Review
Critical Care Medicine
Christina Kalvelage, Susanne Rademacher, Sandra Dohmen, Gernot Marx, Carina Benstoem
Summary: Decision-making authority in tele-ICU care significantly reduces ICU mortality and length of stay, while expert tele-consultation does not show advantages. Uniform regulations regarding the level of authority can bring potential benefits in providing tele-ICU care.
CRITICAL CARE MEDICINE
(2021)
Review
Medicine, General & Internal
Dominique Lauque, Anna Khalemsky, Zoubir Boudi, Linda Ostlundh, Chang Xu, Mohammed Alsabri, Churchill Onyeji, Jacqueline Cellini, Geroge Intas, Kapil Dev Soni, Detajin Junhasavasdikul, Jose Javier Trujillano Cabello, Niels K. Rathlev, Shan W. Liu, Carlos A. Camargo, Anna Slagman, Michael Christ, Adam J. Singer, Charles-Henri Houze-Cerfon, Elhadi H. Aburawi, Karim Tazarourte, Lisa Kurland, Phillip D. Levy, James H. Paxton, Dionyssios Tsilimingras, Vijaya Arun Kumar, David G. Schwartz, Eddy Lang, David W. Bates, Gabriele Savioli, Shamai A. Grossman, Abdelouahab Bellou
Summary: This systematic review and meta-analysis aimed to determine the association between emergency department length of stay (EDLOS) and in-hospital mortality (IHM). The analysis of multiple studies showed a significant association between EDLOS over 24 hours and IHM in ICU-admitted patients, as well as a correlation between low EDLOS and IHM in non-ICU admitted patients. This highlights the importance of minimizing prolonged stays in the emergency department and providing special attention to patients admitted after a short ED stay.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Critical Care Medicine
Jeremy Cheuk Kin Sin, Lillian King, Emma Ballard, Stacey Llewellyn, Kevin B. Laupland, Alexis Tabah
Summary: This study found that hypophosphatemia in ICU patients was associated with increased length of hospital stay but not higher mortality rates. Therefore, hypophosphatemia may serve as an indicator of disease severity in critically ill patients.
JOURNAL OF INTENSIVE CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Jingyi Wu, Yu Lin, Pengfei Li, Yonghua Hu, Luxia Zhang, Guilan Kong
Summary: This study aimed to construct machine learning models for predicting prolonged length of stay in ICU among general ICU patients, using four different ML methods. The GBDT model achieved the best performance in both internal and external validation, outperforming other models and the customized SAPS II model.
Article
Public, Environmental & Occupational Health
S. Stewart, C. Robertson, J. Pan, S. Kennedy, L. Haahr, S. Manoukian, H. Mason, K. Kavanagh, N. Graves, S. J. Dancer, B. Cook, J. Reilly
Summary: Hospital-associated infections (HAIs) lead to an excess length of stay (LOS) of 7.8 days, with pneumonia, bloodstream infections, and surgical site infections having the greatest impact. Approximately 58,000 bed-days are occupied annually due to HAIs, and a 10% reduction in HAI incidence could free up 5800 bed-days for treating elective patients in Scotland. These findings highlight the importance of investing in infection prevention and control interventions to reduce the burden of HAIs locally, nationally, and internationally.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Critical Care Medicine
Thomas L. Higgins, Maureen M. Stark, Kathy N. Henson, Laura Freeseman-Freeman
Summary: A study compared the mortality and length of stay outcomes of ICU patients with coronavirus disease 2019 and other viral pneumonias, finding that patients with coronavirus disease 2019 had higher mortality and longer length of stay.
CRITICAL CARE MEDICINE
(2021)
Article
Biology
Abdulrahman Al-Dailami, Hulin Kuang, Jianxin Wang
Summary: In this study, a deep learning method is proposed for predicting the remaining Length of Stay (LoS) and mortality risk for ICU patients. The method includes multiple Temporal Dilated Separable Convolution with Context-Aware Feature Fusion (TDSC-CAFF) modules and a multi-view and multi-scale feature fusion. Experimental results demonstrate that the proposed method outperforms several state-of-the-art methods on two publicly available datasets.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Infectious Diseases
Kanika Sehgal, Hind J. Fadel, Aaron J. Tande, Darrell S. Pardi, Sahil Khanna
Summary: The study found that coinfection of COVID-19 and CDI is not uncommon, and the clinical characteristics, treatment, and outcomes of these patients need to be further understood. Further investigations are necessary to explore the relationship between these two infections and to guide future clinical practices effectively.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Infectious Diseases
Patrick Zuercher, Andre Moser, Luis Garcia de Guadiana-Romualdo, Martin J. Llewelyn, Rolf Graf, Theresia Reding, Philippe Eggimann, Yok-Ai Que, Josef Prazak
Summary: The study evaluated the performance of pancreatic stone protein (PSP) as a biomarker for predicting ICU mortality and infection severity in critically ill patients. The results showed that PSP had good discriminative ability for both endpoints, outperforming C-Reactive Protein (CRP) and comparable to procalcitonin (PCT).
Review
Medicine, General & Internal
Nazli Bahtigur, Ragavi Jeyamohan, Mohammad Hamiduzzaman, Arron S. Veltre
Summary: This study compared the postoperative complications of patients who underwent colectomy in urban and rural hospitals and found that rural hospitals have equivalent postoperative complication rates to urban hospitals, but longer length of stay.
POSTGRADUATE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Daiki Takekawa, Hideki Endo, Eiji Hashiba, Kazuyoshi Hirota
Summary: Prolonged ICU stays are associated with high costs and increased mortality. This study aimed to develop predictive models for prolonged stays in Japanese ICUs using different scoring methods. The results showed that severity scores, BMI, MET/RRT, readmission, length of stay before ICU admission, and diagnosis at ICU admission were significantly associated with prolonged stays.
Article
Medicine, General & Internal
Hannah Wozniak, Andre Dos Santos Rocha, Tal Sarah Beckmann, Christophe Larpin, Niccolo Buetti, Herve Quintard, Jerome Pugin, Claudia Paula Heidegger
Summary: Hypophosphatemia upon ICU admission is associated with prolonged duration of mechanical ventilation and length of stay in the ICU, both in the general population and in COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Erin Tuttle, Xuan Wang, Ariel Modrykamien
Summary: Emergency department patient boarding is associated with increased hospital mortality and length of stay. This study examines the impact of an Intensive Care team in the ED on sepsis mortality and ICU length of stay. The results showed that the ICU team in the ED did not reduce hospital mortality, but was associated with prolonged ICU length of stay. Compliance with SEP-1 bundle was associated with reducing ICU length of stay in septic patients. Overall, implementing an ICU team in the ED did not result in a reduction of mortality or ICU length of stay.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Critical Care Medicine
Pedro Kurtz, Igor Tona Peres, Marcio Soares, Jorge I. F. Salluh, Fernando A. Bozza
Summary: This study developed prediction models for hospital length of stay and 30-day mortality in ICU patients with acute stroke using a data-driven approach. The models accurately predicted these outcomes using machine learning methods, even without stroke-specific data. The proposed methods can be used for resource allocation planning and performance assessment in ICUs treating stroke.
NEUROCRITICAL CARE
(2022)
Article
Computer Science, Information Systems
Md. Moddassir Alam
Summary: Patient monitoring is crucial in all stages of care, especially in Intensive Care Units (ICUs). The use of Artificial Intelligent and Vulture-based Remote Patient Monitoring (AIV-RPM) framework allows for real-time tracking of patients' health status and provides timely alerts and recommendations in case of potential medical emergencies. The accuracy of ICU mortality and duration of stay prediction can be improved through pre-processing and feature extraction.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Geriatrics & Gerontology
Styliani Karanika, Christos Grigoras, Myrto E. Flokas, Michail Alevizakos, Tori Kinamon, Erna M. Kojic, Eleftherios Mylonakis
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2017)
Article
Biochemistry & Molecular Biology
Likun Li, Styliani Karanika, Guang Yang, Jiangxiang Wang, Sanghee Park, Bradley M. Broom, Ganiraju C. Manyam, Wenhui Wu, Yong Luo, Spyridon Basourakos, Jian H. Song, Gary E. Gallick, Theodoros Karantanos, Dimitrios Korentzelos, Abul Kalam Azad, Jeri Kim, Paul G. Corn, Ana M. Aparicio, Christopher J. Logothetis, Particia Troncoso, Timothy Heffernan, Carlo Toniatti, Hyun-Sung Lee, Ju-Seog Lee, Xuemei Zuo, Wenjun Chang, Jianhua Yin, Timothy C. Thompson
Article
Oncology
T. Karantanos, S. Karanika, B. Seth, G. Gignac
CLINICAL & TRANSLATIONAL ONCOLOGY
(2019)
Article
Oncology
Yong Luo, Abul Kalam Azad, Styliani Karanika, Spyridon P. Basourakos, Xuemei Zuo, Jianxiang Wang, Luan Yang, Guang Yang, Dimitrios Korentzelos, Jianhua Yin, Sanghee Park, Penglie Zhang, James J. Campbell, Thomas J. Schall, Guangwen Cao, Likun Li, Timothy C. Thompson
INTERNATIONAL JOURNAL OF CANCER
(2018)
Meeting Abstract
Oncology
Theodoros Karantanos, Shruti Chaturvedi, Styliani Karanika, Evan Braunstein, Linda Resar, Jerry Spivak, Alison Moliterno
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2018)
Review
Multidisciplinary Sciences
Myrto Eleni Flokas, Styliani Karanika, Michail Alevizakos, Eleftherios Mylonakis
Meeting Abstract
Hematology
Theodoros Karantanos, Evan M. Braunstein, Shruti Chaturvedi, Jerry L. Spivak, Linda Resar, Styliani Karanika, Donna Marie Williams, Christopher D. Gocke, Alison R. Moliterno
Article
Hematology
Theodoros Karantanos, Shruti Chaturvedi, Evan M. Braunstein, Jerry Spivak, Linda Resar, Styliani Karanika, Donna M. Williams, Ophelia Rogers, Christopher D. Gocke, Alison R. Moliterno
Article
Immunology
James T. T. Gordy, Avinaash K. K. Sandhu, Kaitlyn Fessler, Kun Luo, Aakanksha R. R. Kapoor, Samuel K. K. Ayeh, Yinan Hui, Courtney Schill, Fengyixin Chen, Tianyin Wang, Styliani Karanika, Joel C. C. Sunshine, Petros C. C. Karakousis, Richard B. B. Markham
Summary: The fusion of chemokine MIP-3 alpha gene with melanoma-associated antigen genes in DNA vaccines has shown enhanced anti-tumor immunity. Combination therapy with DNA vaccine, type-I interferon, and 5Aza significantly upregulated intratumoral mRNA expression of immune infiltration chemokines and increased infiltration of CD8+ DCs, CCR7+ DCs, NK cells, and memory T-cells while reducing myeloid-derived suppressor cells. This approach holds promise for melanoma treatment and further studies are needed to understand its mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Styliani Karanika, Theodoros Karantanos, Herman Carneiro, Sabrina A. Assoumou
Summary: The study aimed to develop a model to accurately predict the 10-year cardiovascular disease risk of HIV-infected patients. A retrospective cohort study was conducted, dividing patients into model development and validation cohorts. Logistic regression analysis was used to create a prediction risk model with 11 variables, and the model's discrimination was evaluated using the area under the receiver operating characteristics curve. The model showed good accuracy in predicting cardiovascular disease risk when applied to the validation cohort. Rating: 8/10.
Article
Cell Biology
Stamatia C. Vorri, Ilias Christodoulou, Styliani Karanika, Theodoros Karantanos
Summary: The advancement of antiretroviral therapies has improved the lifespan of people with HIV, but they now face various comorbidities such as cardiovascular disease and malignancies. Recent studies have shown that HIV-infected individuals have a higher prevalence of clonal hematopoiesis (CH), which is associated with increased cardiovascular disease risk. CH in HIV-infected individuals is also linked to poorer control of the virus and an increased risk of myeloid neoplasms. Further understanding through molecular-level research and clinical studies is needed.
Meeting Abstract
Hematology
Theodoros Karantanos, Shruti Chaturvedi, Jerry L. Spivak, Linda Resar, Evan M. Braunstein, Styliani Karanika, Donna Marie Williams, Ophelia Rogers, Alison R. Moliterno
Article
Pharmacology & Pharmacy
Christos A. Grigoras, Styliani Karanika, Elpida Velmahos, Michail Alevizakos, Myrto-Eleni Flokas, Christos Kaspiris-Rousellis, Ioannis-Nektarios Evaggelidis, Panagiotis Artelaris, Constantinos I. Siettos, Eleftherios Mylonakis
Letter
Medicine, General & Internal
Theodoros Karantanos, Styliani Karanika, Kenechukwu Obiokoye, Meg Sullivan, Christine Phillips, Sonia Ananthakrishnan
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2017)
Article
Critical Care Medicine
Marios Detsis, Styliani Karanika, Eleftherios Mylonakis
CRITICAL CARE MEDICINE
(2017)