Article
Medicine, General & Internal
Candela Castillo-Felipe, Asta Tvarijonaviciute, Marina Lopez-Arjona, Luis Pardo-Marin, Eduardo Pons-Fuster, Pia Lopez-Jornet
Summary: Melatonin and clonazepam are effective in reducing burning sensation and improving quality of life in patients with BMS. Both drugs are safe and have no major adverse effects. Melatonin may be considered as an alternative treatment for patients with BMS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Francesco Monaco, Rosalba Siracusa, Marika Cordaro, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola, Daniela Impellizzeri, Tiziana Genovese
Summary: The study found that um-PEA can reduce changes in coagulation markers and proinflammatory cytokine release caused by LPS, as well as prevent the formation of fibrin deposition and lung damage. Furthermore, um-PEA can also reduce the number of mast cells and the release of serine proteases, which are necessary for SARS-CoV-2 infection. These results suggest that um-PEA could be a potential therapeutic approach in managing DIC and associated clinical implications of coagulopathy and lung dysfunction, such as COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Laura Facci, Massimo Barbierato, Mariella Fusco, Pietro Giusti, Morena Zusso
Summary: Remyelination often fails in patients with multiple sclerosis, especially in the chronic phase of the disease. Drug-based therapies, such as PEALut, are emerging as primary approaches to promote endogenous remyelination capability of oligodendrocytes. The study suggests that PEALut promotes oligodendrocyte differentiation through the Tyro3 mRNA increase, and involves mTOR signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Annalisa Noce, Maria Albanese, Giulia Marrone, Manuela Di Lauro, Anna Pietroboni Zaitseva, Daniela Palazzetti, Cristina Guerriero, Agostino Paolino, Giuseppa Pizzenti, Francesca Di Daniele, Annalisa Romani, Cartesio D'Agostini, Andrea Magrini, Nicola Biagio Mercuri, Nicola Di Daniele
Summary: The COVID-19 pandemic has caused over 100 million cases and 2 million deaths worldwide within a year. Palmitoylethanolamide (PEA) shows potential beneficial effects as an adjuvant therapy for SARS-CoV-2 infection, supported by ongoing clinical trials and studies showcasing its immunomodulatory, anti-inflammatory, neuroprotective, and pain-relieving effects.
Review
Medicine, General & Internal
Kim Devon Terga Le, Marcos Fabio DosSantos, Parisa Gazerani
Summary: Burning mouth syndrome (BMS) is a persistent intraoral burning sensation, commonly experienced by postmenopausal women. This systematic review found a higher prevalence of extraoral dryness in BMS patients, suggesting a potential central mechanism.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Pia Lopez-Jornet, Yolanda Collado, Alfonso Zambudio, Eduardo Pons-Fuster, Candela Castillo Felipe, Asta Tvarijonaviciute
Summary: Taste function was significantly different in patients with burning mouth syndrome (BMS) compared to controls, while there were no significant differences in smell function. Further studies are needed to improve management of chemosensory problems, mouth dryness, and oral health-related quality of life in BMS patients.
Review
Biochemistry & Molecular Biology
Marie Orliaguet, Laurent Misery
Summary: This study systematically reviewed literature supporting the neuropathic and psychogenic components of primary BMS, revealing the potential coexistence and importance of both factors in patients, and suggesting that BMS may be considered as nociplastic pain.
Review
Chemistry, Multidisciplinary
Francesco Spadari, Federica Pulicari, Martina Ghizzoni, Massimo Porrini, Moreno Bosotti, Matteo Pellegrini
Summary: Burning mouth syndrome (BMS) is a clinical condition with unclear etiopathogenesis, featuring chronic burning symptom with varying intensities. It predominantly affects females in pre-post-climactic phases and has a neuropathic basis associated with anxiety-depressive traits. Numerous treatments have been reported, but photobiomodulation therapy (PBMT) shows promising results, reducing symptoms in all studies. A scoping review of PBMT in BMS therapy was conducted, analyzing the outcome of the treatment.
APPLIED SCIENCES-BASEL
(2023)
Article
Geriatrics & Gerontology
Federica Canfora, Elena Calabria, Renato Cuocolo, Lorenzo Ugga, Giuseppe Buono, Gaetano Marenzi, Roberta Gasparro, Giuseppe Pecoraro, Massimo Aria, Luca D'Aniello, Michele Davide Mignogna, Daniela Adamo
Summary: The study aimed to assess the prevalence of cognitive impairment in patients with burning mouth syndrome and evaluate its relationship with potential predictors such as pain, mood disorders, blood biomarkers, and white matter changes. Patients with BMS showed impairments in most cognitive domains compared to controls, with higher frequencies of white matter changes in the temporal lobes. Early identification of cognitive impairment and associated factors may help clinicians in addressing potential risks for developing neurodegenerative disorders like Alzheimer's disease and vascular dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Federica Canfora, Elena Calabria, Gianrico Spagnuolo, Noemi Coppola, Niccolo Giuseppe Armogida, Cristina Mazzaccara, Domenico Solari, Luca D'Aniello, Massimo Aria, Giuseppe Pecoraro, Michele Davide Mignogna, Stefania Leuci, Daniela Adamo
Summary: This study analyzed a large sample of 500 BMS patients with different symptom combinations and found that xerostomia is the most frequent additional symptom. The study also identified various sociodemographic, psychological, and medical factors associated with different symptom subgroups. Further research is needed to understand the underlying causes and develop tailored treatment approaches for BMS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Candela Castillo-Felipe, Lorena Franco-Martinez, Asta Tvarijonaviciute, Pia Lopez-Jornet, Elsa Lamy
Summary: Burning mouth syndrome (BMS) is a chronic oral condition characterized by an intraoral burning sensation, taste alterations, and dry mouth sensations. Proteomic analysis of saliva from BMS patients reveals alterations in proteins related to stress, immune system, and inflammation, suggesting their involvement in BMS development. Saliva may serve as a valuable biofluid for studying and diagnosing BMS.
Article
Clinical Neurology
Viviana Versace, Paola Ortelli, Sabrina Dezi, Davide Ferrazzoli, Alessia Alibardi, Ilenia Bonini, Michael Engl, Roberto Maestri, Martina Assogna, Valentina Ajello, Elke Pucks-Faes, Leopold Saltuari, Luca Sebastianelli, Markus Kofler, Giacomo Koch
Summary: The objective of this study was to test the effects of co-ultramicronized palmitoylethanolamide/luteolin (PEA-LUT) on cortical activity in patients experiencing cognitive dysfunction and fatigue after COVID-19. The results showed that treatment with PEA-LUT improved long-interval intracortical inhibition (LICI) and cortical plasticity in these patients.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Psychiatry
Anahita Salehi, Parsa Namaei, Fateme TaghaviZanjani, Sayna Bagheri, Kamyar Moradi, Mohammad-Reza Khodaei Ardakani, Shahin Akhondzadeh
Summary: This study investigated the efficacy and safety of Palmitoylethanolamide (PEA) as an adjunctive therapy for negative symptoms in patients with stable schizophrenia. The results showed that PEA along with risperidone significantly improved negative symptoms and was well-tolerated.
PSYCHIATRY RESEARCH
(2022)
Review
Dentistry, Oral Surgery & Medicine
Maria Fernandez-Agra, Jose Gonzalez-Serrano, Miguel de Pedro, Leire Virto, Vito Carlo Alberto Caponio, Elena Ibanez-Prieto, Gonzalo Hernandez, Rosa Maria Lopez-Pintor
Summary: This systematic review aimed to evaluate the changes in salivary biomarkers in patients with burning mouth syndrome (BMS) compared to a control group (CG). The results showed that cortisol and alpha-amylase levels were higher in BMS patients, while dehydroepiandrosterone had contradictory results. Meta-analysis confirmed that cortisol levels were significantly higher in BMS.
Article
Dentistry, Oral Surgery & Medicine
Moon-Jong Kim, Jihoon Kim, Hong-Seop Kho
Summary: The study found that clonazepam therapy in combination with appropriate medications was effective for managing patients with burning mouth syndrome. The initial intensity of oral symptoms and psychological status were significantly associated with treatment outcomes.
Article
Oncology
Katia Rupel, Giulia Ottaviani, Margherita Gobbo, Augusto Poropat, Valentina Zoi, Serena Zaccchigna, Roberto Di Lenarda, Matteo Biasotto
JOURNAL OF CANCER EDUCATION
(2020)
Correction
Engineering, Biomedical
Luisa Zupin, Fulvio Celsi, Giulia Ottaviani, Sergio Crovella
LASERS IN MEDICAL SCIENCE
(2020)
Letter
Engineering, Biomedical
Giulia Ferri, Paola Maura Tricarico, Isabella Vincelli, Rossella Gratton, Giulia Ottaviani, Michele Boniotto, Luisa Zupin, Sergio Crovella
LASERS IN MEDICAL SCIENCE
(2020)
Review
Dermatology
Paola M. Tricarico, Luisa Zupin, Giulia Ottaviani, Katia Rupel, Fulvio Celsi, Giovanni Genovese, Michele Boniotto, Sergio Crovella, Angelo Marzano
GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
(2020)
Article
Biotechnology & Applied Microbiology
Nunzia Zanotta, Giulia Ottaviani, Giuseppina Campisciano, Augusto Poropat, Massimo Bovenzi, Katia Rupel, Margherita Gobbo, Manola Comar, Roberto Di Lenarda, Matteo Biasotto, Serena Zacchigna
Article
Biochemical Research Methods
Katia Rupel, Luisa Zupin, Silvia Brich, Mario Mardirossian, Giulia Ottaviani, Margherita Gobbo, Roberto Di Lenarda, Sabrina Pricl, Sergio Crovella, Serena Zacchigna, Matteo Biasotto
Summary: This study evaluated the antimicrobial efficacy of nanomicelles loaded with curcumin when activated by blue laser light in an antimicrobial photodynamic therapy. The results showed that the combination of blue laser APDT with CUR-SPM nanomicelles exhibited an effective synergistic activity against resistant species without toxicity on eukaryotic cells.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Geriatrics & Gerontology
Katia Rupel, Mauro Tettamanti, Filomena Vella, Giulia Fontanel, Roberto Di Lenarda, Matteo Biasotto, Gabriella Marcon
Summary: The study investigated oral health parameters of 25 centenarians from September 2017 to May 2019 and found that most centenarians were satisfied with their oral health, with difficulties in chewing and biting being the main causes of discomfort. It was observed that non-demented subjects had higher salivary flow and antioxidant capacity, and there was a higher proportion of supertasters among the centenarians.
Review
Oncology
Priya Patel, D. Paula Robinson, Christina Baggott, Paul Gibson, Gustaf Ljungman, Nicholas Massey, Guilia Ottaviani, Robert Phillips, Gabriel Revon-Riviere, Nathaniel Treister, Marie White, Sandra Cabral, Lee Dupuis, Lillian Sung
Summary: This study updates the clinical practice guideline for preventing oral mucositis in pediatric cancer or hematopoietic stem cell transplant patients, conducting multiple systematic reviews on the efficacy and adverse events of mucositis prevention.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Dentistry, Oral Surgery & Medicine
Michele Lodolo, Margherita Gobbo, Rossana Bussani, Lucio Torelli, Katia Rupel, Giulia Ottaviani, Augusto Poropat, Matteo Biasotto
Summary: This study aimed to describe the histopathology of oral lichen planus and oral lichenoid lesions, and found that oral lichenoid lesions had a higher number of eosinophils and plasma cells compared to oral lichen planus. However, there were no significant differences in demographic, anamnestic, and clinical data between the two conditions. Therefore, a mixed lichenoid inflammatory infiltrate can be used as a reliable histological feature for the diagnosis of oral lichenoid lesions.
Review
Oncology
Margherita Gobbo, Praveen R. Arany, Elisabetta Merigo, Rene-Jean Bensadoun, Alan Roger Santos-Silva, Luiz Alcino Gueiros, Giulia Ottaviani
Summary: The role of photobiomodulation (PBM) in head and neck cancer (HNC) treatment was investigated. PBM showed beneficial effects in improving quality of life (QoL), nutritional status, reducing pain and functional impairment. It may also reduce interruptions in radiotherapy (RT) and improve cancer treatment outcomes. However, it does not directly impact cancer survival/recurrences. PBM should be included in supportive cancer care for HNC patients due to its efficacy, safety, feasibility, and tolerability.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Psychology, Clinical
Daniela Adamo, Giulia Ottaviani, Federica Canfora, Stefania Leuci, Noemi Coppola, Giuseppe Pecoraro, Katia Rupel, Magdalena Theodora Bogdan Preda, Veronica Vello, Umberto Albert, Margherita Gobbo, Luca Guarda-Nardini, Amerigo Giudice, Elena Calabria, Massimo Aria, Luca D'Aniello, Matteo Biasotto, Michele Davide Mignogna
Summary: The COVID-19 pandemic and lockdown measures have significantly increased feelings of loneliness in both patients with burning mouth syndrome (BMS) and the general population. BMS patients experienced lower satisfaction in relationships with relatives and perceived less social support compared to the controls. Loneliness in the BMS group was significantly correlated with age, higher education level, stress, and lower satisfaction in relationships with relatives, while in the control group, only stress was significant.
DEPRESSION AND ANXIETY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Margherita Gobbo, Giulia Ottaviani, Katia Rupel, Valentina Zoi, Roberto Di Lenarda, Matteo Biasotto, Augusto Poropat
MINERVA STOMATOLOGICA
(2020)
Article
Dentistry, Oral Surgery & Medicine
Margherita Gobbo, Maurizio Franco, Giulia Ottaviani, Katia Rupel, Augusto Poropat, Matteo Biasotto