Review
Pharmacology & Pharmacy
Jessica A. Spiteri, Gabrielle Camilleri, Carlo Piccinni, Janet Sultana
Summary: This article reviews the safety of drug management in pregnant women with migraine, highlighting the challenges of conducting drug safety research during pregnancy and the reliance on observational studies. Improving statistical tools, study designs, and international collaboration are necessary to advance knowledge on drug safety in pregnancy.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Min Dong, Russell E. Ware, Andre Dallmann, Alexander A. Vinks
Summary: Sickle cell anemia (SCA) is a genetic condition that can contribute to high-risk pregnancies. With improved management, SCA has become a chronic disease of adults and many patients are now considering parenthood. It is important to provide continuous management and avoid SCA-related complications for a healthy pregnancy.
Article
Clinical Neurology
Gianni Allais, Giulia Chiarle, Emma Sinatra, Gisella Airola, Fabiola Bergandi, Sara Rolando, Silvia Sinigaglia, Paola Schiapparelli, Chiara Benedetto
Summary: Preliminary data from this study suggest that acupuncture may be safe for pregnant women with migraines, with no significant side effects observed. Although there is limited data on acupuncture for migraines during pregnancy, there is ample evidence supporting the efficacy and safety of acupuncture for migraines in the general population.
NEUROLOGICAL SCIENCES
(2022)
Article
Plant Sciences
Di Wu, Juanjuan Wu, Xinying Cheng, Jianrui Qian, Ruiliang Du, Shusheng Tang, Yunhe Lian, Yanjiang Qiao
Summary: This study aimed to evaluate the safety of marigold flavonoids extracted from marigold inflorescence residues. The study included acute oral toxicity, in vitro Ames test, sperm aberration study, bone marrow micronucleus test, subchronic oral toxicity test, and teratogenic potential tests.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Marie Jouanne, Sarah Oddoux, Antoine Noel, Anne Sophie Voisin-Chiret
Summary: A woman's nutritional status during pregnancy and breastfeeding is crucial for both her own health and that of future generations. Different countries have varying recommendations for nutritional supplementation during pregnancy, and the nutritional requirements during pregnancy and lactation may differ due to maternal physiological adaptations.
Review
Pharmacology & Pharmacy
Patricio A. Castro, Ingrid Pinto-Borguero, Gonzalo E. Yevenes, Gustavo Moraga-Cid, Jorge Fuentealba
Summary: The main strategy for treating epilepsy is through the use of antiseizure medication (ASM), however, some drugs are contraindicated during pregnancy. This review focuses on the potential effects of ASM on ion channels and proteins involved in embryonic development, aiming to explain the observed fetal malformations. Currently, there is limited understanding of the action of ASM and its targets, and this review aims to provide more insight into these mechanisms.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Clinical Neurology
F. Proenca, C. Guerreiro, G. Sa, S. Reimao
Summary: Imaging studies are crucial for pregnant and lactating women, with the choice of imaging modality needing to prioritize the safety of mother and child. A risk/benefit assessment is essential when selecting the most appropriate neuroimaging modality during pregnancy and lactation.
Article
Clinical Neurology
Roberta Noseda, Francesca Bedussi, Claudio Gobbi, Chiara Zecca, Alessandro Ceschi
Summary: The study assessed the safety profile of erenumab, galcanezumab, and fremanezumab during pregnancy and lactation. Although no specific maternal toxicities or major birth defects were found, continuous surveillance is necessary due to the limited number of reported adverse reactions and lack of long-term safety data.
Article
Medicine, Research & Experimental
Dailson Nogueira de Souza, Caio Jordao Teixeira, Vanessa Barbosa Veronesi, Gilson Masahiro Murata, Junia Carolina Santos-Silva, Fernanda Ballerini Hecht, Julia Modesto Vicente, Silvana Bordin, Gabriel Forato Anhe
Summary: The male offspring born and breastfed by mothers treated with dexamethasone during pregnancy displayed reduced adiposity, lower circulating triacylglycerol levels in the fed-state, and decreased expression of specific genes in the jejunum. These findings suggest that reduced fat absorption by the jejunum may contribute to the lower adiposity observed in the adult offspring.
Review
Gastroenterology & Hepatology
Reezwana Chowdhury, Sunanda Kane
Summary: Approximately 50% of inflammatory bowel disease patients are female and it is important for them to be in remission prior to and during pregnancy. The approved medications for Crohn's disease are generally considered safe during pregnancy and postpartum, and should be continued to control maternal disease.
GASTROENTEROLOGY REPORT
(2022)
Review
Clinical Neurology
Manuel Toledo, Barbara Mostacci, Magdalena Bosak, Joanna Jedrzejzak, Rhys H. Thomas, Javier Salas-Puig, Arnaud Biraben, Bettina Schmitz
Summary: Valproate, a broad-spectrum antiepileptic drug, is particularly effective in certain types of epilepsy syndromes. The European Medicines Agency introduced new restrictions on its use in females of childbearing potential, leading to controversy and debate. Limited information on the teratogenic potential of alternative treatments presents challenges in the clinical management of pregnant women and women of childbearing age.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Iris E. Verhagen, Britt W. H. van der Arend, Daphne S. van Casteren, Niels J. S. Thiermann, Evelien Tange, Antoinette MaassenVanDenBrink, Gisela M. Terwindt
Summary: Previous studies have conflicting results on whether the perimenstrual window is associated with an increased susceptibility to migraine attacks with aura. This study found that there is no difference in the prevalence of menstrual migraine between women with migraine with aura and without aura. However, both groups have a similar increased risk of migraine attacks without aura during the perimenstrual window.
Review
Pharmacology & Pharmacy
Jamil M. Kazma, John Van den Anker, Homa K. Ahmadzia
Summary: There is a lack of evidence to support clinical decision making and counseling regarding medication use in pregnancy. The inclusion of pregnant women in clinical drug trials assessing efficacy and safety remains scarce despite efforts from legislative bodies and advocacy groups. This review presents the status of pregnant women in clinical trials and highlights the ethical stigma and potential future directions.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Clinical Neurology
Erez Berman, Natalia Erenburg, Ron Beloosesky, Sara Eyal, Michal Kovo
Summary: The study found that CBD is sequestered in placental tissue, with lower concentrations in the fetal compartment. CBD did not significantly alter placental gene expression. While the placenta acts as a depot for CBD, there are still potential risks associated with its use during pregnancy.
Article
Endocrinology & Metabolism
Jia-Jia Wang, Ou Wang, Ya-Bing Wang, Jing Yang, An Song, Yan Jiang, Mei Li, Wei-Bo Xia, Xiao-Ping Xing
Summary: Studies on hypoparathyroidism during pregnancy and lactation are limited. In this retrospective study on 19 patients with hypoparathyroidism before pregnancy, different changes in calcium homeostasis and a high prevalence of adverse outcomes during pregnancy were observed. Close monitoring and optimal serum calcium level maintenance are crucial for female patients with hypoparathyroidism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
