Article
Oncology
Estefania Carrasco-Garcia, Lidia Lopez, Veronica Moncho-Amor, Fernando Carazo, Paula Aldaz, Manuel Collado, Donald Bell, Ayman Gaafar, Eva Karamitopoulou, Alexandar Tzankov, Manuel Hidalgo, Angel Rubio, Manuel Serrano, Charles H. Lawrie, Robin Lovell-Badge, Ander Matheu
Summary: The study shows that SOX9 plays a crucial role in the progression and metastasis of pancreatic cancer by regulating stemness and EMT processes. High levels of SOX9 are associated with metastases in clinical samples.
Review
Cell Biology
Shuang Wang, Yang Liu, Jun Li, Lei Zhao, Wei Yan, Baiqiang Lin, Xiao Guo, Yunwei Wei
Summary: This review summarizes the biological characteristics of Fusobacterium nucleatum (F. nucleatum) and its epidemiological associations with colorectal cancer (CRC), highlighting the mechanisms by which F. nucleatum participates in CRC progression, metastasis, and chemoresistance. The research gap in this field is discussed, and the authors provide their perspective for future studies. These findings suggest potential strategies for manipulating gut F. nucleatum to address CRC in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Ye Zhang, Jian-Ge Qiu, Xiao-Yu Jia, Yu Ke, Ming-Kun Zhang, David Stieg, Wen-Jing Liu, Ling-Zhi Liu, Lin Wang, Bing-Hua Jiang
Summary: In this study, we found that IFFO1 is a novel tumor suppressor that plays an important role in tumor development, metastasis, and chemoresistance in ovarian cancer. Overexpression of IFFO1 can inhibit the translocation of β-catenin to the nucleus, thereby reducing tumor metastasis and drug resistance. The study also found that the expression of IFFO1 is regulated by histone deacetylase and RNA methylation, and the IFFO1 signaling pathway may be a potential therapeutic target for cancer.
Review
Oncology
Simona Pompili, Antonella Vetuschi, Roberta Sferra, Alfredo Cappariello
Summary: This article discusses the issue of drug resistance in cancer treatment, arguing that resistance is closely related to multiple mechanisms, including the expression of transporter proteins, mutations in oncogenes and transcription factors, and the role of extracellular vesicles.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mehrdokht Sadrkhanloo, Maliheh Entezari, Mohsen Rashidi, Mehrdad Hashemi, Rasoul Raesi, Sam Saghari, Salman Daneshi, Shokooh Salimimoghadam, Kiavash Hushmandi, Sepideh Mirzaei, Afshin Taheriazam
Summary: ncRNAs play a significant role in regulating EMT, impacting cancer progression, including different types of non-coding RNAs such as miRNAs, LncRNAs, CircRNAs, etc.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
V. A. Subramanian, Ravindra Kumar Bairwa, Pradeep Kumar Sharma, Bhawana Bissa
Summary: This article discusses the roles of autophagy and exosomes in the cancer cell's adaptation to the tumor microenvironment and how the two pathways are coordinately regulated to facilitate cancer cell survival.
Article
Chemistry, Multidisciplinary
Qi Shang, Shiyao Zhou, Zijia Zhou, Yue Jiang, Yuxia Luan
Summary: Targeting breast cancer stem cells (BCSCs) therapy is a promising strategy to eliminate tumors by remolding the disequilibrium state and blocking the EMT process, demonstrating a potential photodynamic platform against tumor progression and metastasis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Oncology
Hsin-Yi Chen, Shu-Jou Chan, Xinxin Liu, An-Chi Wei, Ru-In Jian, Kuan-Wei Huang, Yaw-Dong Lang, Jou-Ho Shih, Chun-Chieh Liao, Chiu-Lin Luan, Yu-Tung Kao, Shang-Yin Chiang, Pei-Wen Hsiao, Yuh-Shan Jou, Yunching Chen, Ruey-Hwa Chen
Summary: This study identifies the lncRNA Smyca as an oncogene that promotes poor prognosis in multiple cancer types. Smyca enhances tumor metabolic reprogramming, migration, invasion, cancer stemness, metastasis, and chemoresistance by potentiating TGF-beta/Smad signaling and c-Myc-mediated transcription. Targeting Smyca prevents metastasis and overcomes chemoresistance.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Oncology
Hussein Chehade, Roslyn Tedja, Harry Ramos, Tejeshwar Singh Bawa, Nicholas Adzibolosu, Radhika Gogoi, Gil Mor, Ayesha B. Alvero
Summary: Adipocytes play a crucial role in the ovarian tumor microenvironment, as their secreted factors and direct interaction with ovarian cancer cells can support tumor progression. Elucidating the molecular pathways involved is vital in identifying relevant targets.
Article
Oncology
Zhiyong Mi, Marissa C. Kuo, Paul C. Kuo
Summary: An RNA aptamer was developed to target and inhibit the extracellular sheddase domain of Adam8 in both in vitro and in vivo studies. This aptamer effectively blocked the activities of extracellular Adam8, leading to the reversal of myofibroblast cancer-associated fibroblast phenotype induced by cancer-derived osteopontin. The findings suggest that the signal pathways involved in the development and maintenance of the myCAF phenotype may differ, and that targeting extracellular Adam8 sheddase activity could be a potential therapeutic approach.
Article
Oncology
Md Arafat Khan, Parvez Khan, Aatiya Ahmad, Mahek Fatima, Mohd Wasim Nasser
Summary: Transcription factors (TFs) play a crucial role in regulating signaling pathways associated with cell homeostasis and disease, and FOXM1 is a critical TF involved in various aspects of cancer cells. It affects cancer growth, metastasis, recurrence, stem cell features, as well as the outcomes of targeted therapies, chemotherapies, and immune checkpoint inhibitors. Recent studies highlight the specific role of FOXM1 in cancer and suggest its potential as a target for therapy.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Claire Y. Li, Stav Brown, Babak J. Mehrara, Raghu P. Kataru
Summary: The lymphatic system plays a crucial role in tumor growth and immune response. Understanding the complex interactions between lymphatic vessels, tumor cells, and the tumor microenvironment can lead to the development of novel therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Evelyne Lopez-Crapez, Luca Costa, Guillaume Tosato, Jeanne Ramos, Thibault Mazard, Janique Guiramand, Alain Thierry, Jacques Colinge, Pierre-Emmanuel Milhiet, Christine Benistant
Summary: In addition to standard parameters, new features are needed in CRC management to improve survival rates. By using a multidisciplinary approach, we characterized the stiffness of healthy and malignant colon specimens and found that tumor tissue rigidity is associated with clinical parameters.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Aiping Zheng, Yuhao Wei, Yunuo Zhao, Tao Zhang, Xuelei Ma
Summary: Ovarian cancer is a common malignant tumor in females with limited treatment options. Cancer-associated mesothelial cells in the tumor microenvironment play a significant role in the progression and prognosis of ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Aditi Kulkarni, Sharan Gayathrinathan, Soumya Nair, Anamika Basu, Taslim A. Al-Hilal, Sourav Roy
Summary: This article reviews the regulatory functions of noncoding RNAs (ncRNAs) in the development, progression, chemoresistance, and health disparities of gastrointestinal (GI) cancer. It also highlights the potential roles of ncRNAs as therapeutic targets and biomarkers, with a focus on their ethnicity-/race-specific prognostic value. The prospects of genome-wide association studies (GWAS) in investigating the contribution of ncRNAs in GI tumorigenesis are also discussed.
Article
Medicine, Research & Experimental
Goekhan Guener, Marlene Assfalg, Kai Zhao, Tobias Dreyer, Shibojyoti Lahiri, Yun Lo, Bianca Ionela Slivinschi, Axel Imhof, Georg Jocher, Laura Strohm, Christian Behrends, Dieter Langosch, Holger Bronger, Christopher Nimsky, Joerg W. Bartsch, Stanley R. Riddell, Harald Steiner, Stefan F. Lichtenthaler
Summary: Fn14 is cleaved by the protease gamma-secretase, leading to secretion of sFn14. Inhibition of gamma-secretase increases full-length Fn14 at the cell surface and enhances TWEAK ligand-stimulated Fn14 signaling. The release of sFn14 can be detected in tumor cells, plasma, and blood from cancer patients, suggesting it as a biomarker for monitoring gamma-secretase activity.
EMBO MOLECULAR MEDICINE
(2022)
Article
Oncology
Xiaojin Liu, Yimin Huang, Yiwei Qi, Shiqiang Wu, Feng Hu, Junwen Wang, Kai Shu, Huaqiu Zhang, Jorg W. Bartsch, Christopher Nimsky, Fangyong Dong, Ting Lei
Summary: This study revealed a malignant positive feedback loop between tumor-associated macrophages (TAMs) and GBM cells mediated by ADAM8 under TMZ treatment. This loop involves the activation of the HB-EGF/EGFR signaling pathway and up-regulation of CCL2 expression, leading to TAM recruitment and further enhancing ADAM8 expression in GBM cells, resulting in TMZ resistance in GBM.
Article
Oncology
Suresh Sivakumar, Sonja Lieber, Damiano Librizzi, Corinna Keber, Leah Sommerfeld, Florian Finkernagel, Katrin Roth, Silke Reinartz, Joerg W. Bartsch, Johannes Graumann, Sabine Mueller-Bruesselbach, Rolf Mueller
Summary: Different forms of BCAM protein are associated with metastasis and poor prognosis in ovarian cancer. The soluble form of BCAM inhibits tumor cell adhesion and migration, but promotes the dispersion and invasion of tumor cell spheroids. These findings provide new insights for the treatment of ovarian cancer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Panagiota-Eleni Tsalouchidou, Johann Philipp Zoellner, Annika Kirscht, Christina Julia Mueller, Christopher Nimsky, Maximilian Schulze, Elke Hattingen, Georgios Chatzis, Thomas M. Freiman, Adam Strzelczyk, Sven Fuest, Katja Menzler, Felix Rosenow, Susanne Knake
Summary: This study aimed to identify coexisting structural lesions in patients with epilepsy and known temporal encephaloceles (TEs). Results showed that TEs can occur with other lesions, potentially impacting surgical evaluation and approach. Additionally, TEs may be associated with malformations of cortical development.
Article
Oncology
Maren Nicole Stillger, Chia-Yi Chen, Zon Weng Lai, Mujia Li, Agnes Schaefer, Axel Pagenstecher, Christopher Nimsky, Joerg Walter Bartsch, Oliver Schilling
Summary: This study found that the expression of calcium-dependent protease calpain-2 is increased in glioblastoma. Treatment with a calpain inhibitor increased the sensitivity of primary glioblastoma cells to TMZ. The knockdown of calpain-2 resulted in DNA damage and disrupted TP53 signaling. Therefore, calpain-2 may serve as a prognostic factor for GBM outcome.
CANCER CELL INTERNATIONAL
(2023)
Article
Clinical Neurology
Stefanie T. Jost, Agni Konitsioti, Philipp A. Loehrer, Keyoumars Ashkan, Alexandra Rizos, Anna Sauerbier, Maria Gabriela dos Santos Ghilardi, Franz Rosenkranz, Lena Strobel, Alexandra Gronostay, Michael T. Barbe, Julian Evans, Veerle Visser-Vandewalle, Christopher Nimsky, Gereon R. Fink, Monty Silverdale, Rubens G. Cury, Erich T. Fonoff, Angelo Antonini, K. Ray Chaudhuri, Lars Timmermann, Pablo Martinez-Martin, Haidar S. Dafsari
Summary: This study suggests that patients with 'postural instability and gait difficulty' (PIGD) may experience more beneficial non-motor effects compared to patients with 'tremor-dominant' symptoms undergoing deep brain stimulation (DBS) for Parkinson's disease (PD). These differences in clinical efficacy on non-motor aspects should be taken into consideration when advising and monitoring PD patients undergoing DBS.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Andreas Schulze-Bonhage, Martin Hirsch, Susanne Knake, Elisabeth Kaufmann, Josua Kegele, Michael Rademacher, Kristl Vonck, Volker Arnd Coenen, Martin Glaser, Carolin Jenkner, Yaroslav Winter, Sergiu Groppa, EASEE Study Grp
Summary: A pooled analysis of two clinical trials showed that a novel stimulation device could effectively reduce seizure frequency in patients with drug-refractory focal epilepsy, providing a promising treatment option for patients with a predominant epileptic focus.
Article
Neurosciences
Lara Evers, Agnes Schaefer, Raffaella Pini, Kai Zhao, Susanne Stei, Christopher Nimsky, Joerg W. Bartsch
Summary: This study explored changes in miRNA expression profiles in patient-derived glioblastoma stem-like cells (GSCs) upon differentiation into glial fiber acid protein (GFAP)-expressing astrocytic tumor cells. The results showed that miR-17-5p and miR-425-5p were downregulated, while miR-223-3p and let-7-5p were upregulated in differentiated cells. Among them, miR-425-5p consistently showed the highest downregulation in all GSCs. Transfection of a 425-5p miRNA mimic demonstrated downregulation of GFAP protein in differentiated patient-derived GBM cells, suggesting direct regulation of miRNAs in the GSC/GBM cell transition.
Article
Oncology
Biao Xing, Zhuowei Lei, Zihan Wang, Quanji Wang, Qian Jiang, Zhuo Zhang, Xiaojin Liu, Yiwei Qi, Sihan Li, Xiang Guo, Yanchao Liu, Xingbo Li, Kai Shu, Huaqiu Zhang, Joerg Walter Bartsch, Christopher Nimsky, Yimin Huang, Ting Lei
Summary: This study found that ADAM22 is overexpressed in pituitary adenoma (PA) and promotes its growth and invasion through activating the ITGB1 signaling pathway. It also revealed that PKA may regulate ADAM22 levels through phosphorylation and delaying degradation. ITGB1 may be a potential therapeutic target for PA.
Article
Oncology
Miguel Cosenza-Contreras, Agnes Schafer, Justin Sing, Lena Cook, Maren N. Stillger, Chia-Yi Chen, Jose Villacorta Hidalgo, Niko Pinter, Larissa Meyer, Tilman Werner, Darleen Bug, Zeno Haberl, Oliver Kuebeck, Kai Zhao, Susanne Stei, Anca Violeta Gafencu, Radu Ionita, Felix M. Brehar, Jaime Ferrer-Lozano, Gloria Ribas, Leo Cerda-Alberich, Luis Marti-Bonmati, Christopher Nimsky, Alexis Van Straaten, Martin L. Biniossek, Melanie Foll, Nina Cabezas-Wallscheid, Jorg Buscher, Hannes Rost, Armelle Arnoux, Jorg W. Bartsch, Oliver Schilling
Summary: This study utilized proteomics and lipidomics to analyze patient-matched initial and recurrent glioblastoma specimens, revealing increased immune cell infiltration and extracellular matrix reorganization in recurrent glioblastoma. ASAH1 and SYNM were identified as potential plasma markers for the progression of recurrent glioblastoma.
Article
Clinical Neurology
Alexander Calvano, Laura Beccaria, Lars Timmermann, Miriam H. A. Bopp, Marko Gjorgjevski, Christopher Nimsky, David J. Pedrosa
Summary: Personalized structural considerations, particularly using patient-specific connectome analysis, can provide important insights for the treatment of secondary myoclonus-dystonia syndromes.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Corinna Keil, Siegmund Koehler, Benjamin Sass, Maximilian Schulze, Gerald Kalmus, Michael Belfort, Nicolas Schmitt, Daniele Diehl, Alice King, Stefanie Gross, Caitlin D. Sutton, Luc Joyeux, Mirjam Wege, Christopher Nimsky, Wiliam E. Whitehead, Eberhard Uhl, Thierry A. G. M. Huisman, Bernd A. Neubauer, Stefanie Weber, Helmut Hummler, Roland Axt-Fliedner, Ivonne Bedei
Summary: Open spina bifida (OSB) is a congenital malformation that can be treated through prenatal fetal therapy. The University of Giessen and Marburg (UKGM) has successfully performed a three-port, three-layer fetoscopic repair of OSB via laparotomy-assisted approach. The transfer of technique to a different setting is possible with experienced centers and intensive multidisciplinary preparation and training.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Ziyu Qi, Miriam H. A. Bopp, Christopher Nimsky, Xiaolei Chen, Xinghua Xu, Qun Wang, Zhichao Gan, Shiyu Zhang, Jingyue Wang, Haitao Jin, Jiashu Zhang
Summary: This study proposes a novel registration method for mixed reality navigation (MRN) using a laser crosshair simulator, which achieves low user dependency, high accuracy, and clinical applicability. The method was successfully implemented and showed promising results in efficiency and intuitiveness. It marks a valuable advancement in low-cost, easy-to-use MRN systems and has the potential to improve surgical outcomes.
BIOENGINEERING-BASEL
(2023)