Article
Oncology
Kevin M. Turner, Aaron M. Delman, Allison M. Ammann, Davendra Sohal, Olugbenga Olowokure, Kyuran A. Choe, Milton T. Smith, Jordan R. Kharofa, Syed A. Ahmad, Gregory C. Wilson, Sameer H. Patel
Summary: The study found that adjuvant chemotherapy is associated with improved overall survival in resected Stage IA PDAC patients, especially in those with good prognostic features. However, in certain specific cohorts, such as those with body/tail tumors or all good prognostic features, adjuvant chemotherapy did not lead to improved survival. Further research is needed to personalize treatment for patients with PDAC.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Yingying Cao, Rui Zhao, Kai Guo, Shuai Ren, Yaping Zhang, Zipeng Lu, Lei Tian, Tao Li, Xiao Chen, Zhongqiu Wang
Summary: This study developed a novel metabolic model using both serum and tissue samples for early detection of stage-I pancreatic ductal adenocarcinoma (PDAC). The model showed high diagnostic accuracy and outperformed the traditional CA19-9 marker.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Nausika Betriu, Juan Bertran-Mas, Anna Andreeva, Carlos E. Semino
Summary: Syndecans, a subfamily of proteoglycans, play critical roles in various physiological processes and have implications in disease progression. Their interactions with other macromolecules contribute to normal cellular functions and disease pathogenesis.
Review
Oncology
Sheng-Kai Hsu, Mahendra Jadhao, Wei-Ting Liao, Wen-Tsan Chang, I-Ling Lin, Chien-Chih Chiu
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal malignancy that is often diagnosed at a late stage, leading to poor clinical outcomes despite advances in cancer therapeutics. Exosomes, small extracellular vesicles, have been found to have specific surface markers that can distinguish PDAC patients from healthy individuals. Detectable in various bodily fluids, exosomes hold promise as liquid biopsies for early detection and monitoring of PDAC. This review highlights the role of exosomes in PDAC progression and their potential as diagnostic and prognostic biomarkers.
Article
Oncology
Liva K. K. Stuhr, Kasper Madsen, Astrid Z. Z. Johansen, Inna M. M. Chen, Carsten P. P. Hansen, Lars H. H. Jensen, Torben F. F. Hansen, Kirstine Klove-Mogensen, Kaspar R. R. Nielsen, Julia S. S. Johansen
Summary: The CA 19-9 blood test has been widely used as a biomarker for pancreatic ductal adenocarcinoma (PDAC), but new biomarkers are needed to improve diagnosis. In this study, we found that combining the CA 19-9 test with the sCD163 blood test provided better diagnostic results compared to CA 19-9 alone. These findings suggest that sCD163 could be a valuable diagnostic marker for PDAC.
Article
Oncology
Yasuhiro Adachi, Norihiro Sato, Takuya Oba, Takao Amaike, Yuzan Kudo, Shiro Kohi, Toshiyuki Nakayama, Keiji Hirata
Summary: High expression of HABP1 is associated with shorter overall survival in PDAC patients. Knockdown of HABP1 decreases cell proliferation, colony formation, and cell migration activity in PDAC cells. HABP1 may serve as a prognostic factor and a potential therapeutic target in PDAC.
Article
Biochemistry & Molecular Biology
Rama Krishna Nimmakayala, Frank Leon, Satyanarayana Rachagani, Sanchita Rauth, Palanisamy Nallasamy, Saravanakumar Marimuthu, Gautam K. Shailendra, Yashpal S. Chhonker, Seema Chugh, Ramakanth Chirravuri, Rohitesh Gupta, Kavita Mallya, Dipakkumar R. Prajapati, Subodh M. Lele, Thomas C. Caffrey, Jean L. Grem, Paul M. Grandgenett, Michael A. Hollingsworth, Daryl J. Murry, Surinder K. Batra, Moorthy P. Ponnusamy
Summary: The study identified distinct subtypes of cancer stem cells (CSCs) in pancreatic ductal adenocarcinoma (PDAC) with specific metabolic and stemness signatures, which play a crucial role in organ-specific metastasis. Liver metastasis exhibited drug-resistant CSC- and EMT-like phenotype with glyco-oxidative metabolism, while lung metastasis displayed ALDH+/CD133+ and MET-like phenotype with oxidative metabolism.
Article
Oncology
Rong Liu, Ya-Zhou Liao, Wei Zhang, Hong-Hao Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with high heterogeneity and poor survival rates. The study identified specific immune cell types closely associated with the survival rate and chemotherapy sensitivity of PDAC patients, and different immune cell subgroups have different effects on the survival pattern and chemotherapy response of PDAC patients. High expression of PD1 is associated with better overall survival. The study suggests that exploring the immune cellular composition infiltrate in PDAC may help identify candidates for immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jingpiao Bao, Chaoliang Xu, Bin Li, Zengkai Wu, Jie Shen, Pengli Song, Qi Peng, Guoyong Hu
Summary: This study discovered that KPNA4 is significantly upregulated in PDAC and is associated with tumor progression and unfavorable prognosis. Knocking down KPNA4 suppressed the proliferation and migration of PDAC cells. Additionally, KPNA4 was also correlated with immune-suppressive cell infiltration and T cell exhaustion.
FRONTIERS IN ONCOLOGY
(2022)
Article
Genetics & Heredity
Wenjing Song, Xin He, Pengju Gong, Yan Yang, Sirui Huang, Yifan Zeng, Lei Wei, Jingwei Zhang
Summary: This study identified novel prognostic genes related to glycolysis in PDAC and developed a risk prediction model based on these genes. The high-risk group patients showed worse prognosis and immunosuppressed status, with more macrophage infiltration. Internal and external validations confirmed the predictive ability of the model for PDAC prognosis.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Weiliang Jiang, Congying Chen, Li Huang, Jie Shen, Lijuan Yang
Summary: The study revealed that overexpression of GATA4 exacerbates inflammation-induced pancreatic cancer cell invasion and growth, while silencing of GATA4 attenuates these processes. Inflammation-driven cancer progression is dependent on GATA4 expression and is mediated through the STAT3 and NF-kappa B signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hao Li, Wang Jiang, Shi-Rong Zhang, Peng-Cheng Li, Tian-Jiao Li, Wei Jin, Hua-Xiang Xu, Xian-Jun Yu, Liang Liu
Summary: This study found that CD41+/CD62P+ platelets are closely associated with the prognosis of pancreatic ductal adenocarcinoma (PDAC). High levels of CD41+/CD62P+ platelets were correlated with microvascular invasion, advanced AJCC stage, and high CA19-9 level, and independently predicted a poor prognosis for resectable PDAC. Mechanistically, Panx1 in CD41+/CD62P+ platelets promotes PDAC cell invasion and metastasis by enhancing IL-1 beta secretion through the phosphorylation of p38 MAPK. In addition, a novel compound named PC63435 was synthesized, which blocked the Panx1/IL-1 beta pathway and reduced the proportion of CD41+/CD62P+ platelets, leading to the suppression of PDAC tumor invasion and metastasis.
Article
Gastroenterology & Hepatology
Veronica R. Placencio-Hickok, Marie Lauzon, Natalie Moshayedi, Michelle Guan, Sungjin Kim, Nicholas Nissen, Simon Lo, Stephen Pandol, Brent K. Larson, Jun Gong, Andrew E. Hendifar, Arsen Osipov
Summary: Hyaluronan (HA) plays a critical role in the progression and survival of pancreatic ductal adenocarcinoma (PDAC). This study found that HA expression was significantly higher in primary PDAC than in metastatic sites, and liver metastases had higher HA expression compared to other metastatic sites. Patients with high HA status in liver metastases had decreased progression-free survival and overall survival. HA levels can serve as a potential biomarker for guiding pancreatic cancer treatments and trial design.
Review
Cell Biology
Tianyi Zhang, Yanxian Ren, Pengfei Yang, Jufang Wang, Heng Zhou
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high deposition of extracellular matrix (ECM) and poor prognosis. ECM proteins derived from tumor cells reduce the effectiveness of conventional cancer treatment and contribute to tumor progression and metastasis. Cancer-associated fibroblasts (CAFs) in the ECM are promising targets for novel anti-tumor interventions.
CELL DEATH & DISEASE
(2022)
Review
Pharmacology & Pharmacy
Jinlu Liu, Wenbi Wu, Qing Zhu, Hong Zhu
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly tumor characterized by a tumor microenvironment consisting of fibroblasts and immunosuppressive cells. Traditional therapies are limited by poor drug delivery efficiency, immunosuppressive tumor microenvironment, and adverse effects. Therefore, there is an urgent need for effective and safe treatments. In recent years, hydrogel-based therapies have been developed as potential therapeutic options for PDAC, offering controlled drug delivery with excellent biocompatibility and high drug load capacity.
Article
Cell Biology
Chiakang Ho, Ya Gao, Danning Zheng, Yanjun Liu, Shengzhou Shan, Bin Fang, Yixuan Zhao, Dingzhong Song, Yifan Zhang, Qingfeng Li
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Dermatology
Ya Gao, Zhibo Xie, Chiakang Ho, Jing Wang, Qingfeng Li, Yifan Zhang, Jia Zhou
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Cell Biology
Quan-Jun Lin, Zhi-Bo Xie, Ya Gao, Yi-Fan Zhang, Lie Yao, De-Liang Fu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Surgery
Danning Zheng, Jia Zhou, Li Yu, Yifan Zhang, Jian Wang
JOURNAL OF CRANIOFACIAL SURGERY
(2020)
Article
Cell Biology
Yixuan Zhao, Xin Huang, Zewei Zhang, Yifan Zhang, Guoyou Zhang, Tao Zan, Qingfeng Li
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Dermatology
Jing Wang, Yifan Zhang, Ya Gao, Shengzhou Shan, Qingfeng Li
Summary: Short-term mechanical stretch can promote stem cell proliferation by activating YAP, while long-term mechanical stretch can induce cell growth arrest through EZH2 regulation. The unexpected correlation between SC proliferation and mechanical stretch duration reveals a potential strategy for promoting skin regeneration in clinical translation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Letter
Medicine, General & Internal
Zhibo Xie, Ya Gao, Chiakang Ho, Xinyu Cheng, Yifan Zhang
Article
Surgery
Huaian Lin, Yifan Zhang, Li Yu, Danning Zheng, Juan An
Summary: In this study, Salvia miltiorrhiza injection was found to enhance adipogenic differentiation of adipose-derived stem cells, potentially improving fat graft survival. However, further in vivo research is needed to fully understand the effects of this treatment on fat graft outcomes.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Cell Biology
Jiahao He, Bin Fang, Shengzhou Shan, Yun Xie, Chuandong Wang, Yifan Zhang, Xiaoling Zhang, Qingfeng Li
Summary: The study identified that Piezo1 channel is overexpressed in myofibroblasts of hypertrophic scar (HS) tissues and plays a regulatory role in fibroblasts, thus participating in HS formation. Piezo1 activity enhances various cellular biological behaviors in response to mechanical stretch in dermal fibroblasts, including proliferation, motility, and differentiation. Additionally, blocking Piezo1 with GsMTx4 peptide injection protected rats from stretch-induced HS formation, suggesting Piezo1 as a potential therapeutic target for HS.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Zhibo Xie, Ya Gao, Chiakang Ho, Lequn Li, Chen Jin, Xiaoyi Wang, Caifeng Zou, Yishen Mao, Xiaobo Wang, Qingfeng Li, Deliang Fu, Yi-Fan Zhang
Summary: This study revealed that PDAC-derived exosomes play a crucial role in modulating the liver microenvironment and promoting liver metastasis. The CD44v6/C1QBP complex delivered by exosomes to hepatic satellite cells leads to activation of insulin-like growth factor 1 signaling molecules and liver fibrosis. High expression of exosomal CD44v6 and C1QBP in PDAC patients is associated with liver metastasis.
Article
Cell & Tissue Engineering
Jia-Ming Sun, Chia-Kang Ho, Ya Gao, Chio-Hou Chong, Dan-Ning Zheng, Yi-Fan Zhang, Li Yu
Summary: The study demonstrated that salvianolic acid B could significantly increase the weight and volume of fat grafts, improving fat integrity and viability of adipocytes. In vitro experiments also showed that salvianolic acid B could promote the proliferation and adipogenesis of adipose stem cells, indicating its potential therapeutic usage in improving fat transplantation survival.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Chia-kang Ho, Danning Zheng, Jiaming Sun, Dongsheng Wen, Shan Wu, Li Yu, Ya Gao, Yifan Zhang, Qingfeng Li
Summary: In this study, researchers identified a secretory glycoprotein called LRG-1 that can increase the retention rate of fat grafts by promoting RAB31-mediated inhibition of hypoxia-induced apoptosis. This finding suggests that using LRG-1 for fat grafts may have clinical applications.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Dongsheng Wen, Ya Gao, Chiakang Ho, Li Yu, Yuguang Zhang, Guozhong Lyu, Dahai Hu, Qingfeng Li, Yifan Zhang
Summary: This review provides a comprehensive overview of mechanoregulation in fibrosis, covering cellular mechanosensing, intracellular mechanotransduction and processing, and mechanoeffecting. The contents expand beyond cellular mechanisms to include related disorders and current clinical trials, offering insights into the disease and potentially inspiring new approaches for the treatment of tissue fibrosis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Correction
Biochemistry & Molecular Biology
Dongsheng Wen, Ya Gao, Chiakang Ho, Li Yu, Yuguang Zhang, Guozhong Lyu, Dahai Hu, Qingfeng Li, Yifan Zhang
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ya Gao, Yangdan Liu, Danning Zheng, Chiakang Ho, Dongsheng Wen, Jiaming Sun, Lu Huang, Yuxin Liu, Qingfeng Li, Yifan Zhang
Summary: This study reveals the overexpression of HDAC5 in hypertrophic scars and its depletion can inhibit scar formation. Knockdown of HDAC5 downregulates Smad2/3 phosphorylation in the TGF-8 signaling pathway and increases Smad7 expression. Moreover, HDAC5 interacts with MEF2A to suppress its binding to the Smad7 promoter region, resulting in repression of Smad7 promoter activity. Luciferase reporter assays and ChIP-qPCR assays confirmed this mechanism.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
