Image-Guided Hydrodynamic Gene Delivery: Current Status and Future Directions

Safety Assessment of Liver-Targeted Hydrodynamic Gene Delivery in Dogs

(2014) Kenya Kamimura et al.   PLoS One

Kallistatin Modulates Immune Cells and Confers Anti-Inflammatory Response To Protect Mice from Group A Streptococcal Infection

(2013) Shiou-Ling Lu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel Antihypoglycemic Role of Inducible Nitric Oxide Synthase in Liver Inflammatory Response Induced by Dietary Cholesterol and Endotoxemia

(2013) Sarit Anavi et al.   ANTIOXIDANTS & REDOX SIGNALING

The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels

(2013) N. Rydz et al.   BLOOD

Effect of hydrodynamics-based delivery of IL-18BP fusion gene on rat experimental autoimmune myocarditis

(2013) He Chang et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Hydrodynamic delivery of adiponectin and adiponectin receptor 2 gene blocks high-fat diet-induced obesity and insulin resistance

(2013) Y Ma et al.   GENE THERAPY

Novel electric power-driven hydrodynamic injection system for gene delivery: safety and efficacy of human factor IX delivery in rats

(2013) T Yokoo et al.   GENE THERAPY

Gene therapy clinical trials worldwide to 2012 - an update

(2013) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

Melanoma Differentiation-Associated Gene 5 Senses Hepatitis B Virus and Activates Innate Immune Signaling To Suppress Virus Replication

(2013) H.-L. Lu et al.   JOURNAL OF IMMUNOLOGY

Role of recombinant plasmid pEGFP-N1-IGF-1 transfection in alleviating osteoporosis in ovariectomized rats

(2013) Hai Chun Liu et al.   JOURNAL OF MOLECULAR HISTOLOGY

A Titratable Two-Step Transcriptional Amplification Strategy for Targeted Gene Therapy Based on Ligand-Induced Intramolecular Folding of a Mutant Human Estrogen Receptor

(2013) Ian Y. Chen et al.   MOLECULAR IMAGING AND BIOLOGY

Expression Profile-Dependent Improvement of Insulin Sensitivity by Gene Delivery of Interleukin-6 in a Mouse Model of Type II Diabetes

(2013) Hanae Mukumoto et al.   MOLECULAR PHARMACEUTICS

Inactivation of Hepatitis B Virus Replication in Cultured Cells and In Vivo with Engineered Transcription Activator-Like Effector Nucleases

(2013) Kristie Bloom et al.   MOLECULAR THERAPY

Hydrodynamic Delivery of mIL10 Gene Protects Mice From High-fat Diet-induced Obesity and Glucose Intolerance

(2013) Mingming Gao et al.   MOLECULAR THERAPY

Leu452His Mutation in Lipoprotein Lipase Gene Transfer Associated with Hypertriglyceridemia in Mice in vivo

(2013) Kaiyue Sun et al.   PLoS One

Inhibition of hepatitis B virus (HBV) gene expression and replication by HBx gene silencing in a hydrodynamic injection mouse model with a new clone of HBV genotype B

(2013) Lei Li et al.   Virology Journal

Parameters Affecting Image-guided, Hydrodynamic Gene Delivery to Swine Liver

(2013) Kenya Kamimura et al.   Molecular Therapy-Nucleic Acids

Pancreatic STAT3 Protects Mice against Caerulein-Induced Pancreatitis via PAP1 Induction

(2012) Minoru Shigekawa et al.   AMERICAN JOURNAL OF PATHOLOGY

Gene Transfer of c-met Confers Protection Against d-Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure

(2012) Chuanlong Zhu et al.   DIGESTIVE DISEASES AND SCIENCES

Regulation of immunological balance by sustained interferon-γ gene transfer for acute phase of atopic dermatitis in mice

(2012) K Watcharanurak et al.   GENE THERAPY

Simultaneous knockdown of multiple ligands of innate receptor NKG2D prevents natural killer cell-mediated fulminant hepatitis in mice

(2012) Mei Huang et al.   HEPATOLOGY

In vivo studies on non-viral transdifferentiation of liver cells towards pancreatic β cells

(2012) Abdullah Cim et al.   JOURNAL OF ENDOCRINOLOGY

Inactivation of Spry2 accelerates AKT-driven hepatocarcinogenesis via activation of MAPK and PKM2 pathways

(2012) Chunmei Wang et al.   JOURNAL OF HEPATOLOGY

Liver Gene Transfer of Interkeukin-15 Constructs That Become Part of Circulating High Density Lipoproteins for Immunotherapy

(2012) Maria C. Ochoa et al.   PLoS One

Hydrodynamic cell delivery for simultaneous establishment of tumor growth in mouse lung, liver and kidney

(2011) Jianfeng Li et al.   CANCER BIOLOGY & THERAPY

Expression and Function of Fibroblast Growth Factor (FGF) 7 during Liver Regeneration

(2011) Su-Mei Tsai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hydrodynamic delivery of plasmid DNA encoding human FcγR-Ig dimers blocks immune-complex mediated inflammation in mice

(2011) R Shashidharamurthy et al.   GENE THERAPY

In Vivo Expression of Interleukin-37 Reduces Local and Systemic Inflammation in Concanavalin A-Induced Hepatitis

(2011) Ana-Maria Bulau et al.   TheScientificWorldJOURNAL

In vivo knockdown of nicotinic acetylcholine receptor α1 diminishes aortic atherosclerosis

(2010) Guoqiang Zhang et al.   ATHEROSCLEROSIS

RNA interference targeting the platelet-derived growth factor receptor β subunit ameliorates experimental hepatic fibrosis in rats

(2010) Si-Wen Chen et al.   LIVER INTERNATIONAL

Hydrodynamic Gene Delivery and Its Applications in Pharmaceutical Research

(2010) Barbara Bonamassa et al.   PHARMACEUTICAL RESEARCH

Experimental Parathyroid Hormone Gene Therapy Using ØC31 Integrase

(2009) Sihoon LEE et al.   ENDOCRINE JOURNAL

Widespread biochemical correction of murine mucopolysaccharidosis type VII pathology by liver hydrodynamic plasmid delivery

(2009) M Richard et al.   GENE THERAPY

Functional Efficacy of Dystrophin Expression from Plasmids Delivered to mdx Mice by Hydrodynamic Limb Vein Injection

(2009) Guofeng Zhang et al.   HUMAN GENE THERAPY

Image-guided, Lobe-specific Hydrodynamic Gene Delivery to Swine Liver

(2009) Kenya Kamimura et al.   MOLECULAR THERAPY

Image-guided, Intravascular Hydrodynamic Gene Delivery to Skeletal Muscle in Pigs

(2009) Kenya Kamimura et al.   MOLECULAR THERAPY

Hydrodynamic gene delivery of baboon trypanosome lytic factor eliminates both animal and human-infective African trypanosomes

(2009) R. Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical Approaches for Nucleic Acid Delivery to Liver

(2008) Kenya Kamimura et al.   AAPS Journal

Suppressive role of leukocyte cell–derived chemotaxin 2 in mouse anti–type II collagen antibody–induced arthritis

(2008) Akinori Okumura et al.   ARTHRITIS AND RHEUMATISM

Sustained liver-specific transgene expression from the albumin promoter in mice following hydrodynamic plasmid DNA delivery

(2008) Christine I. Wooddell et al.   JOURNAL OF GENE MEDICINE

Targeted delivery of siRNA against hepatitis C virus by apolipoprotein A-I-bound cationic liposomes

(2008) Soo In Kim et al.   JOURNAL OF HEPATOLOGY

Computer-assisted Hydrodynamic Gene Delivery

(2008) Takeshi Suda et al.   MOLECULAR THERAPY