Article
Oncology
Tao Wei, Jianfeng Lu, Xue-Lian Xiao, Matthew Weiss, Irinel Popescu, Hugo P. Marques, Luca Aldrighetti, Shishir K. Maithel, Carlo Pulitano, Todd W. Bauer, Feng Shen, George A. Poultsides, Oliver Soubrane, Guillaume Martel, Bas Groot Koerkamp, Endo Itaru, Yi Lv, Xu-Feng Zhang, Timothy M. Pawlik
Summary: Intrahepatic cholangiocarcinoma (ICC) can be classified into two subtypes based on the anatomical origin of tumors, and these subtypes have distinct clinicopathological features and survival outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Jaynee J. A. Vugts, Marcia P. Gaspersz, Eva Roos, Lotte F. Franken, Pim B. Olthof, Robert J. S. Coelen, Jeroen L. A. van Vugt, Tim A. Labeur, Lieke Brouwer, Marc G. H. Besselink, Jan N. M. IJzermans, Sarwa Darwish Murad, Thomas M. van Gulik, Jeroen de Jonge, Wojciech G. Polak, Olivier R. C. Busch, Joris L. Erdmann, Bas Groot Koerkamp, Stefan Buettner
Summary: This study aimed to estimate the eligibility for liver transplantation in patients with perihilar cholangiocarcinoma (pCCA) in two tertiary referral centers. Only 5% of all patients with pCCA were potentially eligible for liver transplantation under the Mayo criteria, with a median overall survival of about 1 year in non-transplanted patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Mitsunobu Oba, Yoshitsugu Nakanishi, Toraji Amano, Keisuke Okamura, Takahiro Tsuchikawa, Toru Nakamura, Takehiro Noji, Toshimichi Asano, Kimitaka Tanaka, Satoshi Hirano
Summary: This study found a significant correlation between invasive tumor thickness (ITT) and postoperative prognosis in patients with perihilar cholangiocarcinoma. Measurement of ITT could help predict patient survival time postoperatively.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Sivesh K. Kamarajah, Wasfi Al-Rawashdeh, Alessandro Parente, Phil Atherton, George Salti, Fadi S. Dahdaleh, Derek Manas, Mohammed Abu Hilal, Steven A. White
Summary: This study found that adjuvant chemotherapy following resection for perihilar cholangiocarcinoma (hCCA) was associated with improved survival, even in margin-negative and node-negative disease.
Review
Oncology
Alejandro Serrablo, Leyre Serrablo, Ruslan Alikhanov, Luis Tejedor
Summary: Perihilar cholangiocarcinoma with vascular involvement presents challenges in treatment options, with varying outcomes in morbidity, mortality, and overall survival rates worldwide. Different approaches, including extended resections and neoadjuvant therapy, are considered to achieve R0 status or potential cure. Despite advances in surgical techniques, there remains variability in outcomes, with positive margins still observed in a significant number of cases.
Article
Surgery
Ryusei Yamamoto, Teiichi Sugiura, Ryo Ashida, Katsuhisa Ohgi, Mihoko Yamada, Shimpei Otsuka, Takeshi Aramaki, Koiku Asakura, Katsuhiko Uesaka
Summary: Carbohydrate antigen 19-9, periductal enation sign, mass-forming tumour, and luminal-occlusion tumour were identified as preoperative risk factors for early recurrence after resection of perihilar cholangiocarcinoma. Risk classification according to these factors was useful for predicting early recurrence.
Review
Oncology
Ryan J. Ellis, Kevin C. Soares, William R. Jarnagin
Summary: In patients with potentially resectable perihilar cholangiocarcinoma, preoperative workup and optimization are crucial. This includes imaging assessment, evaluation of resectability, preoperative drainage, and diagnostic laparoscopy. Volumetric analysis should be performed for resectable lesions. In patients with a functional liver remnant <40%, careful use of biliary drainage and liver hypertrophy induction are advised. Diagnostic laparoscopy can reduce unnecessary laparotomy.
Review
Oncology
Simon Gray, Angela Lamarca, Julien Edeline, Heinz-Josef Klumpen, Richard A. Hubner, Mairead G. McNamara, Juan W. Valle
Summary: Perihilar cholangiocarcinoma is a poor prognosis biliary tract cancer, and targeted therapies based on molecular changes are being developed. This article reviews the molecular changes in perihilar cholangiocarcinoma and the targeted therapies used to improve patient outcomes.
Article
Oncology
Andrea Ruzzenente, Fabio Bagante, Pim B. Olthof, Luca Aldrighetti, Ruslan Alikhanov, Matteo Cescon, Bas Groot Koerkamp, William R. Jarnagin, Silvio Nadalin, Johann Pratschke, Moritz Schmelzle, Ernesto Sparrelid, Hauke Lang, Calogero Iacono, Thomas M. van Gulik, Alfredo Guglielmi
Summary: In this study comparing short- and long-term outcomes for patients with Bismuth-Corlette (BC) type 4 perihilar cholangiocarcinoma (pCCA) versus BC types 2 and 3 pCCA undergoing surgical resection, the results showed significant differences in clinicopathologic characteristics between the two groups. However, the type of BC was not associated with prognosis for survival, indicating that resection remains a viable curative treatment option for selected patients with BC type 4 pCCA.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Anne-Marleen van Keulen, Stijn Franssen, Lydia G. van der Geest, Marieke T. de Boer, Minneke Coenraad, Lydi M. J. W. van Driel, Joris I. Erdmann, Nadia Haj Mohammad, Lara Heij, Heinz-Josef Klumpen, Eric Tjwa, Liselot Valkenburg-van Iersel, Joanne Verheij, Bas Groot Koerkamp, Pim B. Olthof
Summary: In patients with pCCA in the Netherlands, the resection rate and overall survival were higher in patients diagnosed in academic centers. These results demonstrate population-based outcomes of pCCA and emphasize the importance of regional collaboration in treating these patients.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Jun Watanabe, Atsushi Miki, Yasunaru Sakuma, Kentaro Shimodaira, Yuichi Aoki, Yoshiyuki Meguro, Kazue Morishima, Kazuhiro Endo, Hideki Sasanuma, Alan Kawarai Lefor, Takumi Teratani, Noriyoshi Fukushima, Joji Kitayama, Naohiro Sata
Summary: This study aimed to evaluate whether osteopenia is a prognostic factor in patients with perihilar cholangiocarcinoma. The study found that osteopenia is associated with significantly shorter survival in patients with perihilar cholangiocarcinoma, and preoperative osteopenia may be a useful tool for predicting prognosis in these patients.
Article
Gastroenterology & Hepatology
Ola Ahmed, Neeta Vachharajani, Su-Hsin Chang, Yikyung Park, Adeel S. Khan, William C. Chapman, M. B. M. Doyle
Summary: Rigorous patient selection and chemoradiation treatment algorithms can be highly effective in treating perihilar cholangiocarcinoma. Liver transplantation can provide a 52% 5-year survival for appropriately selected candidates who would otherwise have no surgical treatment option.
Review
Gastroenterology & Hepatology
Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Yasuyuki Mizutani, Tadashi Iida, Takeshi Yamamura, Naomi Kakushima, Kazuhiro Furukawa, Masanao Nakamura
Summary: Endoscopic management for perihilar cholangiocarcinoma is evolving to improve diagnosis and drainage. Different imaging methods are used to determine resectability and optimal surgical planning, while new diagnostic imaging methods such as video peroral cholangioscopy and probe-based confocal laser endomicroscopy are being clinically applied. The approach to preoperative drainage has shifted to endoscopic nasobiliary drainage to reduce the risk of metastasis seeding. Various endoscopic techniques, including the use of self-expandable metallic stents and endoscopic ultrasonography-guided approach, are employed depending on the resectability and prognosis.
DIGESTIVE ENDOSCOPY
(2022)
Article
Surgery
Takashi Mizuno, Tomoki Ebata, Yukihiro Yokoyama, Tsuyoshi Igami, Junpei Yamaguchi, Shunsuke Onoe, Nobuyuki Watanabe, Yuzuru Kamei, Masato Nagino
Summary: This study evaluated the efficacy and safety of combined vascular resection (VR) in advanced perihilar cholangiocarcinoma (PHC). The results showed that VR surgery salvages a large number of otherwise unresectable advanced PHC patients and provides acceptable surgical outcomes and substantial survival benefits.
Article
Oncology
Anne-Marleen van Keulen, Pim B. Olthof, Matteo Cescon, Alfredo Guglielmi, William R. Jarnagin, Silvio Nadalin, Johann Pratschke, Francesca Ratti, Roberto I. Troisi, Bas Groot Koerkamp, Stefan Buettner, Joris I. Erdmann
Summary: Long-term survival for patients with perihilar cholangiocarcinoma (pCCA) is rare, with a median overall survival of 29.9 months and a 5% observed cure rate. Factors such as age, tumor type, and presence of residual cancer cells post-surgery may influence the likelihood of cure.
Article
Surgery
Anita Paisant, Jeanne Burgmaier, Paul Calame, Melanie Loison, Sebastien Moliere, Cecile Brigand, Dihia Belabbas, Emilie Duchalais, Jean-Marc Regimbeau, Thierry Yzet, Arnaud Alves, Audrey Fohlen, Damien Bergeat, Estelle Vauclair, Julie Pellegrini, Emilia Ragot, Alexandre Lansier, Emeric Abet, Alexandre Nevot, Pascal Rousset, Mehdi Ouaissi, Marie Besson, Maxime Ronot, Massimo Giacca, Edouard Girard, Yann Tessier, Damien Massalou, Florent Poirier, Zaher Lakkis, Christophe Aube, Jean Francois Hamel, Guillaume Passot, Aurelien Venara
Summary: This study aimed to evaluate the association between the radiological score and the failure of conservative management in adhesive small bowel obstructions (aSBO). The results showed that a history of previous surgery was not a significant risk factor for conservative treatment failure, while a previous episode of aSBO was protective against treatment failure. Additionally, an Angers CT score of >= 5 was identified as an individual risk factor.
WORLD JOURNAL OF SURGERY
(2023)
Article
Oncology
Flavie Thomas, Benjamin Menahem, Gil Lebreton, Karine Bouhier-Leporrier, Olivier Dejardin, Arnaud Alves
Summary: This study aimed to evaluate the incidence and risk factors for permanent stomas after sphincter-preserving surgery for rectal cancer, as well as compare long-term survival outcomes. Out of 257 patients, 16.7% developed permanent stomas after a median follow-up of 4.8 years, with severe post-operative complications and age being significant risk factors. Patients with permanent stomas had significantly lower overall survival and disease-free survival compared to those without stomas.
FRONTIERS IN ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Victor Serenon, Philippe Rouanet, Diane Charleux-Muller, Clarisse Eveno, Karine Poirot, Bertrand Trilling, Stephane Benoist, Gilles Manceau, Yves Panis, Arnaud Alves, Alex Kartheuser, Aurelien Venara, Marc Pocard, Charles Sabbagh, Anais Laforest, Zaher Lakkis, Bogdan Badic, Amelie Chau, Niki Christou, Laura Beyer-Berjot, Frederic Dumont, Adeline Germain, Alain Valverde, Emilie Duchalais, Mehdi Ouaissi, Leonor Benhaim, Maxime Collard, Jean-Jacques Tuech, Etienne Buscail, Diane Mege
Summary: This study aimed to report the incidence of iatrogenic ureteral injury (IUI) during colorectal surgery and analyze the long-term consequences of urological late complications and their impact on oncological outcomes. The results showed that IUI has few consequences if recognized early, but long-term urological sequelae can occur in a third of patients and may affect the timing of adjuvant chemotherapy in colorectal surgery.
COLORECTAL DISEASE
(2023)
Article
Oncology
Alexandre Thobie, Anne-Marie Bouvier, Veronique Bouvier, Valerie Jooste, Lucille Queneherve, Jean-Baptiste Nousbaum, Arnaud Alves, Olivier Dejardin
Summary: The surgical volume of hospitals has a significant impact on the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC). High-volume hospitals have better survival rates, while low-volume hospitals have higher post-operative mortality. The centralization of pancreatic surgery is a complex issue.
Article
Biochemistry & Molecular Biology
Marc Riffet, Benoit Dupont, Maxime Faisant, Damiano Cerasuolo, Benjamin Menahem, Arnaud Alves, Fatemeh Dubois, Guenaelle Levallet, Celine Bazille
Summary: The study aimed to analyze the impact of new histoprognostic factors on the survival of colon cancer patients and optimize their therapeutic management. The presence of isolated tumor deposits and an infiltrative type of tumor invasion significantly worsened overall survival and recurrence-free survival. High-grade budding was associated with a poor prognosis, but with no significant difference. In conclusion, these histoprognostic factors should be integrated into pathological reports of colon cancers to guide more aggressive treatments for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Coralie Lacroix, Marion Zamparini, Hugo Meunier, Anne-Lise Fiant, Yannick Le Roux, Adrien Lee Bion, Veronique Savey, Arnaud Alves, Benjamin Menahem
Summary: In a tertiary referral center, a study was conducted to identify preoperative risk factors for failure to discharge after bariatric surgery on or before postoperative day two. The study found that a history of psychiatric disorder, insulin-dependent diabetes, use of anticoagulant medication, distance to the referral center greater than 100 km, gallbladder lithiasis, and planned additional procedures were independent risk factors for delayed discharge.
WORLD JOURNAL OF SURGERY
(2023)
Review
Surgery
Mathilde Boullier, Audrey Fohlen, Stephanie Viennot, Arnaud Alves
Summary: Gastrointestinal bleeding of undetermined origin (GBUO) refers to gastrointestinal bleeding without an identified cause or location despite endoscopic assessment. The majority of cases of GBUO occur in the small intestine due to vascular, inflammatory, or tumoral causes. Video-capsule endoscopy (VCE) is recommended as the first-intention study in Europe, with CT-enteroscopy performed if intestinal obstruction is suspected. Enteroscopy is used for therapeutic or diagnostic purposes depending on the results of VCE or CT-enteroclysis, and intraoperative enteroscopy (IOE) is reserved for cases where preoperative enteroscopy fails or for recurrent GBUO after other studies and explorations.
JOURNAL OF VISCERAL SURGERY
(2023)
Article
Medicine, General & Internal
Thibaut Waeckel, Khelifa Ait Said, Benjamin Menahem, Anais Briant, Arnaud Doerfler, Arnaud Alves, Xavier Tillou
Summary: A 6-year follow-up study of 83 women who underwent bariatric surgery showed that the procedure had long-term effects in improving stress urinary incontinence (SUI) and overactive bladder disorders (OAB), leading to a positive impact on quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Alexandre Thobie, Fabien Robin, Benjamin Menahem, Jean Lubrano, Karim Boudjema, Arnaud Alves, Olivier Dejardin, Laurent Sulpice
Summary: This retrospective study focused on the impact of post-pancreatectomy hemorrhage (PPH) on long-term survival after pancreatoduodenectomy (PD) for cancer. The results showed that PPH significantly increased mortality rate and severe postoperative complication rate, but after 6 months, PPH had no impact on mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Josephine Gardy, Sarah Wilson, Anne-Valerie Guizard, Veronique Bouvier, Laure Tron, Ludivine Launay, Arnaud Alves, Guy Launoy, Florence Molinie, Josephine Bryere, Olivier Dejardin
Summary: In this French population-based study, travel time was found to have an impact on cancer survival for different cancer types. Patients residing farther from the referral center had lower survival rates for some cancer sites. The effect of travel time varied depending on the tumor type, with different patterns observed.
Article
Surgery
Gautier Gelly, Hugo Meunier, Adrien Lee Bion, Marion Zamparini, Anne-Lise Fiant, Veronique Savey, Arnaud Alves, Benjamin Menahem
Summary: Revisional bariatric surgery (RBS) is a challenging procedure and this study analyzed data from 252 patients who underwent RBS after laparoscopic adjustable gastric banding (LAGB) or laparoscopic sleeve gastrectomy (LSG). The study found that RBS after LSG had a higher overall morbidity rate, while RBS after LAGB had more perioperative issues.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Surgery
Alexandra Pellegrin, Charles Sabbagh, Stephane Berdah, Benjamin Menahem, Jean-Marc Regimbeau, Laura Beyer-Berjot, Arnaud Alves
Summary: This study reports on the quality of life of patients with sigmoid diverticulitis. The results show that long-term quality of life does not differ significantly between patients who received antibiotic therapy and those who received symptomatic treatment alone. However, for patients who experienced recurrent events, elective surgery appears to improve their quality of life. In conclusion, assessment of quality of life is important in diverticular disease and should guide operative indications.
JOURNAL OF VISCERAL SURGERY
(2023)
Article
Oncology
Audrey Fohlen, Remi Beaudouin, Arnaud Alves, Karine Bouhier-Leporrier, Christophe Pasik, Jean-Pierre Pelage
Summary: This study evaluated the tolerability and clinical, biological and radiological tumor response and survival rates in patients with unresectable neuroendocrine liver metastases treated by trans-catheter arterial embolization with conventional chemoembolization, using streptozocin, Lipiodol, and embolization microspheres. The results showed that this procedure using streptozocin is an effective and well-tolerated palliative option for patients with unresectable neuroendocrine liver metastases, with a high objective response rate and non-progressive disease rate. The overall survival rate at different time points was also encouraging.
Review
Health Care Sciences & Services
Roukaya Belhadjamor, Gilles Manceau, Benjamin Menahem, Charles Sabbagh, Arnaud Alves
Summary: The optimal resection of the left colonic angle in cancer treatment remains controversial. Recent advances in imaging techniques have allowed for better identification of the anatomical variations in this area.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Veterinary Sciences
Augusto Cesar de Oliveira Rodrigues, Ronaldo de Oliveira Sales, Abelardo Ribeiro de Azevedo, Arnaud Azevedo Alves
Summary: The objective of this research was to evaluate the effect of the inclusion of biological silage of fish residues in the digestibility of various nutrients in sheep. The results showed that the inclusion of different levels of biological silage of fish residues did not significantly affect the digestibility of dry matter, organic matter, neutral detergent fiber, and energy, but it did have a significant effect on the digestibility of crude protein.
BRAZILIAN JOURNAL OF HYGIENE AND ANIMAL SANITY
(2023)
