Article
Cardiac & Cardiovascular Systems
Hao Zhou, Yi Zhu, Zhongman Zhang, Yong Mei, Jinru Lv, Gang Zhang, Wei Li, Xufeng Chen
Summary: The study identified that independent risk factors for the occurrence of ventricular fibrillation/ventricular tachycardia within 72 hours of VA-ECMO initiation included an initial heart rate > 120 b.p.m. and hyperlactataemia. Additionally, the occurrence of VF/VT did not impact the survival rate of patients receiving VA-ECMO support, and defibrillation did not significantly improve overall patient prognosis.
Article
Cardiac & Cardiovascular Systems
Thomas Bonnin, Pierre Roumegou, Soumaya Sridi, Saagar Mahida, Aurelien Bustin, Josselin Duchateau, Romain Tixier, Nicolas Derval, Thomas Pambrun, Ghassen Chniti, Takamitsu Takagi, Tsukasa Kamakura, Philipp Krisai, Clementine Andre, Remi Chauvel, Meleze Hocini, Michel Haissaguerre, Pierre Jais, Hubert Cochet, Frederic Sacher
Summary: This study assessed the prevalence, risk factors, and management of intra-cardiac thrombus in patients referred for scar-related VT ablation. The results showed that 11% of patients had cardiac thrombi, highlighting the importance of systematic thrombus screening to minimize the risk of embolism.
Article
Cardiac & Cardiovascular Systems
Jonas Rusnak, Michael Behnes, Linda Reiser, Tobias Schupp, Armin Bollow, Thomas Reichelt, Martin Borggrefe, Dominik Ellguth, Niko Engelke, Ibrahim El-Battrawy, Uzair Ansari, Max Barre, Kathrin Weidner, Julian Mueller, Christian Barth, Dirk Grosse Meininghaus, Muharrem Akin, Thomas Bertsch, Gabriel Taton, Ibrahim Akin
Summary: Atrial fibrillation is associated with increased rates of recurrent ventricular tachyarrhythmias and appropriate device therapies in implantable cardioverter defibrillator recipients with ventricular tachyarrhythmias.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Ameenathul M. M. Fawzy, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Gregory Y. H. Lip, Laurent Fauchier
Summary: This study investigated the association between atrial fibrillation (AF) and ventricular arrhythmias (VAs) and sudden death in hospitalized patients in France. The results showed that AF patients had significantly higher incidence and risk of VAs and cardiac arrest compared to non-AF patients. This association remained significant after adjusting for confounders, indicating a clear association between AF and VAs and sudden death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Michael R. Rehorn, Eric Black-Maier, Rahul Loungani, Sounok Sen, Albert Y. Sun, Daniel J. Friedman, Jason Koontz, Jacob N. Schroder, Carmelo A. Milano, Michel G. Khouri, Jason N. Katz, Chetan B. Patel, Sean D. Pokorney, James P. Daubert, Jonathan P. Piccini
Summary: Electrical storms occur in 1 in 10 patients after left ventricular assist device implantation and are associated with higher mortality rates. Risk factors for electrical storms include a history of ventricular arrhythmias, ventricular tachycardia ablation, antiarrhythmic drug use, and perioperative mechanical circulatory support. Management strategies for electrical storms post LVAD implantation remain uncertain.
Article
Medicine, General & Internal
Zuolin Lu, Elif Aribas, Sven Geurts, Jeanine E. Roeters van Lennep, M. Arfan Ikram, Maxime M. Bos, Natasja M. S. de Groot, Maryam Kavousi
Summary: This study found that irregular menstrual cycles, nulliparity, and multiparity were associated with a higher risk of new-onset AF among women.
Article
Veterinary Sciences
Carlo Guglielmini, Carlotta Valente, Giovanni Romito, Chiara Mazzoldi, Marco Baron Toaldo, Marlos Goncalves Sousa, Marcela Wolf, Tamyris Beluque, Oriol Domenech, Valentina Patata, Francesco Porciello, Paolo Ferrari, Domenico Caivano, Barbara Contiero, Helen Poser
Summary: The aim of this study was to identify risk factors for the development of atrial fibrillation in dogs with an echocardiographic diagnosis of dilated cardiomyopathy (DCM). The results showed that increased left atrial diameter and presence of right atrial enlargement were significant predictors of atrial fibrillation development.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Andrei Alexandru Mircea, Mihaela Rusu, Elisa Anamaria Liehn, Octavian Bucur
Summary: This review focuses on newly developed strategies, such as vernakalant and stereotactic ablative therapy, for the treatment of arrhythmias. These therapies are important for improving the management of atrial fibrillation and ventricular tachycardia, offering higher success rates and lower costs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Sheldon Cheskes, P. Richard Verbeek, Ian R. R. Drennan, Shelley L. L. McLeod, Linda Turner, Ruxandra Pinto, Michael Feldman, Matthew Davis, Christian Vaillancourt, Laurie J. J. Morrison, Paul Dorian, Damon C. C. Scales
Summary: This study found that among patients with shock-refractory ventricular fibrillation, survival to hospital discharge occurred more frequently in those who received double sequential external defibrillation or vector-change defibrillation compared to standard defibrillation.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kenichiro Suzuki, Yasunori Inoue, Kazuo Ogawa, Tomohisa Nagoshi, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura
Summary: This study investigated the effects of coronary risk factors on left ventricular size and cardiac function using structure equation modeling. It found that each risk factor directly affected the shape of the heart. Managing risk factors is crucial in reducing the heart failure pandemic, as vascular risk and heart failure risk are likely to evolve simultaneously.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Tejas Deshmukh, Joshua G. Kovoor, Karen Byth, Clara K. Chow, Sarah Zaman, James J. H. Chong, Gemma A. Figtree, Aravinda Thiagalingam, Pramesh Kovoor
Summary: In patients with recent STEMI and impaired left ventricular function, the presence of any SMuRFs, apart from being a current smoker, conferred an increased risk of inducible VT at EPS. These results highlight the need to modify SMuRFs in this high-risk subset of patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lucas Malta Westergaard, Amna Alhakak, Rasmus Rorth, Emil L. Fosbol, Soren L. Kristensen, Jesper H. Svendsen, Claus Graff, Jonas B. Nielsen, Gunnar H. Gislason, Lars Kober, Christian Torp-Pedersen, Christina J. Y. Lee, Peter E. Weeke
Summary: This study aimed to evaluate the risk of new-onset heart failure and all-cause mortality in patients with atrial fibrillation (AF) according to ventricular rate. The results showed that patients with ventricular rates ≥100 bpm had a higher risk of new-onset heart failure and all-cause mortality compared to those with rates of 60-79 bpm. This suggests that ventricular rates ≥100 bpm may be associated with increased risk in AF patients receiving rate control drug treatment.
Article
Cardiac & Cardiovascular Systems
Heather M. M. Giacone, Henry Chubb, Anne M. M. Dubin, Kara S. S. Motonaga, Scott R. R. Ceresnak, William R. R. Goodyer, Debra Hanisch, Anthony V. V. Trela, Nicole Boramanand, Erin Lencioni, Derek Boothroyd, Anna Graber-Naidich, Gail Wright, Christiane Haeffele, Seth A. A. Hollander, Doff B. B. McElhinney, Michael Ma, Frank L. L. Hanley, Sharon Chen
Summary: This study assessed the incidence of ventricular arrhythmias (VAs) in Fontan patients and their implications on transplant-free survival. The results showed that 11% of patients were diagnosed with VA, and VA was highly associated with the risk of transplant or death. Older age at Fontan and a history of right ventricular to pulmonary artery conduit were risk factors for VA. A diagnosis of VA in Fontan patients should lead to increased clinical surveillance.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Raphael Rosso, Aviram Hochstadt, Dana Viskin, Ehud Chorin, Arie Lorin Schwartz, Oholi Tovia-Brodie, Avishag Laish-Farkash, Ofer Havakuk, Lior Gepstein, Shmuel Banai, Sami Viskin
Summary: Distinct types of polymorphic ventricular tachycardia respond differently to therapy, and this study aimed to define the electrocardiographic characteristics of different forms of polymorphic VT. The study group included patients with coronary artery disease and spontaneous polymorphic VT triggered by short-coupled extrasystoles, as well as patients with ventricular fibrillation during acute myocardial infarction and drug-induced TdP. Pseudo-TdP patients had a longer QT interval compared to those with normal QT and a shorter QT interval compared to true TdP patients, with the coupling interval of the ectopic beat playing a crucial role in differentiating these groups.
EUROPEAN HEART JOURNAL
(2021)
Article
Peripheral Vascular Disease
Alexander C. Egbe, William R. Miranda, Carole A. Warnes, Crystal Bonnichsen, Juan Crestanello, Jason H. Anderson, Heidi M. Connolly
Summary: The study aimed to analyze procedural outcomes, hemodynamic improvement, regression of left ventricular mass hypertrophy, and cardiovascular events following repair of coarctation of aorta (COA). Results indicated that persistent hypertension post-repair was associated with suboptimal left ventricular mass index regression and cardiovascular events, suggesting that optimal blood pressure control with medical therapy may lead to improved outcomes.
Article
Biochemistry & Molecular Biology
Istvan Koncz, Arie O. Verkerk, Michele Nicastro, Ronald Wilders, Tamas Arpadffy-Lovas, Tibor Magyar, Noemi Toth, Norbert Nagy, Micah Madrid, Zexu Lin, Igor R. Efimov
Summary: The study found that ACh can influence the repolarization in human ventricular cardiomyocytes by affecting I-Kr, leading to prolonged action potential duration.
Article
Cardiac & Cardiovascular Systems
Kedar Aras, Anna Gams, Ndeye Rokhaya Faye, Jaclyn Brennan, Katherine Goldrick, Jinghua Li, Yishan Zhong, Chia-Han Chiang, Elizabeth H. Smith, Megan D. Poston, Jacqueline Chivers, Peter Hanna, Shumpei Mori, Olujimi A. Ajijola, Kalyanam Shivkumar, Donald B. Hoover, Jonathan Viventi, John A. Rogers, Olivier Bernus, Igor R. Efimov
Summary: The electrophysiology of human right ventricular outflow tract (RVOT) is characterized by shorter action potential duration and the arrhythmogenic effects of adrenergic stimulation can be attenuated by cholinergic stimulation. Additionally, arrhythmia wave fronts and rotors in RVOT are relatively more organized in the endocardium compared to the epicardium.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Auriane C. Ernault, Arie O. Verkerk, Jason D. Bayer, Kedar Aras, Pablo Montanes-Agudo, Rajiv A. Mohan, Marieke Veldkamp, Mathilde R. Rivaud, Rosan de Winter, Makiri Kawasaki, Shirley C. M. van Amersfoorth, Eva R. Meulendijks, Antoine H. G. Driessen, Igor R. Efimov, Joris R. de Groot, Ruben Coronel
Summary: The accumulation of epicardial adipose tissue (EAT) is associated with cardiac arrhythmias, and the secretome of EATs has effects on cardiac electrophysiology. In this study, it was found that incubation with EATs decreases the expression of the potassium channel subunit Kcnj2 and the inward rectifier K+ current I-K1 in cardiomyocytes, leading to depolarization of the resting membrane potential. EATs also decrease the expression of connexin43 and alter electrical cell-cell coupling.
Article
Multidisciplinary Sciences
Dmitry Rybashlykov, Jaclyn Brennan, Zexu Lin, Igor R. Efimov, Roman Syunyaev
Summary: Fluorescent imaging, an important technique to study cardiac or neural electrophysiology, is usually expensive. This study presents a complete solution, priced below $1,000, with an open-source software. The results show that the camera used in this study is capable of recording action potential with sufficient signal-to-noise ratio for accurate measurements and research.
Article
Multidisciplinary Sciences
Yeon Sik Choi, Hyoyoung Jeong, Rose T. Yin, Raudel Avila, Anna Pfenniger, Jaeyoung Yoo, Jong Yoon Lee, Andreas Tzavelis, Young Joong Lee, Sheena W. Chen, Helen S. Knight, Seungyeob Kim, Hak-Young Ahn, Grace Wickerson, Abraham Vazquez-Guardado, Elizabeth Higbee-Dempsey, Bender A. Russo, Michael A. Napolitano, Timothy J. Holleran, Leen Abdul Razzak, Alana N. Miniovich, Geumbee Lee, Beth Geist, Brandon Kim, Shuling Han, Jaclyn A. Brennan, Kedar Aras, Sung Soo Kwak, Joohee Kim, Emily Alexandria Waters, Xiangxing Yang, Amy Burrell, Keum San Chun, Claire Liu, Changsheng Wu, Alina Y. Rwei, Alisha N. Spann, Anthony Banks, David Johnson, Zheng Jenny Zhang, Chad R. Haney, Sung Hun Jin, Alan Varteres Sahakian, Yonggang Huang, Gregory D. Trachiotis, Bradley P. Knight, Rishi K. Arora, Igor R. Efimov, John A. Rogers
Summary: This study presents a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden.
Article
Biology
Sharon A. George, Zexu Lin, Igor R. Efimov
Summary: In this study, triple-parametric optical mapping was used to simultaneously assess multiple parameters in cardiac physiology and pathophysiology. The technique was applied to study the effects of drugs on cardiac function and to investigate metabolic and electrical changes during ischemia and reperfusion.
COMMUNICATIONS BIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Sofian N. Obaid, Zhiyuan Chen, Micah Madrid, Zexu Lin, Jinbi Tian, Camille Humphreys, Jillian Adams, Nicolas Daza, Jade Balansag, Igor R. Efimov, Luyao Lu
Summary: Researchers have designed a soft implantable electro-optical cardiac device that allows simultaneous high-precision electrical mapping and optogenetics, providing real-time spatiotemporal mapping and control of cardiac rhythm and function. This technology has broad applications in basic and clinical cardiology.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Multidisciplinary Sciences
Jokubas Ausra, Micah Madrid, Rose T. Yin, Jessica Hanna, Suzanne Arnott, Jaclyn A. Brennan, Roberto Peralta, David Clausen, Jakob A. Bakall, Igor R. Efimov, Philipp Gutruf
Summary: Monitoring and control of cardiac function are crucial for studying cardiovascular pathophysiology and developing treatments. However, it is currently challenging to control the heart in freely moving small animal subjects. This study introduces a wireless battery-free device that enables real-time cardiac control and multisite stimulation, allowing optogenetic modulation of the entire rodent heart.
Meeting Abstract
Cardiac & Cardiovascular Systems
Auriane Ernault, Arie Verkerk, Jason D. Bayer, Kedar Aras, Pablo Montanes-Agudo, Rajiv A. Mohan, Marieke Veldkamp, Mathilde Rivaud, Makiri Kawasaki, Shirley C. M. van Amersfoorth, Eva R. Meulendijks, Antoine H. G. Driessen, Igor R. Efimov, Joris R. de Groot, Ruben Coronel
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Biochemical Research Methods
Rose T. Yin, Sheena W. Chen, K. Benjamin Lee, Yeon Sik Choi, Jahyun Koo, Quansan Yang, Michael A. Napolitano, Jokubas Ausra, Timothy J. Holleran, Jessica B. Lapiano, E. Alex Waters, Anlil Brikha, Grant Kowalik, Alana N. Miniovich, Helen S. Knight, Bender A. Russo, Alexi Kiss, Alejandro Murillo-Berlioz, Tatiana Efimova, Chad R. Haney, Philipp Gutruf, John A. Rogers, Gregory D. Trachiotis, Igor R. Efimov
Summary: Genetic engineering and implantable bioelectronics have revolutionized the study of cardiovascular physiology and diseases. However, combining these two approaches in the same species has been challenging. Researchers have recently developed miniature cardiac bioelectronic devices suitable for mice and rats, enabling the integration of molecular tools and implantable devices. The successful implementation of these devices requires reliable microsurgery techniques that minimize disruption to native physiology.
Article
Physiology
Girish S. Ramlugun, Kanchan Kulkarni, Nestor Pallares-Lupon, Bastiaan J. Boukens, Igor R. Efimov, Edward J. Vigmond, Olivier Bernus, Richard D. Walton
Summary: This study establishes an automated activation time-based analytical framework for optical mapping images of complex electrical behavior. The framework is able to accurately process high pacing frequency or irregular activity signals and provide detailed quantitative assessment and visualization.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Physiology
Anna Gams, Alejandro Nevarez, Stephanie Perkail, Aileen Venegas, Sharon A. George, Tatiana Efimova, Igor R. Efimov
Summary: Abnormal heart rate variability (HRV) is commonly observed in cancer patients, but the sex-specific effects of cancer on cardiac function remain underexplored. This study investigated the sex-specific effects of pancreatic and liver cancers on cardiac function in transgenic mouse models. The results showed that female cancer mice had higher HRV, while male cancer mice showed increased HRV only in the liver cancer group. Female cancer mice also had lower median HR and higher HRV. These findings highlight the importance of considering sex when using HRV as a cancer biomarker.
PHYSIOLOGICAL REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Sharon A. George, Alexi Kiss, Katy Anne Trampel, Sofian N. Obaid, Lichao Tang, Igor R. Efimov, Tatiana Efimova
Summary: This study reveals the sex- and isoform-specific roles of p38 MAPKs in DOX-induced cardiac injury. Global p38 beta deletion aggravated DIC and worsened cardiac function deterioration, while cardiomyocyte-specific p38 alpha deletion improved survival of male mice. These findings have important implications for understanding and treating DIC.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sharon A. George, Jaclyn A. Brennan-McLean, Katy A. Trampel, Eric Rytkin, N. Rokhaya Faye, Bjorn C. Knollmann, Igor R. Efimov
Summary: The study investigated the antiarrhythmic potential of dantrolene, a RyR inhibitor, in human hearts. Results showed that dantrolene treatment reduced premature ventricular contractions (PVC) and reversed arrhythmogenic substrates in the heart, suggesting it could be a novel therapy for patients with structural heart diseases.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Sharon Ann George, Katy Trampel, Kelsey Brunner, Igor R. Efimov