Microtubule nucleation by γ-tubulin complexes and beyond

The XMAP215 Ortholog Alp14 Promotes Microtubule Nucleation in Fission Yeast

(2018) Ignacio Flor-Parra et al.   CURRENT BIOLOGY

γ-TuRC Heterogeneity Revealed by Analysis of Mozart1

(2018) Corinne A. Tovey et al.   CURRENT BIOLOGY

XMAP215 joins microtubule nucleation team

(2018) Jens Lüders   NATURE CELL BIOLOGY

XMAP215 is a microtubule nucleation factor that functions synergistically with the γ-tubulin ring complex

(2018) Akanksha Thawani et al.   NATURE CELL BIOLOGY

Microtubules and Microtubule-Associated Proteins

(2018) Holly V. Goodson et al.   Cold Spring Harbor Perspectives in Biology

Assembly and regulation of γ-tubulin complexes

(2018) Dorian Farache et al.   Open Biology

Novel phosphorylation states of the yeast spindle pole body

(2018) Kimberly K. Fong et al.   Biology Open

Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects

(2017) Erica L. Gornstein et al.   EXPERIMENTAL NEUROLOGY

A microtubule bestiary: structural diversity in tubulin polymers

(2017) Sami Chaaban et al.   MOLECULAR BIOLOGY OF THE CELL

NMR secondary structure and interactions of recombinant human MOZART1 protein, a component of the gamma-tubulin complex

(2017) Cyprian D. Cukier et al.   PROTEIN SCIENCE

Regulation of microtubule nucleation mediated by γ-tubulin complexes

(2017) Vadym Sulimenko et al.   PROTOPLASMA

Structural insight into TPX2-stimulated microtubule assembly

(2017) Rui Zhang et al.   eLife

A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy

(2017) Yusuke Fukuda et al.   Frontiers in Neuroscience

Functional Analysis of γ-Tubulin Complex Proteins Indicates Specific Lateral Association via Their N-terminal Domains

(2016) Dorian Farache et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MOZART1 and γ-tubulin complex receptors are both required to turn γ-TuSC into an active microtubule nucleation template

(2016) Tien-chen Lin et al.   JOURNAL OF CELL BIOLOGY

Divergent regulation of functionally distinct γ-tubulin complexes during differentiation

(2016) Andrew Muroyama et al.   JOURNAL OF CELL BIOLOGY

Suppression of microtubule assembly kinetics by the mitotic protein TPX2

(2016) Taylor A. Reid et al.   JOURNAL OF CELL SCIENCE

MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation

(2016) Rosa Ramírez Cota et al.   JOURNAL OF CELL SCIENCE

Higher-order oligomerization of Spc110p drives γ-tubulin ring complex assembly

(2016) Andrew S. Lyon et al.   MOLECULAR BIOLOGY OF THE CELL

Synergistic role of fission yeast Alp16GCP6 and Mzt1MOZART1 in γ-tubulin complex recruitment to mitotic spindle pole bodies and spindle assembly

(2016) Hirohisa Masuda et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule Nucleation in Mitosis by a RanGTP-Dependent Protein Complex

(2015) Jacopo Scrofani et al.   CURRENT BIOLOGY

An Amino-Terminal Polo Kinase Interaction Motif Acts in the Regulation of Centrosome Formation and Reveals a Novel Function forcentrosomin(cnn) inDrosophila

(2015) Robert C. Eisman et al.   GENETICS

Microtubule-associated proteins control the kinetics of microtubule nucleation

(2015) Michal Wieczorek et al.   NATURE CELL BIOLOGY

Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module

(2015) Johanna Roostalu et al.   NATURE CELL BIOLOGY

Microtubule nucleation at the centrosome and beyond

(2015) Sabine Petry et al.   NATURE CELL BIOLOGY

Ring closure activates yeast γTuRC for species-specific microtubule nucleation

(2015) Justin M Kollman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Novel Alternative Splice Variants of Mouse Cdk5rap2

(2015) Nadine Kraemer et al.   PLoS One

The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle

(2015) Takumi Chinen et al.   Nature Communications

Mto2 multisite phosphorylation inactivates non-spindle microtubule nucleation complexes during mitosis

(2015) Weronika E. Borek et al.   Nature Communications

Ring closure activates yeast γTuRC for species-specific microtubule nucleation

(2015) Justin M Kollman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Amino-Terminal Polo Kinase Interaction Motif Acts in the Regulation of Centrosome Formation and Reveals a Novel Function forcentrosomin(cnn) inDrosophila

(2015) Robert C. Eisman et al.   GENETICS

Species-Specific Expression of Full-Length and Alternatively Spliced Variant Forms of CDK5RAP2

(2015) John S. Y. Park et al.   PLoS One

GCP-WD Mediates γ-TuRC Recruitment and the Geometry of Microtubule Nucleation in Interphase Arrays of Arabidopsis

(2014) Ankit Walia et al.   CURRENT BIOLOGY

Activation of the γ-Tubulin Complex by the Mto1/2 Complex

(2014) Eric M. Lynch et al.   CURRENT BIOLOGY

The Centrosome-Specific Phosphorylation of Cnn by Polo/Plk1 Drives Cnn Scaffold Assembly and Centrosome Maturation

(2014) Paul T. Conduit et al.   DEVELOPMENTAL CELL

γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning

(2014) Anaїs Bouissou et al.   EMBO JOURNAL

A newly identified myomegalin isoform functions in Golgi microtubule organization and ER-Golgi transport

(2014) Z. Wang et al.   JOURNAL OF CELL SCIENCE

NME7 is a functional component of the γ-tubulin ring complex

(2014) Pengfei Liu et al.   MOLECULAR BIOLOGY OF THE CELL

A molecular mechanism of mitotic centrosome assembly in Drosophila

(2014) Paul T Conduit et al.   eLife

Cell-cycle dependent phosphorylation of yeast pericentrin regulates γ-TuSC-mediated microtubule nucleation

(2014) Tien-chen Lin et al.   eLife

Chemotherapy-induced peripheral neuropathy in adults: a comprehensive update of the literature

(2014) Andreas Argyriou et al.   Cancer Management and Research

Functional replacement of fission yeast  -tubulin small complex proteins Alp4 and Alp6 by human GCP2 and GCP3

(2013) T. D. Riehlman et al.   JOURNAL OF CELL SCIENCE

Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly

(2013) Hirohisa Masuda et al.   MOLECULAR BIOLOGY OF THE CELL

Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3Alp6

(2013) Deepsharan K. Dhani et al.   MOLECULAR BIOLOGY OF THE CELL

Effects of eribulin, vincristine, paclitaxel and ixabepilone on fast axonal transport and kinesin-1 driven microtubule gliding: Implications for chemotherapy-induced peripheral neuropathy

(2013) Nichole E. LaPointe et al.   NEUROTOXICOLOGY

Virtual and Biophysical Screening Targeting the γ-Tubulin Complex – A New Target for the Inhibition of Microtubule Nucleation

(2013) Olivier Cala et al.   PLoS One

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells

(2013) Marie-Laure Fogeron et al.   Nature Communications

Coordination of Chromatid Separation and Spindle Elongation by Antagonistic Activities of Mitotic and S-Phase CDKs

(2013) Fengshan Liang et al.   PLoS Genetics

The GIP gamma-tubulin complex-associated proteins are involved in nuclear architecture in Arabidopsis thaliana

(2013) Morgane Batzenschlager et al.   Frontiers in Plant Science

Nek9 Phosphorylation of NEDD1/GCP-WD Contributes to Plk1 Control of γ-Tubulin Recruitment to the Mitotic Centrosome

(2012) Sara Sdelci et al.   CURRENT BIOLOGY

The Role of NEDD1 Phosphorylation by Aurora A in Chromosomal Microtubule Nucleation and Spindle Function

(2012) Roser Pinyol et al.   CURRENT BIOLOGY

Novel NEDD1 phosphorylation sites regulate  -tubulin binding and mitotic spindle assembly

(2012) M. A. Gomez-Ferreria et al.   JOURNAL OF CELL SCIENCE

GCP6 is a substrate of Plk4 and required for centriole duplication

(2012) R. Bahtz et al.   JOURNAL OF CELL SCIENCE

The where, when and how of microtubule nucleation - one ring to rule them all

(2012) N. Teixido-Travesa et al.   JOURNAL OF CELL SCIENCE

The GCP3-Interacting Proteins GIP1 and GIP2 Are Required for  -Tubulin Complex Protein Localization, Spindle Integrity, and Chromosomal Stability

(2012) N. Janski et al.   PLANT CELL

Arabidopsis GCP3-interacting protein 1/MOZART 1 is an integral component of the γ-tubulin-containing microtubule nucleating complex

(2012) Masayoshi Nakamura et al.   PLANT JOURNAL

Dgp71WD is required for the assembly of the acentrosomal Meiosis I spindle, and is not a general targeting factor for the  -TuRC

(2012) R. F. Reschen et al.   Biology Open

PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis

(2011) Kwanwoo Lee et al.   JOURNAL OF CELL BIOLOGY

Microtubule nucleation by γ-tubulin complexes

(2011) Justin M. Kollman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation

(2011) Valérie Guillet et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Phosphorylation of the Yeast γ-Tubulin Tub4 Regulates Microtubule Function

(2011) Tien-chen Lin et al.   PLoS One

Regulation of microtubule-based microtubule nucleation by mammalian polo-like kinase 1

(2011) Y. Johmura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cell Cycle Phosphoproteome of the Yeast Centrosome

(2011) J. M. Keck et al.   SCIENCE

An essential function for the centrosomal protein NEDD1 in zebrafish development

(2010) J A Manning et al.   CELL DEATH AND DIFFERENTIATION

NEDD1 is crucial for meiotic spindle stability and accurate chromosome segregation in mammalian oocytes

(2010) Wei Ma et al.   DEVELOPMENTAL BIOLOGY

Kinetochores Generate Microtubules with Distal Plus Ends: Their Roles and Limited Lifetime in Mitosis

(2010) Etsushi Kitamura et al.   DEVELOPMENTAL CELL

CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex

(2010) Yuk-Kwan Choi et al.   JOURNAL OF CELL BIOLOGY

The Plk1-dependent Phosphoproteome of the Early Mitotic Spindle

(2010) Anna Santamaria et al.   MOLECULAR & CELLULAR PROTEOMICS

The γTuRC Revisited: A Comparative Analysis of Interphase and Mitotic Human γTuRC Redefines the Set of Core Components and Identifies the Novel Subunit GCP8

(2010) Neus Teixidó-Travesa et al.   MOLECULAR BIOLOGY OF THE CELL

Microtubule nucleating γ-TuSC assembles structures with 13-fold microtubule-like symmetry

(2010) Justin M. Kollman et al.   NATURE

A Direct Interaction with NEDD1 Regulates γ-Tubulin Recruitment to the Centrosome

(2010) Jantina A. Manning et al.   PLoS One

Systematic Analysis of Human Protein Complexes Identifies Chromosome Segregation Proteins

(2010) J. R. A. Hutchins et al.   SCIENCE

Paclitaxel induces axonal microtubules polar reconfiguration and impaired organelle transport: implications for the pathogenesis of paclitaxel-induced polyneuropathy

(2009) Or A. Shemesh et al.   ACTA NEUROPATHOLOGICA

HAUS, the 8-Subunit Human Augmin Complex, Regulates Centrosome and Spindle Integrity

(2009) Steffen Lawo et al.   CURRENT BIOLOGY

Centrosomin: A Complex Mix of Long and Short Isoforms Is Required for Centrosome Function During Early Development in Drosophila melanogaster

(2009) Robert C. Eisman et al.   GENETICS

γ-Tubulin ring complexes regulate microtubule plus end dynamics

(2009) Anaïs Bouissou et al.   JOURNAL OF CELL BIOLOGY

FAM29A, a target of Plk1 regulation, controls the partitioning of NEDD1 between the mitotic spindle and the centrosomes

(2009) H. Zhu et al.   JOURNAL OF CELL SCIENCE

Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the  TuRC to the centrosome

(2009) X. Zhang et al.   JOURNAL OF CELL SCIENCE

In vivo analysis of the functions of  -tubulin-complex proteins

(2009) Y. Xiong et al.   JOURNAL OF CELL SCIENCE

The centrosome protein NEDD1 as a potential pharmacological target to induce cell cycle arrest

(2009) Vanessa Tillement et al.   Molecular Cancer

SADB phosphorylation of γ-tubulin regulates centrosome duplication

(2009) María Alvarado-Kristensson et al.   NATURE CELL BIOLOGY

The WD40 Repeat Protein NEDD1 Functions in Microtubule Organization during Cell Division in Arabidopsis thaliana

(2009) C.J. T. Zeng et al.   PLANT CELL

Plk1-Dependent Recruitment of γ-Tubulin Complexes to Mitotic Centrosomes Involves Multiple PCM Components

(2009) Laurence Haren et al.   PLoS One

The augmin complex plays a critical role in spindle microtubule generation for mitotic progression and cytokinesis in human cells

(2009) R. Uehara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FAM29A promotes microtubule amplification via recruitment of the NEDD1–γ-tubulin complex to the mitotic spindle

(2008) Hui Zhu et al.   JOURNAL OF CELL BIOLOGY

Two distinct regions of Mto1 are required for normal microtubule nucleation and efficient association with the  -tubulin complex in vivo

(2008) I. Samejima et al.   JOURNAL OF CELL SCIENCE

Xenopus NEDD1 is required for microtubule organization in Xenopus egg extracts

(2008) L. Liu et al.   JOURNAL OF CELL SCIENCE

Phosphoproteome Analysis ofDrosophila melanogasterEmbryos

(2008) Bo Zhai et al.   JOURNAL OF PROTEOME RESEARCH

A Multicomponent Assembly Pathway Contributes to the Formation of Acentrosomal Microtubule Arrays in Interphase Drosophila Cells

(2008) Gregory C. Rogers et al.   MOLECULAR BIOLOGY OF THE CELL

PhosphoPep—a database of protein phosphorylation sites in model organisms

(2008) Bernd Bodenmiller et al.   NATURE BIOTECHNOLOGY

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide RNAi Screen to Dissect Centriole Duplication and Centrosome Maturation in Drosophila

(2008) Jeroen Dobbelaere et al.   PLOS BIOLOGY

Identification of a novel small Arabidopsis protein interacting with gamma-tubulin complex protein 3

(2007) N JANSKI et al.   CELL BIOLOGY INTERNATIONAL

The Structure of the γ-Tubulin Small Complex: Implications of Its Architecture and Flexibility for Microtubule Nucleation

(2007) Justin M. Kollman et al.   MOLECULAR BIOLOGY OF THE CELL

CDK5RAP2 Is a Pericentriolar Protein That Functions in Centrosomal Attachment of the γ-Tubulin Ring Complex

(2007) Ka-Wing Fong et al.   MOLECULAR BIOLOGY OF THE CELL