Article
Biochemistry & Molecular Biology
Xueli Jin, Yongjia Hu, Ting Lin, Fei Gao, Ziqi Xu, Xiao Hou, Yu Yin, Shidong Kan, Hui Zhu, Daijie Chen
Summary: This study aims to investigate the relieving effects of selenium-enriched Bifidobacterium longum DD98 on chronic unpredictable mild stress (CUMS)-induced irritable bowel syndrome (IBS) in mice. The results suggest that Se-B. longum DD98 significantly relieved the intestinal symptoms of IBS mice and reduced intestinal permeability and inflammation. Furthermore, Se-B. longum DD98 effectively restored the relative abundance of intestinal microbes and regulated the impaired diversity of gut microbiota in IBS mice.
Review
Gastroenterology & Hepatology
Iam van Thiel, W. J. de Jonge, R. M. van den Wijngaard
Summary: Although the gut microbiota consists of bacteria, viruses, and fungi, most studies on the microbiota-gut-brain axis in IBS have primarily focused on bacteria due to their higher presence. However, recent research on the intestinal mycobiome in inflammatory bowel disease suggests that the low numbers of fungi and viruses may still have relevance. This review discusses the current IBS mycobiome data and how these findings could relate to previous observations in IBS, as well as identifies questions for future research.
Review
Gastroenterology & Hepatology
William L. Hasler, Gintautas Grabauskas, Prashant Singh, Chung Owyang
Summary: Abnormalities in mast cell structure or function may play a significant role in the development of irritable bowel syndrome (IBS) symptoms. Mast cells, which release bioactive substances in response to various stimuli, are closely associated with sensory nerves. Visceral hypersensitivity, disrupted epithelial barrier function, and mast cell products including histamine, proteases, prostaglandins, and cytokines are all linked to the pathogenesis of IBS. Furthermore, interactions between the enteric microbiome and mast cells may induce inflammatory responses that contribute to these effects. Therapies targeting mast cell activity or function have shown modest benefits in alleviating IBS symptoms.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Multidisciplinary Sciences
Isabelle A. M. van Thiel, Aimilia A. Stavrou, Auke de Jong, Bart Theelen, Mark Davids, Theodorus B. M. Hakvoort, Iris Admiraal-van den Berg, Isabelle C. M. Weert, Martine A. M. Hesselink-van de Kruijs, Duong Vu, Christine Moissl-Eichinger, Sigrid E. M. Heinsbroek, Daisy M. A. E. Jonkers, Ferry Hagen, Teun Boekhout, Wouter J. de Jonge, Rene M. van den Wijngaard
Summary: Irritable bowel syndrome (IBS) is a common disorder characterized by chronic abdominal pain and changes in bowel movements. Visceral hypersensitivity may be caused by intestinal fungi, but the diversity of fungal communities does not differ between IBS subgroups. The study highlights the importance of conducting strain-specific cause-and-effect studies in IBS research.
SCIENTIFIC REPORTS
(2022)
Review
Gastroenterology & Hepatology
Mariana Brizuela, Joel Castro, Andrea M. Harrington, Stuart M. Brierley
Summary: This review discusses the underlying causes of chronic visceral pain in patients with IBS, highlighting the role of mediators and receptors that induce itch in the skin acting as gut irritants. Activation of these receptors triggers changes in neuronal excitability, leading to visceral hypersensitivity and pain, suggesting potential therapeutic targets for more effective treatment options.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Siyu Tian, Hang Zhang, Siqi Chen, Pengning Wu, Min Chen
Summary: This bibliometric study provides a comprehensive summary of the research trend and developments in visceral hypersensitivity in Irritable Bowel Syndrome (IBS). The study reveals that China, the United States, and Belgium are the main contributors in this field, focusing on exploring the disease mechanisms and sensitizing factors. Additionally, the study highlights the potential relationship between gut microbiota and visceral hypersensitivity, suggesting probiotics as a promising direction for future research in this area.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Sahar M. El-Haggar, Sahar K. Hegazy, Sherief M. Abd-Elsalam, Mostafa M. Bahaa
Summary: The study suggests that pentoxifylline could be a promising adjuvant anti-inflammatory drug in the treatment of abdominal pain in IBS patients, reducing inflammation and alleviating pain.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Article
Immunology
Yan Chen, Jiafei Cheng, Yiling Zhang, Jiande D. Z. Chen, Florin M. Seralu
Summary: The study investigated the effects of electroacupuncture at ST36 on rectal hypersensitivity and compliance in DSS-treated rats, with a focus on the involvement of the mast cells-triggered NGF/TrkA/TRPV1 peripheral afferent pathway. 100 Hz EA was more effective in improving rectal compliance and visceral hypersensitivity, while daily EA only improved visceral hypersensitivity. The expression and activation of mast cells were significantly reduced after the 2-week EA treatment, leading to a decrease in the expression of colonic NGF/TrkA and TRPV1.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Chemistry, Medicinal
Ewa Dudzinska, Andreas M. Grabrucker, Pawel Kwiatkowski, Robert Sitarz, Monika Sienkiewicz
Summary: Visceral stimuli from the digestive tract are transmitted to the brain via nerves, causing overreaction in the brain of irritable bowel syndrome (IBS) patients. Stress and dysbiosis can lead to inflammation and gastrointestinal hypersensitivity. Treating IBS involves reducing visceral hypersensitivity and regulating the intestinal microbiota.
Article
Clinical Neurology
Zhong Chen, Yuan Liu, Xianhe Wu, Wei Lin, Zihan Liu, Yang Huang, Yu Chen, Ying Tang, Aiqin Chen, Chun Lin
Summary: The dysregulation of circRNAs is functionally associated with chronic pain, and this study found that circKcnk9 expression is increased in IBS-like rats. The study also revealed that circKcnk9 regulates c-Fos expression and visceral hypersensitivity through binding with miR-124-3p. This study provides a potential therapeutic target for IBS through targeting circKcnk9.
Review
Gastroenterology & Hepatology
Brennan Spiegel
Summary: This article proposes a hypothesis, known as the gravity hypothesis, that seeks to explain the pathogenesis of irritable bowel syndrome (IBS) by relating it to the influence of gravity on human evolution. It suggests that ineffective gravity management systems may lead to the development of IBS. The article reviews the impact of gravity on human evolution, discusses the imperfect adaptation of Homo sapiens to gravity, and explores the consequences of gravity intolerance in relation to IBS. It also considers the diagnostic and therapeutic implications of this hypothesis and suggests further experiments to support or reject it.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Microbiology
Enfu Tao, Yuhao Wu, Chenmin Hu, Zhenya Zhu, Diya Ye, Gao Long, Bo Chen, Rui Guo, Xiaoli Shu, Wei Zheng, Ting Zhang, Xinyi Jia, Xiao Du, Marong Fang, Mizu Jiang
Summary: The study demonstrates that maternal separation induces irritable bowel syndrome (IBS) from early life to adulthood in mice. The disrupted intestinal mitochondrial structure and significant dysbiosis of intestinal microbiota in early life may contribute to the initiation and progression of IBS.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yuanxia Lv, Jing Wen, Yingying Fang, Haoyuan Zhang, Jianwu Zhang
Summary: CRF is a 41-amino acid polypeptide that coordinates various systems in the body, mediating visceral hypersensitivity like in irritable bowel syndrome. However, the lack of sufficient understanding of the multiple variants of CRF-R1 and CRF-R1 antagonists hinders the successful translation of preclinical studies into clinical trials. Investigating the sites of action of central and peripheral CRF is crucial for accelerating this translation process.
Review
Neurosciences
Yuanzhen Yang, Jiaqi Wang, Chaoyang Zhang, Yi Guo, Meidan Zhao, Man Zhang, Zhongzheng Li, Feifei Gao, Yu Luo, Yiru Wang, Junyi Cao, Mingfang Du, Yuzhe Wang, Xiaowei Lin, Zhifang Xu
Summary: This review explores the central and peripheral analgesic mechanisms of acupuncture in the treatment of Irritable Bowel Syndrome (IBS). Acupuncture can alleviate inflammation and pain, regulate emotional components, and improve pain caused by IBS.
FRONTIERS IN NEUROSCIENCE
(2023)
