Journal
CLINICAL BIOCHEMISTRY
Volume 65, Issue -, Pages 45-52Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2019.01.002
Keywords
Hepatocellular carcinoma; TACE response; Serum microRNAs; Prognostic markers
Categories
Funding
- Texas A&M Health Science Center Rangel College of Pharmacy
- NIH/NCI [R21CA194750]
- Science and Technology Development Fund (STDF), Ministry of Higher Education and Scientific Research, Egypt [1729]
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Background: A number of hepatocellular carcinoma (HCC) patients have developed resistance against transcatheter arterial chemoembolization (FACE) treatment. In this study, we aimed to develop a panel of microRNAs (miRs) biomarkers to predict clinical outcomes in HCC patients after TACE treatment. Methods: The expression level of twenty miRs was evaluated in FFPE tissues collected from 33 HCC patients. We selected four differentially expressed miRs in TACE-responders versus non-responders and re-assessed their expression in 51 serum samples. The expressions of miRs associated with overall survival (OS), progression-free survival (PFS), and treatment outcomes were investigated. The diagnostic accuracy of these miRs in predicting patients' response to TACE was also evaluated. Results: The baseline of miR-106b, miR-107 and miR-133b was significantly elevated (p < .001) in sera of TACE-responders while miR-26a was elevated (p < .001) in non-responders. miR-26a and miR-133b recorded the highest diagnostic performance as individual classifiers in response to TACE (AUC = 1.0 and 100% sensitivity and specificity). Intriguingly, miR-133b distinguished complete responders from partial responders and non-responders (AUC >= 0.90). The PFS was improved (p < .05) in the high expression group of miR-31, miR-200b, miR-133b and miR-181a over their low expression group. Conclusion: Circulating miR-133b, miR-26a, miR-107 and miR-106 in serum are potential candidates to be utilized as prognostic biomarkers for predication of TACE treatment outcomes in HCC patients.
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