Alkaloids from leaves of Annona salzmannii and Annona vepretorum (Annonaceae)

Phytochemical investigation of the leaves of Annona salzmannii and Annona vepretorum (Annonaceae) led to the identification of seven aporphine alkaloids, anonaine, asimilobine, norcorydine, lanuginosine, liriodenine, lysicamine and oxonantenine, as well as, 1,3,6,6-tetramethyl-5,6,7,8-tetrahydro-isoquinolin-8-one and vomifoliol. Liriodenine, anonaine, asimilobine and norcorydine were found in A. salzmannii, while liriodenine, oxonantenine, lanuginosine, lysicamine, vomifoliol and 1,3,6,6-tetramethyl-5,6,7,8-tetrahydro-isoquinolin-8-one were found in A. vepretorum. All these compounds are being described for the first time in the leaves of A. salzmannii and A. vepretorum. This is the first report of 1,3,6,6-tetramethyl-5,6,7,8-tetrahydro-isoquinolin-8-one in the Annonaceae. The NMR data for oxonantenine, lanuginosine and lysicamine were reviewed. (C) 2015 Elsevier Ltd. All rights reserved.