Article
Oncology
Toru Sakatani, Yuki Kita, Masakazu Fujimoto, Takeshi Sano, Akihiro Hamada, Kenji Nakamura, Hideaki Takada, Takayuki Goto, Atsuro Sawada, Shusuke Akamatsu, Takashi Kobayashi
Summary: The study investigated the expression of immune markers in the tumor microenvironment of 26 advanced urothelial carcinoma patients receiving Pembrolizumab treatment. High levels of CD8(+) tumor-infiltrating lymphocytes were associated with favorable objective responses, progression-free survival, and overall survival. Additionally, high interferon-gamma (IFN gamma) expression levels were linked to longer post-progression survival. Low infiltration of CD8(+) TILs and low IFN gamma expression were identified as an independent prognostic factor for an unfavorable response to Pembrolizumab.
Article
Biochemical Research Methods
Hao Zhang, Nan Zhang, Wantao Wu, Ran Zhou, Shuyu Li, Zeyu Wang, Ziyu Dai, Liyang Zhang, Zaoqu Liu, Jian Zhang, Peng Luo, Zhixiong Liu, Quan Cheng
Summary: A computational framework was used to identify immune cell-specific long noncoding RNAs (lncRNAs) in glioblastoma (GBM) and develop a signature that could predict survival outcomes and response to immunotherapy. This signature showed superior performance compared to previous signatures and was correlated with immune cell infiltration and immunotherapy response.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Oncology
Cong Zhou, Xiaojiao Cheng, Shuiping Tu
Summary: ICIs are revolutionizing cancer immunotherapy, with significant effects on melanoma and NSCLC. In the case of CRC, patients with high immunogenicity benefit from ICIs, while those with low immunogenicity do not. Ongoing clinical trials aim to improve response to ICIs in CRC patients through better selection and combination strategies.
Article
Cell Biology
Syn Kok Yeo, Michael Haas, Kanakaraju Manupati, Mingang Hao, Fuchun Yang, Song Chen, Jun-Lin Guan
Summary: This study identified a novel sensitization strategy for breast cancer treatment by activating the TBK-IFN pathway. Disrupting the selective autophagy function was found to activate the AZI2-TBK1-IFN signaling pathway, making breast cancer more responsive to immunotherapy.
Article
Oncology
Won Ik Seo, Chan Ho Lee, Soo Jin Jung, Dae Sim Lee, Ha Young Park, Dae Hoon Jeong, Wansuk Kim, Jae Il Chung, Inhak Choi
Summary: This study investigated the expression of VISTA and PD-L1 in bladder cancer, finding a correlation between VISTA expression in ICs and clinicopathologic variables. The results suggest VISTA as a potential immunotherapeutic target and immunologic biomarker in bladder cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Review
Medicine, General & Internal
Robert J. Walsh, David S. P. Tan
Summary: Immune checkpoint inhibitors (ICI) are considered a potential option for the treatment of cervical cancer, but the majority of patients do not benefit from their use. Challenges in clinical application include the role of biomarkers in selecting ICI use, mechanisms of resistance, and strategies to overcome resistance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Rongbin Qi, Yingying Yu, Mo Shen, Dongqing Lv, Susu He
Summary: This article summarizes the immune escape mechanisms and role of biomarkers in ALK-mutated NSCLC. It also evaluates the clinical studies of novel immune combination regimens and discusses the prospects of in vivo application of novel immune technologies in patients with ALK rearranged NSCLC.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Immunology
Senthilnath Lakshmanachetty, Siddhartha S. Mitra
Summary: The dynamic changes in immune cell infiltration during the progression of glioblastoma (GBM) are still not well understood. Single-cell RNA sequencing and flow cytometry are now being used to deconstruct the tumor immune microenvironment in early- and late-stage GBMs.
Article
Oncology
Richard J. Straker, Katharine Krupp, Cimarron E. Sharon, Alexandra S. Thaler, Nicholas J. Kelly, Emily Y. Chu, David E. Elder, Xiaowei Xu, John T. Miura, Giorgos C. Karakousis
Summary: The study investigated the prognostic impact of primary tumor-infiltrating lymphocytes (TILs) in melanoma patients, showing associations with regression rates, histology, and sentinel lymph node positivity. However, no significant associations were found with disease-specific survival. The presence of brisk TILs may be associated with an advantage in recurrence-free survival, but further studies are needed to confirm this relationship.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Immunology
Johnny Duerinck, Sandra Tuyaerts, Kiavash Movahedi, Bart Neyns
Summary: Despite efforts to improve outcomes, glioblastoma prognosis remains poor. Immunotherapy, including immune checkpoint inhibition, has limited efficacy in glioblastoma due to its low immunogenicity and strong immunosuppressive tumor microenvironment. This review discusses strategies to overcome immune suppression in glioblastoma, highlighting the potential advantages of incorporating surgical resection in immunotherapy clinical trials and the use of combination strategies for an effective immunological response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Abolfazl Maghrouni, Maryam Givari, Mohammad Jalili-Nik, Hamid Mollazadeh, Bahram Bibak, Mohammad Montazami Sadeghi, Amir R. Afshari, Thomas P. Johnston, Amirhossein Sahebkar
Summary: GBM, an immunosuppressive brain tumor, remains difficult to manage despite current treatments. Immunotherapy, particularly checkpoint inhibitors, has potential for GBM treatment but faces challenges due to the tumor's immunosuppressive microenvironment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Tianrui Yang, Ziren Kong, Wenbin Ma
Summary: Immune checkpoint inhibitors have revolutionized tumor immunotherapy, but face challenges in the treatment of glioblastoma due to its unique immunosuppressive characteristics. Recent clinical studies are focusing on combination therapies involving standard treatments, targeted therapies, and other immunotherapies to improve outcomes for patients with GBM.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Oncology
Ying-Chun Shen, Ching-Ping Yeh, Yung-Ming Jeng, Chiun Hsu, Chih-Hung Hsu, Zhong-Zhe Lin, Yu-Yun Shao, Li-Chun Lu, Tsung-Hao Liu, Chien-Hung Chen, Ann-Lii Cheng
Summary: In patients with advanced hepatocellular carcinoma, tumor-infiltrating CD8 tissue-resident memory T cells (T-RM) or their subsets do not provide additional advantages in predicting the efficacy of immunotherapy compared to total tumor-infiltrating CD8 T cells.
Article
Cell Biology
Xiangzheng Liu, Xueqian Shang, Jian Li, Shijie Zhang
Summary: The study found that B cells and DC1 could predict the prognosis and immune checkpoint blockade efficacy of LUAD and LUSC patients respectively. Tissues with high infiltration of B cells and DC1 may benefit more from ICB therapy, and certain genes and KEGG pathways may serve as novel immunotherapy targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wentao Feng, Mingrong Zuo, Wenhao Li, Siliang Chen, Zhihao Wang, Yunbo Yuan, Yuan Yang, Yanhui Liu
Summary: In this study, a novel score system based on arginine metabolism, ArMRS, was constructed, which showed good efficacy in prognosis prediction and strong potential to predict unique immunological features and resistance to immunotherapy in IDH-wildtype glioblastoma. Moreover, ArMRS was correlated with the expression of multiple immunotherapy targets and infiltration of cytotoxic T cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Nursing
Soomin Hong, JuHee Lee, Jiyeon Lee, Jong Hee Chang, Chang Gi Park, Tae Hee Kim
Summary: This study aims to identify the characteristics of uncertainty in illness among people with primary malignant brain tumors through a mixed-methods systematic review. The results reveal that the progression of uncertainty in people with primary malignant brain tumors is complex and ambiguous due to physical, psychological, and social risk factors. The proposed model provides directions for nursing practice and future research.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Clinical Neurology
Myung Ji Kim, Hyun Ho Jung, Yong Bae Kim, Jong Hee Chang, Jin Woo Chang, Keun Young Park, Won Seok Chang
Summary: This study retrospectively analyzed data from 453 AVM patients and found that combined neoadjuvant or adjuvant embolization with GKRS treatment had better outcomes compared to GKRS alone, reducing the risk of bleeding during the latency period. Additionally, the study also found that neoadjuvant embolization may be a negative predictive factor for complete obliteration of AVMs more than 36 months after GKRS.
Article
Oncology
Yae Won Park, Kyunghwa Han, Sooyon Kim, Hyuk Kwon, Sung Soo Ahn, Ju Hyung Moon, Eui Hyun Kim, Jinna Kim, Seok-Gu Kang, Jong Hee Chang, Se Hoon Kim, Seung-Koo Lee
Summary: This study investigated prognostic factors in adult glioma patients with leptomeningeal metastases. It found that chemotherapy and antiangiogenic therapy were associated with longer overall survival, while male sex and initial leptomeningeal metastases were associated with shorter survival.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Won Ick Chang, Hwa Kyung Byun, Joo Ho Lee, Chul-Kee Park, In Ah Kim, Chae-Yong Kim, Jong Hee Chang, Seok-Gu Kang, Sang Hyung Lee, Yuki Kuranari, Ryota Tamura, Masahiro Toda, Chan Woo Wee, Hong In Yoon
Summary: This study investigated the prognostic impact of serum biomarkers in patients with newly diagnosed atypical meningiomas. The findings revealed that tumor size, surgical resection, and postoperative serum markers were associated with the progression/recurrence rate. Further studies are needed to validate their clinical significance and biological background.
Article
Oncology
Junseong Park, Jin-Kyoung Shim, Mirae Lee, Dokyeong Kim, Seon-Jin Yoon, Ju Hyung Moon, Eui Hyun Kim, Jeong-Yoon Park, Jong Hee Chang, Seok-Gu Kang
Summary: In this study, we identified PCBP1, STAT3, and SRF as transcription factors that collectively regulate invasion-related genes in glioblastoma (GBM). Knockdown of these TFs reduced the invasiveness of GBM tumorspheres and prolonged survival in a mouse model. These findings suggest that targeting these TFs could be a potential therapeutic approach for GBM.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Beomseok Sohn, Kisung Park, Sung Soo Ahn, Yae Won Park, Seung Hong Choi, Seok-Gu Kang, Se Hoon Kim, Jong Hee Chang, Seung-Koo Lee
Summary: A radiomics model based on dynamic contrast-enhanced (DCE) MRI was developed and validated to predict epidermal growth factor receptor (EGFR) amplification in patients with glioblastoma, isocitrate dehydrogenase (IDH) wildtype.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Immunology
Hoyoung Lee, Min Kyung Jung, Ji Yun Noh, Su-Hyung Park, Yeonseok Chung, Sang-Jun Ha, Eui-Cheol Shin
Summary: The first conference on 'Infection and Immunity' focused on the biology of CD8+ T cells in the context of viral disease and cancer.
Article
Oncology
Kyungwon Kim, Dong Kyu Kim, Ju Hyung Moon, Eui Hyun Kim, Sun Ho Kim, Cheol Ryong Ku, Eun Jig Lee
Summary: This study evaluated whether dexamethasone (DEX) suppression can improve the localization of adrenocorticotropic hormone-secreting adenomas in the pituitary gland in Cushing's disease (CD) using fluorine-fluoro-deoxy-glucose (18F-FDG) positron emission tomography (PET). The results showed that DEX suppression did not improve PET localization in patients with CD.
Editorial Material
Immunology
Yong Woo Jung, Su-Hyung Park, Chang-Duk Jun
Review
Immunology
Joon Seok, Sung-Dong Cho, Seong Jun Seo, Su-Hyung Park
Summary: Memory T cells are generated upon recognition of foreign antigens and provide fast and effective protection against reinfections. However, there is a population of memory-like T cells called virtual memory T (T-VM) cells that acquire a memory phenotype without foreign antigens. While T-VM cells have been reported to play a role in first-line defense to bacterial or viral infections, their roles in immune-related diseases such as infections and cancers are still largely unknown. This review discusses the current understanding of T-VM cells, focusing on their distinct characteristics, immunological properties, and potential roles in immune-related diseases.
Article
Medicine, General & Internal
Junseong Park, Dongkyu Lee, Jin-Kyoung Shim, Seon-Jin Yoon, Ju Hyung Moon, Eui Hyun Kim, Jong Hee Chang, Su -Jae Lee, Seok-Gu Kang
Summary: This study reveals the role of ventricle-derived mesenchymal stem-like cells (vMSLCs) in promoting the invasiveness of GBM tumorspheres. It provides important insights into how GBM cells acquire infiltrative features through vMSLCs.
YONSEI MEDICAL JOURNAL
(2023)
Article
Oncology
Beomseok Sohn, Kisung Park, Sung Soo Ahn, Yae Won Park, Seung Hong Choi, Seok-Gu Kang, Se Hoon Kim, Jong Hee Chang, Seung-Koo Lee
Summary: The study developed and validated a radiomics model based on dynamic contrast-enhanced (DCE) MRI to predict EGFR amplification in glioblastoma patients. The radiomics model using the K-trans map showed higher accuracy than conventional MRI in predicting EGFR amplification.
JOURNAL OF NEURO-ONCOLOGY
(2023)