Review
Medicine, General & Internal
Martin D. Rosenthal, Erin L. Vanzant, Frederick A. Moore
Summary: Patients with CCI after sepsis often exhibit persistent inflammation, immunosuppression, and catabolism syndrome, leading to global resistance to nutritional supplements. Traditional nutrition protocols may not be effective in improving the condition of these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Lee-Anne S. Chapple, Imre W. K. Kouw, Matthew J. Summers, Luke M. Weinel, Samuel Gluck, Eamon Raith, Peter Slobodian, Stijn Soenen, Adam M. Deane, Luc J. C. van Loon, Marianne J. Chapman
Summary: The ability of critically ill patients to synthesize muscle protein from ingested protein is significantly reduced, despite relatively normal protein digestion and amino acid absorption.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Nutrition & Dietetics
Junichi Hoshino
Summary: Renal rehabilitation, which includes exercise intervention and nutrition programs, is popular for CKD patients with frailty. Exercise has positive effects on exercise tolerance, physical ability, and quality of life in these patients, while the impact on overall mortality remains unclear. Adequate protein intake and exercise are crucial for preventing muscle loss in CKD patients.
Review
Nutrition & Dietetics
Tomoko Tadokoro, Asahiro Morishita, Takashi Himoto, Tsutomu Masaki
Summary: Malnutrition is common in alcohol use disorders and is associated with the prognosis of patients with alcoholic liver disease (ALD). Deficiencies in vitamins and trace elements are frequently seen in these patients, increasing the risk of anemia and cognitive changes. The causes of malnutrition in ALD patients are complex and include inadequate dietary intake, abnormal absorption and digestion, increased protein catabolism, and abnormal interactions between ethanol and lipid metabolism. This review aims to summarize important nutritional therapies for the treatment of ALD.
Article
Nutrition & Dietetics
Anne-Francoise Rousseau, Sara Lucania, Marjorie Fadeur, Anne-Marie Verbrugge, Etienne Cavalier, Camille Colson, Benoit Misset
Summary: This observational study investigated the energy and protein intakes of critically ill survivors attending a follow-up clinic, and found that one year after discharge, the intake levels were still below the targets for ICU survivors in the recovery phase.
Review
Critical Care Medicine
Lee-anne S. Chapple, Rob J. J. van Gassel, Olav Rooyackers
Summary: Critically ill patients often experience muscle wasting, and protein intake may help attenuate this condition. However, actual protein delivery is often inadequate, and high-dose protein intake has limited effects on muscle mass, strength, and function in these patients. Critically ill patients have minimal deficits in protein digestion and amino acid absorption, but postprandial muscle protein synthesis is impaired.
CURRENT OPINION IN CRITICAL CARE
(2022)
Review
Nutrition & Dietetics
Giorgina Barbara Piccoli, Tommy Cederholm, Carla Maria Avesani, Stephan J. L. Bakker, Vincenzo Bellizzi, Cristina Cuerda, Adamasco Cupisti, Alice Sabatino, Stephane Schneider, Massimo Torreggiani, Denis Fouque, Juan Jesus Carrero, Rocco Barazzoni
Summary: Increased life expectancy presents significant challenges to healthcare systems globally, including the rise in chronic kidney disease (CKD) and malnutrition-protein-energy wasting (PEW) in older adults, leading to poor clinical outcomes. A critical review paper by ESPEN and ERN-ERA aims to summarize key concepts in preventing and treating CKD progression and impaired nutritional status, and provide guidance on defining optimal protein and energy intake in varying CKD severity. Careful assessment and individualized approach are necessary, considering malnutrition-PEW status, kidney function, and patient preferences. Greater awareness and research are needed to improve nutritional care for this growing patient subgroup.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Guilhem Dreydemy, Alexis Coussy, Alexandre Lannou, Laurent Petit, Matthieu Biais, Cedric Carrie
Summary: This pilot study aimed to investigate the association between augmented renal clearance (ARC), urinary nitrogen loss, and muscle wasting in critically ill trauma patients. The findings suggest that patients with ARC have lower nitrogen balance and increased muscle loss in the first 10 days after ICU admission. The benefits of increased protein intake (>1.5 g/kg/day) in these patients are still a matter of controversy and require further randomized trials for confirmation.
Review
Biochemistry & Molecular Biology
Roberto Cannataro, Leandro Carbone, Jorge L. Petro, Erika Cione, Salvador Vargas, Heidy Angulo, Diego A. Forero, Adrian Odriozola-Martinez, Richard B. Kreider, Diego A. Bonilla
Summary: Sarcopenia, an age-related decline in skeletal muscle mass and function, presents a significant impact on quality of life. Current research focuses on nutritional interventions primarily on protein intake, while the effects of other nutrition strategies remain unclear. A comprehensive nutritional approach and miRNAs may play crucial roles in mitigating the adverse effects of sarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Naoya Yanagi, Tomotaka Koike, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Atsuhiko Matsunaga, Masayuki Kuroiwa, Masayasu Arai
Summary: Sarcopenia diagnosed in the ICU, based on low skeletal muscle mass and function, is significantly associated with 1-year mortality, indicating that muscle mass and function assessments at the bedside could help identify higher-risk patients in the ICU.
Review
Biochemistry & Molecular Biology
Felix Klawitter, Johannes Ehler, Rika Bajorat, Robert Patejdl
Summary: Mitochondria play a crucial role in providing energy and participating in metabolism and signaling processes. However, mitochondrial dysfunction in critical illness can lead to organ failure and muscle wasting. This review aims to discuss the molecular mechanisms underlying mitochondrial dysfunction in intensive care unit-acquired weakness and critical illness myopathy, and its implications for muscle function and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Sport Sciences
Abbie E. Smith-Ryan, Hannah E. Cabre, Sam R. Moore
Summary: Women, as the largest consumers of dietary supplements, can benefit from the role of such supplements in health and performance. Growing evidence and knowledge about physiological differences between sexes support the development of new products and evidence-based education for active women. This review explores hormonal and metabolic considerations that may impact nutritional recommendations for active women and proposes four areas of opportunity to support their health and well-being.
Article
Biochemistry & Molecular Biology
Joanna Schneider, Devakumar Sundaravinayagam, Alexander Blume, Andreas Marg, Stefanie Grunwald, Eric Metzler, Helena Escobar, Stefanie Muethel, Haicui Wang, Tobias Wollersheim, Steffen Weber-Carstens, Altuna Akalin, Michela Di Virgilio, Baris Tursun, Simone Spuler
Summary: Critical illness myopathy (CIM) is a devastating muscle-wasting disease that has a significant impact on healthcare costs and quality of life. Impairment of muscle stem cells (MuSC) and epigenetic alterations may contribute to the incomplete recovery observed in CIM patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Alex B. Addinsall, Nicola Cacciani, Anders Backeus, Yvette Hedstrom, Ganna Shevchenko, Jonas Bergquist, Lars Larsson
Summary: This study found that chronic supramaximal electrical stimulation (ES) can alleviate the symptoms of critical illness myopathy (CIM) and maintain muscle glucose homeostasis by increasing the AMPK-TBC1D4 signaling pathway, reducing muscle protein degradation.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Critical Care Medicine
Paul E. Wischmeyer, Danielle E. Bear, Mette M. Berger, Elisabeth De Waele, Jan Gunst, Stephen A. Mcclave, Carla M. Prado, Zudin Puthucheary, Emma J. Ridley, Greet Van den Berghe, Arthur R. H. van Zanten
Summary: Personalization of ICU nutrition is important for the future of critical care. Guidelines recommend low-dose enteral or parenteral nutrition within 48 hours of admission, with consideration for alternative routes when necessary. Indirect calorimetry should be used to measure energy expenditure, and protein delivery should be adjusted based on patient stability. Micronutrient evaluation and muscle monitoring are also important considerations in post-ICU nutrition. Further research is needed on specialized anabolic nutrients and rehabilitation interventions for post-ICU recovery.
Article
Nutrition & Dietetics
Marie Blanquet, Guillaume Ducher, Anais Sauvage, Sylvain Dadet, Vincent Guiyedi, Nicolas Farigon, Candy Guiguet-Auclair, Pauline Berland, Jerome Bohatier, Yves Boirie, Laurent Gerbaud
Summary: The study found that handgrip strength can be used as a valid tool for early screening of sarcopenia in acute care wards.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Health Care Sciences & Services
Constanta Urzeala, Martine Duclos, Ukadike Chris Ugbolue, Aura Bota, Mickael Berthon, Keri Kulik, David Thivel, Reza Bagheri, Yaodong Gu, Julien S. Baker, Nicolas Andant, Bruno Pereira, Karine Rouffiac, Maelys Clinchamps, Frederic Dutheil
Summary: This study investigated the changes in Body Mass Index and Perceived Fragility of different populations worldwide during COVID-19 lockdown, finding a significant increase in Body Mass Index during the lockdown period, with older adults being more susceptible to the effects.
HEALTH EXPECTATIONS
(2022)
Article
Nutrition & Dietetics
Lorenzo M. Donini, Luca Busetto, Stephan C. Bischoff, Tommy Cederholm, Maria D. Ballesteros-Pomar, John A. Batsis, Juergen M. Bauer, Yves Boirie, Alfonso J. Cruz-Jentoft, Dror Dicker, Stefano Frara, Gema Fruhbeck, Laurence Genton, Yftach Gepner, Andrea Giustina, Maria Cristina Gonzalez, Ho-Seong Han, Steven B. Heymsfield, Takashi Higashiguchi, Alessandro Laviano, Andrea Lenzi, Ibolya Nyulasi, Edda Parrinello, Eleonora Poggiogalle, Carla M. Prado, Javier Salvador, Yves Rolland, Ferruccio Santini, Mireille J. Serlie, Hanping Shi, Cornel C. Sieber, Mario Siervo, Roberto Vettor, Dennis T. Villareal, Dorothee Volkert, Jianchun Yu, Mauro Zamboni, Rocco Barazzoni
Summary: Sarcopenic obesity (SO), the coexistence of excess adiposity and low muscle mass/function, is common in individuals with obesity and negatively impacts patient outcomes. This article presents an initiative by ESPEN and EASO to establish a consensus on the definition and diagnostic criteria for SO. The proposed diagnostic procedure includes assessment of skeletal muscle function and body composition to confirm the diagnosis of SO. The authors advocate for the implementation of these criteria in routine clinical practice.
CLINICAL NUTRITION
(2022)
Article
Transplantation
Clarisse Greze, Bruno Pereira, Yves Boirie, Laurent Guy, Clementine Millet, Guillaume Clerfond, Cyril Garrouste, Anne-Elisabeth Heng
Summary: The study compared patient and graft survival rates in obese and non-obese kidney transplant recipients, finding that graft survival was lower in obese patients but patient survival was similar. Pre-transplant weight loss in obese patients had a significant impact on graft survival, but not on patient survival. These findings suggest that obesity alone should not be a barrier to kidney transplantation and weight loss before transplant may not be necessary for waitlist registration.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Endocrinology & Metabolism
Lorenzo M. Donini, Luca Busetto, Stephan C. Bischoff, Tommy Cederholm, Maria D. Ballesteros-Pomar, John A. Batsis, Juergen M. Bauer, Yves Boirie, Alfonso J. Cruz-Jentoft, Dror Dicker, Stefano Frara, Gema Fruehbeck, Laurence Genton, Yftach Gepner, Andrea Giustina, Maria Cristina Gonzalez, Ho-Seong Han, Steven B. Heymsfield, Takashi Higashiguchi, Alessandro Laviano, Andrea Lenzi, Ibolya Nyulasi, Edda Parrinello, Eleonora Poggiogalle, Carla M. Prado, Javier Salvador, Yves Rolland, Ferruccio Santini, Mireille J. Serlie, Hanping Shi, Cornel C. Sieber, Mario Siervo, Roberto Vettor, Dennis T. Villareal, Dorothee Volkert, Jianchun Yu, Mauro Zamboni, Rocco Barazzoni
Summary: Loss of skeletal muscle mass and function is common in individuals with obesity. The co-existence of excess adiposity and low muscle mass/function, known as sarcopenic obesity (SO), negatively impacts patient outcomes. However, the lack of a universally established definition and diagnostic criteria for SO hampers prevention and treatment efforts.
Article
Endocrinology & Metabolism
Valerie Julian, Daniela Costa, Grace O'Malley, Lore Metz, Alicia Fillon, Maud Miguet, Charlotte Cardenoux, Frederic Dutheil, Yves Boirie, Martine Duclos, Daniel Courteix, Bruno Pereira, David Thivel
Summary: The study found that compared to MICT, HIIT can more effectively reduce BMI and FM percentage in adolescents with obesity, and improve bone density, geometry, and strength at multiple sites.
Article
Nutrition & Dietetics
Marie Blanquet, Gregoire Massoulie, Yves Boirie, Candy Guiguet-Auclair, Aurelien Mulliez, Stefan Anker, Marie-Claire D'agrosa Boiteux, Frederic Jean, Nicolas Combaret, Geraud Souteyrand, Clement Riocreux, Bruno Pereira, Pascal Motreff, Patrick Rossignol, Guillaume Clerfond, Romain Eschalier
Summary: This study showed that handgrip strength (HGS) can be used as an effective tool to screen for sarcopenia in patients with chronic heart failure, with different cutoff values for different genders.
CLINICAL NUTRITION ESPEN
(2022)
Article
Nutrition & Dietetics
Melanie Pouget, Maelys Clinchamps, Celine Lambert, Bruno Pereira, Nicolas Farigon, Elodie Gentes, Magalie Miolanne, Mathilde Picard, Anne Tyrode, Maud Alligier, Frederic Dutheil, Yves Boirie
Summary: This study examined changes in eating habits and mood among the French population during the first lockdown period of the COVID-19 pandemic. The findings showed increased stress levels, sedentary behavior, deterioration in sleep quality, and decreased physical activity. The study also identified different profiles based on changes in eating habits, food consumption, lifestyle, and mood.
Article
Environmental Sciences
Alicia Fillon, Bruno Pereira, Jeremy Vanhelst, Joanna Baran, Julie Masurier, Terry Guirado, Yves Boirie, Martine Duclos, Valerie Julian, David Thivel
Summary: This study aimed to assess the psychometric properties of the Children and Adolescents Physical Activity and Sedentary-Questionnaire (CAPAS-Q) in healthy French children and adolescents. The results showed that CAPAS-Q is a reliable and valid tool for evaluating physical activity and sedentary behavior in children and adolescents.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Nutrition & Dietetics
Lena Pelissier, Sarah Bagot, Jennifer Lynn Miles-Chan, Bruno Pereira, Yves Boirie, Martine Duclos, Abdul Dulloo, Laurie Isacco, David Thivel
Summary: The present study aimed to systematically review the studies implicating diet restriction and body weight evolution in normal-weight individuals. The findings suggest that dieting could be a major risk factor for long-term weight gain in this population. Observational studies showed a relationship between dieting and significant later weight gain, while the meta-analysis indicated that 'dieters' have a higher body weight than 'non-dieters'. However, caution should be exercised due to methodological heterogeneity and publication bias.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Pediatrics
Juliette Hazart, Florence Montel, Elodie Gentes, Clement Lahaye, Melanie Pouget, Nicolas Farigon, Magalie Miolanne, Aurelien Mulliez, Yves Boirie
Summary: Regardless of absolute BMI values, the amount, onset date, and duration of early body weight gain may impact cardio-metabolic health in adulthood. This study analyzed the association between early weight history and metabolic syndrome occurrence in adults using data from a cohort study of severely obese patients. The results showed that the magnitude of weight gain after age 18 years was significantly associated with an increased risk of MetS.
Article
Oncology
Nicolas Saroul, Nicolas Tardif, Bruno Pereira, Alexis Dissard, Laura Montrieul, Phelipe Sanchez, Jerome Salles, Jens Erik Petersen, Towe Jakobson, Laurent Gilain, Thierry Mom, Yves Boirie, Olav Rooyakers, Stephane Walrand
Summary: Cancer cachexia, particularly muscle loss, in head and neck cancer (HNC) is not solely attributed to decreased food intake. The exact role of secreted factors from tumor cells in driving cancer cachexia is still unknown. This study used conditioned media from HNC cell lines and mix of sera from HNC patients to analyze their impact on skeletal muscle protein catabolism, and found similar metabolic responses in both cases. These findings suggest that muscle atrophy in HNC patients is not solely caused by reduced food intake.
Article
Nutrition & Dietetics
Jerome Salles, Marine Gueugneau, Veronique Patrac, Carmen Malnero-Fernandez, Christelle Guillet, Olivier Le Bacquer, Christophe Giraudet, Phelipe Sanchez, Marie-Laure Collin, Julien Hermet, Corinne Pouyet, Yves Boirie, Heidi Jacobs, Stephane Walrand
Summary: Aging is associated with muscle loss and decreased muscle function, which increases the risk of mobility limitations and frailty. Dietary interventions with pea proteins and inulin have shown promise in attenuating age-related muscle loss. This study found that supplementing old rats with pea proteins and inulin resulted in preserved muscle mass and improved muscle function.
Article
Nutrition & Dietetics
Marie Blanquet, Candy Guiguet-Auclair, Pauline Berland, Guillaume Ducher, Anais Sauvage, Sylvain Dadet, Vincent Guiyedi, Nicolas Farigon, Jerome Bohatier, Laurent Gerbaud, Yves Boirie
Summary: This study aimed to evaluate the gaps between energy and protein intakes and requirements in older adults in hospitals and nursing homes. It found that regardless of malnutrition status, the intakes of older adults in both settings fell significantly short of requirements. Therefore, a patient-centered approach should be developed to adapt meals served in hospitals and nursing homes.
Review
Nutrition & Dietetics
Isabel M. van Ruijven, Jose Abma, Anja H. Brunsveld-Reinders, Sandra N. Stapel, Faridi van Etten-Jamaludin, Yves Boirie, Rocco Barazzoni, Peter J. M. Weijs
Summary: High protein provision of more than 1.2 g/kg in critically ill patients appeared to improve nitrogen balance and changes in muscle mass in the short term and may reduce 60-day mortality. Long-term effects on quality of life need to be urgently studied.
CLINICAL NUTRITION
(2023)
