Journal
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
Volume 25, Issue 36, Pages 36136-36146Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s11356-018-3492-y
Keywords
PM2.5; Lung; Injury; Inflammation; Oxidative stress; Extracellular matrix
Categories
Funding
- National Natural Science Foundation of China [30872083]
- Shenyang Nonprofit Science and Technology Project
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Particulate matter smaller than 2.5m (PM2.5) is a continuing challenge to pulmonary health. Here, we investigated the mechanisms involved in PM2.5 exposure-induced acute lung injury in rats. We analyzed biochemical and morphological changes following a 2-week real-world exposure. And then we found that PM2.5 exposure increased the concentrations of total protein, malondialdehyde, hydrogen peroxide, nitric oxide, and soluble elastin in bronchoalveolar lavage fluid, levels of cytokines in blood, and expression of MMP-9 in airways. Further, alveolar macrophage and neutrophil counts increased following PM2.5 exposure, and edema and lung lesions were observed. Our results suggest that PM2.5 exposure can induce oxidative stress and acute inflammatory responses, which can damage the micro-environment and decrease the repair ability of the lung, resulting in tissue damage.
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