Review
Allergy
Sander Vandeweege, Britt Debaene, Hilde Lapeere, Hans Verstraelen
Summary: This study reviewed the literature on vulvar allergic contact dermatitis (vACD) and irritative contact dermatitis (vICD), providing a comprehensive reference list of potential vulvar allergens and irritants, and emphasizing the importance of patch testing for identifying causal allergens. Multiple allergens were identified, but not all positive reactions were relevant to the disease. Additional testing methods and late readings should be considered in standard practice. Limited information was found on irritants, highlighting the need for further research.
CONTACT DERMATITIS
(2023)
Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Anne Birgitte Simonsen, Jojo Biel-Nielsen Dietz, Jeanne Duus Johansen
Summary: This study aimed to explore the epidemiology, aetiology and severity of hand eczema (HE) among Danish adolescents. The study found a high prevalence of HE among Danish adolescents, raising concerns about this significant clinical problem.
CONTACT DERMATITIS
(2023)
Review
Medicine, General & Internal
Marta Tramontana, Katharina Hansel, Leonardo Bianchi, Chiara Sensini, Nicolo Malatesta, Luca Stingeni
Summary: Allergic contact dermatitis (ACD) is a common inflammatory skin disease with a high impact on quality of life. It is triggered by contact with an allergen in previously sensitized individuals. Symptoms include eczematous dermatitis, erythema, edema, vesicles, scaling, and intense itch. Occupational and non-occupational exposure to allergens is common, and patch testing is required for diagnosis. Nickel, fragrance mix, isothiazolinones, and para-phenylenediamine are commonly positive allergens. Treatment involves avoiding contact with the allergen and using corticosteroid therapy.
FRONTIERS IN MEDICINE
(2023)
Article
Dermatology
Jonathan Silverberg, Erin M. Warshaw, Amber R. Atwater, Howard Maibach, Kathryn A. Zug, Margo J. Reeder, Denis Sasseville, James S. Taylor, Joseph F. Fowler, Melanie D. Pratt, Anthony F. Fransway, Matthew J. Zirwas, Donald Belsito, James G. Marks, Vincent A. DeLeo, Joel G. DeKoven
Summary: This study retrospectively analyzed data from a large number of patients with hand eczema (HE), and found that HE was associated with higher proportions of positive patch tests, with a heterogeneous profile of allergens.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Allergy
Anne B. Simonsen, Iben F. Ruge, Anna S. Quaade, Jeanne D. Johansen, Jacob P. Thyssen, Claus Zachariae
Summary: After implementing more intensive hand hygiene measures in Danish daycare centers, a high proportion of young children rapidly developed hand eczema. Prophylactic skin care could have potentially prevented some children from developing hand eczema.
CONTACT DERMATITIS
(2021)
Article
Dermatology
Holly Neale, Anna Cristina Garza-Mayers, Idy Tam, JiaDe Yu
Summary: ACD is a delayed hypersensitivity skin reaction to environmental allergens that affects children and adults similarly. However, pediatric patch testing for ACD is less common due to challenges such as smaller surface area for testing and difficulty in cooperation, particularly with younger children. Clinical suspicion guided by patient presentation and history is key in diagnosing ACD in children.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Allergy
Morgan Nguyen, Slaton Case, Nina Botto, Walter Liszewski
Summary: This study identified discussions about allergic contact dermatitis (ACD) across various social media platforms, including content created by patients, physicians, professional organizations, and companies. Instagram had the most content, while Facebook had patient support groups. However, YouTube videos presented poor quality medical information.
CONTACT DERMATITIS
(2022)
Article
Allergy
Jacob P. Thyssen, Marie L. A. Schuttelaar, Jose H. Alfonso, Klaus E. Andersen, Irena Angelova-Fischer, Bernd W. M. Arents, Andrea Bauer, Richard Brans, Alicia Cannavo, Wianda A. Christoffers, Marie-Noelle Crepy, Peter Elsner, Manige Fartasch, Francesca Larese Filon, Ana M. Gimenez-Arnau, Margarida Goncalo, Maria G. Guzman-Perera, Carsten R. Hamann, Wolfram Hoetzenecker, Jeanne Duus Johansen, Swen M. John, Amalia C. M. Kunkeler, Suzana Ljubojevic Hadzavdic, Sonja Molin, Rosemary Nixon, Jart A. F. Oosterhaven, Thomas Rustemeyer, Esther Serra-Baldrich, Mili Shah, Dagmar Simon, Christoph Skudlik, Radoslaw Spiewak, Skaidra Valiukeviciene, Angelique N. Voorberg, Elke Weisshaar, Tove Agner
Summary: Hand eczema is a common inflammatory skin disorder. This article aims to update the European Society of Contact Dermatitis guideline on the diagnosis, prevention, and treatment of hand eczema. Consensus was reached for several statements and management strategies through analysis of evidence for therapeutic and preventive interventions using a structured method of developing consensus. The updated guideline should improve the management of hand eczema.
CONTACT DERMATITIS
(2022)
Review
Pharmacology & Pharmacy
Kong Yen Liew, Nurain Irdayani Kamise, Hui Ming Ong, Poi Yi Aw Yong, Fahmida Islam, Ji Wei Tan, Chau Ling Tham
Summary: Allergic diseases are a global health burden, and the current available medications have side effects, poor perceived effectiveness, and high cost. Propolis, a natural herbal medicine with antioxidant, antimicrobial, and anticancer properties, has the potential to be a prophylactic or therapeutic option for allergic diseases. Preclinical studies have shown that propolis extracts have therapeutic effects on allergic inflammation, asthma, allergic rhinitis, atopic dermatitis, and food allergy by inhibiting mast cell and basophil activation. Clinically, propolis consumption as a supplement or adjunct therapy is safe and attenuates pathological conditions in asthma. Flavonoids and cinnamic acid derivatives in propolis contribute to its anti-allergic activities, but their presence varies in different propolis samples. Future studies should focus on the relationship between propolis's anti-allergic activity and its chemical contents.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Dermatology
Alix Danoy, Howard Maibach
Summary: The study found enantiospecificity in allergic reactions to certain chemicals, and proposed a link between one chemical and chronic actinic dermatitis. However, there was no clear evidence of enantio-stereospecificity in inducing allergic reactions. Future research combining modern analytical chemistry and new immunological knowledge is needed to gain clearer insights into the mechanism of allergens.
Article
Chemistry, Multidisciplinary
Zheng Liu, Zhan Fan, Jinxin Liu, Jialu Wang, Mengli Xu, Xinlin Li, Yilun Xu, Yafang Lu, Chenlu Han, Zhihong Zhang
Summary: An immunomodulatory approach based on lipid nanoparticles carrying alpha-helical configurational melittin is developed to treat allergic contact dermatitis and atopic dermatitis by suppressing T cell-mediated inflammatory reactions.
Review
Environmental Sciences
Hua Wang, Xian-Bao Li, Xiu-Jie Chu, Nv-Wei Cao, Hong Wu, Rong-Gui Huang, Bao-Zhu Li, Dong-Qing Ye
Summary: Recent meta-analysis indicates that exposure to air pollutants may increase the risk of IgE-mediated allergic diseases, including eczema, atopic dermatitis, and allergic rhinitis. Long-term exposure to PM2.5 and PM10, as well as short-term exposure to NO2 and SO2, are associated with these allergic diseases.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, General & Internal
Yu-Jih Su, Sheng-Dean Luo, Chung-Yuan Hsu, Ho-Chang Kuo
Summary: This study compared gut microbiota differences between patients with eczema, hives, and allergic rhinitis, revealing significant differences in gut flora between skin allergy and nose allergy patients, indicating the existence of gut-skin and gut-nose axes. Certain Bacteroidales species may be a clinical link between gut flora and skin allergies.
Article
Biochemistry & Molecular Biology
Jinhong Xu, Hui Xiong, Zhongqiu Zhao, Miao Luo, Yankun Ju, Guangzhong Yang, Zhinan Mei
Summary: Genistein shows strong antipruritic and anti-inflammatory effects in ACD mice by inhibiting the production of pro-inflammatory cytokines and intracellular MAP2K2/ERK cell signaling, making it a potential valuable candidate for the treatment of skin conditions and systemic syndromes in the setting of contact dermatitis.