Article
Psychology, Clinical
Chittaranjan Andrade
Summary: This article introduces a method for converting standardized mean differences (SMD) into percentile scores to improve understanding. By converting SMDs into percentile scores, readers can gain a clearer understanding of the practical significance of research findings for the average patient.
JOURNAL OF CLINICAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Ji-Won Kim, Wook-Young Baek, Ju-Yang Jung, Hyoun-Ah Kim, Cheong In Yang, Seung-Ju Kim, Chang-Hee Suh
Summary: This study found that seasonal vitamin D levels are correlated with clinical manifestations and disease activity in lupus patients. Adequate vitamin D levels are important for achieving a low disease activity state in both winter and summer.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Jiajia Ni, Jingyi Li, Yuyao Wang, Liying Guan, Haiyan Lin, Li Zhang, Haiqing Zhang
Summary: This study aimed to determine the prevalence of hypothyroidism in patients with systemic lupus erythematosus (SLE) and investigate the relationship between hypothyroidism and SLE-related organic damage. The results showed that SLE patients had a higher prevalence of hypothyroidism, especially in young patients with lupus nephritis, liver abnormality, and cardiac insufficiency. The study suggested that SLE might contribute to the development of hypothyroidism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Lina Wirestam, Birgitta Gullstrand, Andreas Jern, Andreas Jonsen, Petrus Linge, Helena Tyden, Robin Kahn, Anders A. Bengtsson
Summary: Platelets play important roles in SLE as immune modulators, with smaller MPV values in SLE patients compared to controls. Individual MPV variation was low, and fluctuations in disease activity did not significantly impact MPV over time. Further studies are needed to evaluate MPV as a biomarker in SLE and to determine underlying mechanisms affecting platelet size.
FRONTIERS IN MEDICINE
(2021)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Summary: Serum metabolic fingerprints can be used for disease diagnosis and biomarker discovery. By analyzing the serum metabolic fingerprints of systemic lupus erythematosus (SLE) patients and healthy controls, early diagnosis and precision medicine for SLE can be achieved. This study identified the unique metabolic pattern of SLE patients and screened out a panel of metabolic biomarkers.
Article
Rheumatology
Christine Chew, John A. Reynolds, Apinya Lertratanakul, Peggy Wu, Murray Urowitz, Dafna D. Gladman, Paul R. Fortin, Sang-Cheol Bae, Caroline Gordon, Ann E. Clarke, Sasha Bernatsky, John G. Hanly, David Isenberg, Anisur Rahman, Jorge Sanchez-Guerrero, Juanita Romero-Diaz, Joan Merrill, Daniel Wallace, Ellen Ginzler, Munther Khamashta, Ola Nived, Andreas Jonsen, Kristjan Steinsson, Susan Manzi, Ken Kalunian, Mary Anne Dooley, Michelle Petri, Cynthia Aranow, Ronald van Vollenhoven, Thomas Stoll, Graciela S. Alarcon, S. Sam Lim, Guillermo Ruiz-Irastorza, Christine A. Peschken, Anca D. Askanase, Diane L. Kamen, Murat Inanc, Rosalind Ramsey-Goldman, Ian N. Bruce
Summary: Vitamin D deficiency and MetS may increase cardiovascular risk in SLE patients. Lower 25(OH)D levels were associated with a higher likelihood of MetS and insulin resistance, as well as components of MetS such as hypertension, hypertriglyceridemia, and decreased HDL levels.
Review
Medicine, General & Internal
Johan Frostegard
Summary: The prognosis in systemic lupus erythematosus (SLE) has improved, but cardiovascular disease (CVD) still remains a significant clinical problem. Atherosclerosis and antiphospholipid antibody syndrome are the main underlying causes of CVD in SLE. Inflammation and low levels of anti-phosphorylcholine also contribute to the increased risk of CVD in SLE. Close monitoring and treatment of both traditional and non-traditional risk factors are important.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Immunology
Jiaxuan Chen, Shuzhen Liao, Wanxian Pang, Fengbiao Guo, Lawei Yang, Hua-feng Liu, Qingjun Pan
Summary: Systemic lupus erythematosus (SLE) is a highly heterogeneous autoimmune disease that primarily affects women. This review explores the mechanisms of SLE pathogenesis, focusing on the impact of lifestyle factors. Studies have found associations between diet, cigarette smoking, ultraviolet radiation exposure, alcohol and caffeine-rich beverage consumption, and SLE susceptibility. The review summarizes these relationships and outlines directions for future research.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haitao Yu, Yasuo Nagafuchi, Keishi Fujio
Summary: Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease characterized by immune dysfunction. Clinical and immunological biomarkers are crucial for diagnosing, assessing, and controlling SLE, including novel biomarkers discovered through omics research.
Review
Immunology
Weijie Wang, Yongsheng Fan, Xinchang Wang
Summary: This review discusses the dual role of Lactobacillus in systemic lupus erythematosus (SLE), as it can both affect the development of SLE and have therapeutic and anti-inflammatory effects. The involvement of Lactobacillus in SLE sheds light on the understanding of its development and provides evidence for the development of microbiota-targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Multidisciplinary
Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disorder with unknown pathogenesis and heterogeneous clinical manifestations. By conducting glycomic analyses, we identified two N-glycans on serum immunoglobulin G (IgG) as excellent diagnostic biomarkers for SLE, with specificity and suitability for all stages of the disease. These findings are important for the early and precise diagnosis of SLE and provide insights into the pathogenic factors of the disease.
Review
Immunology
Qian Chen, Jie Wang, Mengmeng Xiang, Yilun Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu
Summary: This review summarizes the potential links between ferroptosis and systemic lupus erythematosus (SLE), elucidates the role of ferroptosis in SLE pathogenesis, and proposes a new therapeutic strategy for SLE.
FRONTIERS IN IMMUNOLOGY
(2022)