Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity

Title

Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity

Authors

Keywords

DNA methylation, DNMT, Arx, Myt1, azacytidine, combinatorial lineage tracing, β cell, insulin, diabetes, α cell, glucagon, specification, single-cell RNA-seq, trajectory, pseudotime, p-Creode, epigenetics, stochastic gene expression, transcriptional noise, lineage priming, DMR, HMR

Journal

DEVELOPMENTAL CELL

Volume 48, Issue 1, Pages 49-63.e7

Publisher

Elsevier BV

Online

2019-01-09

DOI

10.1016/j.devcel.2018.11.048