted from a filtered lamp showed significantly lower levels of DNA damage compared to those exposed to UVC emitted from an unfiltered lamp.
Article
Biochemistry & Molecular Biology
Su Jin Lee, Ji Eun Kim, Yun Ju Choi, Jeong Eun Gong, So Hae Park, Bounleuane Douangdeuane, Onevilay Souliya, Ju Min Park, Hee Seob Lee, Bae-Hwan Kim, Dae Youn Hwang
Summary: The methanol extracts of Dipterocarpus tuberculatus Roxb. (MED) showed therapeutic effects against UV-induced photoaging by enhancing antioxidant activity, anti-apoptotic effects, ECM modulation, skin appearances, and anti-inflammatory response in both NHDF cells and nude mice. The identified active components in MED, along with the recovered levels of NO concentration, SOD activity, and Nrf2 expression, contributed to the observed anti-photoaging effects. Furthermore, MED treatment suppressed COX-2-induced iNOS mediated pathway, inflammatory cytokine expression, and inflammasome activation in UV-radiated NHDF cells.
Article
Chemistry, Medicinal
Ebtesam A. Mohamad, Aya A. Aly, Aya A. Khalaf, Mona Ahmed, Reham M. Kamel, Sherouk M. Abdelnaby, Yasmine H. Abdelzaher, Marize G. Sedrak, Shaker A. Mousa
Summary: Punicalagin extracted from pomegranate shows promising antioxidant properties in protecting human skin from aging, reducing cell growth arrest, activating collagen production, lowering harmful substance levels, maintaining collagen levels, and increasing TERT concentration in skin cells.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Chemistry, Medicinal
Alfonsina Milito, Immacolata Castellano, Elisabetta Damiani
Summary: The thinning of the ozone layer due to increased atmospheric pollution has worsened the negative effects of excessive exposure to solar ultraviolet radiation, making skin cancer a major public health concern. While sunscreens are the main solution to prevent skin damage, some synthetic compounds in them have been found to cause harm to marine ecosystems. Marine-derived natural products show promise as potential eco-friendly alternatives for human photoprotection, but further research is needed to fully explore their benefits.
Article
Biochemistry & Molecular Biology
Jana Jandova, Jeremy Snell, Anh Hua, Sally Dickinson, Jocelyn Fimbres, Georg T. Wondrak
Summary: The study focuses on the stress response induced by hypochlorous acid (HOCl) in the skin and its combination effects with solar ultraviolet (UV) radiation, showing that HOCl can inhibit UV-induced skin inflammation, potentially contributing to the treatment of inflammatory skin conditions and preventing UV-induced skin cancer.
Review
Oncology
Piia Takabe, Hanna Siiskonen, Aino Ronkae, Kirsi Kainulainen, Sanna Pasonen-Seppanen
Summary: The incidence of cutaneous melanoma is rapidly increasing worldwide, and ultraviolet radiation is the main risk factor for melanoma. Hyaluronan plays an important role in the development of melanoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Javier Ruiz-Lopez, Juan C. Cardona, Ingrid Garzon, Maria M. Perez, Miguel Alaminos, Jesus Chato-Astrain, Ana M. Ionescu
Summary: The study evaluated the absorbance and transmittance of bioengineered human skin substitutes in the UV spectral range, finding that UV absorbance increased and UV transmission decreased with culture time, with samples at 21 and 28 days showing histological similarities with native skin.
Article
Multidisciplinary Sciences
Tae Kyeong Ryu, Hanna Lee, Dong Keon Yon, Da Yeong Nam, Soo Yun Lee, Byung Ho Shin, Go Woon Choi, Da Som Jeon, Bo Bae Oh, Ji Hyun Kim, Young Yoon, Hyun Jeong Kim, Luc Duteil, Christelle Bruno-Bonnet, Chan Yeong Heo, So Min Kang
Summary: Various substances, including collagen and ascorbic acid, have been studied for their inhibitory effects on skin aging. The synergistic effect of collagen and ascorbic acid was achieved in a product called TEENIALL. In vitro and clinical trials confirmed the effectiveness of this product in improving wrinkles, lifting skin, and reducing pigmentation.
Article
Geriatrics & Gerontology
Duozhuang Tang, Jianying Wu, Yiting Wang, Hui Cui, Zhendong Tao, Lang Lei, Zhuangfa Zhou, Si Tao
Summary: This study demonstrates for the first time that dietary restriction (DR) can protect mouse skin from high dose UVB radiation-induced damage. Continuous DR significantly improves UVB-induced skin damage and inflammatory responses.
REJUVENATION RESEARCH
(2022)
Article
Engineering, Biomedical
Yusen Hao, Hui Li, Jiajun Guo, Dan Wang, Jiamin Zhang, Jinjian Liu, Cuihong Yang, Yumin Zhang, Guoliang Li, Jianfeng Liu
Summary: Radiotherapy is an important cancer treatment method, but it can cause adverse reactions and injuries to the skin. This study designed an antioxidant heparin-mimetic peptide hydrogel (K16) for repairing radiation-induced skin injuries (RISI). The K16 hydrogel can scavenge excess reactive oxygen species (ROS), prevent radiation damage to DNA, promote cell proliferation, migration, and angiogenesis, and eliminate inflammation at the wound site. In vivo experiments demonstrated that the K16 hydrogel inhibits wound degradation, reduces inflammation, and promotes wound healing. Therefore, the K16 hydrogel has great potential for application in repairing radiation-induced skin injuries.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Engineering, Biomedical
Xiyong Huang, Andrew N. Chalmers
Summary: Sunlight is a vital environmental resource for all living organisms on Earth, with UV radiation playing a crucial role in synthesizing vitamin D in the human body. While sun exposure has health benefits, excessive UV exposure can lead to adverse effects such as eye diseases and skin cancers. UV intensity depends on environmental factors, personal outdoor activities, and skin sensitivity. Various UV sensors have been developed over the years to monitor personal UV exposure and protect individuals from potential health risks.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Michal Biernacki, Anna Jastrzab, Elzbieta Skrzydlewska
Summary: The study shows that topical application of CBD can regulate liver antioxidants and phospholipid metabolism to counteract oxidative stress and inflammation caused by UV radiation.
Article
Multidisciplinary Sciences
Gareth Hazell, Marina Khazova, Paul O'Mahoney
Summary: Sunlight exposure in the UK has been shown to upregulate the cardio protectant nitric oxide (NO) in in vitro skin cell lines, with minimal impact on DNA damage and cell death. The release of NO is primarily driven by the whole UV-A spectrum, with higher efficiency observed at shorter wavelengths.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Janet E. Lubov, William Cvammen, Michael G. Kemp
Summary: Research shows that the global incidence of skin cancer is rapidly increasing, primarily due to exposure to ultraviolet sunlight. Recent studies have found a close relationship between the timing of UV exposure, DNA repair, skin cancer development, and the body's circadian clock.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Otilia Gag, Stefania Dinu, Horatiu Manea, Iasmina Marcovici, Iulia Pinzaru, Ramona Popovici, Zorin Crainiceanu, Zsolt Gyori, Gheorghe Iovanescu, Sorin Chiriac
Summary: This study evaluated the phototoxic effects of UVA and UVB radiation on healthy and pathologic skin cells. The results showed that UVA had no cytotoxicity on the tested cells, while UVB significantly reduced cell viability and induced apoptosis. The combination of UVA and UVB resulted in the highest cytotoxicity. The findings provide insights into the behavior of normal and cancer skin cells under UVR treatments.
Article
Chemistry, Applied
Iunia Podolean, Simona M. Coman, Cristina Bucur, Cristian Teodorescu, Stefanos Kikionis, Efstathia Ioannou, Vassilios Roussis, Ana Primo, Hermenegildo Garcia, Vasile Parvulescu
Summary: Ulva rigida, a green macroalga, is considered a promising feedstock for biorefinary due to its fast growth and widespread distribution. The cell walls of U. rigida contain a sulfated glucuronorhamnan polysaccharide called ulvan, which, due to its high sulfate content, can be efficiently recovered as rhamnose through hydrothermal autohydrolysis at 130 degrees C. Under different catalytic conditions, including triflate-based graphene oxide, significant amounts of tartaric acid and succinic acid can also be obtained. The catalyst shows good reusability, maintaining its activity for at least five consecutive cycles.
Article
Chemistry, Medicinal
Marta Carnovali, Maria Letizia Ciavatta, Ernesto Mollo, Vassilios Roussis, Giuseppe Banfi, Marianna Carbone, Massimo Mariotti
Summary: With longer life expectancy, there has been an increased focus on discovering new healing agents for age-related disorders, including bone diseases. Marine organisms, known for their diverse bioactive metabolites, are being recognized as potential sources for therapeutic options. Additionally, the zebrafish model has proven to be an efficient and cost-effective platform for screening molecules that regulate bone development. In this study, the effects of the crude acetonic extract from the marine sponge Aplysina aerophoba and its bromotyrosine components on bone development were evaluated using zebrafish larvae. The results led to the identification of aerophobin-1 as a promising candidate for regenerative medicine and a potential novel therapeutic option for osteoporosis treatment.
Article
Chemistry, Medicinal
Kyriakos C. Prousis, Stefanos Kikionis, Efstathia Ioannou, Silvia Morgana, Marco Faimali, Veronica Piazza, Theodora Calogeropoulou, Vassilios Roussis
Summary: Marine biofouling is a global issue that causes significant economic problems for the shipping industry and aquaculture companies, and its prevention often leads to adverse environmental effects. In this study, bromosphaerol and its derivatives were found to have strong antifouling activity and low toxicity, making them potential candidates for the development of effective antifouling agents.
Article
Chemistry, Medicinal
Maxence Quemener, Stefanos Kikionis, Marilyne Fauchon, Yannick Toueix, Fanny Aulanier, Antonios M. Makris, Vassilios Roussis, Efstathia Ioannou, Claire Hellio
Summary: This study identified two active compounds against key biofoulers, which can be produced by cultivable algae, showing great potential. This research approach is beneficial for discovering new environmentally friendly antifouling compounds.
Review
Chemistry, Medicinal
Noujoud Gabed, Frederic Verret, Aurelie Peticca, Igor Kryvoruchko, Romain Gastineau, Orlane Bosson, Julie Seveno, Olga Davidovich, Nikolai Davidovich, Andrzej Witkowski, Jon Bent Kristoffersen, Amel Benali, Efstathia Ioannou, Aikaterini Koutsaviti, Vassilios Roussis, Helene Gateau, Suliya Phimmaha, Vincent Leignel, Myriam Badawi, Feriel Khiar, Nellie Francezon, Mostefa Fodil, Pamela Pasetto, Jean-Luc Mouget
Summary: The marine pennate diatom Haslea ostrearia, known for its blue pigment marennine, has potential applications in various industries. The discovery of a new blue Haslea species revealed previously unknown biodiversity. This study advocates for establishing H. ostrearia as a new model organism, highlighting its advantages and the challenges involved.
Article
Biochemistry & Molecular Biology
Vasiliki Palli, Georgios Leonis, Nikoletta Zoupanou, Nikitas Georgiou, Maria Chountoulesi, Nikolaos Naziris, Demeter Tzeli, Costas Demetzos, Georgia Valsami, Konstantinos D. Marousis, Georgios A. Spyroulias, Thomas Mavromoustakos
Summary: In this study, the molecular interactions between losartan potassium salt and 2-hydroxypropyl-beta-cyclodextrin were investigated using experimental methods including Differential Scanning Calorimetry, Nuclear Magnetic Resonance, and Molecular Dynamics. The results demonstrated the complexation of losartan potassium salt with 2-hydroxypropyl-beta-cyclodextrin, suggesting the potential for further biological experiments.
Article
Chemistry, Medicinal
Leto-Aikaterini Tziveleka, Stefanos Kikionis, Labros Karkatzoulis, Kostas Bethanis, Vassilios Roussis, Efstathia Ioannou
Summary: By comparing the collagen content of fish scales from five Mediterranean fish species and Atlantic salmon, it was found that fish scales could be efficiently utilized for the production of high added-value biomaterials. The isolated collagenous materials showed typical electrophoretic patterns of type I collagen, and were morphologically and physicochemically characterized for potential applications in the biomedical sector.
Article
Chemistry, Medicinal
Mohamed A. A. Tammam, Maria G. G. Daskalaki, Nikolaos Tsoureas, Ourania Kolliniati, Aldoushy Mahdy, Sotirios C. C. Kampranis, Christos Tsatsanis, Vassilios Roussis, Efstathia Ioannou
Summary: The chemical investigation of the organic extract of the red alga Laurencia majuscula resulted in the isolation of several new natural products with significant anti-inflammatory activity. The structures and configurations of these natural products were determined through NMR, MS, and single-crystal X-ray diffraction analysis. The most prominent anti-inflammatory activity was exhibited by compounds 5 and 18.
Article
Chemistry, Medicinal
Stefanos Kikionis, Paraskevi Papakyriakopoulou, Panagiotis Mavrogiorgis, Elena A. A. Vasileva, Natalia P. P. Mishchenko, Sergey A. A. Fedoreyev, Georgia Valsami, Efstathia Ioannou, Vassilios Roussis
Summary: By incorporating Echinochrome A (EchA) isolated from sea urchins into electrospun micro-/nanofibrous matrices composed of polycaprolactone and polyvinylpyrrolidone, the dissolution and bioavailability of EchA can be improved, making it suitable for oral administration, while also increasing its stability and solubility.
Article
Chemistry, Medicinal
Stefanos Kikionis, Konstantina Iliou, Aikaterini G. Karra, Georgios Polychronis, Ioannis Choinopoulos, Hermis Iatrou, George Eliades, Efthymia Kitraki, Ioulia Tseti, Spiros Zinelis, Efstathia Ioannou, Vassilios Roussis
Summary: Nanofibrous GTR/GBR membranes based on carrageenans and other biocompatible polymers were developed for the regeneration of periodontal tissue. The membranes exhibited favorable morphological, thermal, and mechanical properties, and demonstrated the potential for periodontal tissue regeneration through evaluation of cell attachment, biocompatibility, and osteogenic differentiation.
Article
Chemistry, Medicinal
Paolo Giaccio, Despoina Charou, Dafni-Ioanna Diakaki, Anna Chita, Achille Gravanis, Ioannis Charalampopoulos, Vassilios Roussis, Efstathia Ioannou
Summary: Neurodegenerative diseases are incurable and debilitating conditions. Currently, effective therapies for most neurodegenerative disorders are lacking. A study evaluated the activity of various extracts on TrkB-expressing cells and found that a certain strain of actinobacteria called Streptomyces sp. BI0788 exhibited neuroprotective activity. Further chemical analysis resulted in the identification of new and previously known compounds, some of which showed protective effects on cells through the activation of TrkB.
Article
Biochemistry & Molecular Biology
Yao-Tao Duan, Aikaterini Koutsaviti, Maria Harizani, Codruta Ignea, Vassilios Roussis, Yong Zhao, Efstathia Ioannou, Sotirios C. Kampranis
Summary: By combining gene mining, biochemical characterization, and chemical structure analysis, this study reveals the existence of an extensive class of terpenoids with 16 carbon atoms in bacteria.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Engineering, Biomedical
Leto-Aikaterini Tziveleka, Natassa Pippa, Efstathia Ioannou, Costas Demetzos, Vassilios Roussis
Summary: Liposomes, as nanocarriers for antimicrobial delivery, have been extensively studied due to their safety and targeting ability. However, their use is limited by lack of stability and non-specific interaction with cells and proteins. To overcome these limitations, ulvan, a marine sulfated polysaccharide, was incorporated into liposomes to improve their physicochemical properties and stability. Interactions between ulvan and neutral, negatively, and positively charged lipids were studied using Differential Scanning Calorimetry. Ulvan-containing liposomes were prepared based on the results, with ulvan interacting with lipid chains and polar groups in the liposomal bilayer. Fusidic acid, a model antibacterial drug, was entrapped in the liposomes and the antibacterial activity against Staphylococcus aureus was evaluated. The physicochemical properties, stability, morphology, and entrapment efficiency of the liposomal formulations were determined.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
