Application of Human-Induced Pluripotent Stem Cells (hiPSCs) to Study Synaptopathy of Neurodevelopmental Disorders

Risk factors in early and late onset schizophrenia

(2018) Laura Chen et al.   COMPREHENSIVE PSYCHIATRY

Astrocyte-enriched feeder layers from cryopreserved cells support differentiation of spontaneously active networks of human iPSC-derived neurons

(2018) Ryan J. Schutte et al.   JOURNAL OF NEUROSCIENCE METHODS

Common proteomic profiles of induced pluripotent stem cell-derived three-dimensional neurons and brain tissue from Alzheimer patients

(2018) Mei Chen et al.   Journal of Proteomics

Of Men and Mice: Modeling the Fragile X Syndrome

(2018) Regina Dahlhaus   Frontiers in Molecular Neuroscience

Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence

(2018) Minori Ohashi et al.   Stem Cell Reports

Selective rescue of heightened anxiety but not gait ataxia in a premutation 90CGG mouse model of Fragile X-associated tremor/ataxia syndrome

(2017) Hoanna Castro et al.   HUMAN MOLECULAR GENETICS

Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness

(2017) Gregg W. Crabtree et al.   JOURNAL OF NEUROSCIENCE

Synaptic Mitochondria Sustain More Damage than Non-Synaptic Mitochondria after Traumatic Brain Injury and Are Protected by Cyclosporine A

(2017) Jacqueline R. Kulbe et al.   JOURNAL OF NEUROTRAUMA

Environmental factors influencing the risk of autism

(2017) Mojgan Karahmadi et al.   Journal of Research in Medical Sciences

Systematic gene tagging using CRISPR/Cas9 in human stem cells to illuminate cell organization

(2017) Brock Roberts et al.   MOLECULAR BIOLOGY OF THE CELL

Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development

(2017) A Kathuria et al.   MOLECULAR PSYCHIATRY

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells

(2017) N Gunhanlar et al.   MOLECULAR PSYCHIATRY

Unexpected exacerbations following initiation of disease-modifying drugs in neuromyelitis optica spectrum disorder: Which factor is responsible, anti-aquaporin 4 antibodies, B cells, Th1 cells, Th2 cells, Th17 cells, or others?

(2017) Jun-ichi Kira   Multiple Sclerosis Journal

SHANK proteins: roles at the synapse and in autism spectrum disorder

(2017) Patricia Monteiro et al.   NATURE REVIEWS NEUROSCIENCE

Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells

(2017) Abinaya Chandrasekaran et al.   Stem Cell Research

Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro

(2017) Maxi Hofrichter et al.   Stem Cell Research

3D Bioprinting Human Induced Pluripotent Stem Cell Constructs for In Situ Cell Proliferation and Successive Multilineage Differentiation

(2017) Qi Gu et al.   Advanced Healthcare Materials

Unexpected exacerbations following initiation of disease-modifying drugs in neuromyelitis optica spectrum disorder: Which factor is responsible, anti-aquaporin 4 antibodies, B cells, Th1 cells, Th2 cells, Th17 cells, or others?

(2017) Jun-ichi Kira   Multiple Sclerosis Journal

Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes

(2017) Robert Krencik et al.   Stem Cell Reports

Electrospun polystyrene scaffolds as a synthetic substrate for xeno-free expansion and differentiation of human induced pluripotent stem cells

(2016) Meng Fatt Leong et al.   Acta Biomaterialia

Mutation analysis of the NRXN1 gene in autism spectrum disorders

(2016) H Onay et al.   Balkan Journal of Medical Genetics

Neural Subtype Specification from Human Pluripotent Stem Cells

(2016) Yunlong Tao et al.   Cell Stem Cell

DISC1 is a coordinator of intracellular trafficking to shape neuronal development and connectivity

(2016) M. J. Devine et al.   JOURNAL OF PHYSIOLOGY-LONDON

Aggregate formation and suspension culture of human pluripotent stem cells and differentiated progeny

(2016) Tracy A. Hookway et al.   METHODS

In Vitro Differentiation of Human iPS Cells into Neural like Cells on a Biomimetic Polyurea

(2016) Elham Hoveizi et al.   MOLECULAR NEUROBIOLOGY

Mice with Shank3 Mutations Associated with ASD and Schizophrenia Display Both Shared and Distinct Defects

(2016) Yang Zhou et al.   NEURON

Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction

(2016) Zhen-Ning Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons

(2016) F. Yi et al.   SCIENCE

Mfn2 is Required for Mitochondrial Development and Synapse Formation in Human Induced Pluripotent Stem Cells/hiPSC Derived Cortical Neurons

(2016) Du Fang et al.   Scientific Reports

Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells

(2016) Alfred Xuyang Sun et al.   Cell Reports

CGG-repeat dynamics and FMR1 gene silencing in fragile X syndrome stem cells and stem cell-derived neurons

(2016) Yifan Zhou et al.   Molecular Autism

Transplantation of neurons derived from human iPS cells cultured on collagen matrix into guinea-pig cochleae

(2015) Masaaki Ishikawa et al.   Journal of Tissue Engineering and Regenerative Medicine

Altered neuronal network and rescue in a human MECP2 duplication model

(2015) S Nageshappa et al.   MOLECULAR PSYCHIATRY

The role of SHANK2 rare variants in schizophrenia susceptibility

(2015) J Costas   MOLECULAR PSYCHIATRY

Identification and functional characterization of rare SHANK2 variants in schizophrenia

(2015) S Peykov et al.   MOLECULAR PSYCHIATRY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

Phelan–McDermid Syndrome and SHANK3: Implications for Treatment

(2015) Jesse L. Costales et al.   Neurotherapeutics

Disrupted-in-Schizophrenia-1 SNPs and Susceptibility to Schizophrenia: Evidence from Malaysia

(2015) A. Talib Norlelawati et al.   Psychiatry Investigation

Generation of Isogenic Human iPS Cell Line Precisely Corrected by Genome Editing Using the CRISPR/Cas9 System

(2015) Benjamin Grobarczyk et al.   Stem Cell Reviews and Reports

Production of Gene-Corrected Adult Beta Globin Protein in Human Erythrocytes Differentiated from Patient iPSCs After Genome Editing of the Sickle Point Mutation

(2015) Xiaosong Huang et al.   STEM CELLS

Human Induced Pluripotent Stem Cell Derived Neuronal Cells Cultured on Chemically-Defined Hydrogels for Sensitive In Vitro Detection of Botulinum Neurotoxin

(2015) Sabine Pellett et al.   Scientific Reports

Reversion of FMR1 Methylation and Silencing by Editing the Triplet Repeats in Fragile X iPSC-Derived Neurons

(2015) Chul-Yong Park et al.   Cell Reports

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate

(2015) Priya Srikanth et al.   Cell Reports

Generation of Isogenic Human iPS Cell Line Precisely Corrected by Genome Editing Using the CRISPR/Cas9 System

(2015) Benjamin Grobarczyk et al.   Stem Cell Reviews and Reports

The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation

(2014) Stefanie Grabrucker et al.   EXPERIMENTAL NEUROLOGY

CNS expression of murine fragile X protein (FMRP) as a function of CGG-repeat size

(2014) A. L. Ludwig et al.   HUMAN MOLECULAR GENETICS

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

(2014) K Brennand et al.   MOLECULAR PSYCHIATRY

Synaptic dysregulation in a human iPS cell model of mental disorders

(2014) Zhexing Wen et al.   NATURE

Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders

(2014) Kazue Hashimoto-Torii et al.   NEURON

Synapse Assembly and Neurodevelopmental Disorders

(2014) Philip Washbourne   NEUROPSYCHOPHARMACOLOGY

A Time Course Analysis of the Electrophysiological Properties of Neurons Differentiated from Human Induced Pluripotent Stem Cells (iPSCs)

(2014) Deborah Prè et al.   PLoS One

Comparison and Optimization of hiPSC Forebrain Cortical Differentiation Protocols

(2014) Christina R. Muratore et al.   PLoS One

Disc1 Variation Leads to Specific Alterations in Adult Neurogenesis

(2014) Jayanth S. Chandran et al.   PLoS One

iPSC-Derived Forebrain Neurons from FXS Individuals Show Defects in Initial Neurite Outgrowth

(2014) Matthew E. Doers et al.   STEM CELLS AND DEVELOPMENT

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

(2014) Claire S. Leblond et al.   PLoS Genetics

Functional Maturation of hPSC-Derived Forebrain Interneurons Requires an Extended Timeline and Mimics Human Neural Development

(2013) Cory R. Nicholas et al.   Cell Stem Cell

Transcriptional regulation in pluripotent stem cells by methyl CpG-binding protein 2 (MeCP2)

(2013) Yoshiaki Tanaka et al.   HUMAN MOLECULAR GENETICS

SUMOylation of MeCP2 is essential for transcriptional repression and hippocampal synapse development

(2013) Ju Cheng et al.   JOURNAL OF NEUROCHEMISTRY

SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients

(2013) Aleksandr Shcheglovitov et al.   NATURE

Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells

(2013) Yan Liu et al.   Nature Protocols

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons against α-synuclein-induced synapse damage

(2013) A.H. Alhebshi et al.   NEUROSCIENCE LETTERS

Functional Impacts of NRXN1 Knockdown on Neurodevelopment in Stem Cell Models

(2013) Liyun Zeng et al.   PLoS One

The Inverse F-BAR Domain Protein srGAP2 Acts through srGAP3 to Modulate Neuronal Differentiation and Neurite Outgrowth of Mouse Neuroblastoma Cells

(2013) Yue Ma et al.   PLoS One

A fully defined and scalable 3D culture system for human pluripotent stem cell expansion and differentiation

(2013) Y. Lei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astroglial cells regulate the developmental timeline of human neurons differentiated from induced pluripotent stem cells

(2013) Xin Tang et al.   Stem Cell Research

Toward a 3D model of human brain development for studying gene/environment interactions

(2013) Helena T Hogberg et al.   Stem Cell Research & Therapy

Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay

(2013) Ozlem Bozdagi et al.   Molecular Autism

Efficient neuronal differentiation and maturation of human pluripotent stem cells encapsulated in 3D microfibrous scaffolds

(2012) Hong Fang Lu et al.   BIOMATERIALS

Inhibition of SRGAP2 Function by Its Human-Specific Paralogs Induces Neoteny during Spine Maturation

(2012) Cécile Charrier et al.   CELL

A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models

(2012) Qiurong Ding et al.   Cell Stem Cell

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks

(2012) Yichen Shi et al.   Nature Protocols

Disrupted-in-Schizophrenia (DISC1) Functions Presynaptically at Glutamatergic Synapses

(2012) Brady J. Maher et al.   PLoS One

Comparative Study of Human and Mouse Postsynaptic Proteomes Finds High Compositional Conservation and Abundance Differences for Key Synaptic Proteins

(2012) Àlex Bayés et al.   PLoS One

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

(2011) Pascal S. Kaeser et al.   CELL

A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis

(2011) Leonhard Lennertz et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation

(2011) Aaron Y.L. Cheung et al.   HUMAN MOLECULAR GENETICS

Development of Patient-Specific Neurons in Schizophrenia Using Induced Pluripotent Stem Cells

(2011) Erika Pedrosa et al.   JOURNAL OF NEUROGENETICS

Regulation of the cytoskeleton by Disrupted-in-Schizophrenia 1 (DISC1)

(2011) Qi Wang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation

(2011) C-H Chiang et al.   MOLECULAR PSYCHIATRY

Modelling schizophrenia using human induced pluripotent stem cells

(2011) Kristen J. Brennand et al.   NATURE

Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory

(2011) Hongda Li et al.   NATURE NEUROSCIENCE

Sequencing of DISC1 Pathway Genes Reveals Increased Burden of Rare Missense Variants in Schizophrenia Patients from a Northern Swedish Population

(2011) Lotte N. Moens et al.   PLoS One

Isogenic Pairs of Wild Type and Mutant Induced Pluripotent Stem Cell (iPSC) Lines from Rett Syndrome Patients as In Vitro Disease Model

(2011) Gene Ananiev et al.   PLoS One

Epigenetic Characterization of the FMR1 Gene and Aberrant Neurodevelopment in Human Induced Pluripotent Stem Cell Models of Fragile X Syndrome

(2011) Steven D. Sheridan et al.   PLoS One

Investigating synapse formation and function using human pluripotent stem cell-derived neurons

(2011) J.-E. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal ordering deficits in female CGG KI mice heterozygous for the fragile X premutation

(2010) Michael R. Hunsaker et al.   BEHAVIOURAL BRAIN RESEARCH

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Comparative analysis of DNA methylation in transgenic mice with unstable CGG repeats from FMR1 gene

(2010) Mohammad Parwez Alam et al.   Epigenetics

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

De novo mutations in the gene encoding the synaptic scaffolding proteinSHANK3in patients ascertained for schizophrenia

(2010) Julie Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DISC1 in Schizophrenia: Genetic Mouse Models and Human Genomic Imaging

(2010) M. Johnstone et al.   SCHIZOPHRENIA BULLETIN

Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

Roles of glial cells in synapse development

(2009) Frank W. Pfrieger   CELLULAR AND MOLECULAR LIFE SCIENCES

Autism genome-wide copy number variation reveals ubiquitin and neuronal genes

(2009) Joseph T. Glessner et al.   NATURE

DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms

(2009) K. Nakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Novel de novo SHANK3 mutation in autistic patients

(2008) Julie Gauthier et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Neuroligins and neurexins link synaptic function to cognitive disease

(2008) Thomas C. Südhof   NATURE

Specific mutations in Methyl-CpG-Binding Protein 2 confer different severity in Rett syndrome

(2008) J. L. Neul et al.   NEUROLOGY

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

(2008) M. Kvajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case–control sample

(2008) P SAETRE et al.   SCHIZOPHRENIA RESEARCH