Journal
DEVELOPMENT GROWTH & DIFFERENTIATION
Volume 60, Issue 9, Pages 531-541Publisher
WILEY
DOI: 10.1111/dgd.12577
Keywords
epithelial-mesenchymal interaction; functional unit formation; niche; skin; stem cell heterogeneity
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Funding
- JSPS KAKENHI [25122720, 26670533]
- Uehara Memorial Foundation
- Takeda Science Foundation
- Cosmetology Research Foundation
- Grants-in-Aid for Scientific Research [26670533] Funding Source: KAKEN
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Over the past decade, multiple stem cell compartments have been identified within the epidermis. These stem cell pools have different transcriptional properties, proliferative modes and anatomical locations, and they maintain distinct epidermal compartments. The importance of this stem cell heterogeneity and compartmentalization has been understood as a key feature in epidermal homeostasis. However, recent studies have revealed that these heterogeneous stem cells themselves act as a niche for neighboring cells, thereby establishing spatially and temporally patterned epidermal-dermal functional units. These studies provide a new perspective for interpreting the biological significance of stem cell heterogeneity and compartmentalization beyond their role in epidermal maintenance.
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