Article
Cell Biology
Min Chen, Soochi Kim, Liang Li, Sourav Chattopadhyay, Thomas A. Rando, Brian J. Feldman
Summary: Through single-cell RNA sequencing, a population of CD31- CD45- cells with a specific expression profile is discovered in the stromal vascular fraction of adipose tissue. This population is placed on an epistatic pathway upstream of preadipocytes and functional properties with broad implications, including physiological mechanisms regulating adipogenesis, are revealed.
Article
Cell Biology
Farah Najdi, Peter Krueger, Karima Djabali
Summary: Hutchinson-Gilford progeria syndrome (HGPS) is a segmental premature aging disease caused by a mutation in the LMNA gene, leading to features of normal aging such as lipodystrophy in affected individuals. The development of lipodystrophy in HGPS patients may be associated with increased rates of cellular senescence and chronic inflammation.
Article
Environmental Sciences
Yong Pu, Elvis Ticiani, Anita A. Waye, Kunzhe Dong, Huanmin Zhang, Almudena Veiga-Lopez
Summary: Gestational exposure to BPA can accelerate adipogenic differentiation in female ovine fetal preadipocytes and alter pathways associated with extracellular matrix components.
Article
Biochemistry & Molecular Biology
Tongsheng Chen, Yanfei Zhang, Yingyue Dong, Dandan Zhang, Lisha Xia, Xiaozhe Sun, Hanxiao Li, Chunmiao Han, Huamin Wang, Guoheng Xu
Summary: Our study revealed that mast cells, adipose progenitor cells, and mature adipocytes were closely associated in certain fascia areas, and heparin-loaded granules released from mast cells were found around fascial preadipocytes. The presence of heparin in mast cell supernatants effectively activated adipogenic gene expressions and increased adipogenic differentiation of fascia- or epididymal adipose-derived stromal cells. Local administration of heparin-loaded microspheres in rats induced adipogenesis in superficial fascia, suggesting heparin as an endogenous physiological factor for adipogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Toxicology
Elvis Ticiani, Yong Pu, Madison White, Victoria Adomshick, Almudena Veiga-Lopez
Summary: Butyltins and phenyltins, widely used organometallic chemicals, have been found to stimulate adipogenic differentiation. Among them, tributyltin (TBT) is the most potent inducer, followed by triphenyltin (TPT) and dibutyltin (DBT). However, TPT and DBT can weaken the adipogenic effect of TBT. These findings indicate the antagonistic effects among organotins and the involvement of PPAR gamma signaling in their adipogenic outcomes.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Dingshuang Chen, Yaqiu Lin, Nan Zhao, Yong Wang, Yanyan Li
Summary: In this study, it was discovered that Hoxa5 promotes adipogenesis and inhibits proliferation in goat subcutaneous preadipocyte cells. This provides a theoretical basis for understanding the regulation of goat adipocyte differentiation and proliferation mediated by Hoxa5.
Article
Endocrinology & Metabolism
Muhammad Bilal, Allah Nawaz, Tomonobu Kado, Muhammad Rahil Aslam, Yoshiko Igarashi, Ayumi Nishimura, Yoshiyuki Watanabe, Takahide Kuwano, Jianhui Liu, Hiroyuki Miwa, Takumi Era, Koichi Ikuta, Johji Imura, Kunimasa Yagi, Takashi Nakagawa, Shiho Fujisaka, Kazuyuki Tobe
Summary: The expansion of adipose tissue during obesity through the recruitment of newly generated adipocytes is metabolically healthy, particularly in the gonadal white adipose tissue of male mice receiving a high-fat diet. Contrary to previous findings, the inguinal white adipose tissue of male mice also shows a high potential for proliferation and differentiation of adipocyte progenitors, leading to hyperplasia in response to high-fat diet feeding.
MOLECULAR METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Zhongchang Hu, Jian Wu, Lihong Qin, Haiguo Jin, Yang Lv, Ran Zhang, Cheng Xiao, Yang Cao, Yumin Zhao
Summary: ALDH1A1 plays a significant regulatory role in the differentiation of preadipocyte cells in Yan Yellow Cattle. Modulation of ALDH1A1 gene expression can affect acetaldehyde oxidation and adipocyte development, with changes in lipid accumulation and triglyceride production observed in mature adipocytes. The protein expression levels of ALDH1A1 and adipogenic factors corresponded to the mRNA levels, indicating an important role of ALDH1A1 in fat cell growth and development.
ANIMAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jasmine A. Burrell, Jacqueline M. Stephens
Summary: KAT8 is essential for adipocyte differentiation, with its loss inhibiting the formation of adipocytes in the early stages. However, its absence does not significantly impact later stages of adipocyte differentiation. Further studies are needed to determine the specific functions and regulation of KAT8 in adipose tissue.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Endocrinology & Metabolism
Tammy Ying, Rebecca A. Simmons
Summary: Understanding the development of adipocyte precursors is crucial for preventing obesity-related diseases. Recent studies using new techniques to analyze adipocyte precursors have revealed insights into their lineages and regulatory mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Weiguo Cui, Qian Zhang, Hanqiong Wang, Xiaohan Zhang, Ming Tian, Di Liu, Xiuqin Yang
Summary: This study reveals the role of HOXC8 in fat accumulation by showing its association with fat contents in muscles and its promotion of preadipocyte proliferation and differentiation. Mechanisms underlying HOXC8's regulation of preadipocyte proliferation and differentiation are identified, highlighting the IL-17 signaling pathway as an important mediator of fat accumulation regulated by HOXC8.
Article
Agriculture, Dairy & Animal Science
Zhongchang Hu, Jian Wu, Lihong Qin, Haiguo Jin, Yang Cao, Yumin Zhao
Summary: The study revealed that the expression levels of the IGFBP7 gene are specifically regulated during the adipocyte differentiation in Yan Yellow Cattle. Overexpression and RNA interference of the IGFBP7 gene had significant effects on lipid accumulation and triglyceride production in mature adipocytes.
ANIMAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Akiko Katano-Toki, Satoshi Yoshino, Yasuyo Nakajima, Takuya Tomaru, Ayaka Nishikido, Emi Ishida, Kazuhiko Horiguchi, Tsugumichi Saito, Atsushi Ozawa, Tetsurou Satoh, Masanobu Yamada
Summary: HELZ2 deficiency leads to resistance to obesity and NAFFL/NASH in mice, and the association of tyrosine-phosphorylated HELZ2 with SFPQ protein affects the expression levels of key factors for adipocyte differentiation, thus impacting the process of cell differentiation and maturation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Ewa Bielczyk-Maczynska, Disha Sharma, Montgomery Blencowe, Peter Saliba Gustafsson, Michael J. Gloudemans, Xia Yang, Ivan Carcamo-Orive, Martin Wabitsch, Katrin J. Svensson, Chong Y. Park, Thomas Quertermous, Joshua W. Knowles, Jiehan Li
Summary: CROP-Seq, which combines CRISPR interference with single-cell RNA sequencing, was used to study adipogenesis and adipocyte biology. The technique successfully identified novel regulators of adipogenesis and provided insights into the function of preadipocytes and adipocytes associated with metabolic diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Lidan Zhao, Dan Jia, Zhendong Tan, Honglin Jiang
Summary: In this study, it was found that growth hormone inhibits adipose tissue growth by inhibiting the formation of adipocytes from stem cells. The GH deficient mice had higher adipogenic potential, indicating that GH inhibits adipose tissue growth by inhibiting the formation of preadipocytes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Alisa O. Girard, Tessa E. Muss, Amanda H. Loftin, Richa Kalsi, Amy K. Bodine, Christopher D. Lopez, Georg J. Furtmueller, Joanna W. Etra, Jessica Izzi, Jessica Plunkard, Mallory G. Brown, Byoung Chol Oh, Gerald Brandacher
Summary: This article describes a protocol for the insertion and maintenance of a tunneled Hickman catheter in swine, which has resulted in complication-free lines and no catheter-related mortality or infection. It provides guidance for optimizing the lifespan of the catheter and addressing issues during use.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Veterinary Sciences
Mallory Gwendolyn Brown, Laine Elizabeth Feller, John Gregory Trupkiewicz, Eric Kenneth Hutchinson, Jessica Marie Izzi
Summary: The study found that caloric restriction and SMT, either alone or in combination, can effectively reduce liver enzyme levels in obese marmosets.
JOURNAL OF MEDICAL PRIMATOLOGY
(2023)
