Journal
CURRENT PROTEIN & PEPTIDE SCIENCE
Volume 19, Issue 12, Pages 1138-1154Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389203718666171117103418
Keywords
Mesenchymal stem cells; transforming growth factor beta; osteogenic; adipogenic; chondrogenic; myogenic; differentiation; microRNA
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Funding
- Ministry of Education, Science and Technological Development of the Republic of Serbia [175062]
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The ability to differentiate into cells of different lineage, such as muscle, bone, cartilage and fat, is the chief value of adult mesenchymal stem cells (MSCs) which can be used with the final aim to regenerate damaged tissue. Due to potential use, as well as importance in tissue development, a number of questions have been raised regarding the molecular mechanisms of MSC differentiation. As one of the crucial mediators in organism development, transforming growth factor beta (TGF-beta) superfamily directs MSCs commitment in the selection of differentiation pathways. In this review we aim to give an overview of the current knowledge on the mechanisms of MSCs differentiation, on the involvement of TGF-beta superfamily in MSCs differentiation with additional insight into the mutual regulation of microRNAs and TGF-beta in MSCs differentiation. Particular focus has been given to the signaling and transcriptional networks governing the differentiation processes.
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